LOCUS       NM_002609               5700 bp    mRNA    linear   PRI 05-FEB-2025
DEFINITION  Homo sapiens platelet derived growth factor receptor beta (PDGFRB),
            transcript variant 1, mRNA.
ACCESSION   NM_002609
VERSION     NM_002609.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5700)
  AUTHORS   Ma,Q., He,X., Wang,X., Zhao,G., Zhang,Y., Su,C., Wei,M., Zhang,K.,
            Liu,M., Zhu,Y. and He,J.
  TITLE     PTPN14 aggravates neointimal hyperplasia via boosting PDGFRbeta
            signaling in smooth muscle cells
  JOURNAL   Nat Commun 15 (1), 7398 (2024)
   PUBMED   39191789
  REMARK    GeneRIF: PTPN14 aggravates neointimal hyperplasia via boosting
            PDGFRbeta signaling in smooth muscle cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5700)
  AUTHORS   Xu,F., Chen,H., Zhou,C., Zang,T., Wang,R., Shen,S., Li,C., Yu,Y.,
            Pei,Z., Shen,L., Qian,J. and Ge,J.
  TITLE     Targeting deubiquitinase OTUB1 protects vascular smooth muscle
            cells in atherosclerosis by modulating PDGFRbeta
  JOURNAL   Front Med 18 (3), 465-483 (2024)
   PUBMED   38644399
  REMARK    GeneRIF: Targeting deubiquitinase OTUB1 protects vascular smooth
            muscle cells in atherosclerosis by modulating PDGFRbeta.
REFERENCE   3  (bases 1 to 5700)
  AUTHORS   Hao,L., Ya,X., Wu,J., Tao,C., Ma,R., Zheng,Z., Mou,S., Ling,Y.,
            Yang,Y., Wang,J., Zhang,Y., Lin,Q. and Zhao,J.
  TITLE     Somatic PDGFRB activating variants promote smooth muscle cell
            phenotype modulation in intracranial fusiform aneurysm
  JOURNAL   J Biomed Sci 31 (1), 51 (2024)
   PUBMED   38741091
  REMARK    GeneRIF: Somatic PDGFRB activating variants promote smooth muscle
            cell phenotype modulation in intracranial fusiform aneurysm.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5700)
  AUTHORS   Porter,T., Del Valle,M.M. and Kucheryavykh,L.
  TITLE     Ethnicity-Based Variations in Focal Adhesion Kinase Signaling in
            Glioblastoma Gene Expression: A Study of the Puerto Rican Hispanic
            Population
  JOURNAL   Int J Mol Sci 25 (9), 4947 (2024)
   PUBMED   38732165
  REMARK    GeneRIF: Ethnicity-Based Variations in Focal Adhesion Kinase
            Signaling in Glioblastoma Gene Expression: A Study of the Puerto
            Rican Hispanic Population.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5700)
  AUTHORS   Ramos,E.M., Oliveira,J., Sobrido,M.J. and Coppola,G.
  TITLE     Primary Familial Brain Calcification
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301594
REFERENCE   6  (bases 1 to 5700)
  AUTHORS   Klein,C., Lohmann,K., Marras,C. and Munchau,A.
  TITLE     Hereditary Dystonia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301334
REFERENCE   7  (bases 1 to 5700)
  AUTHORS   Goldstein,D.J., Andresson,T., Sparkowski,J.J. and Schlegel,R.
  TITLE     The BPV-1 E5 protein, the 16 kDa membrane pore-forming protein and
            the PDGF receptor exist in a complex that is dependent on
            hydrophobic transmembrane interactions
  JOURNAL   EMBO J 11 (13), 4851-4859 (1992)
   PUBMED   1334459
REFERENCE   8  (bases 1 to 5700)
  AUTHORS   Panayotou,G., Bax,B., Gout,I., Federwisch,M., Wroblowski,B.,
            Dhand,R., Fry,M.J., Blundell,T.L., Wollmer,A. and Waterfield,M.D.
