LOCUS       NM_001100399            7131 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens PDS5 cohesin associated factor A (PDS5A), transcript
            variant 1, mRNA.
ACCESSION   NM_001100399
VERSION     NM_001100399.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7131)
  AUTHORS   van Ruiten,M.S., van Gent,D., Sedeno Cacciatore,A., Fauster,A.,
            Willems,L., Hekkelman,M.L., Hoekman,L., Altelaar,M.,
            Haarhuis,J.H.I., Brummelkamp,T.R., de Wit,E. and Rowland,B.D.
  TITLE     The cohesin acetylation cycle controls chromatin loop length
            through a PDS5A brake mechanism
  JOURNAL   Nat Struct Mol Biol 29 (6), 586-591 (2022)
   PUBMED   35710836
  REMARK    GeneRIF: The cohesin acetylation cycle controls chromatin loop
            length through a PDS5A brake mechanism.
REFERENCE   2  (bases 1 to 7131)
  AUTHORS   Wang,Y., Yao,J., Zhu,Y., Zhao,X., Lv,J. and Sun,F.
  TITLE     Knockdown of CDCA5 suppresses malignant progression of breast
            cancer cells by regulating PDS5A
  JOURNAL   Mol Med Rep 25 (6) (2022)
   PUBMED   35506437
  REMARK    GeneRIF: Knockdown of CDCA5 suppresses malignant progression of
            breast cancer cells by regulating PDS5A.
REFERENCE   3  (bases 1 to 7131)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 7131)
  AUTHORS   Zhang,N., Coutinho,L.E. and Pati,D.
  TITLE     PDS5A and PDS5B in Cohesin Function and Human Disease
  JOURNAL   Int J Mol Sci 22 (11), 5868 (2021)
   PUBMED   34070827
  REMARK    GeneRIF: PDS5A and PDS5B in Cohesin Function and Human Disease.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7131)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 7131)
  AUTHORS   Losada,A., Yokochi,T. and Hirano,T.
  TITLE     Functional contribution of Pds5 to cohesin-mediated cohesion in
            human cells and Xenopus egg extracts
  JOURNAL   J Cell Sci 118 (Pt 10), 2133-2141 (2005)
   PUBMED   15855230
REFERENCE   7  (bases 1 to 7131)
  AUTHORS   Rankin,S., Ayad,N.G. and Kirschner,M.W.
  TITLE     Sororin, a substrate of the anaphase-promoting complex, is required
            for sister chromatid cohesion in vertebrates
  JOURNAL   Mol Cell 18 (2), 185-200 (2005)
   PUBMED   15837422
  REMARK    Erratum:[Mol Cell. 2005 May 27;18(5):609]
REFERENCE   8  (bases 1 to 7131)
  AUTHORS   Kumar,D., Sakabe,I., Patel,S., Zhang,Y., Ahmad,I., Gehan,E.A.,
            Whiteside,T.L. and Kasid,U.
  TITLE     SCC-112, a novel cell cycle-regulated molecule, exhibits reduced
            expression in human renal carcinomas
  JOURNAL   Gene 328, 187-196 (2004)
   PUBMED   15019998
  REMARK    GeneRIF: Findings suggest that the SCC-112 gene expression is
            likely to be associated with normal cell growth and proliferation.
REFERENCE   9  (bases 1 to 7131)
  AUTHORS   Gregson,H.C., Schmiesing,J.A., Kim,J.S., Kobayashi,T., Zhou,S. and
            Yokomori,K.
  TITLE     A potential role for human cohesin in mitotic spindle aster
            assembly
  JOURNAL   J Biol Chem 276 (50), 47575-47582 (2001)
   PUBMED   11590136
REFERENCE   10 (bases 1 to 7131)
  AUTHORS   Sumara,I., Vorlaufer,E., Gieffers,C., Peters,B.H. and Peters,J.M.
