LOCUS       NM_020992               1431 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens PDZ and LIM domain 1 (PDLIM1), mRNA.
ACCESSION   NM_020992
VERSION     NM_020992.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1431)
  AUTHORS   Lei,Y., He,L., Li,Y., Hou,J., Zhang,H. and Li,G.
  TITLE     PDLIM1 interacts with HK2 to promote gastric cancer progression
            through enhancing the Warburg effect via Wnt/beta-catenin signaling
  JOURNAL   Cell Tissue Res 395 (1), 105-116 (2024)
   PUBMED   37930472
  REMARK    GeneRIF: PDLIM1 interacts with HK2 to promote gastric cancer
            progression through enhancing the Warburg effect via
            Wnt/beta-catenin signaling.
REFERENCE   2  (bases 1 to 1431)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1431)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1431)
  AUTHORS   Dhanda,A.S., Yang,D., Kooner,A. and Guttman,J.A.
  TITLE     Distribution of PDLIM1 at actin-rich structures generated by
            invasive and adherent bacterial pathogens
  JOURNAL   Anat Rec (Hoboken) 304 (5), 919-938 (2021)
   PUBMED   33022122
  REMARK    GeneRIF: Distribution of PDLIM1 at actin-rich structures generated
            by invasive and adherent bacterial pathogens.
REFERENCE   5  (bases 1 to 1431)
  AUTHORS   Fricke,J., Mambetsariev,I., Pharaon,R., Subbiah,S., Rajurkar,S. and
            Salgia,R.
  TITLE     Hyperprogression on immunotherapy with complete response to
            chemotherapy in a NSCLC patient with high PD-L1 and STK11: A case
            report
  JOURNAL   Medicine (Baltimore) 99 (46), e22323 (2020)
   PUBMED   33181636
  REMARK    GeneRIF: Hyperprogression on immunotherapy with complete response
            to chemotherapy in a NSCLC patient with high PD-L1 and STK11: A
            case report.
REFERENCE   6  (bases 1 to 1431)
  AUTHORS   Bauer,K., Kratzer,M., Otte,M., de Quintana,K.L., Hagmann,J.,
            Arnold,G.J., Eckerskorn,C., Lottspeich,F. and Siess,W.
  TITLE     Human CLP36, a PDZ-domain and LIM-domain protein, binds to
            alpha-actinin-1 and associates with actin filaments and stress
            fibers in activated platelets and endothelial cells
  JOURNAL   Blood 96 (13), 4236-4245 (2000)
   PUBMED   11110697
  REMARK    GeneRIF: CLP-36 contains a PDZ- and LIM domain, is widely
            expressed, interacts with actinin-1, actinin-2 and actinin-4, and
            localizes to actin stress fibers. The gene (7 exons) is localised
            to contig NT_008878.2 on chromosome 10.
REFERENCE   7  (bases 1 to 1431)
  AUTHORS   Kotaka,M., Kostin,S., Ngai,S., Chan,K., Lau,Y., Lee,S.M., Li,Hy.,
            Ng,E.K., Schaper,J., Tsui,S.K., Fung,Kp., Lee,Cy. and Waye,M.M.
  TITLE     Interaction of hCLIM1, an enigma family protein, with alpha-actinin
            2
  JOURNAL   J Cell Biochem 78 (4), 558-565 (2000)
   PUBMED   10861853
  REMARK    GeneRIF: Enigma protein shown to interact with alpha actinin 2 by
            yeast two-hybrid screening and immunochemistry (co-localization at
            myocardial Z-disks).
REFERENCE   8  (bases 1 to 1431)
  AUTHORS   Vallenius,T., Luukko,K. and Makela,T.P.
  TITLE     CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1
            and alpha-actinin-4
  JOURNAL   J Biol Chem 275 (15), 11100-11105 (2000)
   PUBMED   10753915
REFERENCE   9  (bases 1 to 1431)
  AUTHORS   Kotaka,M., Ngai,S.M., Garcia-Barcelo,M., Tsui,S.K., Fung,K.P.,
            Lee,C.Y. and Waye,M.M.
