LOCUS       NM_001355016            5654 bp    mRNA    linear   PRI 05-FEB-2025
DEFINITION  Homo sapiens platelet derived growth factor receptor beta (PDGFRB),
            transcript variant 2, mRNA.
ACCESSION   NM_001355016 XM_005268464
VERSION     NM_001355016.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5654)
  AUTHORS   Ma,Q., He,X., Wang,X., Zhao,G., Zhang,Y., Su,C., Wei,M., Zhang,K.,
            Liu,M., Zhu,Y. and He,J.
  TITLE     PTPN14 aggravates neointimal hyperplasia via boosting PDGFRbeta
            signaling in smooth muscle cells
  JOURNAL   Nat Commun 15 (1), 7398 (2024)
   PUBMED   39191789
  REMARK    GeneRIF: PTPN14 aggravates neointimal hyperplasia via boosting
            PDGFRbeta signaling in smooth muscle cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5654)
  AUTHORS   Xu,F., Chen,H., Zhou,C., Zang,T., Wang,R., Shen,S., Li,C., Yu,Y.,
            Pei,Z., Shen,L., Qian,J. and Ge,J.
  TITLE     Targeting deubiquitinase OTUB1 protects vascular smooth muscle
            cells in atherosclerosis by modulating PDGFRbeta
  JOURNAL   Front Med 18 (3), 465-483 (2024)
   PUBMED   38644399
  REMARK    GeneRIF: Targeting deubiquitinase OTUB1 protects vascular smooth
            muscle cells in atherosclerosis by modulating PDGFRbeta.
REFERENCE   3  (bases 1 to 5654)
  AUTHORS   Hao,L., Ya,X., Wu,J., Tao,C., Ma,R., Zheng,Z., Mou,S., Ling,Y.,
            Yang,Y., Wang,J., Zhang,Y., Lin,Q. and Zhao,J.
  TITLE     Somatic PDGFRB activating variants promote smooth muscle cell
            phenotype modulation in intracranial fusiform aneurysm
  JOURNAL   J Biomed Sci 31 (1), 51 (2024)
   PUBMED   38741091
  REMARK    GeneRIF: Somatic PDGFRB activating variants promote smooth muscle
            cell phenotype modulation in intracranial fusiform aneurysm.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5654)
  AUTHORS   Porter,T., Del Valle,M.M. and Kucheryavykh,L.
  TITLE     Ethnicity-Based Variations in Focal Adhesion Kinase Signaling in
            Glioblastoma Gene Expression: A Study of the Puerto Rican Hispanic
            Population
  JOURNAL   Int J Mol Sci 25 (9), 4947 (2024)
   PUBMED   38732165
  REMARK    GeneRIF: Ethnicity-Based Variations in Focal Adhesion Kinase
            Signaling in Glioblastoma Gene Expression: A Study of the Puerto
            Rican Hispanic Population.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5654)
  AUTHORS   Ramos,E.M., Oliveira,J., Sobrido,M.J. and Coppola,G.
  TITLE     Primary Familial Brain Calcification
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301594
REFERENCE   6  (bases 1 to 5654)
  AUTHORS   Klein,C., Lohmann,K., Marras,C. and Munchau,A.
  TITLE     Hereditary Dystonia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301334
REFERENCE   7  (bases 1 to 5654)
  AUTHORS   Goldstein,D.J., Andresson,T., Sparkowski,J.J. and Schlegel,R.
  TITLE     The BPV-1 E5 protein, the 16 kDa membrane pore-forming protein and
            the PDGF receptor exist in a complex that is dependent on
            hydrophobic transmembrane interactions
  JOURNAL   EMBO J 11 (13), 4851-4859 (1992)
   PUBMED   1334459
REFERENCE   8  (bases 1 to 5654)
  AUTHORS   Panayotou,G., Bax,B., Gout,I., Federwisch,M., Wroblowski,B.,
            Dhand,R., Fry,M.J., Blundell,T.L., Wollmer,A. and Waterfield,M.D.