  TITLE     Characterization of vertebrate cohesin complexes and their
            regulation in prophase
  JOURNAL   J Cell Biol 151 (4), 749-762 (2000)
   PUBMED   11076961
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC041361.1, AC098591.4 and
            BC114218.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001100399.1.
            
            Summary: The protein encoded by this gene binds to the cohesin
            complex and associates with chromatin through most of the cell
            cycle. The encoded protein may play a role in regulating sister
            chromatid cohesion during mitosis. Two transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, May 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC114218.1, AB621803.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303538.13/ ENSP00000303427.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                BC041361.1         50-96
            48-48               AC098591.4         27340-27340         c
            49-271              BC041361.1         98-320
            272-5022            BC114218.1         13-4763
            5023-7131           BC114218.1         4765-6873
FEATURES             Location/Qualifiers
     source          1..7131
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p14"
     gene            1..7131
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /note="PDS5 cohesin associated factor A"
                     /db_xref="GeneID:23244"
                     /db_xref="HGNC:HGNC:29088"
                     /db_xref="MIM:613200"
     exon            1..455
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     exon            456..633
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     CDS             496..4509
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sister chromatid cohesion protein PDS5 homolog A; sister
                     chromatid cohesion protein 112; cell
                     proliferation-inducing gene 54 protein; PDS5, regulator of
                     cohesion maintenance, homolog A"
                     /codon_start=1
                     /product="sister chromatid cohesion protein PDS5 homolog A
                     isoform 1"
                     /protein_id="NP_001093869.1"
                     /db_xref="CCDS:CCDS47045.1"
                     /db_xref="GeneID:23244"
                     /db_xref="HGNC:HGNC:29088"
                     /db_xref="MIM:613200"
                     /translation="MDFTAQPKPATALCGVVSADGKIAYPPGVKEITDKITTDEMIKR
                     LKMVVKTFMDMDQDSEDEKQQYLPLALHLASEFFLRNPNKDVRLLVACCLADIFRIYA
                     PEAPYTSHDKLKDIFLFITRQLKGLEDTKSPQFNRYFYLLENLAWVKSYNICFELEDC
                     NEIFIQLFRTLFSVINNSHNKKVQMHMLDLMSSIIMEGDGVTQELLDSILINLIPAHK
                     NLNKQSFDLAKVLLKRTVQTIEACIANFFNQVLVLGRSSVSDLSEHVFDLIQELFAID
                     PHLLLSVMPQLEFKLKSNDGEERLAVVRLLAKLFGSKDSDLATQNRPLWQCFLGRFND
                     IHVPVRLESVKFASHCLMNHPDLAKDLTEYLKVRSHDPEEAIRHDVIVTIITAAKRDL
                     ALVNDQLLGFVRERTLDKRWRVRKEAMMGLAQLYKKYCLHGEAGKEAAEKVSWIKDKL
                     LHIYYQNSIDDKLLVEKIFAQYLVPHNLETEERMKCLYYLYASLDPNAVKALNEMWKC