  TITLE     Characterization of the human 36-kDa carboxyl terminal LIM domain
            protein (hCLIM1)
  JOURNAL   J Cell Biochem 72 (2), 279-285 (1999)
   PUBMED   10022510
REFERENCE   10 (bases 1 to 1431)
  AUTHORS   Wang,H., Harrison-Shostak,D.C., Lemasters,J.J. and Herman,B.
  TITLE     Cloning of a rat cDNA encoding a novel LIM domain protein with high
            homology to rat RIL
  JOURNAL   Gene 165 (2), 267-271 (1995)
   PUBMED   8522188
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC000915.2 and AL160288.21.
            
            On Nov 22, 2018 this sequence version replaced NM_020992.3.
            
            Summary: This gene encodes a member of the enigma protein family.
            The protein contains two protein interacting domains, a PDZ domain
            at the amino terminal end and one to three LIM domains at the
            carboxyl terminal. It is a cytoplasmic protein associated with the
            cytoskeleton. The protein may function as an adapter to bring other
            LIM-interacting proteins to the cytoskeleton. Pseudogenes
            associated with this gene are located on chromosomes 3, 14 and 17.
            [provided by RefSeq, Oct 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.305224.1, BC000915.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2152474 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329399.7/ ENSP00000360305.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BC000915.2         22-31
            11-11               AL160288.21        32705-32705         c
            12-1431             BC000915.2         33-1452
FEATURES             Location/Qualifiers
     source          1..1431
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.33"
     gene            1..1431
                     /gene="PDLIM1"
                     /gene_synonym="CLIM1; CLP-36; CLP36; hCLIM1; HEL-S-112"
                     /note="PDZ and LIM domain 1"
                     /db_xref="GeneID:9124"
                     /db_xref="HGNC:HGNC:2067"
                     /db_xref="MIM:605900"
     exon            1..184
                     /gene="PDLIM1"
                     /gene_synonym="CLIM1; CLP-36; CLP36; hCLIM1; HEL-S-112"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1078
                     /gene="PDLIM1"
                     /gene_synonym="CLIM1; CLP-36; CLP36; hCLIM1; HEL-S-112"
                     /note="carboxyl terminal LIM domain protein 1; epididymis
                     secretory protein Li 112; elfin; LIM domain protein
                     CLP-36"
                     /codon_start=1
                     /product="PDZ and LIM domain protein 1"
                     /protein_id="NP_066272.1"
                     /db_xref="CCDS:CCDS7441.1"
                     /db_xref="GeneID:9124"
                     /db_xref="HGNC:HGNC:2067"
                     /db_xref="MIM:605900"
                     /translation="MTTQQIDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANL
                     CIGDVITAIDGENTSNMTHLEAQNRIKGCTDNLTLTVARSEHKVWSPLVTEEGKRHPY
                     KMNLASEPQEVLHIGSAHNRSAMPFTASPASSTTARVITNQYNNPAGLYSSENISNFN
                     NALESKTAASGVEANSRPLDHAQPPSSLVIDKESEVYKMLQEKQELNEPPKQSTSFLV
                     LQEILESEEKGDPNKPSGFRSVKAPVTKVAASIGNAQKLPMCDKCGTGIVGVFVKLRD
                     RHRHPECYVCTDCGTNLKQKGHFFVEDQIYCEKHARERVTPPEGYEVVTVFPK"
