LOCUS       NM_006457               6043 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens PDZ and LIM domain 5 (PDLIM5), transcript variant 1,
            mRNA.
ACCESSION   NM_006457
VERSION     NM_006457.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6043)
  AUTHORS   Huang,X., Qu,R., Peng,Y., Yang,Y., Fan,T., Sun,B., Khan,A.U.,
            Wu,S., Wei,K., Xu,C., Dai,J., Ouyang,J. and Zhong,S.
  TITLE     Mechanical Sensing Element PDLIM5 Promotes Osteogenesis of Human
            Fibroblasts by Affecting the Activity of Microfilaments
  JOURNAL   Biomolecules 11 (5), 759 (2021)
   PUBMED   34069539
  REMARK    GeneRIF: Mechanical Sensing Element PDLIM5 Promotes Osteogenesis of
            Human Fibroblasts by Affecting the Activity of Microfilaments.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6043)
  AUTHORS   Shi,Y., Wang,X., Xu,Z., He,Y., Guo,C., He,L., Huan,C., Cai,C.,
            Huang,J., Zhang,J., Li,Y., Zeng,C., Zhang,X., Wang,L., Ke,Y. and
            Cheng,H.
  TITLE     PDLIM5 inhibits STUB1-mediated degradation of SMAD3 and promotes
            the migration and invasion of lung cancer cells
  JOURNAL   J Biol Chem 295 (40), 13798-13811 (2020)
   PUBMED   32737199
  REMARK    GeneRIF: PDLIM5 inhibits STUB1-mediated degradation of SMAD3 and
            promotes the migration and invasion of lung cancer cells.
REFERENCE   3  (bases 1 to 6043)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 6043)
  AUTHORS   Lasorella,A. and Iavarone,A.
  TITLE     The protein ENH is a cytoplasmic sequestration factor for Id2 in
            normal and tumor cells from the nervous system
  JOURNAL   Proc Natl Acad Sci U S A 103 (13), 4976-4981 (2006)
   PUBMED   16549780
  REMARK    GeneRIF: ENH is a restraining factor of the oncogenic activity of
            inhibitor of DNA binding 2 proteins in neural tumors
REFERENCE   5  (bases 1 to 6043)
  AUTHORS   Niederlander,N., Fayein,N.A., Auffray,C. and Pomies,P.
  TITLE     Characterization of a new human isoform of the enigma homolog
            family specifically expressed in skeletal muscle
  JOURNAL   Biochem Biophys Res Commun 325 (4), 1304-1311 (2004)
   PUBMED   15555569
  REMARK    GeneRIF: Western blot studies of muscle tissues revealed that ENH4
            is present only in skeletal muscle and there is a specific
            distribution of ENH members between skeletal and cardiac muscles,
            which is different in human and mouse.
REFERENCE   6  (bases 1 to 6043)
  AUTHORS   Wu,M., Li,Y., Ji,C., Xu,J., Zheng,H., Zou,X., Gu,S., Lou,Y., Xie,Y.
            and Mao,Y.
  TITLE     Cloning and identification of a novel human gene PDLIM5, a homolog
            of AD-associated neuronal thread protein (AD7c-NTP)
  JOURNAL   DNA Seq 15 (2), 144-147 (2004)
   PUBMED   15346770
REFERENCE   7  (bases 1 to 6043)
  AUTHORS   Maeno-Hikichi,Y., Chang,S., Matsumura,K., Lai,M., Lin,H.,
            Nakagawa,N., Kuroda,S. and Zhang,J.F.
  TITLE     A PKC epsilon-ENH-channel complex specifically modulates N-type
            Ca2+ channels
  JOURNAL   Nat Neurosci 6 (5), 468-475 (2003)
   PUBMED   12665800
REFERENCE   8  (bases 1 to 6043)
  AUTHORS   Nakagawa,N., Hoshijima,M., Oyasu,M., Saito,N., Tanizawa,K. and
            Kuroda,S.
  TITLE     ENH, containing PDZ and LIM domains, heart/skeletal muscle-specific
            protein, associates with cytoskeletal proteins through the PDZ
            domain
  JOURNAL   Biochem Biophys Res Commun 272 (2), 505-512 (2000)
   PUBMED   10833443
REFERENCE   9  (bases 1 to 6043)
  AUTHORS   Ueki,N., Seki,N., Yano,K., Masuho,Y., Saito,T. and Muramatsu,M.
