LOCUS       NM_030815               1957 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens p53 and DNA damage regulated 1 (PDRG1), mRNA.
ACCESSION   NM_030815
VERSION     NM_030815.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1957)
  AUTHORS   Sun,J., Xu,Y., Liu,J., Cui,H., Cao,H. and Ren,J.
  TITLE     PDRG1 promotes the proliferation and migration of GBM cells by the
            MEK/ERK/CD44 pathway
  JOURNAL   Cancer Sci 113 (2), 500-516 (2022)
   PUBMED   34812552
  REMARK    GeneRIF: PDRG1 promotes the proliferation and migration of GBM
            cells by the MEK/ERK/CD44 pathway.
REFERENCE   2  (bases 1 to 1957)
  AUTHORS   Xu,Y., Liu,J., Jiang,T., Shi,L., Shang,L., Song,J. and Li,L.
  TITLE     PDRG1 predicts a poor prognosis and facilitates the proliferation
            and metastasis of colorectal cancer
  JOURNAL   Exp Cell Res 409 (2), 112924 (2021)
   PUBMED   34780783
  REMARK    GeneRIF: PDRG1 predicts a poor prognosis and facilitates the
            proliferation and metastasis of colorectal cancer.
REFERENCE   3  (bases 1 to 1957)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1957)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1957)
  AUTHORS   Tao,Z., Zhang,Y., Zhu,S., Ni,Z., You,Q., Sun,X. and Xu,D.
  TITLE     Knockdown of PDRG1 Could Inhibit the Wnt Signaling Pathway in
            Esophageal Cancer Cells
  JOURNAL   Ann Clin Lab Sci 49 (6), 794-803 (2019)
   PUBMED   31882431
  REMARK    GeneRIF: PDRG1 association with the Wnt signaling pathway in
            esophageal cancer cells.PDRG1 may promote proliferation while
            inhibiting apoptosis and chemotherapy sensitivity in esophageal
            cancer cells.
REFERENCE   6  (bases 1 to 1957)
  AUTHORS   Jiang,L., Luo,X., Shi,J., Sun,H., Sun,Q., Sheikh,M.S. and Huang,Y.
  TITLE     PDRG1, a novel tumor marker for multiple malignancies that is
            selectively regulated by genotoxic stress
  JOURNAL   Cancer Biol Ther 11 (6), 567-573 (2011)
   PUBMED   21193842
  REMARK    GeneRIF: PDRG1 expression is increased in multiple human
            malignancies suggesting it to be a high-value novel tumor marker
            that could play a role in cancer development and/or progression.
REFERENCE   7  (bases 1 to 1957)
  AUTHORS   Cloutier,P., Al-Khoury,R., Lavallee-Adam,M., Faubert,D., Jiang,H.,
            Poitras,C., Bouchard,A., Forget,D., Blanchette,M. and Coulombe,B.
  TITLE     High-resolution mapping of the protein interaction network for the
            human transcription machinery and affinity purification of RNA
            polymerase II-associated complexes
  JOURNAL   Methods 48 (4), 381-386 (2009)
   PUBMED   19450687
  REMARK    GeneRIF: Is part of an RNA polymerase II-associated complex with
            possible chaperone activity.
REFERENCE   8  (bases 1 to 1957)
  AUTHORS   Bouwmeester,T., Bauch,A., Ruffner,H., Angrand,P.O., Bergamini,G.,
            Croughton,K., Cruciat,C., Eberhard,D., Gagneur,J., Ghidelli,S.,
            Hopf,C., Huhse,B., Mangano,R., Michon,A.M., Schirle,M., Schlegl,J.,
            Schwab,M., Stein,M.A., Bauer,A., Casari,G., Drewes,G., Gavin,A.C.,
            Jackson,D.B., Joberty,G., Neubauer,G., Rick,J., Kuster,B. and
            Superti-Furga,G.
  TITLE     A physical and functional map of the human TNF-alpha/NF-kappa B
            signal transduction pathway
  JOURNAL   Nat Cell Biol 6 (2), 97-105 (2004)
   PUBMED   14743216
  REMARK    Erratum:[Nat Cell Biol. 2004 May;6(5):465]
REFERENCE   9  (bases 1 to 1957)
  AUTHORS   Luo,X., Huang,Y. and Sheikh,M.S.
  TITLE     Cloning and characterization of a novel gene PDRG that is
            differentially regulated by p53 and ultraviolet radiation
  JOURNAL   Oncogene 22 (46), 7247-7257 (2003)
   PUBMED   14562055
  REMARK    GeneRIF: Cloning and characterization of a novel gene PDRG that is
            differentially regulated by p53 and ultraviolet radiation
REFERENCE   10 (bases 1 to 1957)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY286301.1, BC009334.2, BM679702.1 and AL031658.11.
