LOCUS       NM_015027               4598 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens pyridoxal dependent decarboxylase domain containing 1
            (PDXDC1), transcript variant 1, mRNA.
ACCESSION   NM_015027 XM_352158
VERSION     NM_015027.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4598)
  AUTHORS   Cannon-Albright,L.A., Farnham,J.M., Stevens,J., Teerlink,C.C.,
            Palmer,C.A., Rowe,K., Cessna,M.H. and Blumenthal,D.T.
  TITLE     Genome-wide analysis of high-risk primary brain cancer pedigrees
            identifies PDXDC1 as a candidate brain cancer predisposition gene
  JOURNAL   Neuro Oncol 23 (2), 277-283 (2021)
   PUBMED   32644145
  REMARK    GeneRIF: Genome-wide analysis of high-risk primary brain cancer
            pedigrees identifies PDXDC1 as a candidate brain cancer
            predisposition gene.
REFERENCE   2  (bases 1 to 4598)
  AUTHORS   Feldcamp,L.A., Boutros,P.C., Raymond,R., Fletcher,P.J.,
            Nobrega,J.N. and Wong,A.H.C.
  TITLE     Pdxdc1 modulates prepulse inhibition of acoustic startle in the
            mouse
  JOURNAL   Transl Psychiatry 7 (5), e1125 (2017)
   PUBMED   28485732
  REMARK    GeneRIF: This study's results suggest that Pdxdc1 may regulate
            acoustic pre-pulse inhibition and could be a good target for
            further investigation as a potential treatment for schizophrenia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4598)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4598)
  AUTHORS   Guan,W., Steffen,B.T., Lemaitre,R.N., Wu,J.H.Y., Tanaka,T.,
            Manichaikul,A., Foy,M., Rich,S.S., Wang,L., Nettleton,J.A.,
            Tang,W., Gu,X., Bandinelli,S., King,I.B., McKnight,B., Psaty,B.M.,
            Siscovick,D., Djousse,L., Chen,Y.I., Ferrucci,L., Fornage,M.,
            Mozafarrian,D., Tsai,M.Y. and Steffen,L.M.
  TITLE     Genome-wide association study of plasma N6 polyunsaturated fatty
            acids within the cohorts for heart and aging research in genomic
            epidemiology consortium
  JOURNAL   Circ Cardiovasc Genet 7 (3), 321-331 (2014)
   PUBMED   24823311
REFERENCE   5  (bases 1 to 4598)
  AUTHORS   Shin,S.Y., Fauman,E.B., Petersen,A.K., Krumsiek,J., Santos,R.,
            Huang,J., Arnold,M., Erte,I., Forgetta,V., Yang,T.P., Walter,K.,
            Menni,C., Chen,L., Vasquez,L., Valdes,A.M., Hyde,C.L., Wang,V.,
            Ziemek,D., Roberts,P., Xi,L., Grundberg,E., Waldenberger,M.,
            Richards,J.B., Mohney,R.P., Milburn,M.V., John,S.L., Trimmer,J.,
            Theis,F.J., Overington,J.P., Suhre,K., Brosnan,M.J., Gieger,C.,
            Kastenmuller,G., Spector,T.D. and Soranzo,N.
