LOCUS       NM_020381               3536 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens decaprenyl diphosphate synthase subunit 2 (PDSS2),
            mRNA.
ACCESSION   NM_020381
VERSION     NM_020381.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3536)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 3536)
  AUTHORS   Yang,K., Song,H. and Yin,D.
  TITLE     PDSS2 Inhibits the Ferroptosis of Vascular Endothelial Cells in
            Atherosclerosis by Activating Nrf2
  JOURNAL   J Cardiovasc Pharmacol 77 (6), 767-776 (2021)
   PUBMED   33929387
  REMARK    GeneRIF: PDSS2 Inhibits the Ferroptosis of Vascular Endothelial
            Cells in Atherosclerosis by Activating Nrf2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3536)
  AUTHORS   Zeng,T., Tang,Z., Liang,L., Suo,D., Li,L., Li,J., Yuan,Y.,
            Guan,X.Y. and Li,Y.
  TITLE     PDSS2-Del2, a new variant of PDSS2, promotes tumor cell metastasis
            and angiogenesis in hepatocellular carcinoma via activating
            NF-kappaB
  JOURNAL   Mol Oncol 14 (12), 3184-3197 (2020)
   PUBMED   33064899
  REMARK    GeneRIF: PDSS2-Del2, a new variant of PDSS2, promotes tumor cell
            metastasis and angiogenesis in hepatocellular carcinoma via
            activating NF-kappaB.
REFERENCE   4  (bases 1 to 3536)
  AUTHORS   Hu,L., Chen,Q., Wang,Y., Zhang,N., Meng,P., Liu,T. and Bu,Y.
  TITLE     Sp1 Mediates the Constitutive Expression and Repression of the
            PDSS2 Gene in Lung Cancer Cells
  JOURNAL   Genes (Basel) 10 (12), 977 (2019)
   PUBMED   31783675
  REMARK    GeneRIF: Study identified the promoter region of the PDSS2 gene for
            the first time and demonstrated that Sp1 transcription factor could
            directly regulate the transcription of PDSS2. Also, the expression
            of Sp1 and PDSS2 are negatively correlated, and higher Sp1
            expression with low PDSS2 expression is significantly associated
            with poor prognosis in lung cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3536)
  AUTHORS   Vieira,A.R., McHenry,T.G., Daack-Hirsch,S., Murray,J.C. and
            Marazita,M.L.
  TITLE     Candidate gene/loci studies in cleft lip/palate and dental
            anomalies finds novel susceptibility genes for clefts
  JOURNAL   Genet Med 10 (9), 668-674 (2008)
   PUBMED   18978678
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 3536)
  AUTHORS   Diomedi-Camassei,F., Di Giandomenico,S., Santorelli,F.M.,
            Caridi,G., Piemonte,F., Montini,G., Ghiggeri,G.M., Murer,L.,
            Barisoni,L., Pastore,A., Muda,A.O., Valente,M.L., Bertini,E. and
            Emma,F.
  TITLE     COQ2 nephropathy: a newly described inherited mitochondriopathy
            with primary renal involvement
  JOURNAL   J Am Soc Nephrol 18 (10), 2773-2780 (2007)
   PUBMED   17855635
REFERENCE   7  (bases 1 to 3536)
  AUTHORS   Saiki,R., Nagata,A., Kainou,T., Matsuda,H. and Kawamukai,M.
  TITLE     Characterization of solanesyl and decaprenyl diphosphate synthases
            in mice and humans
  JOURNAL   FEBS J 272 (21), 5606-5622 (2005)
   PUBMED   16262699
  REMARK    GeneRIF: murine and human solanesyl and decaprenyl diphosphate
            synthases are heterotetramers composed of newly characterized hDPS1
            (mSPS1) and hDLP1 (mDLP1).
REFERENCE   8  (bases 1 to 3536)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   9  (bases 1 to 3536)
  AUTHORS   Salviati,L., Trevisson,E., Agosto,C., Doimo,M. and Navas,P.