  TITLE     Isolation, tissue expression, and chromosomal assignment of a human
            LIM protein gene, showing homology to rat enigma homologue (ENH)
  JOURNAL   J Hum Genet 44 (4), 256-260 (1999)
   PUBMED   10429367
REFERENCE   10 (bases 1 to 6043)
  AUTHORS   Kuroda,S., Tokunaga,C., Kiyohara,Y., Higuchi,O., Konishi,H.,
            Mizuno,K., Gill,G.N. and Kikkawa,U.
  TITLE     Protein-protein interaction of zinc finger LIM domains with protein
            kinase C
  JOURNAL   J Biol Chem 271 (49), 31029-31032 (1996)
   PUBMED   8940095
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC109925.4, AC093778.3 and
            AC108067.3.
            
            On May 17, 2019 this sequence version replaced NM_006457.4.
            
            Summary: This gene encodes a member of a family of proteins that
            possess a 100-amino acid PDZ domain at the N terminus and one to
            three LIM domains at the C-terminus. This family member functions
            as a scaffold protein that tethers protein kinases to the Z-disk in
            striated muscles. It is thought to function in cardiomyocyte
            expansion and in restraining postsynaptic growth of excitatory
            synapses. Alternative splicing of this gene results in multiple
            transcript variants. [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (1) encodes isoform a (also known
            as ENH1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.61879.1,
                                           SRR1803613.166446.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317968.9/ ENSP00000321746.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                AC109925.4         129578-129631
            55-192              AC109925.4         132883-133020
            193-344             AC093778.3         42505-42656
            345-387             AC093778.3         92132-92174
            388-806             AC093778.3         94397-94815
            807-979             AC093778.3         104346-104518
            980-1016            AC093778.3         105189-105225
            1017-1204           AC093778.3         136785-136972
            1205-1379           AC108067.3         18531-18705
            1380-1560           AC108067.3         32715-32895
            1561-1681           AC108067.3         35682-35802
            1682-1797           AC108067.3         40677-40792
            1798-6043           AC108067.3         42233-46478
FEATURES             Location/Qualifiers
     source          1..6043
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q22.3"
     gene            1..6043
                     /gene="PDLIM5"
                     /gene_synonym="ENH; ENH1; L9; LIM"
                     /note="PDZ and LIM domain 5"
                     /db_xref="GeneID:10611"
                     /db_xref="HGNC:HGNC:17468"
                     /db_xref="MIM:605904"
     exon            1..54
                     /gene="PDLIM5"
                     /gene_synonym="ENH; ENH1; L9; LIM"
                     /inference="alignment:Splign:2.1.0"
     exon            55..192
                     /gene="PDLIM5"
                     /gene_synonym="ENH; ENH1; L9; LIM"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1887
                     /gene="PDLIM5"
                     /gene_synonym="ENH; ENH1; L9; LIM"
                     /note="isoform a is encoded by transcript variant 1;
                     enigma homolog; PDZ and LIM domain protein 5; enigma-like
                     LIM domain protein; enigma-like PDZ and LIM domains
                     protein"
                     /codon_start=1