  TITLE     Interaction of the p85 subunit of PI 3-kinase and its N-terminal
            SH2 domain with a PDGF receptor phosphorylation site: structural
            features and analysis of conformational changes
  JOURNAL   EMBO J 11 (12), 4261-4272 (1992)
   PUBMED   1330535
REFERENCE   9  (bases 1 to 5654)
  AUTHORS   Kashishian,A., Kazlauskas,A. and Cooper,J.A.
  TITLE     Phosphorylation sites in the PDGF receptor with different
            specificities for binding GAP and PI3 kinase in vivo
  JOURNAL   EMBO J 11 (4), 1373-1382 (1992)
   PUBMED   1314164
  REMARK    Erratum:[EMBO J 1992 Oct;11(10):3809]
REFERENCE   10 (bases 1 to 5654)
  AUTHORS   McGlade,C.J., Ellis,C., Reedijk,M., Anderson,D., Mbamalu,G.,
            Reith,A.D., Panayotou,G., End,P., Bernstein,A., Kazlauskas,A. et
            al.
  TITLE     SH2 domains of the p85 alpha subunit of phosphatidylinositol
            3-kinase regulate binding to growth factor receptors
  JOURNAL   Mol Cell Biol 12 (3), 991-997 (1992)
   PUBMED   1372092
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005895.1 and AC011382.4.
            
            On May 31, 2019 this sequence version replaced NM_001355016.1.
            
            Summary: The protein encoded by this gene is a cell surface
            tyrosine kinase receptor for members of the platelet-derived growth
            factor family. These growth factors are mitogens for cells of
            mesenchymal origin. The identity of the growth factor bound to a
            receptor monomer determines whether the functional receptor is a
            homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This
            gene is essential for normal development of the cardiovascular
            system and aids in rearrangement of the actin cytoskeleton. This
            gene is flanked on chromosome 5 by the genes for
            granulocyte-macrophage colony-stimulating factor and
            macrophage-colony stimulating factor receptor; all three genes may
            be implicated in the 5-q syndrome. A translocation between
            chromosomes 5 and 12, that fuses this gene to that of the ETV6
            gene, results in chronic myeloproliferative disorder with
            eosinophilia. [provided by RefSeq, Aug 2017].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (2) is
            shorter at the N-terminus compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.468396.1,
                                           SRR1660805.85575.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-449               AC005895.1         23797-24245         c
            450-773             AC005895.1         3955-4278           c
            774-1040            AC005895.1         3150-3416           c
            1041-1168           AC011382.4         86214-86341         c
            1169-1343           AC011382.4         85919-86093         c
            1344-1536           AC011382.4         85083-85275         c
            1537-1652           AC011382.4         84312-84427         c
            1653-1776           AC011382.4         82872-82995         c
            1777-1988           AC011382.4         82090-82301         c
            1989-2083           AC011382.4         78853-78947         c
            2084-2216           AC011382.4         77778-77910         c
            2217-2321           AC011382.4         77060-77164         c
            2322-2432           AC011382.4         76583-76693         c
            2433-2592           AC011382.4         75375-75534         c
            2593-2753           AC011382.4         74213-74373         c
            2754-2872           AC011382.4         73537-73655         c
            2873-2995           AC011382.4         73221-73343         c
            2996-3107           AC011382.4         72345-72456         c
            3108-3207           AC011382.4         71800-71899         c
