LOCUS       NM_002613               7184 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens 3-phosphoinositide dependent protein kinase 1 (PDPK1),
            transcript variant 1, mRNA.
ACCESSION   NM_002613 XM_001130789
VERSION     NM_002613.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7184)
  AUTHORS   Liu,S., Chen,X., Zhang,L. and Lu,B.
  TITLE     CPT1A mediates the succinylation of SP5 which activates
            transcription of PDPK1 to promote the viability and glycolysis of
            prostate cancer cells
  JOURNAL   Cancer Biol Ther 25 (1), 2329372 (2024)
   PUBMED   38494680
  REMARK    GeneRIF: CPT1A mediates the succinylation of SP5 which activates
            transcription of PDPK1 to promote the viability and glycolysis of
            prostate cancer cells.
REFERENCE   2  (bases 1 to 7184)
  AUTHORS   Streeter,S.A., Williams,A.G., Evans,J.R., Wang,J., Guarnaccia,A.D.,
            Florian,A.C., Al-Tobasei,R., Liu,Q., Tansey,W.P. and
            Weissmiller,A.M.
  TITLE     Mitotic gene regulation by the N-MYC-WDR5-PDPK1 nexus
  JOURNAL   BMC Genomics 25 (1), 360 (2024)
   PUBMED   38605297
  REMARK    GeneRIF: Mitotic gene regulation by the N-MYC-WDR5-PDPK1 nexus.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7184)
  AUTHORS   Wu,K., Wu,B., Yan,K., Ding,Q. and Miao,Z.
  TITLE     KLK10 promotes the progression of KRAS mutant colorectal cancer via
            PAR1-PDK1-AKT signaling pathway
  JOURNAL   Cell Biol Int 48 (4), 440-449 (2024)
   PUBMED   38115179
  REMARK    GeneRIF: KLK10 promotes the progression of KRAS mutant colorectal
            cancer via PAR1-PDK1-AKT signaling pathway.
REFERENCE   4  (bases 1 to 7184)
  AUTHORS   Han,D., Wang,W., Jeon,J.H., Shen,T., Huang,X., Yi,P., Dong,B. and
            Yang,F.
  TITLE     Cooperative activation of PDK1 and AKT by MAPK4 enhances cancer
            growth and resistance to therapy
  JOURNAL   PLoS Biol 21 (8), e3002227 (2023)
   PUBMED   37531320
  REMARK    GeneRIF: Cooperative activation of PDK1 and AKT by MAPK4 enhances
            cancer growth and resistance to therapy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7184)
  AUTHORS   You,L., Dou,Y., Zhang,Y., Xiao,H., Lv,H., Wei,G.H. and Xu,D.
  TITLE     SDC2 Stabilization by USP14 Promotes Gastric Cancer Progression
            through Co-option of PDK1
  JOURNAL   Int J Biol Sci 19 (11), 3483-3498 (2023)
   PUBMED   37496999
  REMARK    GeneRIF: SDC2 Stabilization by USP14 Promotes Gastric Cancer
            Progression through Co-option of PDK1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7184)
  AUTHORS   Meier,R., Alessi,D.R., Cron,P., Andjelkovic,M. and Hemmings,B.A.
  TITLE     Mitogenic activation, phosphorylation, and nuclear translocation of
            protein kinase Bbeta
  JOURNAL   J Biol Chem 272 (48), 30491-30497 (1997)
   PUBMED   9374542
REFERENCE   7  (bases 1 to 7184)
  AUTHORS   Shaw,M., Cohen,P. and Alessi,D.R.
  TITLE     Further evidence that the inhibition of glycogen synthase
            kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced
            phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216
  JOURNAL   FEBS Lett 416 (3), 307-311 (1997)
   PUBMED   9373175
REFERENCE   8  (bases 1 to 7184)
  AUTHORS   Alessi,D.R., Deak,M., Casamayor,A., Caudwell,F.B., Morrice,N.,
            Norman,D.G., Gaffney,P., Reese,C.B., MacDougall,C.N., Harbison,D.,
            Ashworth,A. and Bownes,M.