                     QNMLRSHVRELLDLHKQPTSEANCSAMFGKLMTIAKNLPDPGKAQDFVKKFNQVLGDD
                     EKLRSQLELLISPTCSCKQADICVREIARKLANPKQPTNPFLEMVKFLLERIAPVHID
                     SEAISALVKLMNKSIEGTADDEEEGVSPDTAIRSGLELLKVLSFTHPTSFHSAETYES
                     LLQCLRMEDDKVAEAAIQIFRNTGHKIETDLPQIRSTLIPILHQKAKRGTPHQAKQAV
                     HCIHAIFTNKEVQLAQIFEPLSRSLNADVPEQLITPLVSLGHISMLAPDQFASPMKSV
                     VANFIVKDLLMNDRSTGEKNGKLWSPDEEVSPEVLAKVQAIKLLVRWLLGMKNNQSKS
                     ANSTLRLLSAMLVSEGDLTEQKRISKSDMSRLRLAAGSAIMKLAQEPCYHEIITPEQF
                     QLCALVINDECYQVRQIFAQKLHKALVKLLLPLEYMAIFALCAKDPVKERRAHARQCL
                     LKNISIRREYIKQNPMATEKLLSLLPEYVVPYMIHLLAHDPDFTRSQDVDQLRDIKEC
                     LWFMLEVLMTKNENNSHAFMKKMAENIKLTRDAQSPDESKTNEKLYTVCDVALCVINS
                     KSALCNADSPKDPVLPMKFFTQPEKDFCNDKSYISEETRVLLLTGKPKPAGVLGAVNK
                     PLSATGRKPYVRSTGTETGSNINVNSELNPSTGNRSREQSSEAAETGVSENEENPVRI
                     ISVTPVKNIDPVKNKEINSDQATQGNISSDRGKKRTVTAAGAENIQQKTDEKVDESGP
                     PAPSKPRRGRRPKSESQGNATKNDDLNKPINKGRKRAAVGQESPGGLEAGNAKAPKLQ
                     DLAKKAAPAERQIDLQR"
     exon            634..837
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     exon            838..924
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1022
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1149
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1230
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1371
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1487
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1582
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1728
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1880
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..1994
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2076
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2125
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2265
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2381
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..2487
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     exon            2488..2648
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     exon            2649..2772
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..2931
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     exon            2932..3000
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     exon            3001..3137
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     exon            3138..3261
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     exon            3262..3466
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     exon            3467..3581
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     exon            3582..3714
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     exon            3715..3834
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     exon            3835..3897
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     exon            3898..4043
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     exon            4044..4152
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     exon            4153..4505