  CONSRTM   Multiple Tissue Human Expression Resource (MuTHER) Consortium
  TITLE     An atlas of genetic influences on human blood metabolites
  JOURNAL   Nat Genet 46 (6), 543-550 (2014)
   PUBMED   24816252
REFERENCE   6  (bases 1 to 4598)
  AUTHORS   Willer,C.J., Schmidt,E.M., Sengupta,S., Peloso,G.M., Gustafsson,S.,
            Kanoni,S., Ganna,A., Chen,J., Buchkovich,M.L., Mora,S.,
            Beckmann,J.S., Bragg-Gresham,J.L., Chang,H.Y., Demirkan,A., Den
            Hertog,H.M., Do,R., Donnelly,L.A., Ehret,G.B., Esko,T.,
            Feitosa,M.F., Ferreira,T., Fischer,K., Fontanillas,P., Fraser,R.M.,
            Freitag,D.F., Gurdasani,D., Heikkila,K., Hypponen,E., Isaacs,A.,
            Jackson,A.U., Johansson,A., Johnson,T., Kaakinen,M., Kettunen,J.,
            Kleber,M.E., Li,X., Luan,J., Lyytikainen,L.P., Magnusson,P.K.E.,
            Mangino,M., Mihailov,E., Montasser,M.E., Muller-Nurasyid,M.,
            Nolte,I.M., O'Connell,J.R., Palmer,C.D., Perola,M., Petersen,A.K.,
            Sanna,S., Saxena,R., Service,S.K., Shah,S., Shungin,D., Sidore,C.,
            Song,C., Strawbridge,R.J., Surakka,I., Tanaka,T., Teslovich,T.M.,
            Thorleifsson,G., Van den Herik,E.G., Voight,B.F., Volcik,K.A.,
            Waite,L.L., Wong,A., Wu,Y., Zhang,W., Absher,D., Asiki,G.,
            Barroso,I., Been,L.F., Bolton,J.L., Bonnycastle,L.L., Brambilla,P.,
            Burnett,M.S., Cesana,G., Dimitriou,M., Doney,A.S.F., Doring,A.,
            Elliott,P., Epstein,S.E., Ingi Eyjolfsson,G., Gigante,B.,
            Goodarzi,M.O., Grallert,H., Gravito,M.L., Groves,C.J., Hallmans,G.,
            Hartikainen,A.L., Hayward,C., Hernandez,D., Hicks,A.A., Holm,H.,
            Hung,Y.J., Illig,T., Jones,M.R., Kaleebu,P., Kastelein,J.J.P.,
            Khaw,K.T., Kim,E., Klopp,N., Komulainen,P., Kumari,M.,
            Langenberg,C., Lehtimaki,T., Lin,S.Y., Lindstrom,J., Loos,R.J.F.,
            Mach,F., McArdle,W.L., Meisinger,C., Mitchell,B.D., Muller,G.,
            Nagaraja,R., Narisu,N., Nieminen,T.V.M., Nsubuga,R.N., Olafsson,I.,
            Ong,K.K., Palotie,A., Papamarkou,T., Pomilla,C., Pouta,A.,
            Rader,D.J., Reilly,M.P., Ridker,P.M., Rivadeneira,F., Rudan,I.,
            Ruokonen,A., Samani,N., Scharnagl,H., Seeley,J., Silander,K.,
            Stancakova,A., Stirrups,K., Swift,A.J., Tiret,L.,
            Uitterlinden,A.G., van Pelt,L.J., Vedantam,S., Wainwright,N.,
            Wijmenga,C., Wild,S.H., Willemsen,G., Wilsgaard,T., Wilson,J.F.,
            Young,E.H., Zhao,J.H., Adair,L.S., Arveiler,D., Assimes,T.L.,
            Bandinelli,S., Bennett,F., Bochud,M., Boehm,B.O., Boomsma,D.I.,
            Borecki,I.B., Bornstein,S.R., Bovet,P., Burnier,M., Campbell,H.,
            Chakravarti,A., Chambers,J.C., Chen,Y.I., Collins,F.S.,
            Cooper,R.S., Danesh,J., Dedoussis,G., de Faire,U., Feranil,A.B.,
            Ferrieres,J., Ferrucci,L., Freimer,N.B., Gieger,C., Groop,L.C.,
            Gudnason,V., Gyllensten,U., Hamsten,A., Harris,T.B., Hingorani,A.,
            Hirschhorn,J.N., Hofman,A., Hovingh,G.K., Hsiung,C.A.,