  TITLE     3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural
            and functional homology with the Drosophila DSTPK61 kinase
  JOURNAL   Curr Biol 7 (10), 776-789 (1997)
   PUBMED   9368760
REFERENCE   9  (bases 1 to 7184)
  AUTHORS   Moser,B.A., Dennis,P.B., Pullen,N., Pearson,R.B., Williamson,N.A.,
            Wettenhall,R.E., Kozma,S.C. and Thomas,G.
  TITLE     Dual requirement for a newly identified phosphorylation site in
            p70s6k
  JOURNAL   Mol Cell Biol 17 (9), 5648-5655 (1997)
   PUBMED   9271440
REFERENCE   10 (bases 1 to 7184)
  AUTHORS   Alessi,D.R., James,S.R., Downes,C.P., Holmes,A.B., Gaffney,P.R.,
            Reese,C.B. and Cohen,P.
  TITLE     Characterization of a 3-phosphoinositide-dependent protein kinase
            which phosphorylates and activates protein kinase Balpha
  JOURNAL   Curr Biol 7 (4), 261-269 (1997)
   PUBMED   9094314
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC012103.1 and AC141586.2.
            
            On Nov 22, 2018 this sequence version replaced NM_002613.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK222581.1, SRR1660803.30788.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342085.9/ ENSP00000344220.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1907              BC012103.1         18-1924
            1908-7184           AC141586.2         62527-67803         c
FEATURES             Location/Qualifiers
     source          1..7184
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..7184
                     /gene="PDPK1"
                     /gene_synonym="PDK1; PDPK2; PDPK2P; PRO0461"
                     /note="3-phosphoinositide dependent protein kinase 1"
                     /db_xref="GeneID:5170"
                     /db_xref="HGNC:HGNC:8816"
                     /db_xref="MIM:605213"
     exon            1..116
                     /gene="PDPK1"
                     /gene_synonym="PDK1; PDPK2; PDPK2P; PRO0461"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1763
                     /gene="PDPK1"
                     /gene_synonym="PDK1; PDPK2; PDPK2P; PRO0461"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1; PkB
                     kinase like gene 1; 3-phosphoinositide-dependent protein
                     kinase 2 pseudogene; Putative 3-phosphoinositide-dependent
                     protein kinase 2"
                     /codon_start=1
                     /product="3-phosphoinositide-dependent protein kinase 1
                     isoform 1"
                     /protein_id="NP_002604.1"
                     /db_xref="CCDS:CCDS10472.1"
                     /db_xref="GeneID:5170"
                     /db_xref="HGNC:HGNC:8816"
                     /db_xref="MIM:605213"
                     /translation="MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGG
                     SRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLAREL
                     ATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLS
                     YAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMH
                     IQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLV
                     AGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYG
                     PLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSS
                     SSHSLSASDTGLPQRSGSNIEQYIHDLDSNSFELDLQFSEDEKRLLLEKQAGGNPWHQ
                     FVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEA
                     KNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQRYQSHPDAAVQ"
     exon            117..377
                     /gene="PDPK1"
                     /gene_synonym="PDK1; PDPK2; PDPK2P; PRO0461"
                     /inference="alignment:Splign:2.1.0"
     exon            378..420
                     /gene="PDPK1"
                     /gene_synonym="PDK1; PDPK2; PDPK2P; PRO0461"
                     /inference="alignment:Splign:2.1.0"
     exon            421..558
                     /gene="PDPK1"
                     /gene_synonym="PDK1; PDPK2; PDPK2P; PRO0461"
                     /inference="alignment:Splign:2.1.0"
     exon            559..703
                     /gene="PDPK1"
                     /gene_synonym="PDK1; PDPK2; PDPK2P; PRO0461"
                     /inference="alignment:Splign:2.1.0"
     exon            704..801
                     /gene="PDPK1"
                     /gene_synonym="PDK1; PDPK2; PDPK2P; PRO0461"
                     /inference="alignment:Splign:2.1.0"
     exon            802..877
                     /gene="PDPK1"
                     /gene_synonym="PDK1; PDPK2; PDPK2P; PRO0461"
                     /inference="alignment:Splign:2.1.0"
     exon            878..946
                     /gene="PDPK1"
                     /gene_synonym="PDK1; PDPK2; PDPK2P; PRO0461"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1043
                     /gene="PDPK1"
                     /gene_synonym="PDK1; PDPK2; PDPK2P; PRO0461"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1217
                     /gene="PDPK1"
                     /gene_synonym="PDK1; PDPK2; PDPK2P; PRO0461"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1435
                     /gene="PDPK1"
                     /gene_synonym="PDK1; PDPK2; PDPK2P; PRO0461"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1493
                     /gene="PDPK1"
                     /gene_synonym="PDK1; PDPK2; PDPK2P; PRO0461"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1646
                     /gene="PDPK1"
                     /gene_synonym="PDK1; PDPK2; PDPK2P; PRO0461"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..7184
                     /gene="PDPK1"
                     /gene_synonym="PDK1; PDPK2; PDPK2P; PRO0461"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7163..7168
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDPK1"
                     /gene_synonym="PDK1; PDPK2; PDPK2P; PRO0461"
                     /note="hexamer: AATAAA"
     polyA_site      7184
                     /gene="PDPK1"
                     /gene_synonym="PDK1; PDPK2; PDPK2P; PRO0461"
