LOCUS       NM_004911               2767 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens protein disulfide isomerase family A member 4 (PDIA4),
            transcript variant 2, mRNA.
ACCESSION   NM_004911
VERSION     NM_004911.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2767)
  AUTHORS   Kim,H.J. and Kim,D.Y.
  TITLE     Potential Anti-tumor Properties of PDIA4 in Lung Adenocarcinoma
  JOURNAL   Anticancer Res 44 (10), 4309-4315 (2024)
   PUBMED   39348977
  REMARK    GeneRIF: Potential Anti-tumor Properties of PDIA4 in Lung
            Adenocarcinoma.
REFERENCE   2  (bases 1 to 2767)
  AUTHORS   Bu,S., Singh,A., Nguyen,H.C., Peddi,B., Bhatt,K.,
            Ravendranathan,N., Frisbee,J.C. and Singh,K.K.
  TITLE     Protein Disulfide Isomerase 4 Is an Essential Regulator of
            Endothelial Function and Survival
  JOURNAL   Int J Mol Sci 25 (7), 3913 (2024)
   PUBMED   38612722
  REMARK    GeneRIF: Protein Disulfide Isomerase 4 Is an Essential Regulator of
            Endothelial Function and Survival.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2767)
  AUTHORS   Tao,J., Xue,C., Cao,M., Ye,J., Sun,Y., Chen,H., Guan,Y., Zhang,W.,
            Zhang,W. and Yao,Y.
  TITLE     Protein disulfide isomerase family member 4 promotes
            triple-negative breast cancer tumorigenesis and radiotherapy
            resistance through JNK pathway
  JOURNAL   Breast Cancer Res 26 (1), 1 (2024)
   PUBMED   38167446
  REMARK    GeneRIF: Protein disulfide isomerase family member 4 promotes
            triple-negative breast cancer tumorigenesis and radiotherapy
            resistance through JNK pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2767)
  AUTHORS   Xu,M., Xu,H., Wan,W., Jian,X., Jin,R., Wang,L., Wang,J., Xiao,G.,
            Zhang,L., Chen,H. and Wen,Y.
  TITLE     PDIA4 Is a Host Factor Important for Lymphocytic Choriomeningitis
            Virus Infection
  JOURNAL   Viruses 15 (12), 2343 (2023)
   PUBMED   38140584
  REMARK    GeneRIF: PDIA4 Is a Host Factor Important for Lymphocytic
            Choriomeningitis Virus Infection.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2767)
  AUTHORS   Yao,C., Zeng,L., Liu,Q., Qiu,X. and Chen,C.
  TITLE     LncRNA FAM225B Regulates PDIA4-Mediated Ovarian Cancer Cell
            Invasion and Migration via Modulating Transcription Factor DDX17
  JOURNAL   Breast J 2023, 3970444 (2023)
   PUBMED   37720188
  REMARK    GeneRIF: LncRNA FAM225B Regulates PDIA4-Mediated Ovarian Cancer
            Cell Invasion and Migration via Modulating Transcription Factor
            DDX17.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2767)
  AUTHORS   Schaiff,W.T., Hruska,K.A. Jr., McCourt,D.W., Green,M. and
            Schwartz,B.D.
  TITLE     HLA-DR associates with specific stress proteins and is retained in
            the endoplasmic reticulum in invariant chain negative cells
  JOURNAL   J Exp Med 176 (3), 657-666 (1992)
   PUBMED   1512535
REFERENCE   7  (bases 1 to 2767)
  AUTHORS   Weisbart,R.H.
  TITLE     An antibody that binds a neutrophil membrane protein, ERp72, primes
            human neutrophils for enhanced oxidative metabolism in response to
            formyl-methionyl-leucyl-phenylalanine. Implications for ERp72 in
            the signal transduction pathway for neutrophil priming
  JOURNAL   J Immunol 148 (12), 3958-3963 (1992)
   PUBMED   1318337
REFERENCE   8  (bases 1 to 2767)
  AUTHORS   Huang,S.H., Tomich,J.M., Wu,H., Jong,A. and Holcenberg,J.