                     /product="PDZ and LIM domain protein 5 isoform a"
                     /protein_id="NP_006448.5"
                     /db_xref="CCDS:CCDS3641.1"
                     /db_xref="GeneID:10611"
                     /db_xref="HGNC:HGNC:17468"
                     /db_xref="MIM:605904"
                     /translation="MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANV
                     RIGDVVLSIDGINAQGMTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKGEPKE
                     VVKPVPITSPAVSKVTSTNNMAYNKAPRPFGSVSSPKVTSIPSPSSAFTPAHATTSSH
                     ASPSPVAAVTPPLFAASGLHANANLSADQSPSALSAGKTAVNVPRQPTVTSVCSETSQ
                     ELAEGQRRGSQGDSKQQNGPPRKHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTG
                     TTQSRSFRILAQITGTEHLKESEADNTKKANNSQEPSPQLASSVASTRSMPESLDSPT
                     SGRPGVTSLTAAAAFKPVGSTGVIKSPSWQRPNQGVPSTGRISNSATYSGSVAPANSA
                     LGQTQPSDQDTLVQRAEHIPAGKRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCK
                     NTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALKQTWHVSCFVCVAC
                     GKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVC
                     SVCCESLEGQTFFSKKDKPLCKKHAHSVNF"
     exon            193..344
                     /gene="PDLIM5"
                     /gene_synonym="ENH; ENH1; L9; LIM"
                     /inference="alignment:Splign:2.1.0"
     exon            345..387
                     /gene="PDLIM5"
                     /gene_synonym="ENH; ENH1; L9; LIM"
                     /inference="alignment:Splign:2.1.0"
     exon            388..806
                     /gene="PDLIM5"
                     /gene_synonym="ENH; ENH1; L9; LIM"
                     /inference="alignment:Splign:2.1.0"
     exon            807..979
                     /gene="PDLIM5"
                     /gene_synonym="ENH; ENH1; L9; LIM"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1016
                     /gene="PDLIM5"
                     /gene_synonym="ENH; ENH1; L9; LIM"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1204
                     /gene="PDLIM5"
                     /gene_synonym="ENH; ENH1; L9; LIM"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1379
                     /gene="PDLIM5"
                     /gene_synonym="ENH; ENH1; L9; LIM"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1560
                     /gene="PDLIM5"
                     /gene_synonym="ENH; ENH1; L9; LIM"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1681
                     /gene="PDLIM5"
                     /gene_synonym="ENH; ENH1; L9; LIM"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1797
                     /gene="PDLIM5"
                     /gene_synonym="ENH; ENH1; L9; LIM"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..6043
                     /gene="PDLIM5"
                     /gene_synonym="ENH; ENH1; L9; LIM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6020..6025
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDLIM5"
                     /gene_synonym="ENH; ENH1; L9; LIM"
                     /note="hexamer: AATAAA"
     polyA_site      6043
                     /gene="PDLIM5"
                     /gene_synonym="ENH; ENH1; L9; LIM"
                     /note="major polyA site"
ORIGIN      
        1 acttgtcagc ccttgtctga ggcggaggca gccccgcgcc gcgccggacc cgagcatatt
       61 tcattttctg tcattggact ttgagccatt agaaccatga gcaactacag tgtgtcactg
      121 gttggcccag ctccttgggg tttccggctg cagggcggta aggatttcaa catgcctctg
      181 acaatctcta gtctaaaaga tggcggcaag gcagcccagg caaatgtaag aataggcgat
