LOCUS       NM_006810               1844 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens protein disulfide isomerase family A member 5 (PDIA5),
            transcript variant 1, mRNA.
ACCESSION   NM_006810
VERSION     NM_006810.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1844)
  AUTHORS   Ji,Q., Tu,Z., Liu,J., Zhou,Z., Li,F., Zhu,X. and Huang,K.
  TITLE     RUNX1-PDIA5 Axis Promotes Malignant Progression of Glioblastoma by
            Regulating CCAR1 Protein Expression
  JOURNAL   Int J Biol Sci 20 (11), 4364-4381 (2024)
   PUBMED   39247813
  REMARK    GeneRIF: RUNX1-PDIA5 Axis Promotes Malignant Progression of
            Glioblastoma by Regulating CCAR1 Protein Expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1844)
  AUTHORS   Chen,Y., He,J., Chen,R., Wang,Z., Dai,Z., Liang,X., Wu,W., Luo,P.,
            Zhang,J., Peng,Y., Zhang,N., Liu,Z., Zhang,L., Zhang,H. and
            Cheng,Q.
  TITLE     Pan-Cancer Analysis of the Immunological Role of PDIA5: A Potential
            Target for Immunotherapy
  JOURNAL   Front Immunol 13, 881722 (2022)
   PUBMED   36003400
  REMARK    GeneRIF: Pan-Cancer Analysis of the Immunological Role of PDIA5: A
            Potential Target for Immunotherapy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1844)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1844)
  AUTHORS   Zhang,H., He,J., Dai,Z., Wang,Z., Liang,X., He,F., Xia,Z., Feng,S.,
            Cao,H., Zhang,L. and Cheng,Q.
  TITLE     PDIA5 is Correlated With Immune Infiltration and Predicts Poor
            Prognosis in Gliomas
  JOURNAL   Front Immunol 12, 628966 (2021)
   PUBMED   33664747
  REMARK    GeneRIF: PDIA5 is Correlated With Immune Infiltration and Predicts
            Poor Prognosis in Gliomas.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1844)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1844)
  AUTHORS   Kozlov,G., Maattanen,P., Thomas,D.Y. and Gehring,K.
  TITLE     A structural overview of the PDI family of proteins
  JOURNAL   FEBS J 277 (19), 3924-3936 (2010)
   PUBMED   20796029
  REMARK    GeneRIF: Protein disulfide isomerases are enzymes that mediate
            oxidative protein folding in the endoplasmic reticulum.
            Review article
REFERENCE   7  (bases 1 to 1844)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   8  (bases 1 to 1844)
  AUTHORS   Alanen,H.I., Salo,K.E., Pirneskoski,A. and Ruddock,L.W.
  TITLE     pH dependence of the peptide thiol-disulfide oxidase activity of
            six members of the human protein disulfide isomerase family
  JOURNAL   Antioxid Redox Signal 8 (3-4), 283-291 (2006)
   PUBMED   16677074
REFERENCE   9  (bases 1 to 1844)
  AUTHORS   Horibe,T., Gomi,M., Iguchi,D., Ito,H., Kitamura,Y., Masuoka,T.,
            Tsujimoto,I., Kimura,T. and Kikuchi,M.
  TITLE     Different contributions of the three CXXC motifs of human
            protein-disulfide isomerase-related protein to isomerase activity
            and oxidative refolding
  JOURNAL   J Biol Chem 279 (6), 4604-4611 (2004)
   PUBMED   14627699
  REMARK    GeneRIF: Three thioredoxin motifs (CXXC) of purified PDIR were
            found to contribute to its isomerase activity.
REFERENCE   10 (bases 1 to 1844)
  AUTHORS   Hayano,T. and Kikuchi,M.
  TITLE     Molecular cloning of the cDNA encoding a novel protein disulfide
            isomerase-related protein (PDIR)
  JOURNAL   FEBS Lett 372 (2-3), 210-214 (1995)
   PUBMED   7556671
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM549365.1, D49490.1 and CA414869.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006810.3.