  TITLE     Primary Coenzyme Q10 Deficiency Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   28125198
REFERENCE   10 (bases 1 to 3536)
  AUTHORS   Perlman,S.
  TITLE     Hereditary Ataxia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301317
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC341808.1, BC039906.1 and
            AL832290.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_020381.3.
            
            Summary: The protein encoded by this gene is an enzyme that
            synthesizes the prenyl side-chain of coenzyme Q, or ubiquinone, one
            of the key elements in the respiratory chain. The gene product
            catalyzes the formation of all trans-polyprenyl pyrophosphates from
            isopentyl diphosphate in the assembly of polyisoprenoid side
            chains, the first step in coenzyme Q biosynthesis. Defects in this
            gene are a cause of coenzyme Q10 deficiency.[provided by RefSeq,
            Oct 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039906.1, SRR1803611.136125.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369037.9/ ENSP00000358033.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DC341808.1         13-25
            14-1281             BC039906.1         11-1278
            1282-2523           AL832290.1         98-1339
            2524-2524           BC039906.1         2521-2521
            2525-3511           AL832290.1         1340-2326
            3512-3536           AL832290.1         2328-2352
FEATURES             Location/Qualifiers
     source          1..3536
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..3536
                     /gene="PDSS2"
                     /gene_synonym="bA59I9.3; C6orf210; COQ10D3; COQ1B; DLP1;
                     hDLP1"
                     /note="decaprenyl diphosphate synthase subunit 2"
                     /db_xref="GeneID:57107"
                     /db_xref="HGNC:HGNC:23041"
                     /db_xref="MIM:610564"
     exon            1..575
                     /gene="PDSS2"
                     /gene_synonym="bA59I9.3; C6orf210; COQ10D3; COQ1B; DLP1;
                     hDLP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             280..1479
                     /gene="PDSS2"
                     /gene_synonym="bA59I9.3; C6orf210; COQ10D3; COQ1B; DLP1;
                     hDLP1"
                     /EC_number="2.5.1.91"
                     /note="decaprenyl pyrophosphate synthetase subunit 2;
                     subunit 2 of decaprenyl diphosphate synthase; decaprenyl
                     pyrophosphate synthase subunit 2;
                     all-trans-decaprenyl-diphosphate synthase subunit 2;
                     prenyl (decaprenyl) diphosphate synthase, subunit 2;
                     solanesyl-diphosphate synthase subunit 2"
                     /codon_start=1
                     /product="all trans-polyprenyl-diphosphate synthase PDSS2"
                     /protein_id="NP_065114.3"
                     /db_xref="CCDS:CCDS5059.1"
                     /db_xref="GeneID:57107"
                     /db_xref="HGNC:HGNC:23041"
                     /db_xref="MIM:610564"
                     /translation="MNFRQLLLHLPRYLGASGSPRRLWWSPSLDTISSVGSWRGRSSK
                     SPAHWNQVVSEAEKIVGYPTSFMSLRCLLSDELSNIAMQVRKLVGTQHPLLTTARGLV
