LOCUS       NM_006474               2737 bp    mRNA    linear   PRI 07-MAY-2024
DEFINITION  Homo sapiens podoplanin (PDPN), transcript variant 1, mRNA.
ACCESSION   NM_006474 NM_013317
VERSION     NM_006474.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2737)
  AUTHORS   Luo,J., Zhou,J., Luo,J.Z., Wang,H.L., Zhao,X.L. and Zhou,R.D.
  TITLE     Inhibiting MMP13 Attenuates Deep Vein Thrombosis in a Mouse Model
            by Reducing the Expression of Pdpn
  JOURNAL   Curr Med Sci 44 (2), 369-379 (2024)
   PUBMED   38619683
  REMARK    GeneRIF: Inhibiting MMP13 Attenuates Deep Vein Thrombosis in a
            Mouse Model by Reducing the Expression of Pdpn.
REFERENCE   2  (bases 1 to 2737)
  AUTHORS   Wu,M., Shi,Y., Liu,Y., Huang,H., Che,J., Shi,J. and Xu,C.
  TITLE     Exosome-transmitted podoplanin promotes tumor-associated
            macrophage-mediated immune tolerance in glioblastoma
  JOURNAL   CNS Neurosci Ther 30 (3), e14643 (2024)
   PUBMED   38470096
  REMARK    GeneRIF: Exosome-transmitted podoplanin promotes tumor-associated
            macrophage-mediated immune tolerance in glioblastoma.
REFERENCE   3  (bases 1 to 2737)
  AUTHORS   Gabusi,A., Asioli,S., Fabbri,V.P., Fellegara,G., Gibertoni,D.,
            Rossi,R., Battaglia,S., Tarsitano,A., Balbi,T., Marchetti,C.,
            Montebugnoli,L., Foschini,M.P. and Gissi,D.B.
  TITLE     Pre-operative incisional biopsy of oral squamous cell carcinoma:
            high podoplanin expression is related to perineural invasion and
            may be a useful predictor of disease progression
  JOURNAL   Oral Surg Oral Med Oral Pathol Oral Radiol 137 (1), 53-60 (2024)
   PUBMED   37891118
  REMARK    GeneRIF: Pre-operative incisional biopsy of oral squamous cell
            carcinoma: high podoplanin expression is related to perineural
            invasion and may be a useful predictor of disease progression.
REFERENCE   4  (bases 1 to 2737)
  AUTHORS   Murao,K. and Kubo,Y.
  TITLE     Podoplanin-positive cells located in the basal layer of Bowen
            disease include tumor cells with cancer stem cell properties
  JOURNAL   J Dermatol 50 (12), 1560-1567 (2023)
   PUBMED   37658727
  REMARK    GeneRIF: Podoplanin-positive cells located in the basal layer of
            Bowen disease include tumor cells with cancer stem cell properties.
REFERENCE   5  (bases 1 to 2737)
  AUTHORS   Kabra,H., Mohanty,N.R., Tripathy,S., Mohanty,M., Senapati,U. and
            Rath,J.
  TITLE     Expression of Claudin-4 and D2-40 and their significance in
            prostatic adenocarcinoma
  JOURNAL   J Cancer Res Ther 19 (Suppl 2), S800-S806 (2023)
   PUBMED   38384059
  REMARK    GeneRIF: Expression of Claudin-4 and D2-40 and their significance
            in prostatic adenocarcinoma.
REFERENCE   6  (bases 1 to 2737)
  AUTHORS   Kato,Y., Fujita,N., Kunita,A., Sato,S., Kaneko,M., Osawa,M. and
            Tsuruo,T.
  TITLE     Molecular identification of Aggrus/T1alpha as a platelet
            aggregation-inducing factor expressed in colorectal tumors
  JOURNAL   J Biol Chem 278 (51), 51599-51605 (2003)
   PUBMED   14522983
  REMARK    GeneRIF: Aggrus is a platelet aggregation-inducing factor expressed
            in colorectal tumors
REFERENCE   7  (bases 1 to 2737)
  AUTHORS   Zimmer,G., Oeffner,F., Von Messling,V., Tschernig,T., Groness,H.J.,
            Klenk,H.D. and Herrler,G.
  TITLE     Cloning and characterization of gp36, a human mucin-type
            glycoprotein preferentially expressed in vascular endothelium
  JOURNAL   Biochem J 341 (Pt 2) (Pt 2), 277-284 (1999)
   PUBMED   10393083
REFERENCE   8  (bases 1 to 2737)
  AUTHORS   Ma,T., Yang,B., Matthay,M.A. and Verkman,A.S.