      241 gtggttctca gcattgatgg aataaatgca caaggaatga ctcatcttga agcccagaat
      301 aagattaagg gttgtacagg ctctttgaat atgactctgc aaagagcatc tgctgcaccc
      361 aagcctgagc cggttcctgt tcaaaaggga gaacctaaag aagtagttaa acctgtgccc
      421 attacatctc ctgctgtgtc caaagtcact tccacaaaca acatggccta caataaggca
      481 ccacggcctt ttggttctgt gtcttcacca aaagtcacat ccatcccatc accatcgtct
      541 gccttcaccc cagcccatgc gaccacctca tcacatgctt ccccttcacc cgtggctgcc
      601 gtcactcctc ccctgttcgc tgcatctgga ctgcatgcta atgccaatct tagtgctgac
      661 cagtctccat ctgcactgag cgctggtaaa actgcagtta atgtcccacg gcagcccaca
      721 gtcaccagcg tgtgttccga gacttctcag gagctagcag agggacagag aagaggatcc
      781 cagggtgaca gtaaacagca aaatggccca ccaagaaaac acattgtgga gcgctataca
      841 gagttttatc atgtacccac tcacagtgat gccagcaaga agagactgat tgaggatact
      901 gaagactggc gtccaaggac tggaacaact cagtctcgct ctttccgaat ccttgcccag
      961 atcactggga ctgaacattt gaaagaatct gaagccgata atacaaagaa ggcaaataac
     1021 tctcaggagc cttctccgca gttggcttcc tcggtagctt ccacacggag catgcccgag
     1081 agcctggaca gcccaacctc tggcagacca ggggttacca gcctcacagc tgcagctgcc
     1141 ttcaagcctg taggatccac tggcgtcatc aagtcaccaa gctggcaacg gccaaaccaa
     1201 ggagtacctt ccactggaag aatctcaaac agcgctactt actcaggatc agtggcacca
     1261 gccaactcag ctttgggaca aacccagcca agtgaccagg acactttagt gcaaagagct
     1321 gagcacattc cagcagggaa acgaactccg atgtgcgccc attgtaacca ggtcatcaga
     1381 ggaccattct tagtggcact ggggaaatct tggcacccag aagaattcaa ctgcgctcac
     1441 tgcaaaaata caatggccta cattggattt gtagaggaga aaggagccct gtattgtgag
     1501 ctgtgctatg agaaattctt tgcccctgaa tgtggtcgat gccaaaggaa gatccttgga
     1561 gaagtcatca gtgcgttgaa acaaacttgg catgtttcct gttttgtgtg tgtagcctgt
     1621 ggaaagccca ttcggaacaa tgtttttcac ttggaggatg gtgaacccta ctgtgagact
     1681 gattattatg ccctctttgg tactatatgc catggatgtg aatttcccat agaagctggt
     1741 gacatgttcc tggaagctct gggctacacc tggcatgaca cttgctttgt atgctcagtg
     1801 tgttgtgaaa gtttggaagg tcagaccttt ttctccaaga aggacaagcc cctgtgtaag
     1861 aaacatgctc attctgtgaa tttttgaaag tcaacagttc aggagaagag aaggaatttg
     1921 aagagaaaaa ggaaaattaa aattactaat taatttttag attcaatatt tatatggagt
     1981 tttgaaaaat aatagtggcc ctgaaggaat aaattccagc tttaaaaacc aagtctgagg
     2041 aaatatttgg cttcataaag taaagagacg gtttggcatt tattattact ttttcctgta
     2101 ttttatgccc ataaaataag ctttataaaa accaatttcc tgatggacta ttaaattcat
     2161 cttagaataa attagtgaag aatttaattt tagaataaat aatccaatct gaaataatta
     2221 taccttcttt ccttgttagg tagttatgag taaatctgca aaaggcaatg aaaatgcctt
     2281 aaattttatc aataacagaa ttattgtatt taaaaaaaaa ctaatactta tctttaaaat
     2341 agtaaatagg attttaaaca gagaatttta tcagtaatag gtgtcagttt ttaaaaaatt
     2401 gcttgtaggc tgagcgcggt ggctcacgcc tgtaatccca gcactttggg aggccaaggt
     2461 gggtggacca catgaggtca ggagtttgag atcagcctgg ccaacatggt gaaaccccat
     2521 ctctactaaa aatacaaaaa ttagccggac gcagtggcac gcgcctgtaa tcccagctac
     2581 tcaagaggct gaggcacgag aatcacttga acccgggagg gagaggttgc agtgagccaa
     2641 gatcgtacca ctgcactcca gcctgggtga cagagtgaga ctctgtctcc aaaaaaaaac
     2701 tttgcttgta tattattttt gccttacagt ggatcattct agtaggaaag gacaataaga
     2761 ttttttatca aaatgtgtca tgccagtaag agatgttata ttcttttctc atttcttccc
     2821 cacccaaaaa taagctacca tatagcttat aagtctcaaa tttttgcctt ttactaaaat
     2881 gtgattgttt ctattcattg tgtatgcttc atcacctata ttaggcaaat tccatttttt
     2941 tcccttgtgc taaggtaaag atttaattaa ataattttgg cctctcatag ttttctctct
     3001 ctttaaagag aataaataga gggccaggtg tggtggctca cgcctgtgat cccagcactt
     3061 tgggaggcca agacgggcgg atcatgaggt caagagatca agatcatcct ggccaacatg
     3121 gtgaaaccct gtctctacta aaaatacaaa aatgagctgg gcatggtggg gcgtgcctgt
