LOCUS       NM_005451               1712 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens PDZ and LIM domain 7 (PDLIM7), transcript variant 1,
            mRNA.
ACCESSION   NM_005451
VERSION     NM_005451.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1712)
  AUTHORS   Yang,F., Yang,M., Liu,Y., Zhou,C., Chen,Y., Wu,J., Zhang,X. and
            Xiao,S.
  TITLE     PDLIM7 Promotes Tumor Metastasis in Papillary Thyroid Carcinoma via
            Stabilizing Focal Adhesion Kinase Protein
  JOURNAL   Thyroid 34 (5), 598-610 (2024)
   PUBMED   38243825
  REMARK    GeneRIF: PDLIM7 Promotes Tumor Metastasis in Papillary Thyroid
            Carcinoma via Stabilizing Focal Adhesion Kinase Protein.
REFERENCE   2  (bases 1 to 1712)
  AUTHORS   Rood,K., Yamauchi,C.R., Sharma,U., Laxa,R.T., Robins,C., Lanza,G.,
            Sanchez-Ruiz,K., Khan,A., Kim,H.S., Shields,A., Kennedy,K.,
            Mirshahidi,S., Perez,M.C., Firek,A., Munir,I., Simental,A.A. and
            Khan,S.
  TITLE     Regulatory and Interacting Partners of PDLIM7 in Thyroid Cancer
  JOURNAL   Curr Oncol 30 (12), 10450-10462 (2023)
   PUBMED   38132395
  REMARK    GeneRIF: Regulatory and Interacting Partners of PDLIM7 in Thyroid
            Cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1712)
  AUTHORS   Santos,E.R.C.D., Silva,M.S.D.M.E., Canedo,N.H.S., Gaui,M.F.D.,
            Britto,A.L.V.L., Silva,W.M.V.D., Carvalho,M.D.G.D.C. and Bravo
            Neto,G.P.
  TITLE     Epstein-Barr virus in gastric cancer and association with 30 bp
            del-latent membrane protein 1 polymorphism
  JOURNAL   Rev Assoc Med Bras (1992) 69 (5), e20221571 (2023)
   PUBMED   37222327
  REMARK    GeneRIF: Epstein-Barr virus in gastric cancer and association with
            30 bp del-latent membrane protein 1 polymorphism.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1712)
  AUTHORS   Nilsson,G., Leppert,J. and Ohrvik,J.
  TITLE     Enigma of the cholesterol paradox in acute myocardial infarction:
            lessons from an 8-year follow-up of all-cause mortality in an
            age-matched and sex-matched case-control study with controls from
            the patients' recruitment area
  JOURNAL   BMJ Open 12 (7), e057562 (2022)
   PUBMED   35896296
  REMARK    GeneRIF: Enigma of the cholesterol paradox in acute myocardial
            infarction: lessons from an 8-year follow-up of all-cause mortality
            in an age-matched and sex-matched case-control study with controls
            from the patients' recruitment area.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1712)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   6  (bases 1 to 1712)
  AUTHORS   Bach,I.
  TITLE     The LIM domain: regulation by association
  JOURNAL   Mech Dev 91 (1-2), 5-17 (2000)
   PUBMED   10704826
  REMARK    Review article
REFERENCE   7  (bases 1 to 1712)
  AUTHORS   Guy,P.M., Kenny,D.A. and Gill,G.N.
  TITLE     The PDZ domain of the LIM protein enigma binds to beta-tropomyosin
  JOURNAL   Mol Biol Cell 10 (6), 1973-1984 (1999)
   PUBMED   10359609
REFERENCE   8  (bases 1 to 1712)
  AUTHORS   Durick,K., Gill,G.N. and Taylor,S.S.
  TITLE     Shc and Enigma are both required for mitogenic signaling by
            Ret/ptc2
  JOURNAL   Mol Cell Biol 18 (4), 2298-2308 (1998)
   PUBMED   9528800
REFERENCE   9  (bases 1 to 1712)
  AUTHORS   Kuroda,S., Tokunaga,C., Kiyohara,Y., Higuchi,O., Konishi,H.,
            Mizuno,K., Gill,G.N. and Kikkawa,U.
