LOCUS       NM_152835               4113 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens PDLIM1 interacting kinase 1 like (PDIK1L), transcript
            variant 1, mRNA.
ACCESSION   NM_152835
VERSION     NM_152835.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4113)
  AUTHORS   Polyanskaya,S.A., Moreno,R.Y., Lu,B., Feng,R., Yao,Y., Irani,S.,
            Klingbeil,O., Yang,Z., Wei,Y., Demerdash,O.E., Benjamin,L.A.,
            Weiss,M.J., Zhang,Y.J. and Vakoc,C.R.
  TITLE     SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling
            dependency in acute myeloid leukemia
  JOURNAL   Cell Rep 38 (2), 110233 (2022)
   PUBMED   35021089
  REMARK    GeneRIF: SCP4-STK35/PDIK1L complex is a dual phospho-catalytic
            signaling dependency in acute myeloid leukemia.
REFERENCE   2  (bases 1 to 4113)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4113)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   4  (bases 1 to 4113)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4113)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 4113)
  AUTHORS   Taipale,M., Tucker,G., Peng,J., Krykbaeva,I., Lin,Z.Y., Larsen,B.,
            Choi,H., Berger,B., Gingras,A.C. and Lindquist,S.
  TITLE     A quantitative chaperone interaction network reveals the
            architecture of cellular protein homeostasis pathways
  JOURNAL   Cell 158 (2), 434-448 (2014)
   PUBMED   25036637
REFERENCE   7  (bases 1 to 4113)
  AUTHORS   Taipale,M., Krykbaeva,I., Koeva,M., Kayatekin,C., Westover,K.D.,
            Karras,G.I. and Lindquist,S.
  TITLE     Quantitative analysis of HSP90-client interactions reveals
            principles of substrate recognition
  JOURNAL   Cell 150 (5), 987-1001 (2012)
   PUBMED   22939624
REFERENCE   8  (bases 1 to 4113)
  AUTHORS   Goyal,P., Behring,A., Kumar,A. and Siess,W.
  TITLE     Identifying and characterizing a novel protein kinase STK35L1 and
            deciphering its orthologs and close-homologs in vertebrates
  JOURNAL   PLoS One 4 (9), e6981 (2009)
   PUBMED   19756140
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4113)
  AUTHORS   Rual,J.F., Hirozane-Kishikawa,T., Hao,T., Bertin,N., Li,S.,
            Dricot,A., Li,N., Rosenberg,J., Lamesch,P., Vidalain,P.O.,
            Clingingsmith,T.R., Hartley,J.L., Esposito,D., Cheo,D., Moore,T.,
            Simmons,B., Sequerra,R., Bosak,S., Doucette-Stamm,L., Le Peuch,C.,
            Vandenhaute,J., Cusick,M.E., Albala,J.S., Hill,D.E. and Vidal,M.
  TITLE     Human ORFeome version 1.1: a platform for reverse proteomics
  JOURNAL   Genome Res 14 (10B), 2128-2135 (2004)
   PUBMED   15489335
REFERENCE   10 (bases 1 to 4113)
  AUTHORS   Guo,L., Ji,C., Gu,S., Ying,K., Cheng,H., Ni,X., Liu,J., Xie,Y. and
            Mao,Y.
  TITLE     Molecular cloning and characterization of a novel human kinase
            gene, PDIK1L
  JOURNAL   J Genet 82 (1-2), 27-32 (2003)
   PUBMED   14631099
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK312872.1, AL834290.1, BU742621.1 and AL391650.18.
            
            On Nov 23, 2018 this sequence version replaced NM_152835.4.