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     exon            4506..7131
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5657..5662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /note="hexamer: AATAAA"
     polyA_site      5677
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /note="major polyA site"
     regulatory      7107..7112
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
                     /note="hexamer: AATAAA"
     polyA_site      7131
                     /gene="PDS5A"
                     /gene_synonym="PIG54; SCC-112; SCC112"
ORIGIN      
        1 gcgtgctctc gcgccgctcg cgtgaccggc cggtgtgtgc gcgaggcccc ggctcccggg
       61 gcacggacgg ccgggcgcgc gcctctgcga ggggcgtccg ggtccgagtc ggcggtccgg
      121 gccggcgcga ggtgcgtgcg ggcgggccgc gggggtcccg gacggacaca agcgcacaca
      181 ctcccggagg agccttcgag gctgctcttc ctcggccaga cggagagcgg cactgtctcc
      241 ccgcccagcg ctcactcgcc ccgcgtctcc ccccgcggcg gctgctcctc ctcggcaccg
      301 ccagccccag cgccgctccc gggcgggcgg gcggcggcgg cggcggcggc gggacccgcg
      361 gagccgcttt gtgtgcagcc cgactagggg cggcggcgca accacctgac agaggcccgg
      421 gcgctcgatg caccttccgc ccgcatgagg aggagaggcc ggtagaggac tgtgaaccaa
      481 aagttgtccc ccaggatgga cttcaccgcg cagcccaagc ctgccactgc cctctgtggc
      541 gtcgtgagtg ccgacgggaa gatcgcttac cctccggggg taaaagagat caccgacaag
      601 atcaccacgg acgagatgat caaacgcctg aagatggtag tgaaaacctt tatggatatg
      661 gatcaggact cagaagatga aaaacagcag tatctcccac tagccttgca tcttgcatct
      721 gaattcttcc tcaggaaccc caataaagat gtgcgtctcc ttgtagcatg ttgtttggct
      781 gatatctttc gtatctatgc cccagaagct ccatatactt cccatgataa acttaaggac
      841 atatttttgt ttattaccag acaattaaaa ggtttggagg atacaaagag tccacagttt
      901 aatagatact tttatttatt agagaattta gcttgggtta aatcatataa catctgcttt
      961 gaattggaag attgcaatga aatttttatt cagcttttta gaactctctt ctcagtgatc
     1021 aacaatagcc acaataagaa ggtacaaatg cacatgctag atttgatgag ttctatcatc
     1081 atggaaggtg atggagttac tcaagaatta ttggactcca ttcttattaa cctcattcct
     1141 gcacataaga acttaaataa acagtccttt gaccttgcaa aagtgctatt gaaaagaaca
     1201 gtccagacta ttgaggcatg cattgctaat tttttcaatc aagtcctggt gctgggaaga
     1261 tcatcagtaa gtgatttgtc agaacatgta tttgatctga ttcaggaact ttttgctata
     1321 gatcctcatt tattattatc cgtcatgcca cagcttgaat tcaaactaaa gagcaatgat
     1381 ggagaagagc gattagctgt tgttcgactt ctagctaaat tgtttggctc caaagattct
     1441 gatttggcaa cacagaatcg tcctctttgg caatgttttc ttggacgatt taatgatatt
     1501 catgttcctg tgagattaga aagtgtgaaa tttgccagtc attgtttaat gaatcaccca
     1561 gatttagcga aggatctcac agaatattta aaggttagat cacatgatcc agaagaagct
     1621 attcgtcatg atgtcattgt tactataata acagctgcca agagggacct ggccttagta
     1681 aatgatcagc tgcttggctt tgtaagggaa agaacactgg ataaacggtg gcgagtaaga
     1741 aaagaagcta tgatgggtct ggctcagctt tataagaaat actgtcttca tggtgaagca
     1801 ggaaaggaag ctgcagagaa agtcagctgg ataaaggaca aacttctgca tatttattat
     1861 cagaacagca ttgacgacaa actgttggta gagaaaatct ttgctcagta tcttgtcccc
     1921 cacaacctgg aaacagaaga gagaatgaaa tgcttatatt acttatatgc tagtttggat
     1981 ccaaatgctg taaaagctct caacgaaatg tggaagtgtc agaacatgct tcggagccat