  TITLE     Protein-protein interaction of zinc finger LIM domains with protein
            kinase C
  JOURNAL   J Biol Chem 271 (49), 31029-31032 (1996)
   PUBMED   8940095
REFERENCE   10 (bases 1 to 1712)
  AUTHORS   Wu,R.Y. and Gill,G.N.
  TITLE     LIM domain recognition of a tyrosine-containing tight turn
  JOURNAL   J Biol Chem 269 (40), 25085-25090 (1994)
   PUBMED   7929196
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY026171.1 and BC001093.2.
            
            On Nov 23, 2018 this sequence version replaced NM_005451.4.
            
            Summary: The protein encoded by this gene is representative of a
            family of proteins composed of conserved PDZ and LIM domains. LIM
            domains are proposed to function in protein-protein recognition in
            a variety of contexts including gene transcription and development
            and in cytoskeletal interaction. The LIM domains of this protein
            bind to protein kinases, whereas the PDZ domain binds to actin
            filaments. The gene product is involved in the assembly of an actin
            filament-associated complex essential for transmission of ret/ptc2
            mitogenic signaling. The biological function is likely to be that
            of an adapter, with the PDZ domain localizing the LIM-binding
            proteins to actin filaments of both skeletal muscle and nonmuscle
            tissues. Alternative splicing of this gene results in multiple
            transcript variants. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001093.2, SRR3476690.573383.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355841.7/ ENSP00000348099.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-367               HY026171.1         2-368
            368-1712            BC001093.2         347-1691
FEATURES             Location/Qualifiers
     source          1..1712
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..1712
                     /gene="PDLIM7"
                     /gene_synonym="LMP1; LMP3"
                     /note="PDZ and LIM domain 7"
                     /db_xref="GeneID:9260"
                     /db_xref="HGNC:HGNC:22958"
                     /db_xref="MIM:605903"
     exon            1..77
                     /gene="PDLIM7"
                     /gene_synonym="LMP1; LMP3"
                     /inference="alignment:Splign:2.1.0"
     exon            78..184
                     /gene="PDLIM7"
                     /gene_synonym="LMP1; LMP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1462
                     /gene="PDLIM7"
                     /gene_synonym="LMP1; LMP3"
                     /note="isoform 1 is encoded by transcript variant 1; LIM
                     domain protein; 1110003B01Rik; PDZ and LIM domain protein
                     7; LMP; protein enigma; Lim mineralization protein 3; PDZ
                     and LIM domain 7 (enigma)"
                     /codon_start=1
                     /product="PDZ and LIM domain protein 7 isoform 1"
                     /protein_id="NP_005442.2"
                     /db_xref="CCDS:CCDS4422.1"
                     /db_xref="GeneID:9260"
                     /db_xref="HGNC:HGNC:22958"
                     /db_xref="MIM:605903"
                     /translation="MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGV
                     AVGDWVLSIDGENAGSLTHIEAQNKIRACGERLSLGLSRAQPVQSKPQKASAPAADPP
                     RYTFAPSVSLNKTARPFGAPPPADSAPQQNGQPLRPLVPDASKQRLMENTEDWRPRPG
                     TGQSRSFRILAHLTGTEFMQDPDEEHLKKSSQVPRTEAPAPASSTPQEPWPGPTAPSP
                     TSRPPWAVDPAFAERYAPDKTSTVLTRHSQPATPTPLQSRTSIVQAAAGGVPGGGSNN
                     GKTPVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYD
                     VRYAPSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDY
                     EKMFGTKCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCK
                     SHAFSHV"
     exon            185..336
                     /gene="PDLIM7"
                     /gene_synonym="LMP1; LMP3"
                     /inference="alignment:Splign:2.1.0"