                     /note="major polyA site"
ORIGIN      
        1 attgctgggg ctccgcttcg gggaggagga cgctgaggag gcgccgagcc gcgcagcgct
       61 gcgggggagg cgcccgcgcc gacgcggggc ccatggccag gaccaccagc cagctgtatg
      121 acgccgtgcc catccagtcc agcgtggtgt tatgttcctg cccatcccca tcaatggtga
      181 ggacccagac tgagtccagc acgccccctg gcattcctgg tggcagcagg cagggccccg
      241 ccatggacgg cactgcagcc gagcctcggc ccggcgccgg ctccctgcag catgcccagc
      301 ctccgccgca gcctcggaag aagcggcctg aggacttcaa gtttgggaaa atccttgggg
      361 aaggctcttt ttccacggtt gtcctggctc gagaactggc aacctccaga gaatatgcga
      421 ttaaaattct ggagaagcga catatcataa aagagaacaa ggtcccctat gtaaccagag
      481 agcgggatgt catgtcgcgc ctggatcacc ccttctttgt taagctttac ttcacatttc
      541 aggacgacga gaagctgtat ttcggcctta gttatgccaa aaatggagaa ctacttaaat
      601 atattcgcaa aatcggttca ttcgatgaga cctgtacccg attttacacg gctgagattg
      661 tgtctgcttt agagtacttg cacggcaagg gcatcattca cagggacctt aaaccggaaa
      721 acattttgtt aaatgaagat atgcacatcc agatcacaga ttttggaaca gcaaaagtct
      781 tatccccaga gagcaaacaa gccagggcca actcattcgt gggaacagcg cagtacgttt
      841 ctccagagct gctcacggag aagtccgcct gtaagagttc agacctttgg gctcttggat
      901 gcataatata ccagcttgtg gcaggactcc caccattccg agctggaaac gagtatctta
      961 tatttcagaa gatcattaag ttggaatatg actttccaga aaaattcttc cctaaggcaa
     1021 gagacctcgt ggagaaactt ttggttttag atgccacaaa gcggttaggc tgtgaggaaa
     1081 tggaaggata cggacctctt aaagcacacc cgttcttcga gtccgtcacg tgggagaacc
     1141 tgcaccagca gacgcctccg aagctcaccg cttacctgcc ggctatgtcg gaagacgacg
     1201 aggactgcta tggcaattat gacaatctcc tgagccagtt tggctgcatg caggtgtctt
     1261 cgtcctcctc ctcacactcc ctgtcagcct ccgacacggg cctgccccag aggtcaggca
     1321 gcaacataga gcagtacatt cacgatctgg actcgaactc ctttgaactg gacttacagt
     1381 tttccgaaga tgagaagagg ttgttgttgg agaagcaggc tggcggaaac ccttggcacc
     1441 agtttgtaga aaataattta atactaaaga tgggcccagt ggataagcgg aagggtttat
     1501 ttgcaagacg acgacagctg ttgctcacag aaggaccaca tttatattat gtggatcctg
     1561 tcaacaaagt tctgaaaggt gaaattcctt ggtcacaaga acttcgacca gaggccaaga
     1621 attttaaaac tttctttgtc cacacgccta acaggacgta ttatctgatg gaccccagcg
     1681 ggaacgcaca caagtggtgc aggaagatcc aggaggtttg gaggcagcga taccagagcc
     1741 acccggacgc cgctgtgcag tgacgtggcc tgcggccggg ctgcccttcg ctgccaggac
     1801 acctgcccca gcgcggcttg gccgccatcc gggacgcttc cagaccacct gccagccatc
     1861 acaaggggaa cgcagaggcg gaaaccttgc agcattttta tttaaaagaa aagaagaaaa
     1921 aaaacaccca accacacaaa gaacaaaacc agtaacaaac acaaaggaat tcagggtcgc
     1981 tttgcttgct ctctgtgctc cgtggaggcc tccgtgtgcc ctcgttgccg tggggaccca
     2041 gctccatgca cgtcaaccca gtcccgccca gactagtgga cagacctggt gtcaccagtt
     2101 tttcctagca tcagtccgaa ccatgcgccc gccctgcccc aactgtgtgc tggtcctgct
     2161 gtggccgagg ggaccgggtg tgtttggctc tttatgcccc tcccgctgtg gtcctggaac
     2221 tcttcaccag ggagggagcc ctgcgggggc cgcagctttg tggagggagc cgccgtgctt
     2281 ctgtcacctg ctccctttct tgcgtctccc tgtgatgggc ccttaggcct ggctgggccc