            Humphries,S.E., Hunt,S.C., Hveem,K., Iribarren,C., Jarvelin,M.R.,
            Jula,A., Kahonen,M., Kaprio,J., Kesaniemi,A., Kivimaki,M.,
            Kooner,J.S., Koudstaal,P.J., Krauss,R.M., Kuh,D., Kuusisto,J.,
            Kyvik,K.O., Laakso,M., Lakka,T.A., Lind,L., Lindgren,C.M.,
            Martin,N.G., Marz,W., McCarthy,M.I., McKenzie,C.A., Meneton,P.,
            Metspalu,A., Moilanen,L., Morris,A.D., Munroe,P.B., Njolstad,I.,
            Pedersen,N.L., Power,C., Pramstaller,P.P., Price,J.F., Psaty,B.M.,
            Quertermous,T., Rauramaa,R., Saleheen,D., Salomaa,V.,
            Sanghera,D.K., Saramies,J., Schwarz,P.E.H., Sheu,W.H.,
            Shuldiner,A.R., Siegbahn,A., Spector,T.D., Stefansson,K.,
            Strachan,D.P., Tayo,B.O., Tremoli,E., Tuomilehto,J., Uusitupa,M.,
            van Duijn,C.M., Vollenweider,P., Wallentin,L., Wareham,N.J.,
            Whitfield,J.B., Wolffenbuttel,B.H.R., Ordovas,J.M., Boerwinkle,E.,
            Palmer,C.N.A., Thorsteinsdottir,U., Chasman,D.I., Rotter,J.I.,
            Franks,P.W., Ripatti,S., Cupples,L.A., Sandhu,M.S., Rich,S.S.,
            Boehnke,M., Deloukas,P., Kathiresan,S., Mohlke,K.L., Ingelsson,E.
            and Abecasis,G.R.
  CONSRTM   Global Lipids Genetics Consortium
  TITLE     Discovery and refinement of loci associated with lipid levels
  JOURNAL   Nat Genet 45 (11), 1274-1283 (2013)
   PUBMED   24097068
REFERENCE   7  (bases 1 to 4598)
  AUTHORS   Kettunen,J., Tukiainen,T., Sarin,A.P., Ortega-Alonso,A.,
            Tikkanen,E., Lyytikainen,L.P., Kangas,A.J., Soininen,P., Wurtz,P.,
            Silander,K., Dick,D.M., Rose,R.J., Savolainen,M.J., Viikari,J.,
            Kahonen,M., Lehtimaki,T., Pietilainen,K.H., Inouye,M.,
            McCarthy,M.I., Jula,A., Eriksson,J., Raitakari,O.T., Salomaa,V.,
            Kaprio,J., Jarvelin,M.R., Peltonen,L., Perola,M., Freimer,N.B.,
            Ala-Korpela,M., Palotie,A. and Ripatti,S.
  TITLE     Genome-wide association study identifies multiple loci influencing
            human serum metabolite levels
  JOURNAL   Nat Genet 44 (3), 269-276 (2012)
   PUBMED   22286219
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4598)
  AUTHORS   Demirkan,A., van Duijn,C.M., Ugocsai,P., Isaacs,A.,
            Pramstaller,P.P., Liebisch,G., Wilson,J.F., Johansson,A., Rudan,I.,
            Aulchenko,Y.S., Kirichenko,A.V., Janssens,A.C., Jansen,R.C.,
            Gnewuch,C., Domingues,F.S., Pattaro,C., Wild,S.H., Jonasson,I.,
            Polasek,O., Zorkoltseva,I.V., Hofman,A., Karssen,L.C.,
            Struchalin,M., Floyd,J., Igl,W., Biloglav,Z., Broer,L., Pfeufer,A.,
            Pichler,I., Campbell,S., Zaboli,G., Kolcic,I., Rivadeneira,F.,
            Huffman,J., Hastie,N.D., Uitterlinden,A., Franke,L., Franklin,C.S.,
            Vitart,V., Nelson,C.P., Preuss,M., Bis,J.C., O'Donnell,C.J.,
            Franceschini,N., Witteman,J.C., Axenovich,T., Oostra,B.A.,
            Meitinger,T., Hicks,A.A., Hayward,C., Wright,A.F., Gyllensten,U.,
            Campbell,H. and Schmitz,G.