  TITLE     Evidence against a role of mouse, rat, and two cloned human t1alpha
            isoforms as a water channel or a regulator of aquaporin-type water
            channels
  JOURNAL   Am J Respir Cell Mol Biol 19 (1), 143-149 (1998)
   PUBMED   9651190
REFERENCE   9  (bases 1 to 2737)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
REFERENCE   10 (bases 1 to 2737)
  AUTHORS   Cross,S.H., Charlton,J.A., Nan,X. and Bird,A.P.
  TITLE     Purification of CpG islands using a methylated DNA binding column
  JOURNAL   Nat Genet 6 (3), 236-244 (1994)
   PUBMED   8012384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL354712.19, AY194238.1 and
            AL359771.27.
            
            On Jul 8, 2020 this sequence version replaced NM_006474.4.
            
            Summary: This gene encodes a type-I integral membrane glycoprotein
            with diverse distribution in human tissues. The physiological
            function of this protein may be related to its mucin-type
            character. The homologous protein in other species has been
            described as a differentiation antigen and influenza-virus
            receptor. The specific function of this protein has not been
            determined but it has been proposed as a marker of lung injury.
            Alternatively spliced transcript variants encoding different
            isoforms have been identified. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY194238.1, SRR14038196.2285279.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000621990.5/ ENSP00000478125.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                AL354712.19        100373-100463
            92-876              AY194238.1         93-877
            877-2737            AL359771.27        11350-13210
FEATURES             Location/Qualifiers
     source          1..2737
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.21"
     gene            1..2737
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /note="podoplanin"
                     /db_xref="GeneID:10630"
                     /db_xref="HGNC:HGNC:29602"
                     /db_xref="MIM:608863"
     exon            1..269
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..691
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; hT1alpha-1; hT1alpha-2; lung type I cell
                     membrane associated glycoprotein; glycoprotein, 36-KD;
                     lung type-I cell membrane-associated glycoprotein (T1A-2);
                     T1-alpha; PA2.26 antigen; glycoprotein 36"
                     /codon_start=1
                     /product="podoplanin isoform a precursor"
                     /protein_id="NP_006465.4"
                     /db_xref="CCDS:CCDS30602.2"
                     /db_xref="GeneID:10630"
                     /db_xref="HGNC:HGNC:29602"
                     /db_xref="MIM:608863"
                     /translation="MWKVSALLFVLGSASLWVLAEGASTGQPEDDTETTGLEGGVAMP
                     GAEDDVVTPGTSEDRYKSGLTTLVATSVNSVTGIRIEDLPTSESTVHAQEQSPSATAS
                     NVATSHSTEKVDGDTQTTVEKDGLSTVTLVGIIVGVLLAIGFIGAIIVVVMRKMSGRY
                     SP"
     exon            270..403
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /inference="alignment:Splign:2.1.0"
     exon            404..533
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /inference="alignment:Splign:2.1.0"
     exon            534..572
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /inference="alignment:Splign:2.1.0"
     exon            573..684
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /inference="alignment:Splign:2.1.0"
     exon            685..2737
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1012..1017
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /note="hexamer: ATTATA"
     polyA_site      1030
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /note="major polyA site"
     regulatory      1122..1127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /note="hexamer: AGTAAA"