  TITLE     Human deoxycytidine kinase. Sequence of cDNA clones and analysis of
            expression in cell lines with and without enzyme activity
  JOURNAL   J Biol Chem 266 (8), 5353 (1991)
   PUBMED   2002068
  REMARK    Correction to:[J Biol Chem. 1989 Sep 5;264(25):14762-8.. PMID:
            2549034]
REFERENCE   9  (bases 1 to 2767)
  AUTHORS   Mazzarella,R.A., Srinivasan,M., Haugejorden,S.M. and Green,M.
  TITLE     ERp72, an abundant luminal endoplasmic reticulum protein, contains
            three copies of the active site sequences of protein disulfide
            isomerase
  JOURNAL   J Biol Chem 265 (2), 1094-1101 (1990)
   PUBMED   2295602
REFERENCE   10 (bases 1 to 2767)
  AUTHORS   Huang,S.H., Tomich,J.M., Wu,H., Jong,A. and Holcenberg,J.
  TITLE     Human deoxycytidine kinase. Sequence of cDNA clones and analysis of
            expression in cell lines with and without enzyme activity
  JOURNAL   J Biol Chem 264 (25), 14762-14768 (1989)
   PUBMED   2549034
  REMARK    Erratum:[J Biol Chem. 1991 Mar 15;266(8):5353.. PMID: 2002068]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AU139362.1, BC000425.2, CX871856.1 and BC001928.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004911.4.
            
            Summary: This gene encodes a member of the disulfide isomerase
            (PDI) family of endoplasmic reticulum (ER) proteins that catalyze
            protein folding and thiol-disulfide interchange reactions. The
            encoded protein has an N-terminal ER-signal sequence, three
            catalytically active thioredoxin (TRX) domains, two TRX-like
            domains and a C-terminal ER-retention sequence. This protein, when
            bound to cyclophilin B, enhances the rate of immunoglobulin G
            intermolecular disulfide bonding and antibody assembly. [provided
            by RefSeq, Dec 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011754.2, SRR1803617.95934.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154405 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000652332.1/ ENSP00000499129.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AU139362.1         187-239
            54-2071             BC000425.2         1-2018
            2072-2384           CX871856.1         24-336              c
            2385-2767           BC001928.1         2332-2714
FEATURES             Location/Qualifiers
     source          1..2767
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..2767
                     /gene="PDIA4"
                     /gene_synonym="ERp-72; ERP70; ERP72"
                     /note="protein disulfide isomerase family A member 4"
                     /db_xref="GeneID:9601"
                     /db_xref="HGNC:HGNC:30167"
                     /db_xref="MIM:620018"
     exon            1..185
                     /gene="PDIA4"
                     /gene_synonym="ERp-72; ERP70; ERP72"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..2035
                     /gene="PDIA4"
                     /gene_synonym="ERp-72; ERP70; ERP72"
                     /EC_number="5.3.4.1"
                     /note="isofrom 2 precursor is encoded by transcript
                     variant 2; protein disulfide isomerase-associated 4;
                     protein disulfide isomerase related protein
                     (calcium-binding protein, intestinal-related); protein
                     disulfide-isomerase A4; ER protein 70; ER protein 72;
