LOCUS       NM_006206               6378 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens platelet derived growth factor receptor alpha
            (PDGFRA), transcript variant 1, mRNA.
ACCESSION   NM_006206
VERSION     NM_006206.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6378)
  AUTHORS   Jarosz,A., Balcerzyk-Matic,A., Iwanicka,J., Iwanicki,T., Nowak,T.,
            Szyluk,K., Kalita,M., Gorczynska-Kosiorz,S., Kania,W. and
            Niemiec,P.
  TITLE     Association between Platelet-Derived Growth Factor Receptor Alpha
            Gene Polymorphisms and Platelet-Rich Plasma's Efficiency in
            Treating Lateral Elbow Tendinopathy-A Prospective Cohort Study
  JOURNAL   Int J Mol Sci 25 (8), 4266 (2024)
   PUBMED   38673853
  REMARK    GeneRIF: Association between Platelet-Derived Growth Factor
            Receptor Alpha Gene Polymorphisms and Platelet-Rich Plasma's
            Efficiency in Treating Lateral Elbow Tendinopathy-A Prospective
            Cohort Study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6378)
  AUTHORS   Kibe,Y., Ohka,F., Aoki,K., Yamaguchi,J., Motomura,K., Ito,E.,
            Takeuchi,K., Nagata,Y., Ito,S., Mizutani,N., Shiba,Y., Maeda,S.,
            Nishikawa,T., Shimizu,H. and Saito,R.
  TITLE     Pediatric-type high-grade gliomas with PDGFRA amplification in
            adult patients with Li-Fraumeni syndrome: clinical and molecular
            characterization of three cases
  JOURNAL   Acta Neuropathol Commun 12 (1), 57 (2024)
   PUBMED   38605367
  REMARK    GeneRIF: Pediatric-type high-grade gliomas with PDGFRA
            amplification in adult patients with Li-Fraumeni syndrome: clinical
            and molecular characterization of three cases.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6378)
  AUTHORS   Zheng,H., An,M., Luo,Y., Diao,X., Zhong,W., Pang,M., Lin,Y.,
            Chen,J., Li,Y., Kong,Y., Zhao,Y., Yin,Y., Ai,L., Huang,J., Chen,C.
            and Lin,T.
  TITLE     PDGFRalpha+ITGA11+ fibroblasts foster early-stage cancer
            lymphovascular invasion and lymphatic metastasis via ITGA11-SELE
            interplay
  JOURNAL   Cancer Cell 42 (4), 682-700 (2024)
   PUBMED   38428409
  REMARK    GeneRIF: PDGFRalpha[+]ITGA11[+] fibroblasts foster early-stage
            cancer lymphovascular invasion and lymphatic metastasis via
            ITGA11-SELE interplay.
REFERENCE   4  (bases 1 to 6378)
  AUTHORS   Nishida,T., Naito,Y., Takahashi,T., Saito,T., Hisamori,S.,
            Manaka,D., Ogawa,K., Hirota,S. and Ichikawa,H.
  TITLE     Molecular and clinicopathological features of KIT/PDGFRA wild-type
            gastrointestinal stromal tumors
  JOURNAL   Cancer Sci 115 (3), 894-904 (2024)
   PUBMED   38178783
  REMARK    GeneRIF: Molecular and clinicopathological features of KIT/PDGFRA
            wild-type gastrointestinal stromal tumors.
REFERENCE   5  (bases 1 to 6378)
  AUTHORS   Hou,Y., Du,W., Wu,Q., Chai,X., Wang,Y., Mi,Y., Tian,Y., Tang,M.,
            Li,J. and Yan,D.
  TITLE     PDGFRA exhibits potential as an indicator of angiogenesis within
            the tumor microenvironment and is up-regulated in BLCA
  JOURNAL   Microvasc Res 151, 104614 (2024)
   PUBMED   37802365
  REMARK    GeneRIF: PDGFRA exhibits potential as an indicator of angiogenesis
            within the tumor microenvironment and is up-regulated in BLCA.