     exon            185..336
                     /gene="PDLIM1"
                     /gene_synonym="CLIM1; CLP-36; CLP36; hCLIM1; HEL-S-112"
                     /inference="alignment:Splign:2.1.0"
     exon            337..421
                     /gene="PDLIM1"
                     /gene_synonym="CLIM1; CLP-36; CLP36; hCLIM1; HEL-S-112"
                     /inference="alignment:Splign:2.1.0"
     exon            422..621
                     /gene="PDLIM1"
                     /gene_synonym="CLIM1; CLP-36; CLP36; hCLIM1; HEL-S-112"
                     /inference="alignment:Splign:2.1.0"
     exon            622..773
                     /gene="PDLIM1"
                     /gene_synonym="CLIM1; CLP-36; CLP36; hCLIM1; HEL-S-112"
                     /inference="alignment:Splign:2.1.0"
     exon            774..891
                     /gene="PDLIM1"
                     /gene_synonym="CLIM1; CLP-36; CLP36; hCLIM1; HEL-S-112"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1431
                     /gene="PDLIM1"
                     /gene_synonym="CLIM1; CLP-36; CLP36; hCLIM1; HEL-S-112"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1411..1416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDLIM1"
                     /gene_synonym="CLIM1; CLP-36; CLP36; hCLIM1; HEL-S-112"
                     /note="hexamer: AATAAA"
     polyA_site      1431
                     /gene="PDLIM1"
                     /gene_synonym="CLIM1; CLP-36; CLP36; hCLIM1; HEL-S-112"
                     /note="major polyA site"
ORIGIN      
        1 ctccgacagc cgccgggggt gccctgcaag ctgttccgcg cgtcctgccc gtctgtcccc
       61 gcgggtcgtc gcccgccaca gccgcgccat gaccacccag cagatagacc tccagggccc
      121 ggggccgtgg ggcttccgcc tcgtgggcgg caaggacttc gagcagcctc tcgccatttc
      181 ccgggtcact cctggaagca aggcggctct agctaattta tgtattggag atgtaatcac
      241 agccattgat ggggaaaata ctagcaatat gacacacttg gaagctcaga acagaatcaa
      301 aggctgcaca gacaacttga ctctcactgt agccagatct gaacataaag tctggtctcc
      361 tctggtgacg gaggaaggga agcgtcatcc atacaagatg aatttagcct ctgaacccca
      421 ggaggtcctg cacataggaa gcgcccacaa ccgaagtgcc atgcccttta ccgcctcgcc
      481 tgcctccagc actactgcca gggtcatcac aaaccagtac aacaacccag ctggcctcta
      541 ctcttctgaa aatatctcca acttcaacaa tgccctggag tcaaagactg ctgccagcgg
      601 ggtggaggcg aacagcagac ccttagacca tgctcagcct ccaagcagcc ttgtcatcga
      661 caaagaatct gaagtttaca agatgcttca ggagaaacag gagttgaatg agcccccgaa
      721 acagtccacg tctttcttgg ttttgcagga aatcctggag tctgaagaaa aaggggatcc
      781 caacaagccc tcaggattca gaagtgttaa agctcctgtc actaaagtgg ctgcgtcgat
      841 tggaaatgct cagaagttgc ctatgtgtga caaatgtggc actgggattg ttggtgtgtt
      901 tgtgaagctg cgggaccgtc accgccaccc tgagtgttat gtgtgcactg actgtggcac
      961 caacctgaaa cagaagggcc atttctttgt ggaggatcaa atctactgtg agaagcatgc
     1021 ccgggagcga gtcacaccac ctgagggtta tgaagtggtc actgtgttcc ccaagtgagc
     1081 cagcagatct gaccactgtt ctccagcagg cctctgctgc agctttttct ctcagtgttc
     1141 tggccctctc ctctcttgaa agttctctgc ttactttggt tttccctctg cttgtaaaac
     1201 attgagtccc ctccctgcct tggttaattg actcacacca gctgtgcgat gcccgctttt
     1261 acaattaaag gaaaactgtt ttgttcagtg tcaccttgtc agcaacactg tgtcccttcg
     1321 ccccaccgtt cttctctgct gcatttggac atcagccaaa tttgaaccca atcaaatata
     1381 acgtgtctga cactgatttt gtttttactc aataaatgta tagactacaa a
//
