LOCUS       NM_001385053            2717 bp    mRNA    linear   PRI 07-MAY-2024
DEFINITION  Homo sapiens podoplanin (PDPN), transcript variant 5, mRNA.
ACCESSION   NM_001385053 XM_024451415
VERSION     NM_001385053.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2717)
  AUTHORS   Luo,J., Zhou,J., Luo,J.Z., Wang,H.L., Zhao,X.L. and Zhou,R.D.
  TITLE     Inhibiting MMP13 Attenuates Deep Vein Thrombosis in a Mouse Model
            by Reducing the Expression of Pdpn
  JOURNAL   Curr Med Sci 44 (2), 369-379 (2024)
   PUBMED   38619683
  REMARK    GeneRIF: Inhibiting MMP13 Attenuates Deep Vein Thrombosis in a
            Mouse Model by Reducing the Expression of Pdpn.
REFERENCE   2  (bases 1 to 2717)
  AUTHORS   Wu,M., Shi,Y., Liu,Y., Huang,H., Che,J., Shi,J. and Xu,C.
  TITLE     Exosome-transmitted podoplanin promotes tumor-associated
            macrophage-mediated immune tolerance in glioblastoma
  JOURNAL   CNS Neurosci Ther 30 (3), e14643 (2024)
   PUBMED   38470096
  REMARK    GeneRIF: Exosome-transmitted podoplanin promotes tumor-associated
            macrophage-mediated immune tolerance in glioblastoma.
REFERENCE   3  (bases 1 to 2717)
  AUTHORS   Gabusi,A., Asioli,S., Fabbri,V.P., Fellegara,G., Gibertoni,D.,
            Rossi,R., Battaglia,S., Tarsitano,A., Balbi,T., Marchetti,C.,
            Montebugnoli,L., Foschini,M.P. and Gissi,D.B.
  TITLE     Pre-operative incisional biopsy of oral squamous cell carcinoma:
            high podoplanin expression is related to perineural invasion and
            may be a useful predictor of disease progression
  JOURNAL   Oral Surg Oral Med Oral Pathol Oral Radiol 137 (1), 53-60 (2024)
   PUBMED   37891118
  REMARK    GeneRIF: Pre-operative incisional biopsy of oral squamous cell
            carcinoma: high podoplanin expression is related to perineural
            invasion and may be a useful predictor of disease progression.
REFERENCE   4  (bases 1 to 2717)
  AUTHORS   Murao,K. and Kubo,Y.
  TITLE     Podoplanin-positive cells located in the basal layer of Bowen
            disease include tumor cells with cancer stem cell properties
  JOURNAL   J Dermatol 50 (12), 1560-1567 (2023)
   PUBMED   37658727
  REMARK    GeneRIF: Podoplanin-positive cells located in the basal layer of
            Bowen disease include tumor cells with cancer stem cell properties.
REFERENCE   5  (bases 1 to 2717)
  AUTHORS   Kabra,H., Mohanty,N.R., Tripathy,S., Mohanty,M., Senapati,U. and
            Rath,J.
  TITLE     Expression of Claudin-4 and D2-40 and their significance in
            prostatic adenocarcinoma
  JOURNAL   J Cancer Res Ther 19 (Suppl 2), S800-S806 (2023)
   PUBMED   38384059
  REMARK    GeneRIF: Expression of Claudin-4 and D2-40 and their significance
            in prostatic adenocarcinoma.
REFERENCE   6  (bases 1 to 2717)
  AUTHORS   Kato,Y., Fujita,N., Kunita,A., Sato,S., Kaneko,M., Osawa,M. and
            Tsuruo,T.
  TITLE     Molecular identification of Aggrus/T1alpha as a platelet
            aggregation-inducing factor expressed in colorectal tumors
  JOURNAL   J Biol Chem 278 (51), 51599-51605 (2003)
   PUBMED   14522983
  REMARK    GeneRIF: Aggrus is a platelet aggregation-inducing factor expressed
            in colorectal tumors
REFERENCE   7  (bases 1 to 2717)
  AUTHORS   Zimmer,G., Oeffner,F., Von Messling,V., Tschernig,T., Groness,H.J.,
            Klenk,H.D. and Herrler,G.
  TITLE     Cloning and characterization of gp36, a human mucin-type
            glycoprotein preferentially expressed in vascular endothelium
  JOURNAL   Biochem J 341 (Pt 2) (Pt 2), 277-284 (1999)
   PUBMED   10393083
REFERENCE   8  (bases 1 to 2717)
  AUTHORS   Ma,T., Yang,B., Matthay,M.A. and Verkman,A.S.
