LOCUS       NM_006849               1686 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens protein disulfide isomerase family A member 2 (PDIA2),
            mRNA.
ACCESSION   NM_006849
VERSION     NM_006849.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1686)
  AUTHORS   Li,Y., Lv,L., Ye,M., Xie,N., Fazli,L., Wang,Y., Wang,W., Yang,S.,
            Ni,Q., Chen,J., Guo,X., Zhao,Y., Xue,G., Sha,J., Dong,X. and
            Zhang,L.
  TITLE     PDIA2 has a dual function in promoting androgen deprivation therapy
            induced venous thrombosis events and castrate resistant prostate
            cancer progression
  JOURNAL   Oncogene 43 (21), 1631-1643 (2024)
   PUBMED   38589675
  REMARK    GeneRIF: PDIA2 has a dual function in promoting androgen
            deprivation therapy induced venous thrombosis events and castrate
            resistant prostate cancer progression.
REFERENCE   2  (bases 1 to 1686)
  AUTHORS   Ma,Z.G., Liu,Y.X., Zou,N., Huang,Z., Wang,M., Li,T., Zhou,J. and
            Chen,L.G.
  TITLE     Protein Disulfide Isomerase A2 Is Correlated with Immune
            Infiltrates and Is a Novel Prognostic Biomarker in Glioma Patients
  JOURNAL   Curr Med Sci 43 (6), 1107-1115 (2023)
   PUBMED   37978154
  REMARK    GeneRIF: Protein Disulfide Isomerase A2 Is Correlated with Immune
            Infiltrates and Is a Novel Prognostic Biomarker in Glioma Patients.
REFERENCE   3  (bases 1 to 1686)
  AUTHORS   Fang,H., Peng,Z., Tan,B., Peng,N., Li,B., He,D., Xu,M. and Yang,Z.
  TITLE     The involvement of PDIA2 gene in the progression of renal cell
            carcinoma is potentially through regulation of JNK signaling
            pathway
  JOURNAL   Clin Transl Oncol 25 (10), 2938-2949 (2023)
   PUBMED   37017923
  REMARK    GeneRIF: The involvement of PDIA2 gene in the progression of renal
            cell carcinoma is potentially through regulation of JNK signaling
            pathway.
REFERENCE   4  (bases 1 to 1686)
  AUTHORS   Galligan,J.J. and Petersen,D.R.
  TITLE     The human protein disulfide isomerase gene family
  JOURNAL   Hum Genomics 6 (1), 6 (2012)
   PUBMED   23245351
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1686)
  AUTHORS   Fu,X. and Zhu,B.T.
  TITLE     Human pancreas-specific protein disulfide isomerase homolog (PDIp)
            is redox-regulated through formation of an inter-subunit disulfide
            bond
  JOURNAL   Arch Biochem Biophys 485 (1), 1-9 (2009)
   PUBMED   19150607
  REMARK    GeneRIF: structures and functions of human PDIp are redox-regulated
            through formation of an inter-subunit disulfide bond between two
            cysteine-4 residues
REFERENCE   6  (bases 1 to 1686)
  AUTHORS   Fu,X.M. and Zhu,B.T.
  TITLE     Human pancreas-specific protein disulfide isomerase homolog (PDIp)
            is an intracellular estrogen-binding protein that modulates
            estrogen levels and actions in target cells
  JOURNAL   J Steroid Biochem Mol Biol 115 (1-2), 20-29 (2009)
   PUBMED   19429457
  REMARK    GeneRIF: PDIp can also serve as an effective modulator of the
            cellular levels and biological actions of endogenous estrogens in
            the pancreas where estrogen receptors alpha and beta and PDIp are
            co-present.
REFERENCE   7  (bases 1 to 1686)
  AUTHORS   VanderWaal,R.P., Spitz,D.R., Griffith,C.L., Higashikubo,R. and Roti
            Roti,J.L.
  TITLE     Evidence that protein disulfide isomerase (PDI) is involved in
            DNA-nuclear matrix anchoring
  JOURNAL   J Cell Biochem 85 (4), 689-702 (2002)
   PUBMED   11968009
  REMARK    GeneRIF: Evidence that protein disulfide isomerase (PDI) is
            involved in DNA-nuclear matrix anchoring.
REFERENCE   8  (bases 1 to 1686)
  AUTHORS   Liang,Y., Li,J., Chen,J. and Wang,C.C.
  TITLE     Thermodynamics of the folding of D-glyceraldehyde-3-phosphate
            dehydrogenase assisted by protein disulfide isomerase studied by
            microcalorimetry
  JOURNAL   Eur J Biochem 268 (15), 4183-4189 (2001)
   PUBMED   11488911
REFERENCE   9  (bases 1 to 1686)
  AUTHORS   Daniels,R.J., Peden,J.F., Lloyd,C., Horsley,S.W., Clark,K.,
            Tufarelli,C., Kearney,L., Buckle,V.J., Doggett,N.A., Flint,J. and
            Higgs,D.R.