  CONSRTM   DIAGRAM Consortium; CARDIoGRAM Consortium; CHARGE Consortium;
            EUROSPAN consortium
  TITLE     Genome-wide association study identifies novel loci associated with
            circulating phospho- and sphingolipid concentrations
  JOURNAL   PLoS Genet 8 (2), e1002490 (2012)
   PUBMED   22359512
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB019664.1, BC060871.1, AY203955.1, BC042104.2, BM997114.1 and
            AC138932.4.
            
            On May 17, 2019 this sequence version replaced NM_015027.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.198956.1,
                                           SRR1660809.230475.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396410.9/ ENSP00000379691.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               DB019664.1         51-153
            104-1263            BC060871.1         1-1160
            1264-1314           AY203955.1         1072-1122
            1315-1864           BC060871.1         1212-1761
            1865-3953           BC042104.2         27-2115
            3954-3982           BC060871.1         3853-3881
            3983-4596           BM997114.1         15-628              c
            4597-4598           AC138932.4         835-836             c
FEATURES             Location/Qualifiers
     source          1..4598
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.11"
     gene            1..4598
                     /gene="PDXDC1"
                     /gene_synonym="LP8165"
                     /note="pyridoxal dependent decarboxylase domain containing
                     1"
                     /db_xref="GeneID:23042"
                     /db_xref="HGNC:HGNC:28995"
                     /db_xref="MIM:614244"
     exon            1..195
                     /gene="PDXDC1"
                     /gene_synonym="LP8165"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..2541
                     /gene="PDXDC1"
                     /gene_synonym="LP8165"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pyridoxal-dependent decarboxylase domain-containing
                     protein 1"
                     /codon_start=1
                     /product="pyridoxal-dependent decarboxylase
                     domain-containing protein 1 isoform 1"
                     /protein_id="NP_055842.2"
                     /db_xref="CCDS:CCDS32393.1"
                     /db_xref="GeneID:23042"
                     /db_xref="HGNC:HGNC:28995"
                     /db_xref="MIM:614244"
                     /translation="MDASLEKIADPTLAEMGKNLKEAVKMLEDSQRRTEEENGKKLIS
                     GDIPGPLQGSGQDMVSILQLVQNLMHGDEDEEPQSPRIQNIGEQGHMALLGHSLGAYI
                     STLDKEKLRKLTTRILSDTTLWLCRIFRYENGCAYFHEEEREGLAKICRLAIHSRYED
                     FVVDGFNVLYNKKPVIYLSAAARPGLGQYLCNQLGLPFPCLCRVPCNTVFGSQHQMDV
                     AFLEKLIKDDIERGRLPLLLVANAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLAT
                     LALGYVSSSVLAAAKCDSMTMTPGPWLGLPAVPAVTLYKHDDPALTLVAGLTSNKPTD
                     KLRALPLWLSLQYLGLDGFVERIKHACQLSQRLQESLKKVNYIKILVEDELSSPVVVF
                     RFFQELPGSDPVFKAVPVPNMTPSGVGRERHSCDALNRWLGEQLKQLVPASGLTVMDL
                     EAEGTCLRFSPLMTAAVLGTRGEDVDQLVACIESKLPVLCCTLQLREEFKQEVEATAG
                     LLYVDDPNWSGIGVVRYEHANDDKSSLKSDPEGENIHAGLLKKLNELESDLTFKIGPE