  TITLE     Evidence against a role of mouse, rat, and two cloned human t1alpha
            isoforms as a water channel or a regulator of aquaporin-type water
            channels
  JOURNAL   Am J Respir Cell Mol Biol 19 (1), 143-149 (1998)
   PUBMED   9651190
REFERENCE   9  (bases 1 to 2717)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
REFERENCE   10 (bases 1 to 2717)
  AUTHORS   Cross,S.H., Charlton,J.A., Nan,X. and Bird,A.P.
  TITLE     Purification of CpG islands using a methylated DNA binding column
  JOURNAL   Nat Genet 6 (3), 236-244 (1994)
   PUBMED   8012384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL354712.19 and AL359771.27.
            
            On Jul 8, 2020 this sequence version replaced XM_024451415.1.
            
            Summary: This gene encodes a type-I integral membrane glycoprotein
            with diverse distribution in human tissues. The physiological
            function of this protein may be related to its mucin-type
            character. The homologous protein in other species has been
            described as a differentiation antigen and influenza-virus
            receptor. The specific function of this protein has not been
            determined but it has been proposed as a marker of lung injury.
            Alternatively spliced transcript variants encoding different
            isoforms have been identified. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.218609.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-255               AL354712.19        102001-102255
            256-389             AL359771.27        2426-2559
            390-519             AL359771.27        5640-5769
            520-558             AL359771.27        8940-8978
            559-664             AL359771.27        9553-9658
            665-2717            AL359771.27        11158-13210
FEATURES             Location/Qualifiers
     source          1..2717
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.21"
     gene            1..2717
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /note="podoplanin"
                     /db_xref="GeneID:10630"
                     /db_xref="HGNC:HGNC:29602"
                     /db_xref="MIM:608863"
     exon            1..255
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /inference="alignment:Splign:2.1.0"
     exon            256..389
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             315..671
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /note="isoform d is encoded by transcript variant 5;
                     hT1alpha-1; hT1alpha-2; lung type I cell membrane
                     associated glycoprotein; glycoprotein, 36-KD; lung type-I
                     cell membrane-associated glycoprotein (T1A-2); T1-alpha;
                     PA2.26 antigen; glycoprotein 36"
                     /codon_start=1
                     /product="podoplanin isoform d"
                     /protein_id="NP_001371982.1"
                     /db_xref="CCDS:CCDS53270.1"
                     /db_xref="GeneID:10630"
                     /db_xref="HGNC:HGNC:29602"
                     /db_xref="MIM:608863"
                     /translation="MPGAEDDVVTPGTSEDRYKSGLTTLVATSVNSVTGIRIEDLPTS
                     ESTVHAQEQSPSATASNVATSHSTEKVDGDTQTTVEKDGLSTVTLVGIIVGVLLAIGF
                     IGAIIVVVMRKMSGRP"
     exon            390..519
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /inference="alignment:Splign:2.1.0"
     exon            520..558
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /inference="alignment:Splign:2.1.0"
     exon            559..664
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /inference="alignment:Splign:2.1.0"
     exon            665..2717
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      992..997
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /note="hexamer: ATTATA"
     polyA_site      1010
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /note="major polyA site"
     regulatory      1102..1107
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /note="hexamer: AGTAAA"
