LOCUS       NM_198389               2822 bp    mRNA    linear   PRI 07-MAY-2024
DEFINITION  Homo sapiens podoplanin (PDPN), transcript variant 2, mRNA.
ACCESSION   NM_198389
VERSION     NM_198389.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2822)
  AUTHORS   Luo,J., Zhou,J., Luo,J.Z., Wang,H.L., Zhao,X.L. and Zhou,R.D.
  TITLE     Inhibiting MMP13 Attenuates Deep Vein Thrombosis in a Mouse Model
            by Reducing the Expression of Pdpn
  JOURNAL   Curr Med Sci 44 (2), 369-379 (2024)
   PUBMED   38619683
  REMARK    GeneRIF: Inhibiting MMP13 Attenuates Deep Vein Thrombosis in a
            Mouse Model by Reducing the Expression of Pdpn.
REFERENCE   2  (bases 1 to 2822)
  AUTHORS   Wu,M., Shi,Y., Liu,Y., Huang,H., Che,J., Shi,J. and Xu,C.
  TITLE     Exosome-transmitted podoplanin promotes tumor-associated
            macrophage-mediated immune tolerance in glioblastoma
  JOURNAL   CNS Neurosci Ther 30 (3), e14643 (2024)
   PUBMED   38470096
  REMARK    GeneRIF: Exosome-transmitted podoplanin promotes tumor-associated
            macrophage-mediated immune tolerance in glioblastoma.
REFERENCE   3  (bases 1 to 2822)
  AUTHORS   Gabusi,A., Asioli,S., Fabbri,V.P., Fellegara,G., Gibertoni,D.,
            Rossi,R., Battaglia,S., Tarsitano,A., Balbi,T., Marchetti,C.,
            Montebugnoli,L., Foschini,M.P. and Gissi,D.B.
  TITLE     Pre-operative incisional biopsy of oral squamous cell carcinoma:
            high podoplanin expression is related to perineural invasion and
            may be a useful predictor of disease progression
  JOURNAL   Oral Surg Oral Med Oral Pathol Oral Radiol 137 (1), 53-60 (2024)
   PUBMED   37891118
  REMARK    GeneRIF: Pre-operative incisional biopsy of oral squamous cell
            carcinoma: high podoplanin expression is related to perineural
            invasion and may be a useful predictor of disease progression.
REFERENCE   4  (bases 1 to 2822)
  AUTHORS   Murao,K. and Kubo,Y.
  TITLE     Podoplanin-positive cells located in the basal layer of Bowen
            disease include tumor cells with cancer stem cell properties
  JOURNAL   J Dermatol 50 (12), 1560-1567 (2023)
   PUBMED   37658727
  REMARK    GeneRIF: Podoplanin-positive cells located in the basal layer of
            Bowen disease include tumor cells with cancer stem cell properties.
REFERENCE   5  (bases 1 to 2822)
  AUTHORS   Kabra,H., Mohanty,N.R., Tripathy,S., Mohanty,M., Senapati,U. and
            Rath,J.
  TITLE     Expression of Claudin-4 and D2-40 and their significance in
            prostatic adenocarcinoma
  JOURNAL   J Cancer Res Ther 19 (Suppl 2), S800-S806 (2023)
   PUBMED   38384059
  REMARK    GeneRIF: Expression of Claudin-4 and D2-40 and their significance
            in prostatic adenocarcinoma.
REFERENCE   6  (bases 1 to 2822)
  AUTHORS   Kato,Y., Fujita,N., Kunita,A., Sato,S., Kaneko,M., Osawa,M. and
            Tsuruo,T.
  TITLE     Molecular identification of Aggrus/T1alpha as a platelet
            aggregation-inducing factor expressed in colorectal tumors
  JOURNAL   J Biol Chem 278 (51), 51599-51605 (2003)
   PUBMED   14522983
  REMARK    GeneRIF: Aggrus is a platelet aggregation-inducing factor expressed
            in colorectal tumors
REFERENCE   7  (bases 1 to 2822)
  AUTHORS   Zimmer,G., Oeffner,F., Von Messling,V., Tschernig,T., Groness,H.J.,
            Klenk,H.D. and Herrler,G.
  TITLE     Cloning and characterization of gp36, a human mucin-type
            glycoprotein preferentially expressed in vascular endothelium
  JOURNAL   Biochem J 341 (Pt 2) (Pt 2), 277-284 (1999)
   PUBMED   10393083
REFERENCE   8  (bases 1 to 2822)
  AUTHORS   Ma,T., Yang,B., Matthay,M.A. and Verkman,A.S.