            3208-3313           AC011382.4         71080-71185         c
            3314-3546           AC011382.4         69951-70183         c
            3547-5654           AC011382.4         66172-68279         c
FEATURES             Location/Qualifiers
     source          1..5654
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q32"
     gene            1..5654
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /note="platelet derived growth factor receptor beta"
                     /db_xref="GeneID:5159"
                     /db_xref="HGNC:HGNC:8804"
                     /db_xref="MIM:173410"
     exon            1..449
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            450..773
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     CDS             602..3730
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /EC_number="2.7.10.1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     PDGF-R-beta; CD140 antigen-like family member B; beta-type
                     platelet-derived growth factor receptor; platelet-derived
                     growth factor receptor, beta polypeptide; Activated
                     tyrosine kinase PDGFRB; PDGFR-beta; platelet-derived
                     growth factor receptor 1; NDEL1-PDGFRB"
                     /codon_start=1
                     /product="platelet-derived growth factor receptor beta
                     isoform 2"
                     /protein_id="NP_001341945.1"
                     /db_xref="GeneID:5159"
                     /db_xref="HGNC:HGNC:8804"
                     /db_xref="MIM:173410"
                     /translation="MSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGL
                     ETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGD
                     VALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTV
                     VRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAE
                     LEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVF
                     EAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRA
                     FHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKR
                     CPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAV
                     GQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESV
                     SSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMK
                     VAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGD
                     LVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKD
                     ESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLV
                     GFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGS
                     TFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRG
                     YRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFL
                     RSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEG
                     PLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGC
                     PAPRAEAEDSFL"
     exon            774..1040
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1168
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1343
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1536
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1652
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1776
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1988
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2083
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2216
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2321
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2432
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2592
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..2753
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            2754..2872
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            2873..2995