            
            On Nov 23, 2018 this sequence version replaced NM_030815.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.2512425.1,
                                           SRR1803615.213360.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000202017.6/ ENSP00000202017.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AY286301.1         47-87
            42-1330             BC009334.2         1-1289
            1331-1339           BM679702.1         18-26               c
            1340-1957           AL031658.11        56683-57300         c
FEATURES             Location/Qualifiers
     source          1..1957
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.21"
     gene            1..1957
                     /gene="PDRG1"
                     /gene_synonym="C20orf126; PDRG"
                     /note="p53 and DNA damage regulated 1"
                     /db_xref="GeneID:81572"
                     /db_xref="HGNC:HGNC:16119"
                     /db_xref="MIM:610789"
     exon            1..172
                     /gene="PDRG1"
                     /gene_synonym="C20orf126; PDRG"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..487
                     /gene="PDRG1"
                     /gene_synonym="C20orf126; PDRG"
                     /note="epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="p53 and DNA damage-regulated protein 1"
                     /protein_id="NP_110442.1"
                     /db_xref="CCDS:CCDS13194.1"
                     /db_xref="GeneID:81572"
                     /db_xref="HGNC:HGNC:16119"
                     /db_xref="MIM:610789"
                     /translation="MLSPEAERVLRYLVEVEELAEEVLADKRQIVDLDTKRNQNREGL
                     RALQKDLSLSEDVMVCFGNMFIKMPHPETKEMIEKDQDHLDKEIEKLRKQLKVKVNRL
                     FEAQGKPELKGFNLNPLNQDELKALKVILKG"
     exon            173..248
                     /gene="PDRG1"
                     /gene_synonym="C20orf126; PDRG"
                     /inference="alignment:Splign:2.1.0"
     exon            249..323
                     /gene="PDRG1"
                     /gene_synonym="C20orf126; PDRG"
                     /inference="alignment:Splign:2.1.0"
     exon            324..404
                     /gene="PDRG1"
                     /gene_synonym="C20orf126; PDRG"
                     /inference="alignment:Splign:2.1.0"
     exon            405..1957
                     /gene="PDRG1"
                     /gene_synonym="C20orf126; PDRG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1310..1315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDRG1"
                     /gene_synonym="C20orf126; PDRG"
                     /note="hexamer: AATAAA"
     regulatory      1325..1330
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDRG1"
                     /gene_synonym="C20orf126; PDRG"
                     /note="hexamer: AATGAA"
     polyA_site      1330
                     /gene="PDRG1"
                     /gene_synonym="C20orf126; PDRG"
                     /note="major polyA site"
     polyA_site      1343
                     /gene="PDRG1"
                     /gene_synonym="C20orf126; PDRG"
     regulatory      1927..1932
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDRG1"
                     /gene_synonym="C20orf126; PDRG"
                     /note="hexamer: AATAAA"
     polyA_site      1957
                     /gene="PDRG1"
                     /gene_synonym="C20orf126; PDRG"
ORIGIN      
        1 acctagagag cggcgcgtgc gcagcgggag tcgaagcgga gatcccgggg tcgcgcgaga
       61 gccgcaagcg gagttggtgg gcgctatgct atcacccgag gcagagcgag tgctgcggta
      121 ccttgtagaa gtggaggagc tcgccgagga ggtgctggcg gacaagcggc agattgtgga
      181 cctggacact aaaaggaatc agaatcgaga gggcctgagg gccctgcaga aggatctcag
      241 cctctctgaa gatgtgatgg tttgcttcgg gaacatgttt atcaagatgc ctcaccctga
      301 gacaaaggaa atgattgaaa aagatcaaga tcatctggat aaagaaatag aaaaactgcg
      361 gaagcaactt aaagtgaagg tcaaccgcct ttttgaggcc caaggcaaac cggagctgaa
      421 gggttttaac ttgaaccccc tcaaccagga tgagcttaaa gctctcaagg tcatcttgaa
      481 aggatgagac tcaagaacca agatggggga ccagcaaccc cccagggtca tggaggaccc
      541 aggaccctcc aaccttgaca cctgtaagga caggatctgc cctgtaaggg gccagccgtc
      601 aggaatctgg ccatgaaaac ctctttgtag tgcttggcta ctctgtgatg gcaggaggga
      661 accttcagcc tgtctggctg ctggacctgg acaccagggc tcggtggaca caagatctat
      721 tgacgggcct tggtagccac cagtgggtgt gtggggcagt ggctgtgggg gtgtaagaat
      781 gactgcaaca ggcacttccc aacaatggcc tgctgttcac atggaccctg agcaaggaag
      841 gagggaggga ggggcagagt ggagtgtcat tccagcattc ctctcagaag ggagagaggt
      901 tttcaggctg gtgccatgcg attggaataa agcaggaggc tcatgggtgg ttgctgaatg
      961 aagaacagaa tcttggtgct ttgtggctca ccacagccat ctgtggggca ggcacacaca
     1021 cctcccgcca gctccaattt tgcacttttt ccctgcttga ttccaagagt aggtgctgcc
     1081 tagcagccct tcgtggccac tctttactca ggagggcctt gcagagtcct gcaccaggcc
     1141 tgggtgagtg gatgcgcctc ttaccatatg acacgtgtca agatgccctt ccgccccctc
     1201 tgaaagtggg gcccggccag cactgctcgt tactgtctgc cttcagtggt ctgaggtccc
     1261 agtatgaact gccgtgaagt caaaactctt atgtgttcat taagggctca ataaatgtta
     1321 gctgaatgaa tgaatagcag caactagtct ttatttgcct catctagtcc ttcagtaagg
     1381 gcacgccact ccatttagaa tacaacctat gaacatggtt cttgccttga aataaacctg
     1441 tgatttgaca ggcgggtgat aacaaatggc agcatggcag gggcacacct ctcctggtcc
     1501 ccccgctcct tggctctggc tcatagttac atagaaacac aggctgtcat ggccagttct
     1561 tacgtgtttt caagagaagc tagacatatg ggttgtgaag ttgaatctcc ttttaaatat
     1621 ttttgactaa tgcagaaact tttaaaacat gagtgtgggt cacaggtgtt agctccagat
     1681 agtgcaatac catacaacta taatcaagaa taaggaacaa gctccaagat acatcaagtg
     1741 aggaaagcaa ggggaaggct ggtgtcttat aagctaataa tttttgtgca agcacagtgt
     1801 gattccctca gaacagcacc tgcagggttg gggcgcacag gtgggaggga aggagatgtc
     1861 accctatacc cttttgtaaa ctttggattt taaaccgtat gaatatattg cttattttaa
     1921 aatgtaaata aagtagggag ttgcagaatt caccttg
//