  TITLE     Sequence, structure and pathology of the fully annotated terminal 2
            Mb of the short arm of human chromosome 16
  JOURNAL   Hum Mol Genet 10 (4), 339-352 (2001)
   PUBMED   11157797
REFERENCE   10 (bases 1 to 1686)
  AUTHORS   Desilva,M.G., Lu,J., Donadel,G., Modi,W.S., Xie,H., Notkins,A.L.
            and Lan,M.S.
  TITLE     Characterization and chromosomal localization of a new protein
            disulfide isomerase, PDIp, highly expressed in human pancreas
  JOURNAL   DNA Cell Biol 15 (1), 9-16 (1996)
   PUBMED   8561901
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z69667.1.
            
            On Aug 16, 2019 this sequence version replaced NM_006849.3.
            
            Summary: This gene encodes a member of the disulfide isomerase
            (PDI) family of endoplasmic reticulum (ER) proteins that catalyze
            protein folding and thiol-disulfide interchange reactions. The
            encoded protein has an N-terminal ER-signal sequence, two
            catalytically active thioredoxin (TRX) domains, two TRX-like
            domains and a C-terminal ER-retention sequence. The protein plays a
            role in the folding of nascent proteins in the endoplasmic
            reticulum by forming disulfide bonds through its thiol isomerase,
            oxidase, and reductase activity. The encoded protein also possesses
            estradiol-binding activity and can modulate intracellular estradiol
            levels. [provided by RefSeq, Sep 2017].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000537.2, AK295383.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2144835
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000219406.11/ ENSP00000219406.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               Z69667.1           20764-20968
            206-412             Z69667.1           21987-22193
            413-546             Z69667.1           22259-22392
            547-684             Z69667.1           22478-22615
            685-801             Z69667.1           22684-22800
            802-927             Z69667.1           22912-23037
            928-1125            Z69667.1           23106-23303
            1126-1246           Z69667.1           23953-24073
            1247-1428           Z69667.1           24154-24335
            1429-1539           Z69667.1           24435-24545
            1540-1686           Z69667.1           24669-24815
FEATURES             Location/Qualifiers
     source          1..1686
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..1686
                     /gene="PDIA2"
                     /gene_synonym="PDA2; PDI; PDIP; PDIR"
                     /note="protein disulfide isomerase family A member 2"
                     /db_xref="GeneID:64714"
                     /db_xref="HGNC:HGNC:14180"
                     /db_xref="MIM:608012"
     exon            1..205
                     /gene="PDIA2"
                     /gene_synonym="PDA2; PDI; PDIP; PDIR"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..1584
                     /gene="PDIA2"
                     /gene_synonym="PDA2; PDI; PDIP; PDIR"
                     /EC_number="5.3.4.1"
                     /note="protein disulfide isomerase-associated 2; protein
                     disulfide isomerase, pancreatic; protein
                     disulfide-isomerase A2; Rho GDP dissociation inhibitor
                     gamma; pancreatic protein disulfide isomerase;
                     pancreas-specific protein disulfide isomerase"
                     /codon_start=1
                     /product="protein disulfide-isomerase A2 precursor"
                     /protein_id="NP_006840.2"
                     /db_xref="CCDS:CCDS42089.1"
                     /db_xref="GeneID:64714"
                     /db_xref="HGNC:HGNC:14180"
                     /db_xref="MIM:608012"
                     /translation="MSRQLLPVLLLLLLRASCPWGQEQGARSPSEEPPEEEIPKEDGI
                     LVLSRHTLGLALREHPALLVEFYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDG
                     PAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRDAEGIAEWLRRRVGPSAMRLED
                     EAAAQALIGGRDLVVIGFFQDLQDEDVATFLALAQDALDMTFGLTDRPRLFQQFGLTK
                     DTVVLFKKFDEGRADFPVDEELGLDLGDLSRFLVTHSMRLVTEFNSQTSAKIFAARIL