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            2996..3107
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            3108..3207
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            3208..3313
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            3314..3546
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     exon            3547..5654
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5629..5634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /note="hexamer: ATTAAA"
     polyA_site      5654
                     /gene="PDGFRB"
                     /gene_synonym="CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD;
                     PDGFR; PDGFR-1; PDGFR1; PENTT"
                     /note="major polyA site"
ORIGIN      
        1 agcagccagc agtgactgcc cgccctatct gggacccagg atcgctctgt gagcaacttg
       61 gagccagaga ggagatcaac aaggaggagg agagagccgg cccctcagcc ctgctgccca
      121 gcagcagcct gtgctcgccc tgcccaacgc agacagccag acccagggcg gcccctctgg
      181 cggctctgct cctcccgaag gatgcttggg gagtgaggcg aagctgggcc gctcctctcc
      241 cctacagcag cccccttcct ccatccctct gttctcctga gccttcagga gcctgcacca
      301 gtcctgcctg tccttctact cagctgttac ccactctggg accagcagtc tttctgataa
      361 ctgggagagg gcagtaagga ggacttcctg gagggggtga ctgtccagag cctggaactg
      421 tgcccacacc agaagccatc agcagcaagg cgagctgctg ttgctgtctc tcctgttact
      481 tctggaacca cagatctctc agggcctggt cgtcacaccc ccggggccag agcttgtcct
      541 caatgtctcc agcaccttcg ttctgacctg ctcgggttca gctccggtgg tgtgggaacg
      601 gatgtcccag gagcccccac aggaaatggc caaggcccag gatggcacct tctccagcgt
      661 gctcacactg accaacctca ctgggctaga cacgggagaa tacttttgca cccacaatga
      721 ctcccgtgga ctggagaccg atgagcggaa acggctctac atctttgtgc cagatcccac
      781 cgtgggcttc ctccctaatg atgccgagga actattcatc tttctcacgg aaataactga
      841 gatcaccatt ccatgccgag taacagaccc acagctggtg gtgacactgc acgagaagaa
      901 aggggacgtt gcactgcctg tcccctatga tcaccaacgt ggcttttctg gtatctttga
      961 ggacagaagc tacatctgca aaaccaccat tggggacagg gaggtggatt ctgatgccta
     1021 ctatgtctac agactccagg tgtcatccat caacgtctct gtgaacgcag tgcagactgt
     1081 ggtccgccag ggtgagaaca tcaccctcat gtgcattgtg atcgggaatg aggtggtcaa
     1141 cttcgagtgg acataccccc gcaaagaaag tgggcggctg gtggagccgg tgactgactt
     1201 cctcttggat atgccttacc acatccgctc catcctgcac atccccagtg ccgagttaga
     1261 agactcgggg acctacacct gcaatgtgac ggagagtgtg aatgaccatc aggatgaaaa
     1321 ggccatcaac atcaccgtgg ttgagagcgg ctacgtgcgg ctcctgggag aggtgggcac
     1381 actacaattt gctgagctgc atcggagccg gacactgcag gtagtgttcg aggcctaccc
     1441 accgcccact gtcctgtggt tcaaagacaa ccgcaccctg ggcgactcca gcgctggcga
     1501 aatcgccctg tccacgcgca acgtgtcgga gacccggtat gtgtcagagc tgacactggt
     1561 tcgcgtgaag gtggcagagg ctggccacta caccatgcgg gccttccatg aggatgctga
     1621 ggtccagctc tccttccagc tacagatcaa tgtccctgtc cgagtgctgg agctaagtga
     1681 gagccaccct gacagtgggg aacagacagt ccgctgtcgt ggccggggca tgccccagcc
     1741 gaacatcatc tggtctgcct gcagagacct caaaaggtgt ccacgtgagc tgccgcccac
     1801 gctgctgggg aacagttccg aagaggagag ccagctggag actaacgtga cgtactggga
     1861 ggaggagcag gagtttgagg tggtgagcac actgcgtctg cagcacgtgg atcggccact
     1921 gtcggtgcgc tgcacgctgc gcaacgctgt gggccaggac acgcaggagg tcatcgtggt
     1981 gccacactcc ttgcccttta aggtggtggt gatctcagcc atcctggccc tggtggtgct
     2041 caccatcatc tcccttatca tcctcatcat gctttggcag aagaagccac gttacgagat
     2101 ccgatggaag gtgattgagt ctgtgagctc tgacggccat gagtacatct acgtggaccc
     2161 catgcagctg ccctatgact ccacgtggga gctgccgcgg gaccagcttg tgctgggacg
     2221 caccctcggc tctggggcct ttgggcaggt ggtggaggcc acggctcatg gcctgagcca
     2281 ttctcaggcc acgatgaaag tggccgtcaa gatgcttaaa tccacagccc gcagcagtga
     2341 gaagcaagcc cttatgtcgg agctgaagat catgagtcac cttgggcccc acctgaacgt
     2401 ggtcaacctg ttgggggcct gcaccaaagg aggacccatc tatatcatca ctgagtactg
     2461 ccgctacgga gacctggtgg actacctgca ccgcaacaaa cacaccttcc tgcagcacca