  TITLE     Evidence against a role of mouse, rat, and two cloned human t1alpha
            isoforms as a water channel or a regulator of aquaporin-type water
            channels
  JOURNAL   Am J Respir Cell Mol Biol 19 (1), 143-149 (1998)
   PUBMED   9651190
REFERENCE   9  (bases 1 to 2822)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
REFERENCE   10 (bases 1 to 2822)
  AUTHORS   Cross,S.H., Charlton,J.A., Nan,X. and Bird,A.P.
  TITLE     Purification of CpG islands using a methylated DNA binding column
  JOURNAL   Nat Genet 6 (3), 236-244 (1994)
   PUBMED   8012384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BE887331.1, BC014668.1,
            AY194238.1, AF390106.1, AK075327.1, AK075345.1, BF340649.1 and
            AW022996.1.
            
            On Oct 28, 2004 this sequence version replaced NM_198389.1.
            
            Summary: This gene encodes a type-I integral membrane glycoprotein
            with diverse distribution in human tissues. The physiological
            function of this protein may be related to its mucin-type
            character. The homologous protein in other species has been
            described as a differentiation antigen and influenza-virus
            receptor. The specific function of this protein has not been
            determined but it has been proposed as a marker of lung injury.
            Alternatively spliced transcript variants encoding different
            isoforms have been identified. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site compared to variant 1. The resulting isoform (b) has
            the same N- and C-termini but is shorter compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.266107.1,
                                           SRR1803611.51159.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                BE887331.1         1-44
            45-716              BC014668.1         1-672
            717-753             AY194238.1         643-679
            754-945             AY194238.1         686-877
            946-1099            BC014668.1         908-1061
            1100-1101           AF390106.1         1012-1013
            1102-1241           AK075327.1         1027-1166
            1242-1245           AK075345.1         1167-1170
            1246-1783           AY194238.1         1178-1715
            1784-1817           BF340649.1         391-424
            1818-2802           AY194238.1         1749-2733
            2803-2822           AW022996.1         241-260
FEATURES             Location/Qualifiers
     source          1..2822
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.21"
     gene            1..2822
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /note="podoplanin"
                     /db_xref="GeneID:10630"
                     /db_xref="HGNC:HGNC:29602"
                     /db_xref="MIM:608863"
     exon            1..344
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..760
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /note="isoform b is encoded by transcript variant 2;
                     hT1alpha-1; hT1alpha-2; lung type I cell membrane
                     associated glycoprotein; glycoprotein, 36-KD; lung type-I
                     cell membrane-associated glycoprotein (T1A-2); T1-alpha;
                     PA2.26 antigen; glycoprotein 36"
                     /codon_start=1
                     /product="podoplanin isoform b"
                     /protein_id="NP_938203.2"
                     /db_xref="CCDS:CCDS41266.1"
                     /db_xref="GeneID:10630"
                     /db_xref="HGNC:HGNC:29602"
                     /db_xref="MIM:608863"
                     /translation="MLTPLGKFSTAKFAVRLPRVWEARAPSLSGAPAPTPPAPPPSRS
                     SRLGLWPRCFLIFPQLRILLLGPQESNNSTGTMWKVSALLFVLGSASLWVLAEGASTG
                     QPEDDTETTGLEGGVAMPGAEDDVVTPGTSEDRYKSGLTTLVATSVNSVTGIRIEDLP
                     TSESTVHAQEQSPSATASNVATSHSTEKVDGDTQTTVEKDGLSTVTLVGIIVGVLLAI
                     GFIGAIIVVVMRKMSGRP"
     exon            345..478
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /inference="alignment:Splign:2.1.0"
     exon            479..608
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /inference="alignment:Splign:2.1.0"
     exon            609..647
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /inference="alignment:Splign:2.1.0"
     exon            648..753
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /inference="alignment:Splign:2.1.0"