     2341 attacatatc cctgtggtgg ctctggtggc agctttctgt ggcccctgct gtgttggcag
     2401 gcaggtttgc gtggtgagga gcgggagggg ttggagtggt gcgggagcag gctgccgagt
     2461 ggagggtgcc atcgagggct ccggatccct tatcctactt agcagtgttg gtctctgggg
     2521 ctggaagccg agcgcatgct gggagcggta ctgtcagaag tgagcccagt tagtaccccg
     2581 ctggctcact gcacgagaga gtcctgcccc gagccctagg tggggccagg aggtgccttg
     2641 gagaagccag ccagagcaga gagggctgct gacttccgtg tggagcagag aggcctgagg
     2701 gcctcctaaa aggtttaaat gtccacgcct ctccagttgc tgaagtaggg tctgagagaa
     2761 ccctggcatc agcagaccca gggtgcttct gtctcctgca gaccacgcca gggagtgcag
     2821 acaccaccgt cacacacgcc ccttttgtgt tttggttcaa gtttctcaga gcccctcaga
     2881 gcttctacat ctgtgcatca gaaatctcac agccttctca tgctgccggc tcatctgggc
     2941 ccatagagtg ggctttgcca gttgctgttg cacaggaggc gagaacagca cacttcaacc
     3001 ccagcttgct ggtcggcttt cctctagaga gagccggttt tggggccatt tccctttgat
     3061 gctttggtgg ccttgccccg ctctgcagca cagacaggcc agatgcattt gtcctttgcc
     3121 tagctactcc ccaggtagag agtgctcctg gtggcctggc aggtctgggc ccttctctcc
     3181 ctgcccaggt tgtccctgga gggcagccct cactcccttt gggggagagg cagacattgc
     3241 tgcccacaga cctgcctctg actcaactgt gtccaccctc cctggtccct acccccaagt
     3301 cacaggtgac tcagcagtga ccctgtgtgc caggccagat ccaaactgag agggaaggtg
     3361 tcgtttttac actgctaatg acgagagtgg ctctttttag ctaggcgagt acagacgggg
     3421 cctgggaggg ggcagagatg ttccccaggc cctgcctgtg gttcctgcct gggccttggc
     3481 tgctgctgtg tgagagctgc atgtgagcct gtgaccgtga gctggggtga gctgggccgc
     3541 acctaccctg gggccccagg gagcaggacg ctccggggcc cagcacgttg ccctgggcct
     3601 gtggccggag tcggagtcct ctctcctcct cctggctttt ggaaaggctt ggctgtgttg
     3661 gggagtctct cttagccctt tcaggaattt ctgttcaggc ttcctcctcc tcatcagcta
     3721 ttttacccat ctcagaacgt cctgtgtctc catgtaggag agtggctctc tcagatctct
     3781 cagggcgtct ggttataggg aaacaagtgg agcagggacg tggctttaat tggagcactc
     3841 ggctgggctg cttggggaga ctcttccgtg cgttcttcct ctggatagaa ccaccacctc
     3901 ctgggcgtca ctgacaagct ccatcttaac ctccaaagcc acagaactag gggctcagag
     3961 ccagagctgg cagccgccag ccaaaatgat gccattgcct gagctgacag ccaagccctt
     4021 ctgtgggtca cctttctcct cacccagccc cttgctcttc ccttttgaaa ggcccgtgtg
     4081 ttttctttcc ttaccctgtg cttgctcatg tctactccgg ttttctctac cacatcctta
     4141 gagccatcac ctggcacgca ggcgccttac attctacggt agaacgtggg gtactgtgtg
     4201 tgcacataga cacacttacg tggaattaca gttgtgggtt tatccaagat gaggaagatt
     4261 tcacctgctg tttaatagac ttggggccat gtgcctcccc acacatgggc aaggacaggt
     4321 ggaatgtcgg gaccacactg tgcggcttct cggcacaaag cggagggagg ctgtggtcgc
     4381 tgccggccta ggtgtcccag gtgccccgcc tttctctggg acacagttgg gggctggctt
     4441 ctgagggatt cctttctccc ctctttgtgt ggccccagcc agggcggtgg gcagtcctgg
     4501 tgtagagcac aagcctctcc accctagaga aatgcctctg taccacggct accatgtgga
     4561 accttaactt gcagaaggct tgttaacaat tgttttgaga gagatggctg gtcatgccac
     4621 agctgctggg gactccgcct actccagccc tcttgggaca cactgtggga tttgtggccc
     4681 ttccccagag gaattgtgga gactgtccca tggaacaaac cctcaggcac cagcacaggg
     4741 ctctgggtga ctcagtaaaa ctaacgtttg tctctgacaa gatcagctgt aggctcaccg