     2041 gtacgcgaac tattggattt gcacaagcag cctacatcag aggctaactg ttctgccatg
     2101 tttggaaaac tgatgaccat agcaaagaat ttgcctgacc ccgggaaagc acaagatttt
     2161 gtgaagaaat ttaaccaggt tctcggcgat gatgagaaac ttcggtctca gttggagtta
     2221 ttaattagcc caacctgttc ttgcaaacaa gcagatattt gtgtgagaga aatagcccgg
     2281 aaacttgcaa atcctaagca accaacaaat ccttttctag agatggtcaa atttctgttg
     2341 gaaagaatcg cacctgtgca cattgattca gaagccataa gtgcactagt gaaattgatg
     2401 aataagtcaa tagaggggac agcagatgat gaagaggagg gtgtaagtcc agatacagct
     2461 atccgttcag gacttgaact tcttaaggtt ctgtctttta cacatcctac ctcgttccac
     2521 tctgcagaga catatgagtc cttgttacag tgcctaagaa tggaggatga caaggtagca
     2581 gaagctgcta ttcaaatttt tagaaataca ggtcacaaaa tagaaacaga ccttccccag
     2641 atacgatcga ccttaattcc cattttacat caaaaagcaa agaggggtac tccacaccaa
     2701 gcaaaacagg ctgtgcactg tatacacgcc atattcacaa ataaagaagt ccagcttgca
     2761 cagatttttg agccactcag taggagtctg aatgctgatg tgccagaaca acttataact
     2821 ccattagttt cattgggcca catttctatg ttagcaccag atcagtttgc ttccccaatg
     2881 aaatctgtag tagcaaattt tattgtgaaa gatctgctaa tgaatgacag gtcaacaggt
     2941 gaaaagaatg gaaaactgtg gtctccagat gaagaggttt cccctgaagt actagcaaag
     3001 gtacaggcaa ttaaacttct ggtaaggtgg ctgttgggta tgaaaaacaa ccagtctaaa
     3061 tctgccaatt caacccttcg gttattatca gcgatgttgg ttagtgaggg tgacctgaca
     3121 gagcaaaaga ggatcagtaa atctgatatg tctcgcttgc gattagctgc tggtagtgcc
     3181 ataatgaagc ttgctcagga accttgttac catgaaatta ttaccccaga acagtttcag
     3241 ctctgtgcac ttgttattaa tgatgagtgt taccaagtaa ggcagatatt tgctcagaag
     3301 ctgcataagg cacttgtgaa gttactgctc ccattggagt atatggcgat ctttgccttg
     3361 tgtgccaaag atcctgtgaa ggagagaaga gcacacgcac gacaatgttt actgaaaaat
     3421 atcagtatac gcagggaata cattaagcag aatcctatgg ctactgagaa attattatca
     3481 ctgttgcctg aatatgtagt tccatacatg attcacctgc tagcccatga tccagatttt
     3541 acaagatcac aagatgttga tcagcttcgt gatatcaaag agtgcctatg gttcatgctt
     3601 gaagttttaa tgacaaagaa tgaaaacaat agccatgcct ttatgaagaa gatggcagag
     3661 aacatcaagt taaccagaga tgcccagtct ccagatgaat ccaagacaaa tgaaaaactg
     3721 tatacagtat gtgatgtggc tctctgtgtt ataaatagta aaagtgcttt gtgcaatgca
     3781 gattcaccaa aggacccagt cctcccaatg aaatttttta cacaacctga aaaggacttc
     3841 tgtaacgata agagttatat ttcagaagag acaagagtac ttctgttaac aggaaagcca
     3901 aagcctgctg gagtactagg tgcagtaaat aagcctttat cagcaacggg aaggaaaccc
     3961 tatgttagaa gcactggcac tgagactgga agcaatatta atgtaaattc agagctgaac
     4021 ccttcaaccg gaaatcgatc aagggaacag agttcagagg cagcagaaac tggagttagt
     4081 gaaaatgaag agaaccctgt gaggattatt tcagtcacac ctgtaaagaa tattgaccca
     4141 gtaaagaata aggaaattaa ttctgatcag gctacccagg gcaacatcag cagtgaccga
     4201 ggaaagaaaa gaacagtaac agcagctggt gcagagaata tccaacaaaa aacagatgag
     4261 aaagtagatg aatcgggacc tcccgcccct tccaaaccca ggagaggacg tcgacccaag
     4321 tctgaatctc agggcaatgc taccaaaaat gatgatctaa ataaacctat taacaaggga
     4381 aggaagagag ctgcagtggg tcaggagagc cctgggggtt tggaagcagg taatgccaaa
     4441 gcacccaaac tgcaagattt agccaaaaag gcagcaccag cagaaagaca aattgactta
     4501 caaaggtaaa aatgcatttg caaagggaga aaatgaaggc caaacagaag caggctccag
     4561 cttctgcaaa aacttggatt cacaaatgtc cctgaacaga aaatgaagct cacttcagaa
