LOCUS       NM_001372073            1508 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens platelet derived growth factor receptor like (PDGFRL),
            transcript variant 1, mRNA.
ACCESSION   NM_001372073
VERSION     NM_001372073.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1508)
  AUTHORS   Xie,T., Deng,L., Mei,P., Zhou,Y., Wang,B., Zhang,J., Lin,J.,
            Wei,Y., Zhang,X. and Xu,R.
  TITLE     Genome-wide association study combining pathway analysis for
            typical sporadic amyotrophic lateral sclerosis in Chinese Han
            populations
  JOURNAL   Neurobiol Aging 35 (7), 1778 (2014)
   PUBMED   24529757
REFERENCE   2  (bases 1 to 1508)
  AUTHORS   Gialeli,C., Nikitovic,D., Kletsas,D., Theocharis,A.D.,
            Tzanakakis,G.N. and Karamanos,N.K.
  TITLE     PDGF/PDGFR signaling and targeting in cancer growth and
            progression: Focus on tumor microenvironment and cancer-associated
            fibroblasts
  JOURNAL   Curr Pharm Des 20 (17), 2843-2848 (2014)
   PUBMED   23944365
  REMARK    GeneRIF: review elucidates the role of tumor stroma interactions,
            the roles of PDGF receptor signaling in cancer-associated
            fibroblasts via alteration of stromal matrix composition and the
            mitogenic effects of cancer-derived PDGFs.
            Review article
REFERENCE   3  (bases 1 to 1508)
  AUTHORS   Deng,X., Sabino,E.C., Cunha-Neto,E., Ribeiro,A.L., Ianni,B.,
            Mady,C., Busch,M.P. and Seielstad,M.
  CONSRTM   REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology
            Donor Study-II Component International
  TITLE     Genome wide association study (GWAS) of Chagas cardiomyopathy in
            Trypanosoma cruzi seropositive subjects
  JOURNAL   PLoS One 8 (11), e79629 (2013)
   PUBMED   24324551
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1508)
  AUTHORS   Hou,S., Xiao,X., Zhou,Y., Zhu,X., Li,F., Kijlstra,A. and Yang,P.
  TITLE     Genetic variant on PDGFRL associated with Behcet disease in Chinese
            Han populations
  JOURNAL   Hum Mutat 34 (1), 74-78 (2013)
   PUBMED   22926996
  REMARK    GeneRIF: Data indicate the association between SNP rs17633132:C/T
            in PDGFRL with Behcet disease and suggest that the PDGFRL gene may
            be involved in Behcet disease by modulating its transcription.
REFERENCE   5  (bases 1 to 1508)
  AUTHORS   Guo,F.J., Zhang,W.J., Li,Y.L., Liu,Y., Li,Y.H., Huang,J.,
            Wang,J.J., Xie,P.L. and Li,G.C.
  TITLE     Expression and functional characterization of platelet-derived
            growth factor receptor-like gene
  JOURNAL   World J Gastroenterol 16 (12), 1465-1472 (2010)
   PUBMED   20333786
  REMARK    GeneRIF: Results indicate that PDGFRL functions as a tumor
            suppressor, inhibiting the growth of colorectal cancer cells.
REFERENCE   6  (bases 1 to 1508)
  AUTHORS   Seitz,S., Korsching,E., Weimer,J., Jacobsen,A., Arnold,N.,
            Meindl,A., Arnold,W., Gustavus,D., Klebig,C., Petersen,I. and
            Scherneck,S.
  TITLE     Genetic background of different cancer cell lines influences the
            gene set involved in chromosome 8 mediated breast tumor suppression
  JOURNAL   Genes Chromosomes Cancer 45 (6), 612-627 (2006)
   PUBMED   16552773
REFERENCE   7  (bases 1 to 1508)
  AUTHORS   Pils,D., Horak,P., Gleiss,A., Sax,C., Fabjani,G., Moebus,V.J.,
            Zielinski,C., Reinthaller,A., Zeillinger,R. and Krainer,M.