            
            Transcript Variant: This variant (1) represents the shortest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.36699.1,
                                           SRR1660805.156441.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374269.2/ ENSP00000363387.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1135              AK312872.1         48-1182
            1136-4090           AL834290.1         629-3583
            4091-4106           BU742621.1         1-16                c
            4107-4113           AL391650.18        111050-111056
FEATURES             Location/Qualifiers
     source          1..4113
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..4113
                     /gene="PDIK1L"
                     /gene_synonym="CLIK1L; STK35L2"
                     /note="PDLIM1 interacting kinase 1 like"
                     /db_xref="GeneID:149420"
                     /db_xref="HGNC:HGNC:18981"
                     /db_xref="MIM:610785"
     exon            1..92
                     /gene="PDIK1L"
                     /gene_synonym="CLIK1L; STK35L2"
                     /inference="alignment:Splign:2.1.0"
     exon            93..394
                     /gene="PDIK1L"
                     /gene_synonym="CLIK1L; STK35L2"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..1135
                     /gene="PDIK1L"
                     /gene_synonym="CLIK1L; STK35L2"
                     /EC_number="2.7.11.1"
                     /note="casein kinase"
                     /codon_start=1
                     /product="serine/threonine-protein kinase PDIK1L"
                     /protein_id="NP_690048.1"
                     /db_xref="CCDS:CCDS274.1"
                     /db_xref="GeneID:149420"
                     /db_xref="HGNC:HGNC:18981"
                     /db_xref="MIM:610785"
                     /translation="MVSSQPKYDLIREVGRGSYGVVYEAVIRKTSARVAVKKIRCHAP
                     ENVELALREFWALSSIKSQHPNVIHLEECILQKDGMVQKMSHGSNSSLYLQLVETSLK
                     GEIAFDPRSAYYLWFVMDFCDGGDMNEYLLSRKPNRKTNTSFMLQLSSALAFLHKNQI
                     IHRDLKPDNILISQTRLDTSDLEPTLKVADFGLSKVCSASGQNPEEPVSVNKCFLSTA
                     CGTDFYMAPEVWEGHYTAKADIFALGIIIWAMLERITFIDTETKKELLGSYVKQGTEI
                     VPVGEALLENPKMELLIPVKKKSMNGRMKQLIKEMLAANPQDRPDAFELELRLVQIAF
                     KDSSWET"
     exon            395..4113
                     /gene="PDIK1L"
                     /gene_synonym="CLIK1L; STK35L2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4024..4029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDIK1L"
                     /gene_synonym="CLIK1L; STK35L2"
                     /note="hexamer: TATAAA"
     polyA_site      4047
                     /gene="PDIK1L"
                     /gene_synonym="CLIK1L; STK35L2"
     regulatory      4089..4094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDIK1L"
                     /gene_synonym="CLIK1L; STK35L2"
                     /note="hexamer: AACAAA"
     polyA_site      4113
                     /gene="PDIK1L"
                     /gene_synonym="CLIK1L; STK35L2"
                     /note="major polyA site"
ORIGIN      
        1 gactggaggc ggcggcagcg gaggcgcgag ctgcccgata atggcggcct gcagagccca
       61 tgagagggag aagcggcagc gtctaccctg agaaacctcg accttgaaga tggtgagtag
      121 ccagccaaag tacgatctaa tacgggaggt aggccgaggt agttacggtg ttgtgtatga
      181 agcagtcatc agaaagacct ctgcacgggt ggcagtgaag aaaattcgat gtcacgcacc
      241 tgaaaatgtt gaactagccc ttcgtgagtt ctgggcacta agcagtatca agagccaaca
      301 tccaaatgtg attcacttgg aggaatgcat cctacaaaag gatgggatgg tgcaaaagat
      361 gtcccacggc tctaattctt ccctttattt acagcttgta gaaacttcat taaaaggaga
      421 aattgccttt gatcccagaa gcgcctatta tttgtggttt gtgatggatt tttgtgacgg
      481 aggagatatg aatgagtatc tgttgtccag gaaacccaat cgtaaaacta acaccagctt
      541 catgcttcag ctgagcagtg ccctggcttt cttgcataaa aaccagatca tccaccgaga
      601 tcttaagcct gataacatcc tgatttctca aaccaggttg gataccagtg acttggaacc
      661 taccctcaaa gtggctgatt ttggtctaag taaagtttgt tcagcctctg ggcagaaccc
      721 agaagaacct gtcagtgtaa acaagtgttt cctttccaca gcatgtggaa cagattttta