REFERENCE   6  (bases 1 to 6378)
  AUTHORS   Demoulin,J.B. and Essaghir,A.
  TITLE     PDGF receptor signaling networks in normal and cancer cells
  JOURNAL   Cytokine Growth Factor Rev 25 (3), 273-283 (2014)
   PUBMED   24703957
  REMARK    Review article
REFERENCE   7  (bases 1 to 6378)
  AUTHORS   Yu,J.C., Heidaran,M.A., Pierce,J.H., Gutkind,J.S., Lombardi,D.,
            Ruggiero,M. and Aaronson,S.A.
  TITLE     Tyrosine mutations within the alpha platelet-derived growth factor
            receptor kinase insert domain abrogate receptor-associated
            phosphatidylinositol-3 kinase activity without affecting mitogenic
            or chemotactic signal transduction
  JOURNAL   Mol Cell Biol 11 (7), 3780-3785 (1991)
   PUBMED   1646396
REFERENCE   8  (bases 1 to 6378)
  AUTHORS   Kanakaraj,P., Raj,S., Khan,S.A. and Bishayee,S.
  TITLE     Ligand-induced interaction between alpha- and beta-type
            platelet-derived growth factor (PDGF) receptors: role of receptor
            heterodimers in kinase activation
  JOURNAL   Biochemistry 30 (7), 1761-1767 (1991)
   PUBMED   1847074
REFERENCE   9  (bases 1 to 6378)
  AUTHORS   Hsieh,C.L., Navankasattusas,S., Escobedo,J.A., Williams,L.T. and
            Francke,U.
  TITLE     Chromosomal localization of the gene for AA-type platelet-derived
            growth factor receptor (PDGFRA) in humans and mice
  JOURNAL   Cytogenet Cell Genet 56 (3-4), 160-163 (1991)
   PUBMED   1711435
REFERENCE   10 (bases 1 to 6378)
  AUTHORS   Hart,C.E. and Bowen-Pope,D.F.
  TITLE     Platelet-derived growth factor receptor: current views of the
            two-subunit model
  JOURNAL   J Invest Dermatol 94 (6 Suppl), 53S-57S (1990)
   PUBMED   2161888
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA678599.1, M21574.1,
            AC098587.5 and FN174599.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006206.5.
            
            Summary: This gene encodes a cell surface tyrosine kinase receptor
            for members of the platelet-derived growth factor family. These
            growth factors are mitogens for cells of mesenchymal origin. The
            identity of the growth factor bound to a receptor monomer
            determines whether the functional receptor is a homodimer or a
            heterodimer, composed of both platelet-derived growth factor
            receptor alpha and beta polypeptides. Studies suggest that this
            gene plays a role in organ development, wound healing, and tumor
            progression. Mutations in this gene have been associated with
            idiopathic hypereosinophilic syndrome, somatic and familial
            gastrointestinal stromal tumors, and a variety of other cancers.