  TITLE     Five genes from chromosomal band 8p22 are significantly
            down-regulated in ovarian carcinoma: N33 and EFA6R have a potential
            impact on overall survival
  JOURNAL   Cancer 104 (11), 2417-2429 (2005)
   PUBMED   16270321
REFERENCE   8  (bases 1 to 1508)
  AUTHORS   Bo,H., Ghazizadeh,M., Shimizu,H., Kurihara,Y., Egawa,S.,
            Moriyama,Y., Tajiri,T. and Kawanami,O.
  TITLE     Effect of ionizing irradiation on human esophageal cancer cell
            lines by cDNA microarray gene expression analysis
  JOURNAL   J Nippon Med Sch 71 (3), 172-180 (2004)
   PUBMED   15226608
REFERENCE   9  (bases 1 to 1508)
  AUTHORS   Fujiwara,Y., Ohata,H., Kuroki,T., Koyama,K., Tsuchiya,E., Monden,M.
            and Nakamura,Y.
  TITLE     Isolation of a candidate tumor suppressor gene on chromosome
            8p21.3-p22 that is homologous to an extracellular domain of the
            PDGF receptor beta gene
  JOURNAL   Oncogene 10 (5), 891-895 (1995)
   PUBMED   7898930
REFERENCE   10 (bases 1 to 1508)
  AUTHORS   Fujiwara,Y., Ohata,H., Emi,M., Okui,K., Koyama,K., Tsuchiya,E.,
            Nakajima,T., Monden,M., Mori,T., Kurimasa,A. et al.
  TITLE     A 3-Mb physical map of the chromosome region 8p21.3-p22, including
            a 600-kb region commonly deleted in human hepatocellular carcinoma,
            colorectal cancer, and non-small cell lung cancer
  JOURNAL   Genes Chromosomes Cancer 10 (1), 7-14 (1994)
   PUBMED   7519877
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP006248.1 and AC124069.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a protein with significant sequence
            similarity to the ligand binding domain of platelet-derived growth
            factor receptor beta. Mutations in this gene, or deletion of a
            chromosomal segment containing this gene, are associated with
            sporadic hepatocellular carcinomas, colorectal cancers, and
            non-small cell lung cancers. This suggests this gene product may
            function as a tumor suppressor. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D37965.1, BC010927.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000251630.11/ ENSP00000251630.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                AP006248.1         143545-143636
            93-390              AP006248.1         155797-156094
            391-542             AC124069.7         11055-11206
            543-836             AC124069.7         18491-18784
            837-976             AC124069.7         24078-24217
            977-1508            AC124069.7         32617-33148
FEATURES             Location/Qualifiers
     source          1..1508
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p22"
     gene            1..1508
                     /gene="PDGFRL"
                     /gene_synonym="PDGRL; PRLTS"
                     /note="platelet derived growth factor receptor like"
                     /db_xref="GeneID:5157"
                     /db_xref="HGNC:HGNC:8805"
                     /db_xref="MIM:604584"
     exon            1..92
                     /gene="PDGFRL"
                     /gene_synonym="PDGRL; PRLTS"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1165
                     /gene="PDGFRL"
                     /gene_synonym="PDGRL; PRLTS"
                     /note="platelet-derived growth factor-beta-like tumor
                     suppressor; platelet-derived growth factor receptor-like
                     protein; PDGFR-like protein; PDGF receptor beta-like tumor
                     suppressor"
                     /codon_start=1
                     /product="platelet-derived growth factor receptor-like
                     protein precursor"
                     /protein_id="NP_001359002.1"
                     /db_xref="CCDS:CCDS6003.1"
                     /db_xref="GeneID:5157"
                     /db_xref="HGNC:HGNC:8805"