                     YKSMKSCLYVGMASDNVDAAELVETIAATAREIEENSRLLENMTEVVRKGIQEAQVEL
                     QKASEERLLEEGVLRQIPVVGSVLNWFSPVQALQKGRTFNLTAGSLESTEPIYVYKAQ
                     GAGVTLPPTPSGSRTKQRLPGQKPFKRSLRGSDALSETSSVSHIEDLEKVERLSSGPE
                     QITLEASSTEGHPGAPSPQHTDQTEAFQKGVPHPEDDHSQVEGPESLR"
     exon            196..269
                     /gene="PDXDC1"
                     /gene_synonym="LP8165"
                     /inference="alignment:Splign:2.1.0"
     exon            270..335
                     /gene="PDXDC1"
                     /gene_synonym="LP8165"
                     /inference="alignment:Splign:2.1.0"
     exon            336..416
                     /gene="PDXDC1"
                     /gene_synonym="LP8165"
                     /inference="alignment:Splign:2.1.0"
     exon            417..563
                     /gene="PDXDC1"
                     /gene_synonym="LP8165"
                     /inference="alignment:Splign:2.1.0"
     exon            564..753
                     /gene="PDXDC1"
                     /gene_synonym="LP8165"
                     /inference="alignment:Splign:2.1.0"
     exon            754..822
                     /gene="PDXDC1"
                     /gene_synonym="LP8165"
                     /inference="alignment:Splign:2.1.0"
     exon            823..901
                     /gene="PDXDC1"
                     /gene_synonym="LP8165"
                     /inference="alignment:Splign:2.1.0"
     exon            902..986
                     /gene="PDXDC1"
                     /gene_synonym="LP8165"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1035
                     /gene="PDXDC1"
                     /gene_synonym="LP8165"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1137
                     /gene="PDXDC1"
                     /gene_synonym="LP8165"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1263
                     /gene="PDXDC1"
                     /gene_synonym="LP8165"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1314
                     /gene="PDXDC1"
                     /gene_synonym="LP8165"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1378
                     /gene="PDXDC1"
                     /gene_synonym="LP8165"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1467
                     /gene="PDXDC1"
                     /gene_synonym="LP8165"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1573
                     /gene="PDXDC1"
                     /gene_synonym="LP8165"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1745
                     /gene="PDXDC1"
                     /gene_synonym="LP8165"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1864
                     /gene="PDXDC1"
                     /gene_synonym="LP8165"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1986
                     /gene="PDXDC1"
                     /gene_synonym="LP8165"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2079
                     /gene="PDXDC1"
                     /gene_synonym="LP8165"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2176
                     /gene="PDXDC1"
                     /gene_synonym="LP8165"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2281
                     /gene="PDXDC1"