  TITLE     Interaction of the p85 subunit of PI 3-kinase and its N-terminal
            SH2 domain with a PDGF receptor phosphorylation site: structural
            features and analysis of conformational changes
  JOURNAL   EMBO J 11 (12), 4261-4272 (1992)
   PUBMED   1330535
REFERENCE   9  (bases 1 to 5700)
  AUTHORS   Kashishian,A., Kazlauskas,A. and Cooper,J.A.
  TITLE     Phosphorylation sites in the PDGF receptor with different
            specificities for binding GAP and PI3 kinase in vivo
  JOURNAL   EMBO J 11 (4), 1373-1382 (1992)
   PUBMED   1314164
  REMARK    Erratum:[EMBO J 1992 Oct;11(10):3809]
REFERENCE   10 (bases 1 to 5700)
  AUTHORS   McGlade,C.J., Ellis,C., Reedijk,M., Anderson,D., Mbamalu,G.,
            Reith,A.D., Panayotou,G., End,P., Bernstein,A., Kazlauskas,A. et
            al.
  TITLE     SH2 domains of the p85 alpha subunit of phosphatidylinositol
            3-kinase regulate binding to growth factor receptors
  JOURNAL   Mol Cell Biol 12 (3), 991-997 (1992)
   PUBMED   1372092
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005895.1 and AC011382.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002609.3.
            
            Summary: The protein encoded by this gene is a cell surface
            tyrosine kinase receptor for members of the platelet-derived growth
            factor family. These growth factors are mitogens for cells of
            mesenchymal origin. The identity of the growth factor bound to a
            receptor monomer determines whether the functional receptor is a
            homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This
            gene is essential for normal development of the cardiovascular
            system and aids in rearrangement of the actin cytoskeleton. This
            gene is flanked on chromosome 5 by the genes for
            granulocyte-macrophage colony-stimulating factor and
            macrophage-colony stimulating factor receptor; all three genes may
            be implicated in the 5-q syndrome. A translocation between
            chromosomes 5 and 12, that fuses this gene to that of the ETV6
            gene, results in chronic myeloproliferative disorder with
            eosinophilia. [provided by RefSeq, Aug 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032224.1, J03278.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261799.9/ ENSP00000261799.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-449               AC005895.1         23797-24245         c
            450-495             AC005895.1         5408-5453           c
            496-819             AC005895.1         3955-4278           c
            820-1086            AC005895.1         3150-3416           c
            1087-1214           AC011382.4         86214-86341         c
            1215-1389           AC011382.4         85919-86093         c
            1390-1582           AC011382.4         85083-85275         c
            1583-1698           AC011382.4         84312-84427         c
            1699-1822           AC011382.4         82872-82995         c
            1823-2034           AC011382.4         82090-82301         c
            2035-2129           AC011382.4         78853-78947         c
            2130-2262           AC011382.4         77778-77910         c
            2263-2367           AC011382.4         77060-77164         c
            2368-2478           AC011382.4         76583-76693         c
            2479-2638           AC011382.4         75375-75534         c
            2639-2799           AC011382.4         74213-74373         c
            2800-2918           AC011382.4         73537-73655         c
            2919-3041           AC011382.4         73221-73343         c
            3042-3153           AC011382.4         72345-72456         c
            3154-3253           AC011382.4         71800-71899         c
            3254-3359           AC011382.4         71080-71185         c