     exon            754..2806
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1081..1086
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /note="hexamer: ATTATA"
     polyA_site      1099
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /note="major polyA site"
     regulatory      1191..1196
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /note="hexamer: AGTAAA"
     polyA_site      1236
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
     regulatory      2783..2788
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /note="hexamer: AATAAA"
     regulatory      2788..2793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /note="hexamer: AACAAA"
     polyA_site      2803
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
     polyA_site      2806
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /note="major polyA site"
ORIGIN      
        1 agaccacctt gcggccgacc ccgctccccc gcctcctcgg gagagataaa tgctgactcc
       61 gctcggaaag ttctcaactg caaagtttgc tgtccggctg cctagggtct gggaagctcg
      121 ggcaccctcc ctctccgggg ctcctgctcc cacccctccg gcccccccac cgtcgcgctc
      181 ctccaggctg ggcctgtggc cgcggtgctt tttaattttc ccccagctca gaatcttgct
      241 gctcggcccc caggagagca acaactcaac gggaacgatg tggaaggtgt cagctctgct
      301 cttcgttttg ggaagcgcgt cgctctgggt cctggcagaa ggagccagca caggccagcc
      361 agaagatgac actgagacta caggtttgga aggcggcgtt gccatgccag gtgccgaaga
      421 tgatgtggtg actccaggaa ccagcgaaga ccgctataag tctggcttga caactctggt
      481 ggcaacaagt gtcaacagtg taacaggcat tcgcatcgag gatctgccaa cttcagaaag
      541 cacagtccac gcgcaagaac aaagtccaag cgccacagcc tcaaacgtgg ccaccagtca
      601 ctccacggag aaagtggatg gagacacaca gacaacagtt gagaaagatg gtttgtcaac
      661 agtgaccctg gttggaatca tagttggggt cttactagcc atcggcttca ttggtgcaat
      721 catcgttgtg gttatgcgaa aaatgtcggg aaggccctaa agagctgaag ggttacgccc
      781 tgctgccaac gtgcttaaaa aaagaccgtt tctgactctg tgccctgtcc ctgagctcgt
      841 gggagaagat gacccgtgga acacttgcct ggcccactca gaatccacgg tgacctctcc
      901 gcttgccaaa ataaccgaag gaaagaccgt tcaccagact tggctcctct aaacatttgc
      961 tgttcaaaca tgtttttgaa tatacattct ataaaagatt atttgaaaga caaaattcat
     1021 agaaaatgga gcaaaactgt ataaactgat ttgtaactaa cactggacca ttggatcgat
     1081 attatatgct gtaaccatgt gtctccgtct gaccattctt gttattgtta aaatgcagag
     1141 gaatctggaa atatttatat ccacggagtc cttggatcca gtgctacgtc agtaaatagc
     1201 accagcattt tgcaattgct gatctgctga aatgtacaca ttctggtcta gtttggtcta
     1261 tcttttaaag cctgatctgg tgtgaataat caactaggaa atctaaactt ggataacacg
     1321 tggtgaacaa ctgcctttag ctggtccaga ttaatcattt caaagacatc cattttagat
     1381 cacaagcagg aagtcgatag tctcaaaggc actttgtttc tcccaagtag gccaccaggc
     1441 agcctctaga gttgctttac ccaaatcctt ctccagccat gacttggtga ctctaagctt
     1501 gctcccacct gccccctcca cttccctcag atgatgagga gccagggcta agggggcagc
     1561 cttctctctt cccagtgatg cacatccttc acattggctg ctttgttctg gaatatggat
     1621 atctcagcct ggatgccgag gaagctgctg gatgcttaat ggtgctagag gctcaagtgt
     1681 gtttgaaacc aagagccagt tgtcccccat gcagaaagaa atcctgtgtg agcctctggt
     1741 atgagaaata aaatctgcca gttttataac attcactttc tgcctctgag gaaagataca
     1801 gggaacaaaa atcaatttgt acagtcttaa tattaaaagc agcttgacta aatacctgat
     1861 ttaaaaatag aagacatccc cagtcctcat gacataccgc aaatatctgt ggggtcctgt
     1921 tgaaaagaac aaaataaagg agcccaaggg gtcattctgt ctcagcacca tccagcctgg
     1981 cacttctctt cccatatatc cattggattt tttttttttt ttcctaaaca aagtttttac
     2041 actgagcaga tgctctgtca tgatggcggt tgtgcaattc tggtatcctc taaatttgta
     2101 agcattcata aaacaggaaa aagtaaacta tcattcggaa gcacagccca ttcctcccat
     2161 tttttgcaat gatgtctgga tgttatttta aacagtgtgt ctgtgtgttc ccaaatccag
     2221 ctggccccac cagctcagat tccatttttt ttgtgtgtgt gtgtgaaacg tagtctgcaa
     2281 ctctgcctcc cggcaattat acatgtgtca ggatgtcaaa aagcaattct cctgcctcag
     2341 cctcctgagt agctgggact acaggttcct accaccacac ccggccaatt tttgtatttt
     2401 tagtagagat ggggtttcac cgtatcggcg aggatgatct ctatctcttg acctcgtgat
     2461 ctgcccgcct cggcctccca aagtgctggg attacaggcg tgtgccactg cgctcggcct
     2521 cagattccat atttgaacac cagctgattg agagaagggg aatgagaaga gctggatgag
     2581 tttaaataac tcattgttca gattcctgaa caggagttgg gataatggcc atcttttctt
     2641 tcctatcctt tcttcccccc tcactgtgaa aaataacagt ccaccccaag tcatacactg
     2701 gacccagtgc ctgcggggac aggactgtgg gtttcttggt cacacctgtg ttggtgctca
     2761 atgcagtgta gacatgtttt caaataaaac aaatgattgt gtacaaaaaa aaaaaaaaaa
     2821 aa
//