                     /gene_synonym="LP8165"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..4598
                     /gene="PDXDC1"
                     /gene_synonym="LP8165"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3931..3936
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDXDC1"
                     /gene_synonym="LP8165"
                     /note="hexamer: AATAAA"
     polyA_site      3953
                     /gene="PDXDC1"
                     /gene_synonym="LP8165"
                     /note="major polyA site"
     regulatory      4577..4582
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDXDC1"
                     /gene_synonym="LP8165"
                     /note="hexamer: AATAAA"
     polyA_site      4598
                     /gene="PDXDC1"
                     /gene_synonym="LP8165"
ORIGIN      
        1 ctctcaacca tcaggttcgg cagcccgcgg cgccgcctgg cagctcctcc tcttctccgc
       61 cccgccggcc gcgggcgcgg gggacgtcag cgctgccagc gtggaaggag ctgcggggcg
      121 cgggaggagg aagtagagcc cgggaccgcc aggccaccac cggccgcctc agccatggac
      181 gcgtccctgg agaagatagc agaccccacg ttagctgaaa tgggaaaaaa cttgaaggag
      241 gcagtgaaga tgctggagga cagtcagaga agaacagaag aggaaaatgg aaagaagctc
      301 atatccggag atattccagg cccactccag ggcagtgggc aagatatggt gagcatcctc
      361 cagttagttc agaatctcat gcatggagat gaagatgagg agccccagag ccccagaatc
      421 caaaatattg gagaacaagg tcatatggct ttgttgggac atagtctggg agcttatatt
      481 tcaactctgg acaaagagaa gctgagaaaa cttacaacta ggatactttc agataccacc
      541 ttatggctat gcagaatttt cagatatgaa aatgggtgtg cttatttcca cgaagaggaa
      601 agagaaggac ttgcaaagat atgtaggctt gccattcatt ctcgatatga agacttcgta
      661 gtggatggct tcaatgtgtt atataacaag aagcctgtca tatatcttag tgctgctgct
      721 agacctggcc tgggccaata cctttgtaat cagctcggct tgcccttccc ctgcttgtgc
      781 cgtgtaccct gtaacactgt gtttggatcc cagcatcaga tggatgttgc cttcctggag
      841 aaactgatta aagatgatat agagcgagga agactgcccc tgttgcttgt cgcaaatgca
      901 ggaacggcag cagtaggaca cacagacaag attgggagat tgaaagaact ctgtgagcag
      961 tatggcatat ggcttcatgt ggagggtgtg aatctggcaa cattggctct gggttatgtc
     1021 tcctcatcag tgctggctgc agccaaatgt gatagcatga cgatgactcc tggcccgtgg
     1081 ctgggtttgc cagctgttcc tgcggtgaca ctgtataaac acgatgaccc tgccttgact
     1141 ttagttgctg gtcttacatc aaataagccc acagacaaac tccgtgccct gcctctgtgg
     1201 ttatctttac aatacttggg acttgatggg tttgtggaga ggatcaagca tgcctgtcaa
     1261 ctgagtcaac ggttgcagga aagtttgaag aaagtgaatt acatcaaaat cttggtggaa
     1321 gatgagctca gctccccagt ggtggtgttc agatttttcc aggaattacc aggctcagat
     1381 ccggtgttta aagccgtccc agtgcccaac atgacacctt caggagtcgg ccgggagagg
     1441 cactcgtgtg acgcgctgaa tcgctggctg ggagaacagc tgaagcagct ggtgcctgca
     1501 agcggcctca cagtcatgga tctggaagct gagggcacgt gtttgcggtt cagccctttg
     1561 atgaccgcag cagttttagg aactcgggga gaggatgtgg atcagctcgt agcctgcata
     1621 gaaagcaaac tgccagtgct gtgctgtacg ctccagttgc gtgaagagtt caagcaggaa
     1681 gtggaagcaa cagcaggtct cctatatgtt gatgacccta actggtctgg aataggggtt
     1741 gtcaggtatg aacatgctaa tgatgataag agcagtttga aatcagatcc cgaaggggaa
     1801 aacatccatg ctggactcct gaagaagtta aatgaactgg aatctgacct aacctttaaa
     1861 ataggccctg agtataagag catgaagagc tgcctttatg tcggcatggc gagcgacaac
     1921 gtcgatgctg ctgagctcgt ggagaccatt gcggccacag cccgggagat agaggagaac