            3360-3592           AC011382.4         69951-70183         c
            3593-5700           AC011382.4         66172-68279         c
FEATURES             Location/Qualifiers
     source          1..5700
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q32"
     gene            1..5700
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /note="platelet derived growth factor receptor beta"
                     /db_xref="GeneID:5159"
                     /db_xref="HGNC:HGNC:8804"
                     /db_xref="MIM:173410"
     exon            1..449
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            450..495
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     CDS             456..3776
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; PDGF-R-beta; CD140 antigen-like family member
                     B; beta-type platelet-derived growth factor receptor;
                     platelet-derived growth factor receptor, beta polypeptide;
                     Activated tyrosine kinase PDGFRB; PDGFR-beta;
                     platelet-derived growth factor receptor 1; NDEL1-PDGFRB"
                     /codon_start=1
                     /product="platelet-derived growth factor receptor beta
                     isoform 1 precursor"
                     /protein_id="NP_002600.1"
                     /db_xref="CCDS:CCDS4303.1"
                     /db_xref="GeneID:5159"
                     /db_xref="HGNC:HGNC:8804"
                     /db_xref="MIM:173410"
                     /translation="MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVL
                     NVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTH
                     NDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTL
                     HEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSV
                     NAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSIL
                     HIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSR
                     TLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAG
                     HYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSA
                     CRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRC
                     TLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRW
                     KVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSH
                     SQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITE
                     YCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGY
                     MDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVL
                     SYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSN
                     YISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFY
                     NAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQ
                     VDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKP
                     EVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQ
                     LPDSGCPAPRAEAEDSFL"
     exon            496..819
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            820..1086
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1214
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1389
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1582
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1698
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1822
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..2034
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2129
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2262
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2367
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..2478
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            2479..2638
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2799
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            2800..2918