     4621 cacacactct ctgccttgaa aactaaagag actattactt ccttttcaca tgaccacaag
     4681 tcctctgatg gaaatgtaca gcagaaactc ttgagagaga ggctaaaagc aactctgttc
     4741 tcccccttcc cctagacttt tcttacgaaa agtcaataat taagcaaatt gcttaacact
     4801 tggttccagt tcctgcctat ctggagttta aatgcgtaat acaccattaa tttccacgct
     4861 gcagttttta ttttaaagaa agtaacaaga tgtctttaca ctgacactga aaattcatcc
     4921 attttagagc caggaattcc catgttacac aggaaaaaat agaagtctac tgaattaatt
     4981 ttttaaaaga aaagagatca gattaaatat ttctttgttt ttccttttgg aaacttttat
     5041 gtataattct ttctgcctgc ctacttttct gcaaaaatga gatgtacaga tttcggttcc
     5101 ctgctatgaa aagtgatgtg gtagcaattt tataaatgtt gctttctgat ttttatcaga
     5161 gtgagaaaat taaaattatt gatttgcaag tagtaaacag ttcatatttt gatttcccct
     5221 cattttagtt taatataatt tgcaataaat gtacatattg ttgtttgttt cataaagcat
     5281 atcactttaa aatggttttt actcctgtga ttatgttgga atatttggaa ttttaaagga
     5341 gtaaagactg tccagcattt ggttttataa tgtttgtcac cagattttta ttaatgtaaa
     5401 aaaaatcaat ttttaaaaaa tagttggact ttggcagctt ttaaggaaag ttggaggtgt
     5461 tttaggattg ctatcaattt tcagcattgt gctatttgga aataagtgtt ttgcttttgt
     5521 ctgatggtct gggctcattt ttatgtttat tttagaaaac tgttgcatca atatattatg
     5581 tttcttggca ttgttcagca taggtaatgt gtgcacttta tgtgtacaca taatcatatt
     5641 taagtttttt gcataaaata aatgcttcta gatgtcatgg cagtcttttt aatcttttta
     5701 tcatatgctt tcttgtgaat tttttcatgt taaagagcta aagtcataac atgattacag
     5761 tcaactctcc attatctata taaaatagtg actaagcctc aggtttttaa ttttgtgata
     5821 acaaaataac gaaggcatgt aagacctgat tctggaggaa catgaaattt gtcttttctc
     5881 atgtccagag ttctatcctg cccccactgt ccactgtagg gtcatccgca aagccctagc
     5941 agaatgtgct cactccattt ccttacacgt ttctagcatg ggtcagagga aacaacattt
     6001 gtgttataac ttcgtcttga taggctgtag tgtacatggg atgtaaaaca aacaagtgta
     6061 tcaaaggtgg atgattctgt tagagtgaag tttgagagta aatgtcactt acgtttctca
     6121 tagataatca agagttggct gtgtattgac tgaaagatgg gtaattattt taaatatgca
     6181 tttacacaca tttaggtatc agaagatgct tagggaacaa tggataccaa tgatagaaaa
     6241 tgataccttt acaggggcag aaaaatcccc actcttcctt attgcctctt cagaaccctt
     6301 tagaaagtat aaaatattgc ctccaacatg ctgaaaaaga gtatctatgc ataagtatca
     6361 gagaagtccc tcaagcaatc agtaggtgtg ttctatttag agagagttta aagttctctt
     6421 agcatcagac aacttgattc ctaaggtttc cagtgtgtca ccaacaaaaa gtgcattgat
     6481 agggaccttt gtctcttcct ccctttgatt aattgcccgg catcacagtt tactagatta
     6541 ccaagtgtta catcatatta aataaaatgt agcagaacca tctgcatcaa tatattcctg
     6601 tttagatttt tgcaggagag aagttaaaag gatttgctcc ttgtatgatg taagtggccc
     6661 accccaattt tgtaacatga tgcaagtgtc tggcactaag ggaagcaaga gtagggttgt
     6721 ggaaagacca agctgatggg gagggacttg tttacgggaa tttttttagt tttccttttc
     6781 aaaggaaaac attaaaatcc cttaggaatt tggtattcac atctcagaga actacaacac
     6841 aaaagtgcag acttatattt gagaattaat gttaaccctt tgtgtctagt ttgaagcttc
     6901 ttgtatttgt ctaaaacaac aagccagaat tttgtatctc ctttgataaa aagtgtgtat
     6961 aatgtaaagt agttttgcat attcttgtgc tgcacatggg ctgaattttt aaattttttt
     7021 taaaaacttg aagcagaacc ttgtaatttg tgtaaatgac aagtgtaaaa tcctaccata
     7081 aaatgctaaa aatatgcact gtttcaaata aaaccaagaa atgcagcatt a
//