     1981 tcgaggcttc tggaaaacat gacagaagtg gttcggaaag gcattcagga agctcaagtg
     2041 gagctgcaga aggcaagtga agaacggctt ctggaagagg gggtgttgcg gcagatccct
     2101 gtagtgggct ccgtgctgaa ttggttttct ccggtccagg ctttacagaa gggaagaact
     2161 tttaacttga cagcaggctc tctggagtcc acagaaccca tatatgtcta caaagcacaa
     2221 ggtgcaggag tcacgctgcc tccaacgccc tcgggcagtc gcaccaagca gaggcttcca
     2281 ggccagaagc cttttaaaag gtccctgcga ggttcagatg ctttgagtga gaccagctca
     2341 gtcagtcaca ttgaagactt agaaaaggtg gagcgcctat ccagtgggcc ggagcagatc
     2401 accctcgagg ccagcagcac tgagggacac ccaggggctc ccagccctca gcacaccgac
     2461 cagaccgagg ccttccagaa aggggtccca cacccagaag atgaccactc acaggtagaa
     2521 ggaccggaga gcttaagatg agactcattg tgtggtttga gactgtactg agtattgttt
     2581 cagggaagat gaagttctat tggaaatgtg aactgtgcca catactaata taaattactg
     2641 ttgtttgtgc ttcactggga ttttggcaca aatatgtgcc tgaaaggtag gctttctagg
     2701 aggggagtca gcttgtctaa cttcatgtac atgtagaacc acgtttgctg tcctactacg
     2761 acttttccct aagttaccat aaacacattt tattcacaaa aaacacttcg aatttcaagt
     2821 gtctaccagt agcacccttg ctctttctaa acataagcct aagtatatga ggttgcccgt
     2881 ggcaactttt tggtaaaaca gcttttcatt agcactctcc aggttctctg caacacttca
     2941 cagaggcgag actggctgta tcctttgctg tcggtcttta gtacgatcaa gttgcaatat
     3001 acagtgggac tgctagactt gaaggagagc agtgattgtg ggattgtaaa taagagcatc
     3061 agaagccctc cccagctact gctcttcgtg gagacttagt aaggactgtg tctacttgag
     3121 ctgtggcaag gctgctgtct gggactgtcc tctgccacaa ggccatttct cccattatat
     3181 accgtttgta aagagaaact gtaaagtctc ctcctgacca tatattttta aatactggca
     3241 aagcttttaa aattggcaca caagtacaga ctgtgctcat ttctgtttag tatctgaaaa
     3301 cctgatagat gctaccctta agagcttgct cttccgtgtg ctacgtagca cccacctggt
     3361 taaaatctga aaacaagtac ccctttgacc tgtctcccac tgaagcttct actgccctgg
     3421 cagctcgcct gggcccaact cagaaacagg agccagcaga gcactctctc acgctgatcc
     3481 agccgggcac cctgcttaag tcagtagaag ctcgctggca ctgcccgttc ctacttttcc
     3541 gaagtactgc gtcactttgt cgtaagtaat ggcccctgtg ccttcttaat ccagcagtca
     3601 agcttttggg agacctgaaa atgggaaaat tcacactggg tttctggact gtagtattgg
     3661 aagccttagt tatagtatat taagcctata attatactct gatttgatgg gatttttgac
     3721 atttacactt gtcaaaatgc agggggtttt ttttggtgca gatgattaaa cagtcttccc
     3781 tatttggtgc aatgaagtat agcagataaa atgggggagg ggtaaattat caccttcaag
     3841 aaaattacat gtttttatat atatttggaa ttgttaaatt ggttttgctg aaacatttca
     3901 cccttgagat attatttgaa tgttggtttc aataaaggtt cttgaaattg ttaccagtga
     3961 attcagttta taaatcttat tacaaaagac ttacccacgt acctgaaata gctgccgata
     4021 gaccagtgag aggtaggttc tcctctgccc gttattaccg accaaaaaaa aaactggaca
     4081 tcaatttttt agtaaaccaa aaaataagtc tcaacaaatg cctttgccaa aataaggttt
     4141 tattttgaaa gtcatttgat gaaagtcatt tgaaagacac tgaggaggga aggaggccta
     4201 agacccaaca gatgtaggat ccagatctgg attcgtgcca gccccaccaa tggtctgtca
     4261 ggccaagaag gtgctttctt tggtaattca tgttttttaa cttcctggag aagagatctt
     4321 ttcccacaag ccatcttcat tttttttgta gagtagggct ttatttccag aaaacagtgt
     4381 gtgagctgga gatgggtgtt tttttaaaaa catcaaggta gatctaatat gttcaacaaa
     4441 gtggggtggc tcagccagag gcgaagtgga aagattctga aaacacaaga tggtgggcat
     4501 tagagaagcc aaccttactg tcccctgctg tgataaagat gtcaaagtat ctttgttctt
     4561 ggacacaaat atatataata aaatacgtta agaaatga
//