                     HDSWNSLQLRGLVVLLISKAAGPSSVNTSCQNYDMVSGIYSCQRSLAEITELIHIALL
                     VHRGIVNLNELQSSDGPLKDMQFGNKIAILSGDFLLANACNGLALLQNTKVVELLASA
                     LMDLVQGVYHENSTSKESYITDDIGISTWKEQTFLSHGALLAKSCQAAMELAKHDAEV
                     QNMAFQYGKHMAMSHKINSDVQPFIKEKTSDSMTFNLNSAPVVLHQEFLGRDLWIKQI
                     GEAQEKGRLDYAKLRERIKAGKGVTSAIDLCRYHGNKALEALESFPPSEARSALENIV
                     FAVTRFS"
     exon            576..710
                     /gene="PDSS2"
                     /gene_synonym="bA59I9.3; C6orf210; COQ10D3; COQ1B; DLP1;
                     hDLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            711..909
                     /gene="PDSS2"
                     /gene_synonym="bA59I9.3; C6orf210; COQ10D3; COQ1B; DLP1;
                     hDLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            910..981
                     /gene="PDSS2"
                     /gene_synonym="bA59I9.3; C6orf210; COQ10D3; COQ1B; DLP1;
                     hDLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1155
                     /gene="PDSS2"
                     /gene_synonym="bA59I9.3; C6orf210; COQ10D3; COQ1B; DLP1;
                     hDLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1287
                     /gene="PDSS2"
                     /gene_synonym="bA59I9.3; C6orf210; COQ10D3; COQ1B; DLP1;
                     hDLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1320
                     /gene="PDSS2"
                     /gene_synonym="bA59I9.3; C6orf210; COQ10D3; COQ1B; DLP1;
                     hDLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..3536
                     /gene="PDSS2"
                     /gene_synonym="bA59I9.3; C6orf210; COQ10D3; COQ1B; DLP1;
                     hDLP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3519..3524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDSS2"
                     /gene_synonym="bA59I9.3; C6orf210; COQ10D3; COQ1B; DLP1;
                     hDLP1"
                     /note="hexamer: AACAAG"
     polyA_site      3536
                     /gene="PDSS2"
                     /gene_synonym="bA59I9.3; C6orf210; COQ10D3; COQ1B; DLP1;
                     hDLP1"
                     /note="major polyA site"
ORIGIN      
        1 atgcctccaa tatggcgtcc tccacatagg cagtggctgt ggtttctacc ccgggtggcc
       61 gggggcagtg ctgagctggg actgttgttt gcccagcctg ggctgcagaa agcagcagtt
      121 aaagttcgtt tctggtcact gctccaggaa gccaccttac tctgagggtc aagaattgcc
      181 gcttcctttt agttactgta agttcctcct ctgcccctgg tttgtttccc gcggcacttc
      241 tggatacccc caggtcccag acccttccag actcaaacca tgaactttcg gcagctgctg
      301 ttgcacttgc cacgttatct tggagcctcg ggttccccgc gtcgcctgtg gtggtccccg
      361 tccctcgaca ccatctcctc ggtgggctct tggcgtggtc ggtcctccaa gtccccggcc
      421 cactggaatc aggtagtgtc agaggcggag aagatcgtgg ggtaccccac gtccttcatg
      481 agccttcgct gcctgctgag cgacgagctc agcaacatcg ctatgcaggt gcggaagctg
      541 gtgggcactc agcaccctct gcttaccaca gccagggggc ttgtacatga cagctggaat
      601 agcctccagt tgaggggctt ggtggtgctc cttatctcta aagcagctgg gcccagcagc
      661 gtgaacactt catgtcagaa ctatgacatg gtcagtggga tctactcatg tcaaagaagt
      721 ttggcagaga tcacggagct aattcatatt gctctccttg tacatcgtgg gatagtaaat
      781 ttaaatgagt tgcaatcatc tgatggtcca ctgaaagaca tgcaatttgg aaataaaatt
      841 gctatcctga gtggagactt tcttctagca aatgcctgca atggactagc tctgctacag