     exon            337..367
                     /gene="PDLIM7"
                     /gene_synonym="LMP1; LMP3"
                     /inference="alignment:Splign:2.1.0"
     exon            368..486
                     /gene="PDLIM7"
                     /gene_synonym="LMP1; LMP3"
                     /inference="alignment:Splign:2.1.0"
     exon            487..623
                     /gene="PDLIM7"
                     /gene_synonym="LMP1; LMP3"
                     /inference="alignment:Splign:2.1.0"
     exon            624..660
                     /gene="PDLIM7"
                     /gene_synonym="LMP1; LMP3"
                     /inference="alignment:Splign:2.1.0"
     exon            661..722
                     /gene="PDLIM7"
                     /gene_synonym="LMP1; LMP3"
                     /inference="alignment:Splign:2.1.0"
     exon            723..957
                     /gene="PDLIM7"
                     /gene_synonym="LMP1; LMP3"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1138
                     /gene="PDLIM7"
                     /gene_synonym="LMP1; LMP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1259
                     /gene="PDLIM7"
                     /gene_synonym="LMP1; LMP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1375
                     /gene="PDLIM7"
                     /gene_synonym="LMP1; LMP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1712
                     /gene="PDLIM7"
                     /gene_synonym="LMP1; LMP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1691..1696
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDLIM7"
                     /gene_synonym="LMP1; LMP3"
                     /note="hexamer: AATAAA"
     polyA_site      1712
                     /gene="PDLIM7"
                     /gene_synonym="LMP1; LMP3"
                     /note="major polyA site"
ORIGIN      
        1 gtcagaacac tggcggccga tcccaacgag gctccctgga gcccgacgca gagcagcgcc
       61 ctggccgggc caagcaggag ccggcatcat ggattccttc aaagtagtgc tggaggggcc
      121 agcaccttgg ggcttccggc tgcaaggggg caaggacttc aatgtgcccc tctccatttc
      181 ccggctcact cctgggggca aagcggcgca ggccggagtg gccgtgggtg actgggtgct
      241 gagcatcgat ggcgagaatg cgggtagcct cacacacatc gaagctcaga acaagatccg
      301 ggcctgcggg gagcgcctca gcctgggcct cagcagggcc cagccggttc agagcaaacc
      361 gcagaaggcc tccgcccccg ccgcggaccc tccgcggtac acctttgcac ccagcgtctc
      421 cctcaacaag acggcccggc cctttggggc gcccccgccc gctgacagcg ccccgcagca
      481 gaatggacag ccgctccgac cgctggtccc agatgccagc aagcagcggc tgatggagaa
      541 cacagaggac tggcggccgc ggccggggac aggccagtcg cgttccttcc gcatccttgc
      601 ccacctcaca ggcaccgagt tcatgcaaga cccggatgag gagcacctga agaaatcaag
      661 ccaggtgccc aggacagaag ccccagcccc agcctcatct acaccccagg agccctggcc
      721 tggccctacc gcccccagcc ctaccagccg cccgccctgg gctgtggacc ctgcgtttgc
      781 cgagcgctat gccccggaca aaacgagcac agtgctgacc cggcacagcc agccggccac
      841 gcccacgccg ctgcagagcc gcacctccat tgtgcaggca gctgccggag gggtgccagg
      901 agggggcagc aacaacggca agactcccgt gtgtcaccag tgccacaagg tcatccgggg
      961 ccgctacctg gtggcgctgg gccacgcgta ccacccggag gagtttgtgt gtagccagtg
     1021 tgggaaggtc ctggaagagg gtggcttctt tgaggagaag ggcgccatct tctgcccacc
     1081 atgctatgac gtgcgctatg cacccagctg tgccaagtgc aagaagaaga ttacaggcga
     1141 gatcatgcac gccctgaaga tgacctggca cgtgcactgc tttacctgtg ctgcctgcaa
     1201 gacgcccatc cggaacaggg ccttctacat ggaggagggc gtgccctatt gcgagcgaga
     1261 ctatgagaag atgtttggca cgaaatgcca tggctgtgac ttcaagatcg acgctgggga
     1321 ccgcttcctg gaggccctgg gcttcagctg gcatgacacc tgcttcgtct gtgcgatatg
     1381 tcagatcaac ctggaaggaa agaccttcta ctccaagaag gacaggcctc tctgcaagag
     1441 ccatgccttc tctcatgtgt gagccccttc tgcccacagc tgccgcggtg gcccctagcc
     1501 tgaggggcct ggagtcgtgg ccctgcattt ctgggtaggg ctggcaatgg ttgccttaac
     1561 cctggctcct ggcccgagcc tggggctccc tgggccctgc cccacccacc ttatcctccc
     1621 accccactcc ctccaccacc acagcacacc ggtgctggcc acaccagccc cctttcacct
     1681 ccagtgccac aataaacctg tacccagctg tg
//