     polyA_site      1167
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
     regulatory      2714..2719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /note="hexamer: AATAAA"
     regulatory      2719..2724
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /note="hexamer: AACAAA"
     polyA_site      2734
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
     polyA_site      2737
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /note="major polyA site"
ORIGIN      
        1 aactgcaaag tttgctgtcc ggctgcctag ggtctgggaa gctcgggcac cctccctctc
       61 cggggctcct gctcccaccc ctccggcccc cccaccgtcg cgctcctcca ggctgggcct
      121 gtggccgcgg tgctttttaa ttttccccca gctcagaatc ttgctgctcg gcccccagga
      181 gagcaacaac tcaacgggaa cgatgtggaa ggtgtcagct ctgctcttcg ttttgggaag
      241 cgcgtcgctc tgggtcctgg cagaaggagc cagcacaggc cagccagaag atgacactga
      301 gactacaggt ttggaaggcg gcgttgccat gccaggtgcc gaagatgatg tggtgactcc
      361 aggaaccagc gaagaccgct ataagtctgg cttgacaact ctggtggcaa caagtgtcaa
      421 cagtgtaaca ggcattcgca tcgaggatct gccaacttca gaaagcacag tccacgcgca
      481 agaacaaagt ccaagcgcca cagcctcaaa cgtggccacc agtcactcca cggagaaagt
      541 ggatggagac acacagacaa cagttgagaa agatggtttg tcaacagtga ccctggttgg
      601 aatcatagtt ggggtcttac tagccatcgg cttcattggt gcaatcatcg ttgtggttat
      661 gcgaaaaatg tcgggaaggt actcgcccta aagagctgaa gggttacgcc ctgctgccaa
      721 cgtgcttaaa aaaagaccgt ttctgactct gtgccctgtc cctgagctcg tgggagaaga
      781 tgacccgtgg aacacttgcc tggcccactc agaatccacg gtgacctctc cgcttgccaa
      841 aataaccgaa ggaaagaccg ttcaccagac ttggctcctc taaacatttg ctgttcaaac
      901 atgtttttga atatacattc tataaaagat tatttgaaag acaaaattca tagaaaatgg
      961 agcaaaactg tataaactga tttgtaacta acactggacc attggatcga tattatatgc
     1021 tgtaaccatg tgtctccgtc tgaccattct tgttattgtt aaaatgcaga ggaatctgga
     1081 aatatttata tccacggagt ccttggatcc agtgctacgt cagtaaatag caccagcatt
     1141 ttgcaattgc tgatctgctg aaatgtacac attctggtct agtttggtct atcttttaaa
     1201 gcctgatctg gtgtgaataa tcaactagga aatctaaact tggataacac gtggtgaaca
     1261 actgccttta gctggtccag attaatcatt tcaaagacat ccattttaga tcacaagcag
     1321 gaagtcgata gtctcaaagg cactttgttt ctcccaagta ggccaccagg cagcctctag
     1381 agttgcttta cccaaatcct tctccagcca tgacttggtg actctaagct tgctcccacc
     1441 tgccccctcc acttccctca gatgatgagg agccagggct aagggggcag ccttctctct
     1501 tcccagtgat gcacatcctt cacattggct gctttgttct ggaatatgga tatctcagcc
     1561 tggatgccga ggaagctgct ggatgcttaa tggtgctaga ggctcaagtg tgtttgaaac
     1621 caagagccag ttgtccccca tgcagaaaga aatcctgtgt gagcctctgg tatgagaaat
     1681 aaaatctgcc agttttataa cattcacttt ctgcctctga ggaaagatac agggaacaaa
     1741 aatcaatttg tacagtctta atattaaaag cagcttgact aaatacctga tttaaaaata
     1801 gaagacatcc ccagtcctca tgacataccg caaatatctg tggggtcctg ttgaaaagaa
     1861 caaaataaag gagcccaagg ggtcattctg tctcagcacc atccagcctg gcacttctct
     1921 tcccatatat ccattggatt tttttttttt tttcctaaac aaagttttta cactgagcag
     1981 atgctctgtc atgatggcgg ttgtgcaatt ctggtatcct ctaaatttgt aagcattcat
     2041 aaaacaggaa aaagtaaact atcattcgga agcacagccc attcctccca ttttttgcaa
     2101 tgatgtctgg atgttatttt aaacagtgtg tctgtgtgtt cccaaatcca gctggcccca
     2161 ccagctcaga ttccattttt tttgtgtgtg tgtgtgaaac gtagtctgca actctgcctc
     2221 ccggcaatta tacatgtgtc aggatgtcaa aaagcaattc tcctgcctca gcctcctgag
     2281 tagctgggac tacaggttcc taccaccaca cccggccaat ttttgtattt ttagtagaga
     2341 tggggtttca ccgtatcggc gaggatgatc tctatctctt gacctcgtga tctgcccgcc
     2401 tcggcctccc aaagtgctgg gattacaggc gtgtgccact gcgctcggcc tcagattcca
     2461 tatttgaaca ccagctgatt gagagaaggg gaatgagaag agctggatga gtttaaataa
     2521 ctcattgttc agattcctga acaggagttg ggataatggc catcttttct ttcctatcct
     2581 ttcttccccc ctcactgtga aaaataacag tccaccccaa gtcatacact ggacccagtg
     2641 cctgcgggga caggactgtg ggtttcttgg tcacacctgt gttggtgctc aatgcagtgt
     2701 agacatgttt tcaaataaaa caaatgattg tgtacaa
//