            
            Summary: This gene encodes a member of the disulfide isomerase
            (PDI) family of endoplasmic reticulum (ER) proteins that catalyze
            protein folding and thiol-disulfide interchange reactions. The
            encoded protein has an N-terminal ER-signal sequence, three
            catalytically active thioredoxin (TRX) domains, a TRX-like domain,
            and a C-terminal ER-retention sequence. The N-terminal TRX-like
            domain is the primary binding site for the major ER chaperone
            calreticulin and possibly other proteins and substrates as well.
            Alternative splicing results in multiple protein- and
            non-protein-coding transcript variants. [provided by RefSeq, Dec
            2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.262779.1,
                                           SRR1163657.533548.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316218.12/ ENSP00000323313.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                BM549365.1         17-109
            94-1768             D49490.1           10-1684
            1769-1844           CA414869.1         18-93               c
FEATURES             Location/Qualifiers
     source          1..1844
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.1"
     gene            1..1844
                     /gene="PDIA5"
                     /gene_synonym="PDIR"
                     /note="protein disulfide isomerase family A member 5"
                     /db_xref="GeneID:10954"
                     /db_xref="HGNC:HGNC:24811"
                     /db_xref="MIM:616942"
     exon            1..182
                     /gene="PDIA5"
                     /gene_synonym="PDIR"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1700
                     /gene="PDIA5"
                     /gene_synonym="PDIR"
                     /EC_number="5.3.4.1"
                     /note="protein disulfide isomerase-associated 5; protein
                     disulfide-isomerase A5; protein disulfide
                     isomerase-related protein"
                     /codon_start=1
                     /product="protein disulfide-isomerase A5 precursor"
                     /protein_id="NP_006801.1"
                     /db_xref="CCDS:CCDS3020.1"
                     /db_xref="GeneID:10954"
                     /db_xref="HGNC:HGNC:24811"
                     /db_xref="MIM:616942"
                     /translation="MARAGPAWLLLAIWVVLPSWLSSAKVSSLIERISDPKDLKKLLR
                     TRNNVLVLYSKSEVAAENHLRLLSTVAQAVKGQGTICWVDCGDAESRKLCKKMKVDLS
                     PKDKKVELFHYQDGAFHTEYNRAVTFKSIVAFLKDPKGPPLWEEDPGAKDVVHLDSEK
                     DFRRLLKKEEKPLLIMFYAPWCSMCKRMMPHFQKAATQLRGHAVLAGMNVYSSEFENI
                     KEEYSVRGFPTICYFEKGRFLFQYDNYGSTAEDIVEWLKNPQPPQPQVPETPWADEGG
                     SVYHLTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAA
                     VDATVNKALAERFHISEFPTLKYFKNGEKYAVPVLRTKKKFLEWMQNPEAPPPPEPTW
                     EEQQTSVLHLVGDNFRETLKKKKHTLVMFYAPWCPHCKKVIPHFTATADAFKDDRKIA
                     CAAVDCVKDKNQDLCQQEAVKGYPTFHYYHYGKFAEKYDSDRTELGFTNYIRALREGD
                     HERLGKKKEEL"
     exon            183..309
                     /gene="PDIA5"
                     /gene_synonym="PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            310..397
                     /gene="PDIA5"
                     /gene_synonym="PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            398..481
                     /gene="PDIA5"
                     /gene_synonym="PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            482..527
                     /gene="PDIA5"
                     /gene_synonym="PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            528..620
                     /gene="PDIA5"
                     /gene_synonym="PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            621..681
                     /gene="PDIA5"