            [provided by RefSeq, Mar 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK316578.1, M21574.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257290.10/ ENSP00000257290.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                DA678599.1         197-253
            58-1835             M21574.1           62-1839
            1836-1836           AC098587.5         13721-13721
            1837-3356           M21574.1           1841-3360
            3357-6372           AC098587.5         34057-37072
            6373-6378           FN174599.1         9-14                c
FEATURES             Location/Qualifiers
     source          1..6378
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q12"
     gene            1..6378
                     /gene="PDGFRA"
                     /gene_synonym="CD140A; PDGFR-2; PDGFR2"
                     /note="platelet derived growth factor receptor alpha"
                     /db_xref="GeneID:5156"
                     /db_xref="HGNC:HGNC:8803"
                     /db_xref="MIM:173490"
     exon            1..123
                     /gene="PDGFRA"
                     /gene_synonym="CD140A; PDGFR-2; PDGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            124..184
                     /gene="PDGFRA"
                     /gene_synonym="CD140A; PDGFR-2; PDGFR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..3405
                     /gene="PDGFRA"
                     /gene_synonym="CD140A; PDGFR-2; PDGFR2"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; PDGF-R-alpha; CD140 antigen-like family member
                     A; platelet-derived growth factor receptor, alpha
                     polypeptide; alpha-type platelet-derived growth factor
                     receptor; CD140a antigen; platelet-derived growth factor
                     receptor 2"
                     /codon_start=1
                     /product="platelet-derived growth factor receptor alpha
                     isoform 1 precursor"
                     /protein_id="NP_006197.1"
                     /db_xref="CCDS:CCDS3495.1"
                     /db_xref="GeneID:5156"
                     /db_xref="HGNC:HGNC:8803"
                     /db_xref="MIM:173490"
                     /translation="MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSS
                     FSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYY
                     NHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVT
                     LHNSEGVVPASYDSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEM
                     EALKTVYKSGETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLT
                     VPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKH
                     FVVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHY
                     TIVAQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMIC
                     KDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLG
                     AENRELKLVAPTLRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESIS
                     PDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKV
                     AVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDL
                     VNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTT
                     QYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSF
                     TYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTF
                     LPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYR
                     MAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKS
                     DHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPE
                     EEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDSSDLVEDSF
                     L"
     exon            185..502
                     /gene="PDGFRA"