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            2919..3041
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            3042..3153
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            3154..3253
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            3254..3359
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            3360..3592
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            3593..5700
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5675..5680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /note="hexamer: ATTAAA"
     polyA_site      5700
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /note="major polyA site"
ORIGIN      
        1 agcagccagc agtgactgcc cgccctatct gggacccagg atcgctctgt gagcaacttg
       61 gagccagaga ggagatcaac aaggaggagg agagagccgg cccctcagcc ctgctgccca
      121 gcagcagcct gtgctcgccc tgcccaacgc agacagccag acccagggcg gcccctctgg
      181 cggctctgct cctcccgaag gatgcttggg gagtgaggcg aagctgggcc gctcctctcc
      241 cctacagcag cccccttcct ccatccctct gttctcctga gccttcagga gcctgcacca
      301 gtcctgcctg tccttctact cagctgttac ccactctggg accagcagtc tttctgataa
      361 ctgggagagg gcagtaagga ggacttcctg gagggggtga ctgtccagag cctggaactg
      421 tgcccacacc agaagccatc agcagcaagg acaccatgcg gcttccgggt gcgatgccag
      481 ctctggccct caaaggcgag ctgctgttgc tgtctctcct gttacttctg gaaccacaga
      541 tctctcaggg cctggtcgtc acacccccgg ggccagagct tgtcctcaat gtctccagca
      601 ccttcgttct gacctgctcg ggttcagctc cggtggtgtg ggaacggatg tcccaggagc
      661 ccccacagga aatggccaag gcccaggatg gcaccttctc cagcgtgctc acactgacca
      721 acctcactgg gctagacacg ggagaatact tttgcaccca caatgactcc cgtggactgg
      781 agaccgatga gcggaaacgg ctctacatct ttgtgccaga tcccaccgtg ggcttcctcc
      841 ctaatgatgc cgaggaacta ttcatctttc tcacggaaat aactgagatc accattccat
      901 gccgagtaac agacccacag ctggtggtga cactgcacga gaagaaaggg gacgttgcac
      961 tgcctgtccc ctatgatcac caacgtggct tttctggtat ctttgaggac agaagctaca
     1021 tctgcaaaac caccattggg gacagggagg tggattctga tgcctactat gtctacagac
     1081 tccaggtgtc atccatcaac gtctctgtga acgcagtgca gactgtggtc cgccagggtg
     1141 agaacatcac cctcatgtgc attgtgatcg ggaatgaggt ggtcaacttc gagtggacat
     1201 acccccgcaa agaaagtggg cggctggtgg agccggtgac tgacttcctc ttggatatgc
     1261 cttaccacat ccgctccatc ctgcacatcc ccagtgccga gttagaagac tcggggacct
     1321 acacctgcaa tgtgacggag agtgtgaatg accatcagga tgaaaaggcc atcaacatca
     1381 ccgtggttga gagcggctac gtgcggctcc tgggagaggt gggcacacta caatttgctg
     1441 agctgcatcg gagccggaca ctgcaggtag tgttcgaggc ctacccaccg cccactgtcc
     1501 tgtggttcaa agacaaccgc accctgggcg actccagcgc tggcgaaatc gccctgtcca
     1561 cgcgcaacgt gtcggagacc cggtatgtgt cagagctgac actggttcgc gtgaaggtgg
     1621 cagaggctgg ccactacacc atgcgggcct tccatgagga tgctgaggtc cagctctcct
     1681 tccagctaca gatcaatgtc cctgtccgag tgctggagct aagtgagagc caccctgaca
     1741 gtggggaaca gacagtccgc tgtcgtggcc ggggcatgcc ccagccgaac atcatctggt
     1801 ctgcctgcag agacctcaaa aggtgtccac gtgagctgcc gcccacgctg ctggggaaca
     1861 gttccgaaga ggagagccag ctggagacta acgtgacgta ctgggaggag gagcaggagt
     1921 ttgaggtggt gagcacactg cgtctgcagc acgtggatcg gccactgtcg gtgcgctgca
     1981 cgctgcgcaa cgctgtgggc caggacacgc aggaggtcat cgtggtgcca cactccttgc
     2041 cctttaaggt ggtggtgatc tcagccatcc tggccctggt ggtgctcacc atcatctccc
     2101 ttatcatcct catcatgctt tggcagaaga agccacgtta cgagatccga tggaaggtga
     2161 ttgagtctgt gagctctgac ggccatgagt acatctacgt ggaccccatg cagctgccct
     2221 atgactccac gtgggagctg ccgcgggacc agcttgtgct gggacgcacc ctcggctctg
     2281 gggcctttgg gcaggtggtg gaggccacgg ctcatggcct gagccattct caggccacga
     2341 tgaaagtggc cgtcaagatg cttaaatcca cagcccgcag cagtgagaag caagccctta
     2401 tgtcggagct gaagatcatg agtcaccttg ggccccacct gaacgtggtc aacctgttgg
     2461 gggcctgcac caaaggagga cccatctata tcatcactga gtactgccgc tacggagacc
     2521 tggtggacta cctgcaccgc aacaaacaca ccttcctgca gcaccactcc gacaagcgcc