                     /db_xref="MIM:604584"
                     /translation="MKVWLLLGLLLVHEALEDVTGQHLPKNKRPKEPGENRIKPTNKK
                     VKPKIPKMKDRDSANSAPKTQSIMMQVLDKGRFQKPAATLSLLAGQTVELRCKGSRIG
                     WSYPAYLDTFKDSRLSVKQNERYGQLTLVNSTSADTGEFSCWVQLCSGYICRKDEAKT
                     GSTYIFFTEKGELFVPSPSYFDVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPA
                     NGTDIVYDMKRGFVYLQPHSEHQGVVYCRAEAGGRSQISVKYQLLYVAVPSGPPSTTI
                     LASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHT
                     TRISQSVITVEDFETIDAGYYICTAQNLQGQTTVATTVEFS"
     exon            93..390
                     /gene="PDGFRL"
                     /gene_synonym="PDGRL; PRLTS"
                     /inference="alignment:Splign:2.1.0"
     exon            391..542
                     /gene="PDGFRL"
                     /gene_synonym="PDGRL; PRLTS"
                     /inference="alignment:Splign:2.1.0"
     exon            543..836
                     /gene="PDGFRL"
                     /gene_synonym="PDGRL; PRLTS"
                     /inference="alignment:Splign:2.1.0"
     exon            837..976
                     /gene="PDGFRL"
                     /gene_synonym="PDGRL; PRLTS"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1508
                     /gene="PDGFRL"
                     /gene_synonym="PDGRL; PRLTS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1451..1456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDGFRL"
                     /gene_synonym="PDGRL; PRLTS"
                     /note="hexamer: ATTAAA"
     regulatory      1476..1481
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDGFRL"
                     /gene_synonym="PDGRL; PRLTS"
                     /note="hexamer: AATAAA"
     polyA_site      1483
                     /gene="PDGFRL"
                     /gene_synonym="PDGRL; PRLTS"
                     /note="major polyA site"
     polyA_site      1508
                     /gene="PDGFRL"
                     /gene_synonym="PDGRL; PRLTS"
ORIGIN      
        1 gccgcgctcc tgcgctccga ggtccgaggt tcccgagatg aaggtctggc tgctgcttgg
       61 tcttctgctg gtgcacgaag cgctggagga tgttactggc caacaccttc ccaagaacaa
      121 gcgtccaaaa gaaccaggag agaatagaat caaacctacc aacaagaagg tgaagcccaa
      181 aattcctaaa atgaaggaca gggactcagc caattcagca ccaaagacgc agtctatcat
      241 gatgcaagtg ctggataaag gtcgcttcca gaaacccgcc gctaccctga gtctgctggc
      301 ggggcaaact gtagagcttc gatgtaaagg gagtagaatt gggtggagct accctgcgta
      361 tctggacacc tttaaggatt ctcgcctcag cgtcaagcag aatgagcgct acggccagtt
      421 gactctggtc aactccacct cggcagacac aggtgaattc agctgctggg tgcagctctg
      481 cagcggctac atctgcagga aggacgaggc caaaacgggc tccacctaca tcttttttac
      541 agagaaagga gaactctttg taccttctcc cagctacttc gatgttgtct acttgaaccc
      601 ggacagacag gctgtggttc cttgtcgggt gaccgtgctg tcggccaaag tcacgctcca
      661 cagggaattc ccagccaagg agatcccagc caatggaacg gacattgttt atgacatgaa
      721 gcggggcttt gtgtatctgc aacctcattc cgagcaccag ggtgtggttt actgcagggc
      781 ggaggccggg ggcagatctc agatctccgt caagtaccag ctgctctatg tggcggttcc
      841 cagtggccct ccctcaacaa ccatcttggc ttcttcaaac aaagtgaaaa gtggggacga
      901 catcagtgtg ctctgcactg tcctggggga gcccgatgtg gaggtggagt tcacctggat
      961 cttcccaggg cagaaggatg aaaggcctgt gacgatccaa gacacttgga ggttgatcca
     1021 cagaggactg ggacacacca cgagaatctc ccagagtgtc attacagtgg aagactttga
     1081 gacgattgat gcaggatatt acatttgcac tgctcagaat cttcaaggac agaccacagt
     1141 agctaccact gttgagtttt cctgacttgg aaaaggaaat gtaatgaact tatggaaagc
     1201 ccatttgtgt acacagtcag ctttggggtt ccttttatta gtgctttgcc agaggctgat
     1261 gtcaagcacc acaccccaac cccagcgtct cgtgagtccg acccagacat ccaaactaaa
     1321 aggaagtcat ccagtctatt cacagaagtg ttaacttttc taacagaaag catgattttg
     1381 attgcttacc tacatacgtg ttcctagttt ttatacatgt gtaaacaatt ttatataatc
     1441 aatcatttct attaaatgag cacgtttttg taaaaaataa aaagtgggat aagtgttttt
     1501 taagttaa
//