      781 catggctcct gaagtttggg aaggacatta cacagcaaaa gctgacatct ttgctctggg
      841 gattatcatc tgggcaatgc tggaaaggat cacattcata gacacagaga caaagaagga
      901 actcttgggg agttatgtaa aacaaggaac tgagattgtg cctgttgggg aggcacttct
      961 ggaaaatccc aaaatggaac ttctcattcc tgtgaagaaa aaatctatga atgggcgaat
     1021 gaaacaactg attaaggaaa tgctggctgc aaaccctcag gatcgtccag atgcttttga
     1081 actagaactc agattagtac aaattgcatt taaagatagc agctgggaaa cgtgacacat
     1141 attatttgca aataccatgg atgatatgct gcttctgttt aacagtgatg caacattatg
     1201 tggctgaaaa agaatataaa aagctagact ctaccctcta agggtttaga ttttttgtgg
     1261 gatttttttt ttcctcattt ttcttaaatc caagttggcc gttttattag tatgtttcaa
     1321 atgtgtatta ccaatgtggg tgtaaatttt taaaaaatga ttattgatag aagtttggca
     1381 ggaaaattct ttaagagcta acaagagaag agagtccagt tttctggaaa tatgtcttta
     1441 agtattttag acattcctcg tcagtattag gaatttccat gggaaaagag gtttgcatgc
     1501 tggtaatgca acctttgaaa ctttgtaaag gaaacatata tgtatatatt tatgtatatg
     1561 taagtatgtg aatgtgcgca ttttgcattc catatgaaaa aaatgccacg tctgtttaaa
     1621 ttatttgatg taggtttggg tttttgagat ttgctggtga agtcagtgac gaaaaataaa
     1681 ccttccctta tcttcctact ctgcccctcc ccctaatgaa atcatattaa gttgtttttt
     1741 tttttttttg taatatacag cttttttttt aaggcatcat tttcgagggt ctaaaattat
     1801 ctggtaaaac aaatgaaatt aagtgatcca aagctgctga agtatgtttg aactctccag
     1861 tgccctatag ctgcaagagt tgaattagtc atgcagtcat atggcagcag gttggtgatt
     1921 cagtccgacc ttctttaggt aaccgagcat ttatttaacc aactatacca ctgcattggg
     1981 acgtctgcac ttgagcttct acaatctgat ataaatctga atacaggatt attctgtttg
     2041 aaaactttgc tatgtgtgaa ctgtaatact tgatacattt ttggtttgaa gactttgtct
     2101 aagcctcatt atactgaagt tgaagaaacc aaatgagctc caccctcact ttgcctgccc
     2161 tgatatgatc acttgttgag tcactggagt tcctttcatt ttggcactga tgctgttttc
     2221 tcttgtctga tttgaaacag tactggtaat aatatggttg ttgaaaatgt gatcaccttt
     2281 atctaaagtg ggagaagata catacacagt atggcaaatg gataaaatat tgtggcatca
     2341 actactttta aagtagaaaa gctatccatt ttatacaatc actgatacag tctatgtcaa
     2401 aaaaccaaca gaccattatt cctcttgaag ttagtttgat tttatctttg tatggttgtc
     2461 tacaatttgt tttcctgtaa atgcagatag ttaaaatcta aaggatagaa tgctttccta
     2521 aaacagaaca ttagccttta aggttaaata gactttacat tgtatctaag ttaatcttta
     2581 taaagcacta gaatttttgg tcaaaagtca aaatagtatt agaatattga aattattgat
     2641 agctttcata atctcagctt ttttgaactt ccacaatttt tggaatatgt cataattttt
     2701 ttccctgttt caaatgtgtt cagaggaaat agaatgtaaa acatcacaaa aaaaattgca
     2761 gtacataaaa tttctggact atgttagtta cttgatctgg aagtttaaaa tttggactaa
     2821 aaggttttat tgaaataaag cctcttaaaa tgaaaaatca tatactttta acatcacttt
     2881 taagctaata aatataagaa ttcttttgga aattagaggt ggaaacacac tggaacctca
     2941 tgataattga ccctctggat caccagatta gtttaattta acagatatgt ccaaggaagt
     3001 tgagctatag ggagtaagaa aaagcatcat gataacgtct agtcaataac atggcacttc
     3061 agcagagatt catagatgat ggtatgccca tgcatcattt gctcttcaaa tatctatgtg
     3121 cttggagcca cagtttccta agcgcatagt ttttggtcct gcctcatgta aaatagttaa
     3181 tgattatcat ttacttggaa agattttacc tgtgaagtga aattctttca ttgggggtaa
     3241 gggtatgagg tgatcaggaa gtttcttctg gaattttatc aagtccttgt attctaaaat
     3301 agccaagcaa aatgatagta aattctttgt ctttgttctt tcagtcagag gtatttatta
     3361 agtacctact gtgtgctcag cactaaaggt ttgttgataa aatgacaatt aaaaaatggc
     3421 atttagccaa aggccttttc agccaggagt aagaaaagat ggttagtgat atttggaaat
     3481 acctggatat ttgctagagg aaaaatgaaa gcaaaacttc gtacacagtg ccttgcccat
     3541 aataggtact caataagcaa ttgttcctca tagagtcttt tgccatgatt tatggtgttt
     3601 tttgaaattt gtcttaattg aaaaaagacc aaatatttca aatgagctta taggcagctg
     3661 tggccagtga aaatatgggg ttgtacagtt agttcctaga atgttatttt gcactagttg
     3721 tcacttagaa agatggggtt cctgtagatt ttttggtgct aagggatact ttgtcattat
     3781 gatgaagtaa gtgttaagtg tcagataaat agcacacaga atagttcttt ctgctggtct
     3841 gttttttctc ttcgttgttg ttgtttttaa ttgtaaattg ttatcaatca aactattgta
     3901 gcagctacaa agtaattcac cagcatgaca aaatggtcaa aaaataagtc atcagcactt
     3961 aagaaatgaa agcaactttt gaaattttct gttaaaattg tcaaatatat tttatgaaga
     4021 atttataaaa ggggaaaatg attgtaattt attgttcatg actttttttt ttaaataaag
     4081 tgagtttcaa caaaaaaaaa actgaaaatt cta
//