     4801 gccagagaag accactgtga gcattttgcc gtatatcctg ccctgccatt tgttcacttt
     4861 ttaaactaaa ataggaacat ccgacacaca ccgtttgcat cgtcttctcc cttgatattt
     4921 taagcatttt cccatgtcat gagtttctca gaaacatgtt tttaacaatt gtactattta
     4981 gtcattgtcc atttactata atttatctga ccatttccct actgtaaaat acttaagacg
     5041 gtttctgatt tttccactat ttaaataatg ctgtgatgaa tatctttaaa atcttctgat
     5101 ttcttacttt tttccccctt agatgcctgg aagtggtatt ttgaggtgaa agagtttgtt
     5161 cattttgaag atatttctgt ctctctctcg acctgatgtg tagacgctca cttccagtag
     5221 cagaaccacc ttagttgtgt cttacagatt ctgaacaaat cggtttctga taagccatgt
     5281 gttccaaaga atgtctgaat aagaccgctc tttatttaaa tgctaagagg atgtcactac
     5341 tgcaatccat ctgtggccga ttttttccaa gagccaattt ccttgttttg gttgcaagaa
     5401 cctggctctg cctgcatgtc agctctctgc cctccctgct gccgtggctt tcaagcgctt
     5461 ggcagaatct tgtacttcgt gtccacaatg gtactgaatt tgcatctgca cagtcagcag
     5521 agataacaag tgttgaactg accttgccac atgcttagtg agtgatttgt aattaagttt
     5581 atagactcag aaggtatatt aggacatttg gaatcagtag cagagcaaag cctctttgaa
     5641 aaaaaccacg tagctgattg ggttttacaa gagtgcattt gtctccccct tccacccgtg
     5701 gggccccacc ttcaggtctt agtggttcac aagagcccag cagccaggct ggctttttca
     5761 ttgtagggcg tggttgtccc agctggtgta gatttcaggc cgcccccccc aactccctgc
     5821 ccacagtgtt gcagattgcc tggctggcag caagtccaga ccacccaaat ttggttggat
     5881 tcttcatttc tccactgtag ttggggtcca ttgattgtgc aggggaacgt gcaggaggtt
     5941 tttctaggca ccgtgttcag tgctgcttca ctctaccaga gattatggcc aaattgcacg
     6001 gaatttggtt tcttgccctc tgaagcctga gggccccccc ttgcctggct ggttgacaga
     6061 cccggggtgg tcactgctga gacttcagag atcgcagctg ctgtgagaat acggtgaagg
     6121 tactttgttc tggaagatgt tgtcatacac ttttccccag ttattttcaa acttgacatg
     6181 agcctatgtt gactcactgg gtgggggtcc cttcttacgc agcacacgtg gcaagtgcct
     6241 gaatcggggc tggaggcact tcagagcctc tgaggggcca ccacttctgg cccaaaattg
     6301 cagggttgta gatgaggctg cctgtggaga actggtgtga ggaggaagct gtttccaaca
     6361 aagagcactt tcatctgttg agatggctgt ggtgagcaac tgaacgagcc tacgtgtgta
     6421 cctgaatttt ccccgtaact catttcttcc atatgaagaa acaccaaact atgtacagag
     6481 aactttttac aaaaggcaga ccttttttaa gctgtgtaac ccacatagcc taaccacctg
     6541 gcagaatgac tacgaatagg ggtcattgtg ctggtaaaag cctctattac gactgtaagt
     6601 aagttggatg ttggcaaaat taaattgtta cagtatttag agctgctgta gctgttcctt
     6661 cacaacataa aataggataa atgactagta cgtctttcag gtgggtggca agcagaacat
     6721 gcgtaatatt ctctacctgg tctgtagctg taactgtgat gtacagacaa agcaaaaatt
     6781 aaaagaactt atgaaaacaa atgcaatgat actaggatat acacttttgt atttttattc
     6841 ttatataagg ttatttgctg gctattgttg gcctctagtt cagtctgtgt tatttaaatt
     6901 ctaatatatg aattatttga attgaattca tgttcggggc cacgttgttg tatgtattga
     6961 tgtacagcct tgaatgtgaa taattattgt aaactatatt ttacaacttt ttttctggct
     7021 ttattatata aattttctat tgggtcagtg atttaatcat ataatttaat gaatctgttt
     7081 atcctttttt tttttccaaa tacttgtgct ttaggtgtag ttaccagatg atgaattttc
     7141 ctcgtatggt cagtagtctt gtaataaaaa gcatgtagag tgta
//