                     NHLLLFVNQTLAAHRELLAGFGEAAPRFRGQVLFVVVDVAADNEHVLQYFGLKAEAAP
                     TLRLVNLETTKKYAPVDGGPVTAASITAFCHAVLNGQVKPYLLSQEIPPDWDQRPVKT
                     LVGKNFEQVAFDETKNVFVKFYAPWCTHCKEMAPAWEALAEKYQDHEDIIIAELDATA
                     NELDAFAVHGFPTLKYFPAGPGRKVIEYKSTRDLETFSKFLDNGGVLPTEEPPEEPAA
                     PFPEPPANSTMGSKEEL"
     exon            206..412
                     /gene="PDIA2"
                     /gene_synonym="PDA2; PDI; PDIP; PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            413..546
                     /gene="PDIA2"
                     /gene_synonym="PDA2; PDI; PDIP; PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            547..684
                     /gene="PDIA2"
                     /gene_synonym="PDA2; PDI; PDIP; PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            685..801
                     /gene="PDIA2"
                     /gene_synonym="PDA2; PDI; PDIP; PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            802..927
                     /gene="PDIA2"
                     /gene_synonym="PDA2; PDI; PDIP; PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1125
                     /gene="PDIA2"
                     /gene_synonym="PDA2; PDI; PDIP; PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1246
                     /gene="PDIA2"
                     /gene_synonym="PDA2; PDI; PDIP; PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1428
                     /gene="PDIA2"
                     /gene_synonym="PDA2; PDI; PDIP; PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1539
                     /gene="PDIA2"
                     /gene_synonym="PDA2; PDI; PDIP; PDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1686
                     /gene="PDIA2"
                     /gene_synonym="PDA2; PDI; PDIP; PDIR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1662..1667
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDIA2"
                     /gene_synonym="PDA2; PDI; PDIP; PDIR"
                     /note="hexamer: AATAAA"
     polyA_site      1686
                     /gene="PDIA2"
                     /gene_synonym="PDA2; PDI; PDIP; PDIR"
                     /note="major polyA site"
ORIGIN      
        1 agcaccatga gccgccagct tctgcctgta ctgctgctgc tgctgctcag ggcttcgtgc
       61 ccatggggtc aggaacaggg agcgaggagc ccctcggagg agcctccaga ggaggaaatc
      121 cccaaggagg atgggatctt ggtgctgagc cgccacaccc tgggcctggc cctgcgggag
      181 caccctgccc tgctggtgga attctatgcc ccgtggtgtg ggcactgcca ggccctggcc
      241 cccgagtaca gcaaggcagc tgccgtgctc gcggccgagt caatggtggt cacgctggcc
      301 aaggtggatg ggcccgcgca gcgcgagctg gctgaggagt ttggtgtgac ggagtaccct
      361 acgctcaagt tcttccgcaa tgggaaccgc acgcacccgg aggagtacac aggaccacgg
      421 gacgctgagg gcattgccga gtggctgcga cggcgggtgg ggcccagtgc catgcggctg
      481 gaggacgagg cggccgccca ggcgctgatc ggtggccggg acctagtggt cattggcttc
      541 ttccaggacc tgcaggacga ggacgtggcc accttcttgg ccttggccca ggacgccctg
      601 gacatgacct ttggcctcac agaccggccg cggctctttc agcagtttgg cctcaccaag
      661 gacactgtgg ttctcttcaa gaagtttgat gaggggcggg cagacttccc cgtggacgag
      721 gagcttggcc tggacctggg ggatctgtcg cgcttcctgg tcacacacag catgcgcctg
      781 gtcacggagt tcaacagcca gacgtctgcc aagatcttcg cggccaggat cctcaaccac
      841 ctgctgctgt ttgtcaacca gacgctggct gcgcaccggg agctcctagc gggctttggg
      901 gaggcagctc cccgcttccg ggggcaggtg ctgttcgtgg tggtggacgt ggcggccgac
      961 aatgagcacg tgctgcagta ctttggactc aaggctgagg cagcccccac tctgcgcttg
     1021 gtcaaccttg aaaccactaa gaagtatgcg cctgtggatg ggggccctgt caccgcagcg
     1081 tccatcactg ctttctgcca tgcagtcctc aacggccaag tcaagcccta tctcctgagc
     1141 caggagatac cccctgattg ggatcagcgg ccagttaaga ccctcgtggg caagaatttt
     1201 gagcaggtgg cttttgacga aaccaagaat gtgtttgtca agttctatgc cccgtggtgc
     1261 acccactgca aggagatggc ccctgcctgg gaggcattgg ctgagaagta ccaagaccac
     1321 gaggacatca tcattgctga gctggatgcc acggccaacg agctggatgc cttcgctgtg
     1381 cacggcttcc ctactctcaa gtacttccca gcagggccag gtcggaaggt gattgaatac
     1441 aaaagcacca gggacctgga gactttctcc aagttcctgg acaacggggg cgtgctgccc
     1501 acggaggagc ccccggagga gccagcagcc ccgttcccgg agccaccggc caactccact
     1561 atggggtcca aggaggaact gtagctgccc ccgtgtcacc cccgccatca ctgctggaca
     1621 ggagccaccc ccttgggtac cagagggagc tgtgcattgt gaataaagag tgagcttggt
     1681 tctgga
//