                     /gene_synonym="CD140A; PDGFR-2; PDGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            503..763
                     /gene="PDGFRA"
                     /gene_synonym="CD140A; PDGFR-2; PDGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            764..894
                     /gene="PDGFRA"
                     /gene_synonym="CD140A; PDGFR-2; PDGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1066
                     /gene="PDGFRA"
                     /gene_synonym="CD140A; PDGFR-2; PDGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1256
                     /gene="PDGFRA"
                     /gene_synonym="CD140A; PDGFR-2; PDGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1372
                     /gene="PDGFRA"
                     /gene_synonym="CD140A; PDGFR-2; PDGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1499
                     /gene="PDGFRA"
                     /gene_synonym="CD140A; PDGFR-2; PDGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1693
                     /gene="PDGFRA"
                     /gene_synonym="CD140A; PDGFR-2; PDGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1788
                     /gene="PDGFRA"
                     /gene_synonym="CD140A; PDGFR-2; PDGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1921
                     /gene="PDGFRA"
                     /gene_synonym="CD140A; PDGFR-2; PDGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2026
                     /gene="PDGFRA"
                     /gene_synonym="CD140A; PDGFR-2; PDGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2137
                     /gene="PDGFRA"
                     /gene_synonym="CD140A; PDGFR-2; PDGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2291
                     /gene="PDGFRA"
                     /gene_synonym="CD140A; PDGFR-2; PDGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2458
                     /gene="PDGFRA"
                     /gene_synonym="CD140A; PDGFR-2; PDGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2574
                     /gene="PDGFRA"
                     /gene_synonym="CD140A; PDGFR-2; PDGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2697
                     /gene="PDGFRA"
                     /gene_synonym="CD140A; PDGFR-2; PDGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2698..2809
                     /gene="PDGFRA"
                     /gene_synonym="CD140A; PDGFR-2; PDGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2810..2909
                     /gene="PDGFRA"
                     /gene_synonym="CD140A; PDGFR-2; PDGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2910..3015
                     /gene="PDGFRA"
                     /gene_synonym="CD140A; PDGFR-2; PDGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            3016..3257
                     /gene="PDGFRA"
                     /gene_synonym="CD140A; PDGFR-2; PDGFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            3258..6378
                     /gene="PDGFRA"
                     /gene_synonym="CD140A; PDGFR-2; PDGFR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6204..6209
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDGFRA"
                     /gene_synonym="CD140A; PDGFR-2; PDGFR2"
                     /note="hexamer: AAGAAA"
     polyA_site      6230
                     /gene="PDGFRA"
                     /gene_synonym="CD140A; PDGFR-2; PDGFR2"
     regulatory      6353..6358
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDGFRA"
                     /gene_synonym="CD140A; PDGFR-2; PDGFR2"
                     /note="hexamer: AATAAA"
     polyA_site      6378
                     /gene="PDGFRA"
                     /gene_synonym="CD140A; PDGFR-2; PDGFR2"
                     /note="major polyA site"
ORIGIN      
        1 attactgttg gagctacagg gagagaaaca gaggaggaga ctgcaagaga tcattggagg
       61 ccgtgggcac gctctttact ccatgtgtgg gacattcatt gcggaataac atcggaggag