                     endoplasmic reticulum resident protein 70; endoplasmic
                     reticulum resident protein 72; testicular tissue protein
                     Li 137"
                     /codon_start=1
                     /product="protein disulfide-isomerase A4 isofrom 2
                     precursor"
                     /protein_id="NP_004902.1"
                     /db_xref="CCDS:CCDS5893.1"
                     /db_xref="GeneID:9601"
                     /db_xref="HGNC:HGNC:30167"
                     /db_xref="MIM:620018"
                     /translation="MRPRKAFLLLLLLGLVQLLAVAGAEGPDEDSSNRENAIEDEEEE
                     EEEDDDEEEDDLEVKEENGVLVLNDANFDNFVADKDTVLLEFYAPWCGHCKQFAPEYE
                     KIANILKDKDPPIPVAKIDATSASVLASRFDVSGYPTIKILKKGQAVDYEGSRTQEEI
                     VAKVREVSQPDWTPPPEVTLVLTKENFDEVVNDADIILVEFYAPWCGHCKKLAPEYEK
                     AAKELSKRSPPIPLAKVDATAETDLAKRFDVSGYPTLKIFRKGRPYDYNGPREKYGIV
                     DYMIEQSGPPSKEILTLKQVQEFLKDGDDVIIIGVFKGESDPAYQQYQDAANNLREDY
                     KFHHTFSTEIAKFLKVSQGQLVVMQPEKFQSKYEPRSHMMDVQGSTQDSAIKDFVLKY
                     ALPLVGHRKVSNDAKRYTRRPLVVVYYSVDFSFDYRAATQFWRSKVLEVAKDFPEYTF
                     AIADEEDYAGEVKDLGLSESGEDVNAAILDESGKKFAMEPEEFDSDTLREFVTAFKKG
                     KLKPVIKSQPVPKNNKGPVKVVVGKTFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYN
                     SLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGFPTIYFAPSGDKKNPVKFEGGDRDL
                     EHLSKFIEEHATKLSRTKEEL"
     exon            186..366
                     /gene="PDIA4"
                     /gene_synonym="ERp-72; ERP70; ERP72"
                     /inference="alignment:Splign:2.1.0"
     exon            367..572
                     /gene="PDIA4"
                     /gene_synonym="ERp-72; ERP70; ERP72"
                     /inference="alignment:Splign:2.1.0"
     exon            573..711
                     /gene="PDIA4"
                     /gene_synonym="ERp-72; ERP70; ERP72"
                     /inference="alignment:Splign:2.1.0"
     exon            712..917
                     /gene="PDIA4"
                     /gene_synonym="ERp-72; ERP70; ERP72"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1076
                     /gene="PDIA4"
                     /gene_synonym="ERp-72; ERP70; ERP72"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1228
                     /gene="PDIA4"
                     /gene_synonym="ERp-72; ERP70; ERP72"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1385
                     /gene="PDIA4"
                     /gene_synonym="ERp-72; ERP70; ERP72"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1619
                     /gene="PDIA4"
                     /gene_synonym="ERp-72; ERP70; ERP72"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..2767
                     /gene="PDIA4"
                     /gene_synonym="ERp-72; ERP70; ERP72"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2387
                     /gene="PDIA4"
                     /gene_synonym="ERp-72; ERP70; ERP72"
                     /note="major polyA site"
     regulatory      2743..2748
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDIA4"
                     /gene_synonym="ERp-72; ERP70; ERP72"
                     /note="hexamer: AATAAA"
     polyA_site      2767
                     /gene="PDIA4"
                     /gene_synonym="ERp-72; ERP70; ERP72"
ORIGIN      