      901 aacaccaagg ttgtggaact tttagcaagt gctcttatgg acttggtaca aggagtatat
      961 catgaaaatt ctacttcaaa ggaaagttat atcacagatg atattggaat atcgacttgg
     1021 aaggagcaga cttttctctc ccatggtgcc ttactagcaa agagctgcca agctgcaatg
     1081 gaattagcaa agcatgatgc tgaggttcag aatatggcat ttcagtatgg gaagcacatg
     1141 gccatgagtc ataagataaa ttctgatgtc cagcctttta ttaaagaaaa gaccagtgac
     1201 tccatgactt ttaatctaaa ctcagctcct gtagtcttac atcaggaatt tcttggaaga
     1261 gatttgtgga ttaaacagat cggagaggct caagaaaaag gaagattgga ctatgctaag
     1321 ttgcgagaaa gaatcaaagc tggcaaaggt gtgacttcag ctattgacct gtgtcgttac
     1381 catggaaaca aggcactgga ggccctggag agctttcctc cctcggaggc cagatctgct
     1441 ttagaaaaca ttgtgtttgc tgtgaccaga ttttcatgac atcaaattaa aaagacacta
     1501 ttgttagtta gctgaaaatc ctagggaatg aggttgattg ggagcgcttt cacgatgcgt
     1561 taatgacttt taaaacatat gcatttttcc ttccttttat cacattgcta aatgagttct
     1621 gctttctttt tggaactgct acaaacaaaa ttagaagaaa aaaaggtcaa gcagttttca
     1681 cttgtcacgc cagaagcaca cttgaggctg cagtcgcaga aataattaat gagattcgct
     1741 cctgtgacct cagcaaatgg acaggaaata agtccttatt gattggaccg agccagggat
     1801 ggcgccaggg cggtggcctg tggtttttcc tgctagagag gacaaagcaa gttggaagct
     1861 gcaggtgtca agagaaatgc tctcaatacc aaccagggag gattgtctaa tcaaaaacta
     1921 gtgaccaatt tgtcataatg gagagtagtt caatggattg agaaaaatat gttttatttg
     1981 ttggcttgta attatgtctc tggattatta ttattttttt tttagatgta gttttgctct
     2041 tgttgcccag gctggagtgc aatggtgcag ttttgactca ctgcaacctc cgcctcctgg
     2101 gttcaagtga ttctcctgcc tcagcctccc gagtagctgg aattacaggc acctgccacc
     2161 acgcctggct aattttgtat ttttagtaga gatggggttt cactatgttg gtcaggctag
     2221 tctcgaactc ctgacctcag gtgatccgcc tgcctcggcc tcccaaagtg ctgggattag
     2281 aggcttgagc cactgcacct ggcctcatgt ctctggattt ataatgcagt atgaatatac
     2341 tttgtgcttt atggttttta taatgtcttt ttggagaaat tgccgaaaag ttgccaaata
     2401 cttgaagtag gagattaaaa tgttatcaaa tgttaaattg gttatattag gaatagtctg
     2461 tttttctttc ctgaagatca gtttttttat tcaaacacat ttcaaagaac caaatttttt
     2521 ttttctttaa ggaaaaagga gctttttttc aagtgaaatg tattcatttg taatactttg
     2581 gtttaaggca tactttaatt tttacgagtt tcagaaacag aatttttgta ctagggaatt
     2641 cattggtgag agtgttcttt taacctcaga atgtcaaatt ttggtcttga accacagaca
     2701 tccaattaca gaaagaatat aagcaatctc acaggcctgc aatcggacac tgtctctgtg
     2761 tggttcatag gagatgattt ttgaggtttg cactcatgca atttgagaac accgttgaca
     2821 agaaggctga gtttacataa atgatctaga ttgaaactca gctacctttc ttcctcatgt
     2881 ggtgtaatta cagccctatc tggagacagc gaatacagca aacagatttt attacctagt
     2941 tcgctcaaac actacatgaa gttattttag ttaaagccct cccccaaaag ttataaaacc
     3001 attttatcag ggcccaacat gtggcatgca atgaagagaa aatgtaaagc tacagaggtt
     3061 aatgtattgt attataaaat attttaagtg tactcaaaat atcataattg tacagtttat
     3121 gccaccataa tttgaggcct atagatttag cttaagagaa cactgttctg tttgaaatgc
     3181 tttctgtcac tgaaattggc ttaattagta accatggata agatgcttta gatcagacta
     3241 ggttttaatc attaacttcc acaaagaagt catactttgc gttaggtgtg ctggttggat
     3301 gtgcaggaac ttcagcaagc agtaggtttt actaagcaga tggtcgggca ctgcagggca
     3361 ccaggcagga tcctagggcg cctcttattc tgcgttagca tctggtttgc tgtatgacct
     3421 tgcacaagtc acttccttct gagcctcaat tttctcatct gtacaatgag attcaaaagt
     3481 tgacctgaaa gtcaagtgtg aaaaaaaaaa agagattaaa caagataatt atgaaa
//