      121 aagtttccca gagctatggg gacttcccat ccggcgttcc tggtcttagg ctgtcttctc
      181 acagggctga gcctaatcct ctgccagctt tcattaccct ctatccttcc aaatgaaaat
      241 gaaaaggttg tgcagctgaa ttcatccttt tctctgagat gctttgggga gagtgaagtg
      301 agctggcagt accccatgtc tgaagaagag agctccgatg tggaaatcag aaatgaagaa
      361 aacaacagcg gcctttttgt gacggtcttg gaagtgagca gtgcctcggc ggcccacaca
      421 gggttgtaca cttgctatta caaccacact cagacagaag agaatgagct tgaaggcagg
      481 cacatttaca tctatgtgcc agacccagat gtagcctttg tacctctagg aatgacggat
      541 tatttagtca tcgtggagga tgatgattct gccattatac cttgtcgcac aactgatccc
      601 gagactcctg taaccttaca caacagtgag ggggtggtac ctgcctccta cgacagcaga
      661 cagggcttta atgggacctt cactgtaggg ccctatatct gtgaggccac cgtcaaagga
      721 aagaagttcc agaccatccc atttaatgtt tatgctttaa aagcaacatc agagctggat
      781 ctagaaatgg aagctcttaa aaccgtgtat aagtcagggg aaacgattgt ggtcacctgt
      841 gctgttttta acaatgaggt ggttgacctt caatggactt accctggaga agtgaaaggc
      901 aaaggcatca caatgctgga agaaatcaaa gtcccatcca tcaaattggt gtacactttg
      961 acggtccccg aggccacggt gaaagacagt ggagattacg aatgtgctgc ccgccaggct
     1021 accagggagg tcaaagaaat gaagaaagtc actatttctg tccatgagaa aggtttcatt
     1081 gaaatcaaac ccaccttcag ccagttggaa gctgtcaacc tgcatgaagt caaacatttt
     1141 gttgtagagg tgcgggccta cccacctccc aggatatcct ggctgaaaaa caatctgact
     1201 ctgattgaaa atctcactga gatcaccact gatgtggaaa agattcagga aataaggtat
     1261 cgaagcaaat taaagctgat ccgtgctaag gaagaagaca gtggccatta tactattgta
     1321 gctcaaaatg aagatgctgt gaagagctat acttttgaac tgttaactca agttccttca
     1381 tccattctgg acttggtcga tgatcaccat ggctcaactg ggggacagac ggtgaggtgc
     1441 acagctgaag gcacgccgct tcctgatatt gagtggatga tatgcaaaga tattaagaaa
     1501 tgtaataatg aaacttcctg gactattttg gccaacaatg tctcaaacat catcacggag
     1561 atccactccc gagacaggag taccgtggag ggccgtgtga ctttcgccaa agtggaggag
     1621 accatcgccg tgcgatgcct ggctaagaat ctccttggag ctgagaaccg agagctgaag
     1681 ctggtggctc ccaccctgcg ttctgaactc acggtggctg ctgcagtcct ggtgctgttg
     1741 gtgattgtga tcatctcact tattgtcctg gttgtcattt ggaaacagaa accgaggtat
     1801 gaaattcgct ggagggtcat tgaatcaatc agcccagatg gacatgaata tatttatgtg
     1861 gacccgatgc agctgcctta tgactcaaga tgggagtttc caagagatgg actagtgctt
     1921 ggtcgggtct tggggtctgg agcgtttggg aaggtggttg aaggaacagc ctatggatta
     1981 agccggtccc aacctgtcat gaaagttgca gtgaagatgc taaaacccac ggccagatcc
     2041 agtgaaaaac aagctctcat gtctgaactg aagataatga ctcacctggg gccacatttg
     2101 aacattgtaa acttgctggg agcctgcacc aagtcaggcc ccatttacat catcacagag
     2161 tattgcttct atggagattt ggtcaactat ttgcataaga atagggatag cttcctgagc
     2221 caccacccag agaagccaaa gaaagagctg gatatctttg gattgaaccc tgctgatgaa
     2281 agcacacgga gctatgttat tttatctttt gaaaacaatg gtgactacat ggacatgaag
     2341 caggctgata ctacacagta tgtccccatg ctagaaagga aagaggtttc taaatattcc
     2401 gacatccaga gatcactcta tgatcgtcca gcctcatata agaagaaatc tatgttagac
     2461 tcagaagtca aaaacctcct ttcagatgat aactcagaag gccttacttt attggatttg
     2521 ttgagcttca cctatcaagt tgcccgagga atggagtttt tggcttcaaa aaattgtgtc
     2581 caccgtgatc tggctgctcg caacgtcctc ctggcacaag gaaaaattgt gaagatctgt
     2641 gactttggcc tggccagaga catcatgcat gattcgaact atgtgtcgaa aggcagtacc
     2701 tttctgcccg tgaagtggat ggctcctgag agcatctttg acaacctcta caccacactg
     2761 agtgatgtct ggtcttatgg cattctgctc tgggagatct tttcccttgg tggcacccct
     2821 taccccggca tgatggtgga ttctactttc tacaataaga tcaagagtgg gtaccggatg
     2881 gccaagcctg accacgctac cagtgaagtc tacgagatca tggtgaaatg ctggaacagt
     2941 gagccggaga agagaccctc cttttaccac ctgagtgaga ttgtggagaa tctgctgcct
     3001 ggacaatata aaaagagtta tgaaaaaatt cacctggact tcctgaagag tgaccatcct
     3061 gctgtggcac gcatgcgtgt ggactcagac aatgcataca ttggtgtcac ctacaaaaac
     3121 gaggaagaca agctgaagga ctgggagggt ggtctggatg agcagagact gagcgctgac
     3181 agtggctaca tcattcctct gcctgacatt gaccctgtcc ctgaggagga ggacctgggc