        1 gcgtcgctaa ggagcgacgg gctgtcggcc agaccccgag ttctcggtgc gctcagcggc
       61 cgccgacgct aggaggccgc gctccgcccc cgctaccatg aggccccgga aagccttcct
      121 gctcctgctg ctcttggggc tggtgcagct gctggccgtg gcgggtgccg agggcccgga
      181 cgaggattct tctaacagag aaaatgccat tgaggatgaa gaggaggagg aggaggaaga
      241 tgatgatgag gaagaagacg acttggaagt taaggaagaa aatggagtct tggtcctaaa
      301 tgatgcaaac tttgataatt ttgtggctga caaagacaca gtgctgctgg agttttatgc
      361 tccatggtgt ggacattgca agcagtttgc tccggaatat gaaaaaattg ccaacatatt
      421 aaaggataaa gatcctccca ttcctgttgc caagatcgat gcaacctcag cgtctgtgct
      481 ggccagcagg tttgatgtga gtggctaccc caccatcaag atccttaaga aggggcaggc
      541 tgtagactac gagggctcca gaacccagga agaaattgtt gccaaggtca gagaagtctc
      601 ccagcccgac tggacgcctc caccagaagt cacgcttgtg ttgaccaaag agaactttga
      661 tgaagttgtg aatgatgcag atatcattct ggtggagttt tatgccccat ggtgtggaca
      721 ctgcaagaaa cttgcccccg agtatgagaa ggccgccaag gagctcagca agcgttctcc
      781 tccaattccc ctggcaaagg tcgacgccac cgcagaaaca gacctggcca agaggtttga
      841 tgtctctggc tatcccaccc tgaaaatttt ccgcaaagga aggccttatg actacaacgg
      901 cccacgagaa aaatatggaa tcgttgatta catgatcgag cagtccgggc ctccctccaa
      961 ggagattctg accctgaagc aggtccagga gttcctgaag gatggagacg atgtcatcat
     1021 catcggggtc tttaaggggg agagtgaccc agcctaccag caataccagg atgccgctaa
     1081 caacctgaga gaagattaca aatttcacca cactttcagc acagaaatag caaagttctt
     1141 gaaagtctcc caggggcagt tggttgtaat gcagcctgag aaattccagt ccaagtatga
     1201 gccccggagc cacatgatgg acgtccaggg ctccacccag gactcggcca tcaaggactt
     1261 cgtgctgaag tacgccctgc ccctggttgg ccaccgcaag gtgtcaaacg atgctaagcg
     1321 ctacaccagg cgccccctgg tggtcgtcta ctacagtgtg gacttcagct ttgattacag
     1381 agctgcaact cagttttggc ggagcaaagt cctagaggtg gccaaggact tccctgagta
     1441 cacctttgcc attgcggacg aagaggacta tgctggggag gtgaaggacc tggggctcag
     1501 cgagagtggg gaggatgtca atgccgccat cctggacgag agtgggaaga agttcgccat
     1561 ggagccagag gagtttgact ctgacaccct ccgcgagttt gtcactgctt tcaaaaaagg
     1621 aaaactgaag ccagtcatca aatcccagcc agtgcccaag aacaacaagg gacccgtcaa
     1681 ggtcgtggtg ggaaagacct ttgactccat tgtgatggac cccaagaagg acgtcctcat
     1741 cgagttctac gcgccatggt gcgggcactg caagcagcta gagcccgtgt acaacagcct
     1801 ggccaagaag tacaagggcc aaaagggcct ggtcatcgcc aagatggacg ccactgccaa
     1861 cgacgtcccc agcgaccgct ataaggtgga gggcttcccc accatctact tcgcccccag
     1921 tggggacaaa aagaacccag ttaaatttga gggtggagac agagatctgg agcatttgag
     1981 caagtttata gaagaacatg ccacaaaact gagcaggacc aaggaagagc tttgaaggcc
     2041 tgaggtctgc ggaaggtggg aggaggcaga cgccctgcgt ggcccatggt cggggcgtcc
     2101 acgccgaggc cggcaacaaa cgacagtatc tcggattcct tttttttttt ttttaatttt
     2161 ttatactttg gtgtttcact tcatgctctg aatactgaat aaccatgaat gactgaatag
     2221 tttagtccag atttttacag aggatacatc tatttttatc attatttggg gtttgaaaaa
     2281 ttttttttta caccttctaa tttctttatt tctcaaagca gataattctt ctgtgtgaaa
     2341 atgttttctt tttttaattt aaggtttaaa attccttttc caaatcatgt tgattttgct
     2401 ctttgctttt tcgttgtctg agaaattgtt ggcgtagatt tggcttctgg tatgtgtttc
     2461 tgattgcttc ctgttgagca caaagtgaga gctgccactg agcagccctg ccaggggtgc
     2521 tgtttcaggc tgggcatcgc caggcggcct ccctgcaaac caagggctgg gggcaaaggg
     2581 gcatgatcca gggtccccca gggtgggctc agctccaggg agaggccacc cacgtggcag
     2641 ccccacctct tgagagcccc cagtgccgga gcagaaagga ccctggaccc agaggcagat
     2701 actgcggggt ggtagaaaag gtagagtagg ctgtggcaat ggaataaaac acgattaaaa
     2761 acgttaa
//