     polyA_site      1147
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
     regulatory      2694..2699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /note="hexamer: AATAAA"
     regulatory      2699..2704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /note="hexamer: AACAAA"
     polyA_site      2714
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
     polyA_site      2717
                     /gene="PDPN"
                     /gene_synonym="AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1;
                     OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A"
                     /note="major polyA site"
ORIGIN      
        1 cctttttggc gagacaatgt gcaaatgaca ccgttttgtg ctcaccaggg caaagcaagg
       61 gagcgccctc acttcagcat ctcagccctg ctaaagaaaa agctgctggg taacatcctt
      121 tgtttttgcc cagggaagct ttagctgtga ttcccttcag ccggctcctg aatgtcaaag
      181 gtactcctaa aagatggcgt taaaaccgaa aaaccatcgt tggtgctgga aactccacta
      241 ctaaagaaag aagtgccagc acaggccagc cagaagatga cactgagact acaggtttgg
      301 aaggcggcgt tgccatgcca ggtgccgaag atgatgtggt gactccagga accagcgaag
      361 accgctataa gtctggcttg acaactctgg tggcaacaag tgtcaacagt gtaacaggca
      421 ttcgcatcga ggatctgcca acttcagaaa gcacagtcca cgcgcaagaa caaagtccaa
      481 gcgccacagc ctcaaacgtg gccaccagtc actccacgga gaaagtggat ggagacacac
      541 agacaacagt tgagaaagat ggtttgtcaa cagtgaccct ggttggaatc atagttgggg
      601 tcttactagc catcggcttc attggtgcaa tcatcgttgt ggttatgcga aaaatgtcgg
      661 gaaggcccta aagagctgaa gggttacgcc ctgctgccaa cgtgcttaaa aaaagaccgt
      721 ttctgactct gtgccctgtc cctgagctcg tgggagaaga tgacccgtgg aacacttgcc
      781 tggcccactc agaatccacg gtgacctctc cgcttgccaa aataaccgaa ggaaagaccg
      841 ttcaccagac ttggctcctc taaacatttg ctgttcaaac atgtttttga atatacattc
      901 tataaaagat tatttgaaag acaaaattca tagaaaatgg agcaaaactg tataaactga
      961 tttgtaacta acactggacc attggatcga tattatatgc tgtaaccatg tgtctccgtc
     1021 tgaccattct tgttattgtt aaaatgcaga ggaatctgga aatatttata tccacggagt
     1081 ccttggatcc agtgctacgt cagtaaatag caccagcatt ttgcaattgc tgatctgctg
     1141 aaatgtacac attctggtct agtttggtct atcttttaaa gcctgatctg gtgtgaataa
     1201 tcaactagga aatctaaact tggataacac gtggtgaaca actgccttta gctggtccag
     1261 attaatcatt tcaaagacat ccattttaga tcacaagcag gaagtcgata gtctcaaagg
     1321 cactttgttt ctcccaagta ggccaccagg cagcctctag agttgcttta cccaaatcct
     1381 tctccagcca tgacttggtg actctaagct tgctcccacc tgccccctcc acttccctca
     1441 gatgatgagg agccagggct aagggggcag ccttctctct tcccagtgat gcacatcctt
     1501 cacattggct gctttgttct ggaatatgga tatctcagcc tggatgccga ggaagctgct
     1561 ggatgcttaa tggtgctaga ggctcaagtg tgtttgaaac caagagccag ttgtccccca
     1621 tgcagaaaga aatcctgtgt gagcctctgg tatgagaaat aaaatctgcc agttttataa
     1681 cattcacttt ctgcctctga ggaaagatac agggaacaaa aatcaatttg tacagtctta
     1741 atattaaaag cagcttgact aaatacctga tttaaaaata gaagacatcc ccagtcctca
     1801 tgacataccg caaatatctg tggggtcctg ttgaaaagaa caaaataaag gagcccaagg
     1861 ggtcattctg tctcagcacc atccagcctg gcacttctct tcccatatat ccattggatt
     1921 tttttttttt tttcctaaac aaagttttta cactgagcag atgctctgtc atgatggcgg
     1981 ttgtgcaatt ctggtatcct ctaaatttgt aagcattcat aaaacaggaa aaagtaaact
     2041 atcattcgga agcacagccc attcctccca ttttttgcaa tgatgtctgg atgttatttt
     2101 aaacagtgtg tctgtgtgtt cccaaatcca gctggcccca ccagctcaga ttccattttt
     2161 tttgtgtgtg tgtgtgaaac gtagtctgca actctgcctc ccggcaatta tacatgtgtc
     2221 aggatgtcaa aaagcaattc tcctgcctca gcctcctgag tagctgggac tacaggttcc
     2281 taccaccaca cccggccaat ttttgtattt ttagtagaga tggggtttca ccgtatcggc
     2341 gaggatgatc tctatctctt gacctcgtga tctgcccgcc tcggcctccc aaagtgctgg
     2401 gattacaggc gtgtgccact gcgctcggcc tcagattcca tatttgaaca ccagctgatt
     2461 gagagaaggg gaatgagaag agctggatga gtttaaataa ctcattgttc agattcctga
     2521 acaggagttg ggataatggc catcttttct ttcctatcct ttcttccccc ctcactgtga
     2581 aaaataacag tccaccccaa gtcatacact ggacccagtg cctgcgggga caggactgtg
     2641 ggtttcttgg tcacacctgt gttggtgctc aatgcagtgt agacatgttt tcaaataaaa
     2701 caaatgattg tgtacaa
//