     2521 ctccgacaag cgccgcccgc ccagcgcgga gctctacagc aatgctctgc ccgttgggct
     2581 ccccctgccc agccatgtgt ccttgaccgg ggagagcgac ggtggctaca tggacatgag
     2641 caaggacgag tcggtggact atgtgcccat gctggacatg aaaggagacg tcaaatatgc
     2701 agacatcgag tcctccaact acatggcccc ttacgataac tacgttccct ctgcccctga
     2761 gaggacctgc cgagcaactt tgatcaacga gtctccagtg ctaagctaca tggacctcgt
     2821 gggcttcagc taccaggtgg ccaatggcat ggagtttctg gcctccaaga actgcgtcca
     2881 cagagacctg gcggctagga acgtgctcat ctgtgaaggc aagctggtca agatctgtga
     2941 ctttggcctg gctcgagaca tcatgcggga ctcgaattac atctccaaag gcagcacctt
     3001 tttgccttta aagtggatgg ctccggagag catcttcaac agcctctaca ccaccctgag
     3061 cgacgtgtgg tccttcggga tcctgctctg ggagatcttc accttgggtg gcacccctta
     3121 cccagagctg cccatgaacg agcagttcta caatgccatc aaacggggtt accgcatggc
     3181 ccagcctgcc catgcctccg acgagatcta tgagatcatg cagaagtgct gggaagagaa
     3241 gtttgagatt cggcccccct tctcccagct ggtgctgctt ctcgagagac tgttgggcga
     3301 aggttacaaa aagaagtacc agcaggtgga tgaggagttt ctgaggagtg accacccagc
     3361 catccttcgg tcccaggccc gcttgcctgg gttccatggc ctccgatctc ccctggacac
     3421 cagctccgtc ctctatactg ccgtgcagcc caatgagggt gacaacgact atatcatccc
     3481 cctgcctgac cccaaacccg aggttgctga cgagggccca ctggagggtt cccccagcct
     3541 agccagctcc accctgaatg aagtcaacac ctcctcaacc atctcctgtg acagccccct
     3601 ggagccccag gacgaaccag agccagagcc ccagcttgag ctccaggtgg agccggagcc
     3661 agagctggaa cagttgccgg attcggggtg ccctgcgcct cgggcggaag cagaggatag
     3721 cttcctgtag ggggctggcc cctaccctgc cctgcctgaa gctccccccc tgccagcacc
     3781 cagcatctcc tggcctggcc tgaccgggct tcctgtcagc caggctgccc ttatcagctg
     3841 tccccttctg gaagctttct gctcctgacg tgttgtgccc caaaccctgg ggctggctta
     3901 ggaggcaaga aaactgcagg ggccgtgacc agccctctgc ctccagggag gccaactgac
     3961 tctgagccag ggttccccca gggaactcag ttttcccata tgtaaaatgg gaaagttagg
     4021 cttgatgacc cagaatctag gattctctcc ctggctgaca ggtggggaga ccgaatccct
     4081 ccctgggaag attcttggag ttactgaggt ggtaaattaa cttttttctg ttcagccagc
     4141 tacccctcaa ggaatcatag ctctctcctc gcacttttat ccacccagga gctagggaag
     4201 agaccctagc ctccctggct gctggctgag ctagggccta gccttgagca gtgttgcctc
     4261 atccagaaga aagccagtct cctccctatg atgccagtcc ctgcgttccc tggcccgagc
     4321 tggtctgggg ccattaggca gcctaattaa tgctggaggc tgagccaagt acaggacacc
     4381 cccagcctgc agcccttgcc cagggcactt ggagcacacg cagccatagc aagtgcctgt
     4441 gtccctgtcc ttcaggccca tcagtcctgg ggctttttct ttatcaccct cagtcttaat
     4501 ccatccacca gagtctagaa ggccagacgg gccccgcatc tgtgatgaga atgtaaatgt
     4561 gccagtgtgg agtggccacg tgtgtgtgcc agtatatggc cctggctctg cattggacct
     4621 gctatgaggc tttggaggaa tccctcaccc tctctgggcc tcagtttccc cttcaaaaaa
     4681 tgaataagtc ggacttatta actctgagtg ccttgccagc actaacattc tagagtattc
     4741 caggtggttg cacatttgtc cagatgaagc aaggccatat accctaaact tccatcctgg
     4801 gggtcagctg ggctcctggg agattccaga tcacacatca cactctgggg actcaggaac
     4861 catgcccctt ccccaggccc ccagcaagtc tcaagaacac agctgcacag gccttgactt
     4921 agagtgacag ccggtgtcct ggaaagcccc cagcagctgc cccagggaca tgggaagacc
     4981 acgggacctc tttcactacc cacgatgacc tccgggggta tcctgggcaa aagggacaaa
     5041 gagggcaaat gagatcacct cctgcagccc accactccag cacctgtgcc gaggtctgcg
     5101 tcgaagacag aatggacagt gaggacagtt atgtcttgta aaagacaaga agcttcagat
     5161 gggtacccca agaaggatgt gagaggtggg cgctttggag gtttgcccct cacccaccag
     5221 ctgccccatc cctgaggcag cgctccatgg gggtatggtt ttgtcactgc ccagacctag
     5281 cagtgacatc tcattgtccc cagcccagtg ggcattggag gtgccagggg agtcagggtt
     5341 gtagccaaga cgcccccgca cggggagggt tgggaagggg gtgcaggaag ctcaacccct
     5401 ctgggcacca accctgcatt gcaggttggc accttacttc cctgggatcc ccagagttgg
     5461 tccaaggagg gagagtgggt tctcaatacg gtaccaaaga tataatcacc taggtttaca
     5521 aatattttta ggactcacgt taactcacat ttatacagca gaaatgctat tttgtatgct
     5581 gttgagtttt tctatctgtg tacttttttt taagggaaag attttaatat taaacctggt
     5641 gcttctcact caca
//