     3241 aagaggaaca gacacagctc gcagacctct gaagagagtg ccattgagac gggttccagc
     3301 agttccacct tcatcaagag agaggacgag accattgaag acatcgacat gatggatgac
     3361 atcggcatag actcttcaga cctggtggaa gacagcttcc tgtaactggc ggattcgagg
     3421 ggttccttcc acttctgggg ccacctctgg atcccgttca gaaaaccact ttattgcaat
     3481 gcagaggttg agaggaggac ttggttgatg tttaaagaga agttcccagc caagggcctc
     3541 ggggagcgtt ctaaatatga atgaatggga tattttgaaa tgaactttgt cagtgttgcc
     3601 tcttgcaatg cctcagtagc atctcagtgg tgtgtgaagt ttggagatag atggataagg
     3661 gaataatagg ccacagaagg tgaactttgt gcttcaagga cattggtgag agtccaacag
     3721 acacaattta tactgcgaca gaacttcagc attgtaatta tgtaaataac tctaaccaag
     3781 gctgtgttta gattgtatta actatcttct ttggacttct gaagagacca ctcaatccat
     3841 ccatgtactt ccctcttgaa acctgatgtc agctgctgtt gaacttttta aagaagtgca
     3901 tgaaaaacca tttttgaacc ttaaaaggta ctggtactat agcattttgc tatctttttt
     3961 agtgttaaag agataaagaa taataattaa ccaaccttgt ttaatagatt tgggtcattt
     4021 agaagcctga caactcattt tcatattgta atctatgttt ataatactac tactgttatc
     4081 agtaatgcta aatgtgtaat aatgtaacat gatttccctc cagagaaagc acaatttaaa
     4141 acaatcctta ctaagtaggt gatgagtttg acagtttttg acatttatat taaataacat
     4201 gtttctctat aaagtatggt aatagcttta gtgaattaaa tttagttgag catagagaac
     4261 aaagtaaaag tagtgttgtc caggaagtca gaatttttaa ctgtactgaa taggttcccc
     4321 aatccatcgt attaaaaaac aattaactgc cctctgaaat aatgggatta gaaacaaaca
     4381 aaactcttaa gtcctaaaag ttctcaatgt agaggcataa acctgtgctg aacataactt
     4441 ctcatgtata ttacccaatg gaaaatataa tgatcagcaa aaagactgga tttgcagaag
     4501 tttttttttt ttttttcttc atgcctgatg aaagctttgg cgaccccaat atatgtattt
     4561 tttgaatcta tgaacctgaa aagggtcaga aggatgccca gacatcagcc tccttctttc
     4621 accccttacc ccaaagagaa agagtttgaa actcgagacc ataaagatat tctttagtgg
     4681 aggctggatg tgcattagcc tggatcctca gttctcaaat gtgtgtggca gccaggatga
     4741 ctagatcctg ggtttccatc cttgagattc tgaagtatga agtctgaggg aaaccagagt
     4801 ctgtattttt ctaaactccc tggctgttct gatcggccag ttttcggaaa cactgactta
     4861 ggtttcagga agttgccatg ggaaacaaat aatttgaact ttggaacagg gttggcattc
     4921 aaccacgcag gaagcctact atttaaatcc ttggcttcag gttagtgaca tttaatgcca
     4981 tctagctagc aattgcgacc ttaatttaac tttccagtct tagctgaggc tgagaaagct
     5041 aaagtttggt tttgacaggt tttccaaaag taaagatgct acttcccact gtatggggga
     5101 gattgaactt tccccgtctc ccgtcttctg cctcccactc cataccccgc caaggaaagg
     5161 catgtacaaa aattatgcaa ttcagtgttc caagtctctg tgtaaccagc tcagtgtttt
     5221 ggtggaaaaa acattttaag ttttactgat aatttgaggt tagatgggag gatgaattgt
     5281 cacatctatc cacactgtca aacaggttgg tgtgggttca ttggcattct ttgcaatact
     5341 gcttaattgc tgataccata tgaatgaaac atgggctgtg attactgcaa tcactgtgct
     5401 atcggcagat gatgctttgg aagatgcaga agcaataata aagtacttga ctacctactg
     5461 gtgtaatctc aatgcaagcc ccaactttct tatccaactt tttcatagta agtgcgaaga
     5521 ctgagccaga ttggccaatt aaaaacgaaa acctgactag gttctgtaga gccaattaga
     5581 cttgaaatac gtttgtgttt ctagaatcac agctcaagca ttctgtttat cgctcactct
     5641 cccttgtaca gccttatttt gttggtgctt tgcattttga tattgctgtg agccttgcat
     5701 gacatcatga ggccggatga aacttctcag tccagcagtt tccagtccta acaaatgctc
     5761 ccacctgaat ttgtatatga ctgcatttgt gtgtgtgtgt gtgttttcag caaattccag
     5821 atttgtttcc ttttggcctc ctgcaaagtc tccagaagaa aatttgccaa tctttcctac
     5881 tttctatttt tatgatgaca atcaaagccg gcctgagaaa cactatttgt gactttttaa
     5941 acgattagtg atgtccttaa aatgtggtct gccaatctgt acaaaatggt cctatttttg
     6001 tgaagaggga cataagataa aatgatgtta tacatcaata tgtatatatg tatttctata
     6061 tagacttgga gaatactgcc aaaacattta tgacaagctg tatcactgcc ttcgtttata
     6121 tttttttaac tgtgataatc cccacaggca cattaactgt tgcacttttg aatgtccaaa
     6181 atttatattt tagaaataat aaaaagaaag atacttacat gttcccaaaa caatggtgtg
     6241 gtgaatgtgt gagaaaaact aacttgatag ggtctaccaa tacaaaatgt attacgaatg
     6301 cccctgttca tgtttttgtt ttaaaacgtg taaatgaaga tctttatatt tcaataaatg
     6361 atatataatt taaagtta
//