     2581 gcccgcccag cgcggagctc tacagcaatg ctctgcccgt tgggctcccc ctgcccagcc
     2641 atgtgtcctt gaccggggag agcgacggtg gctacatgga catgagcaag gacgagtcgg
     2701 tggactatgt gcccatgctg gacatgaaag gagacgtcaa atatgcagac atcgagtcct
     2761 ccaactacat ggccccttac gataactacg ttccctctgc ccctgagagg acctgccgag
     2821 caactttgat caacgagtct ccagtgctaa gctacatgga cctcgtgggc ttcagctacc
     2881 aggtggccaa tggcatggag tttctggcct ccaagaactg cgtccacaga gacctggcgg
     2941 ctaggaacgt gctcatctgt gaaggcaagc tggtcaagat ctgtgacttt ggcctggctc
     3001 gagacatcat gcgggactcg aattacatct ccaaaggcag cacctttttg cctttaaagt
     3061 ggatggctcc ggagagcatc ttcaacagcc tctacaccac cctgagcgac gtgtggtcct
     3121 tcgggatcct gctctgggag atcttcacct tgggtggcac cccttaccca gagctgccca
     3181 tgaacgagca gttctacaat gccatcaaac ggggttaccg catggcccag cctgcccatg
     3241 cctccgacga gatctatgag atcatgcaga agtgctggga agagaagttt gagattcggc
     3301 cccccttctc ccagctggtg ctgcttctcg agagactgtt gggcgaaggt tacaaaaaga
     3361 agtaccagca ggtggatgag gagtttctga ggagtgacca cccagccatc cttcggtccc
     3421 aggcccgctt gcctgggttc catggcctcc gatctcccct ggacaccagc tccgtcctct
     3481 atactgccgt gcagcccaat gagggtgaca acgactatat catccccctg cctgacccca
     3541 aacccgaggt tgctgacgag ggcccactgg agggttcccc cagcctagcc agctccaccc
     3601 tgaatgaagt caacacctcc tcaaccatct cctgtgacag ccccctggag ccccaggacg
     3661 aaccagagcc agagccccag cttgagctcc aggtggagcc ggagccagag ctggaacagt
     3721 tgccggattc ggggtgccct gcgcctcggg cggaagcaga ggatagcttc ctgtaggggg
     3781 ctggccccta ccctgccctg cctgaagctc cccccctgcc agcacccagc atctcctggc
     3841 ctggcctgac cgggcttcct gtcagccagg ctgcccttat cagctgtccc cttctggaag
     3901 ctttctgctc ctgacgtgtt gtgccccaaa ccctggggct ggcttaggag gcaagaaaac
     3961 tgcaggggcc gtgaccagcc ctctgcctcc agggaggcca actgactctg agccagggtt
     4021 cccccaggga actcagtttt cccatatgta aaatgggaaa gttaggcttg atgacccaga
     4081 atctaggatt ctctccctgg ctgacaggtg gggagaccga atccctccct gggaagattc
     4141 ttggagttac tgaggtggta aattaacttt tttctgttca gccagctacc cctcaaggaa
     4201 tcatagctct ctcctcgcac ttttatccac ccaggagcta gggaagagac cctagcctcc
     4261 ctggctgctg gctgagctag ggcctagcct tgagcagtgt tgcctcatcc agaagaaagc
     4321 cagtctcctc cctatgatgc cagtccctgc gttccctggc ccgagctggt ctggggccat
     4381 taggcagcct aattaatgct ggaggctgag ccaagtacag gacaccccca gcctgcagcc
     4441 cttgcccagg gcacttggag cacacgcagc catagcaagt gcctgtgtcc ctgtccttca
     4501 ggcccatcag tcctggggct ttttctttat caccctcagt cttaatccat ccaccagagt
     4561 ctagaaggcc agacgggccc cgcatctgtg atgagaatgt aaatgtgcca gtgtggagtg
     4621 gccacgtgtg tgtgccagta tatggccctg gctctgcatt ggacctgcta tgaggctttg
     4681 gaggaatccc tcaccctctc tgggcctcag tttccccttc aaaaaatgaa taagtcggac
     4741 ttattaactc tgagtgcctt gccagcacta acattctaga gtattccagg tggttgcaca
     4801 tttgtccaga tgaagcaagg ccatataccc taaacttcca tcctgggggt cagctgggct
     4861 cctgggagat tccagatcac acatcacact ctggggactc aggaaccatg ccccttcccc
     4921 aggcccccag caagtctcaa gaacacagct gcacaggcct tgacttagag tgacagccgg
     4981 tgtcctggaa agcccccagc agctgcccca gggacatggg aagaccacgg gacctctttc
     5041 actacccacg atgacctccg ggggtatcct gggcaaaagg gacaaagagg gcaaatgaga
     5101 tcacctcctg cagcccacca ctccagcacc tgtgccgagg tctgcgtcga agacagaatg
     5161 gacagtgagg acagttatgt cttgtaaaag acaagaagct tcagatgggt accccaagaa
     5221 ggatgtgaga ggtgggcgct ttggaggttt gcccctcacc caccagctgc cccatccctg
     5281 aggcagcgct ccatgggggt atggttttgt cactgcccag acctagcagt gacatctcat
     5341 tgtccccagc ccagtgggca ttggaggtgc caggggagtc agggttgtag ccaagacgcc
     5401 cccgcacggg gagggttggg aagggggtgc aggaagctca acccctctgg gcaccaaccc
     5461 tgcattgcag gttggcacct tacttccctg ggatccccag agttggtcca aggagggaga
     5521 gtgggttctc aatacggtac caaagatata atcacctagg tttacaaata tttttaggac
     5581 tcacgttaac tcacatttat acagcagaaa tgctattttg tatgctgttg agtttttcta
     5641 tctgtgtact tttttttaag ggaaagattt taatattaaa cctggtgctt ctcactcaca
//