     3181 agtcccatgt acttgggagg ctgaggcagg aaaattcttg aacccaggag acggaagttg
     3241 cagtgagctg agatcacacc actgcactcc agcctggtga cagagcaaga ctccggctct
     3301 taaaaaaaaa aaaaaaaaaa aaaaaagaga gagagagaat aaatagaaaa gaatgtggct
     3361 gggaattgtg aatcagaaga ttataccccc caattgtttt tcaatcccct tttctcaaat
     3421 aataaattag ttaaatcagt ttctgagtta tgccactggc tgatgaagag ttgagaggtc
     3481 tctttgcaga atgatctttt tgtttcgttt tgtttcttct tctgcattta aaaattaaaa
     3541 gattggtttg aggatgtgat gaaattgaga ctttttgtgg ttttctctca ataataagtg
     3601 aaccaatttc aaatgtgatc acaaagtttg gaaagctttt attcacagag gttgggtagt
     3661 gttgggaggg gagtttaatt actcagattg gcctgttatt tgatttcctc ctttgggaaa
     3721 agaattatgt agataccaca tggagacagg gaaacaattg tggtaaaact gtggatcctg
     3781 ttgctatttg cccagtgaga aaacagattc tggtatttga tttggttttt ctctttgttt
     3841 ccagaatgga tgaaagtcca tgaacctcct aagttataat ttaaatttgt ttggggcaag
     3901 gtgattttat agtcgagaca gagccctagg tccttcctgc cccatcactc acttacgaca
     3961 tcacttccat tgtgtgcatg tttgttatag aggaggtttt aggctacaat atttgtttaa
     4021 cctccctaag aactttcaag gcatctgtcc tgaaagctgt taatttatgg tctagcagat
     4081 ttatattata tgcagataat aattaactgg ggataaaaga atggcaaggg gtgacacaaa
     4141 gtagcaaact gaatacttct ccaatagcaa ccccaagcta cctcctcacc ctgcatcttg
     4201 gagggaggca ggaaatttct tttgaaataa agtgctggag ctgaattctg cattatttat
     4261 cgttgctgct gaaaccacct ataaaagact tgctggctaa tgtgcattgt catataatgt
     4321 acactgtcac atctttacag tcttgtatgt tatagaatac aaaataagtt gatggttttg
     4381 tttggtgtga gctttttgtt tgtttgttta gttttgcctt cataggttat atgccaagat
     4441 agtatttgat aagtcaatga catttggatg ttttcttcaa agaattttat ttgacccaga
     4501 tttcttataa agttatctta cattaaggat gtcattttca tcagaccttc tttctacata
     4561 ttattcatga agcataatgt tgcatttctc caaattttat gcctgaaagg gtagtgttgc
     4621 ttcctaaggt atcatgttgt ctttgtgctt tgtccatctc ttccgtggcg aagctttata
     4681 tctgttccta aaacagttaa tcctgtgaaa taaatattga acataatcca gaagaatctc
     4741 tctgtttccc ttggggaatg ccatatttaa ttcaccagca gtaatccttt aataactggc
     4801 agagcacttt attcttctgg tgagctccct gaatatttat ttttctgatt ataaattttc
     4861 tatattagta gcatttttta attattactt cttcactata gagcatttac ttttagtctc
     4921 tagatgtata ttttggaatg ctgtacttgg cataacatag attaaaatca taatgcatga
     4981 ctaaaaactc cttggattta tttcccattt taaaattttt agcggtaagt tcagatttat
     5041 aatctttctc tagacttcca tggtctgaat gttgcctgct gaagtagcaa cctaaaaagt
     5101 atcccctgct tatgcttgtc cagttggccc tccatgtcca taggcttcgc atctgtgatt
     5161 cagcccactg tgggtcaaaa atatttgggg aaaaaaatgg atggttgcgc ctttgctgaa
     5221 catgtacaaa cttttttttg tcattaaaca atatagtata acaactattt acaaagcatt
     5281 tacattgtat tagctattat aggtaatcta gagatgattt aaagtgtatg gtaggatgtg
     5341 cataggttat atgcaaatac tacaccattt tctataaggg acttgaacat catggacttt
     5401 agtatcctag ggggttcttg gaacccatca cccatagggg caccatagga caactatagt
     5461 accgtgttta tttcctatta attcaggttc cgtttagagt ctaaaactaa aacctaatca
     5521 tttagtcaca gtgtaaaaac aaatggaaat aacagctcaa atcttcaaaa tattactata
     5581 gcattatgtt taaaataatc tacaacaaaa atgtaccatt ttcaagcagt actacattag
     5641 gagccctttt atagaaaata atttcttctt tacccccgtt ccagtgtgaa tctagtattc
     5701 tgttaacatt tgtgtggcat ttggagtttg tcatccccat tgaagggaga gccttctcag
     5761 acatgaagca agggaaacat actgaatagt tttacacaaa tttgatctgg cttccatttg
     5821 tccccctcat ttcccaaatg tttaaatgta ttggatttgg attctcaatg tataagttgc
     5881 cttatctgtt aatgtctatc ttctgtctct ttaattttgt atatctgctg ttttgctttt
     5941 ggatacattt tctaattaga agtcacatga taaatataat cagtatagta ataataccat
     6001 aatgtgcaca tactcaataa ataaatgact gcattgttgt aaa
//