                     /gene_synonym="PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            682..749
                     /gene="PDIA5"
                     /gene_synonym="PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            750..841
                     /gene="PDIA5"
                     /gene_synonym="PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            842..913
                     /gene="PDIA5"
                     /gene_synonym="PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1050
                     /gene="PDIA5"
                     /gene_synonym="PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1121
                     /gene="PDIA5"
                     /gene_synonym="PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1282
                     /gene="PDIA5"
                     /gene_synonym="PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1413
                     /gene="PDIA5"
                     /gene_synonym="PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1484
                     /gene="PDIA5"
                     /gene_synonym="PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1619
                     /gene="PDIA5"
                     /gene_synonym="PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1844
                     /gene="PDIA5"
                     /gene_synonym="PDIR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1826..1831
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDIA5"
                     /gene_synonym="PDIR"
                     /note="hexamer: AATAAA"
     polyA_site      1844
                     /gene="PDIA5"
                     /gene_synonym="PDIR"
                     /note="major polyA site"
ORIGIN      
        1 agacgtggca ccgggaactc ggaggcgggg agcggctggg aagtggccgt ggtggttggc
       61 cgcggtggag ctagcaggcg ggcgggcggg agcgggcgcc ggagtggaga aaggagccag
      121 cggtgggcag cgctgctggg atggcgcggg ccgggccggc gtggctgctg ctggcaatct
      181 gggtggtcct gccatcatgg ctgtcctctg caaaggtctc ctcgctcatt gagagaatct
      241 ctgaccccaa ggacttgaaa aaactgctca gaacccggaa taatgtactg gtgctttact
      301 ccaaatctga ggtggcagct gaaaatcatc tcaggttact gtccacagtg gcccaggcgg
      361 tgaaaggaca agggaccatc tgctgggtgg actgtggtga tgcagagagt agaaaattgt
      421 gcaagaagat gaaagttgac ctgagcccga aggacaaaaa ggttgaatta ttccattacc
      481 aggatggtgc atttcatact gaatataacc gagctgtgac atttaagtcc atagtggcct
      541 ttttgaagga tccaaaaggg cccccactgt gggaggaaga tcctggagcc aaagatgttg
      601 tccaccttga cagtgaaaag gacttcagac ggctcctgaa gaaggaagag aagccgctcc
      661 tgatcatgtt ttatgccccc tggtgcagca tgtgcaagag gatgatgccg catttccaga
      721 aggctgcgac tcagctgcga ggccacgccg tgctggccgg gatgaatgtc tactcctctg
      781 aatttgaaaa catcaaggag gagtacagcg tgcgcggctt ccccaccatc tgctattttg
      841 agaaaggacg gttcttgttc cagtatgaca actatgggtc cacagctgag gacattgtgg
      901 agtggctgaa gaatccgcag ccgccacagc cccaggtccc tgagactccc tgggcagatg
      961 agggcggctc cgtttatcac ctgaccgatg aagactttga ccagtttgtg aaggaacact
     1021 cctctgtcct cgtcatgttc cacgccccat ggtgtggcca ctgtaagaaa atgaagccgg
     1081 agtttgagaa ggcagcagaa gccctccatg gagaagcgga tagctctggt gtccttgcag
     1141 ctgtcgatgc cactgtcaac aaggccctgg cagaaagatt ccacatctca gagtttccta
     1201 cgttgaagta ttttaagaat ggagagaaat acgcagtgcc tgtgctcagg acaaagaaga
     1261 agtttctcga gtggatgcaa aaccctgagg cccccccgcc cccagagccc acgtgggaag
     1321 agcagcagac aagcgtgttg cacctggtgg gggacaactt ccgggagacc ctgaagaaga
     1381 agaaacacac cttggtcatg ttctacgccc cttggtgccc acactgtaag aaggtcattc
     1441 cgcactttac tgctactgct gatgccttca aagatgaccg aaagattgcc tgtgccgctg
     1501 ttgactgtgt caaagacaag aaccaagacc tgtgccagca ggaggcggtc aagggctacc
     1561 ccactttcca ctactaccac tatgggaagt tcgcagaaaa gtatgacagc gaccgcacag
     1621 aattgggatt taccaattat attcgagccc tccgggaggg agaccatgaa agactaggga
     1681 aaaagaagga agagttataa ttcctgcctc agaaaaagct tttccattac actgtgaatg
     1741 atacctgttt tgttgtttct gaatttccac atgttctgaa gacaaatttt ttatagccgc
     1801 ttatggccat tttgtacaat tttgaaataa aattaaacca ttta
//
