LOCUS       NM_025208               3838 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens platelet derived growth factor D (PDGFD), transcript
            variant 1, mRNA.
ACCESSION   NM_025208
VERSION     NM_025208.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3838)
  AUTHORS   Huang,Y., Cao,D., Zhang,M., Yang,Y., Niu,G., Tang,L., Shen,Z.,
            Zhang,Z., Bai,Y., Min,D. and He,A.
  TITLE     Exploring the impact of PDGFD in osteosarcoma metastasis through
            single-cell sequencing analysis
  JOURNAL   Cell Oncol (Dordr) 47 (5), 1715-1733 (2024)
   PUBMED   38652223
  REMARK    GeneRIF: Exploring the impact of PDGFD in osteosarcoma metastasis
            through single-cell sequencing analysis.
REFERENCE   2  (bases 1 to 3838)
  AUTHORS   Wang,C., Huang,L., Li,J., Liu,D. and Wu,B.
  TITLE     MicroRNA miR-145-5p Inhibits Cutaneous Wound Healing by Targeting
            PDGFD in Diabetic Foot Ulcer
  JOURNAL   Biochem Genet 62 (4), 2437-2454 (2024)
   PUBMED   37950842
  REMARK    GeneRIF: MicroRNA miR-145-5p Inhibits Cutaneous Wound Healing by
            Targeting PDGFD in Diabetic Foot Ulcer.
REFERENCE   3  (bases 1 to 3838)
  AUTHORS   Zhou,Y., Liu,S., Zheng,Y., Wang,Y. and Zhou,Y.
  TITLE     The role of THBS1 and PDGFD in the immune microenvironment of
            Helicobacter pylori-associated gastric cancer
  JOURNAL   Arab J Gastroenterol 25 (2), 194-204 (2024)
   PUBMED   38705811
  REMARK    GeneRIF: The role of THBS1 and PDGFD in the immune microenvironment
            of Helicobacter pylori-associated gastric cancer.
REFERENCE   4  (bases 1 to 3838)
  AUTHORS   Qin,L., Dong,Z., Huang,C., Liu,H., Beebe,J., Subramaniyan,B.,
            Hao,Y., Liu,Y., He,Z., Liu,J.Y. and Zhang,J.T.
  TITLE     Reversible promoter demethylation of PDGFD confers gemcitabine
            resistance through STAT3 activation and RRM1 upregulation
  JOURNAL   Cancer Lett 567, 216266 (2023)
   PUBMED   37321532
  REMARK    GeneRIF: Reversible promoter demethylation of PDGFD confers
            gemcitabine resistance through STAT3 activation and RRM1
            upregulation.
REFERENCE   5  (bases 1 to 3838)
  AUTHORS   Yao,J. and Liu,X.
  TITLE     lncRNA PITPNA-AS1 promotes cell proliferation and metastasis in
            hepatocellular carcinoma by upregulating PDGFD
  JOURNAL   Aging (Albany NY) 15 (10), 4071-4083 (2023)
   PUBMED   37253627
  REMARK    GeneRIF: lncRNA PITPNA-AS1 promotes cell proliferation and
            metastasis in hepatocellular carcinoma by upregulating PDGFD.
REFERENCE   6  (bases 1 to 3838)
  AUTHORS   LaRochelle,W.J., Jeffers,M., Corvalan,J.R., Jia,X.C., Feng,X.,
            Vanegas,S., Vickroy,J.D., Yang,X.D., Chen,F., Gazit,G., Mayotte,J.,
            Macaluso,J., Rittman,B., Wu,F., Dhanabal,M., Herrmann,J. and
            Lichenstein,H.S.
  TITLE     Platelet-derived growth factor D: tumorigenicity in mice and
            dysregulated expression in human cancer
  JOURNAL   Cancer Res 62 (9), 2468-2473 (2002)
   PUBMED   11980634
  REMARK    GeneRIF: Platelet-derived growth factor D: tumorigenicity in mice
            and dysregulated expression in human cancer
REFERENCE   7  (bases 1 to 3838)
  AUTHORS   Uutela,M., Lauren,J., Bergsten,E., Li,X., Horelli-Kuitunen,N.,
            Eriksson,U. and Alitalo,K.
  TITLE     Chromosomal location, exon structure, and vascular expression
            patterns of the human PDGFC and PDGFD genes
  JOURNAL   Circulation 103 (18), 2242-2247 (2001)
   PUBMED   11342471
REFERENCE   8  (bases 1 to 3838)
  AUTHORS   LaRochelle,W.J., Jeffers,M., McDonald,W.F., Chillakuru,R.A.,
            Giese,N.A., Lokker,N.A., Sullivan,C., Boldog,F.L., Yang,M.,
            Vernet,C., Burgess,C.E., Fernandes,E., Deegler,L.L., Rittman,B.,
            Shimkets,J., Shimkets,R.A., Rothberg,J.M. and Lichenstein,H.S.
  TITLE     PDGF-D, a new protease-activated growth factor
  JOURNAL   Nat Cell Biol 3 (5), 517-521 (2001)
   PUBMED   11331882
REFERENCE   9  (bases 1 to 3838)
  AUTHORS   Bergsten,E., Uutela,M., Li,X., Pietras,K., Ostman,A., Heldin,C.H.,
            Alitalo,K. and Eriksson,U.
  TITLE     PDGF-D is a specific, protease-activated ligand for the PDGF
            beta-receptor
  JOURNAL   Nat Cell Biol 3 (5), 512-516 (2001)
   PUBMED   11331881
REFERENCE   10 (bases 1 to 3838)
  AUTHORS   Hamada,T., Ui-Tei,K., Imaki,J. and Miyata,Y.
  TITLE     Molecular cloning of SCDGF-B, a novel growth factor homologous to
            SCDGF/PDGF-C/fallotein
  JOURNAL   Biochem Biophys Res Commun 280 (3), 733-737 (2001)
   PUBMED   11162582
  REMARK    Erratum:[Biochem Biophys Res Commun 2001 Apr 20;282(5):1275]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC030645.2, AF113216.1 and
            AI962915.1.
            
            On Nov 23, 2018 this sequence version replaced NM_025208.4.
            
            Summary: The protein encoded by this gene is a member of the
            platelet-derived growth factor family. The four members of this
            family are mitogenic factors for cells of mesenchymal origin and
            are characterized by a core motif of eight cysteines, seven of
            which are found in this factor. This gene product only forms
            homodimers and, therefore, does not dimerize with the other three
            family members. It differs from alpha and beta members of this
            family in having an unusual N-terminal domain, the CUB domain. Two
            splice variants have been identified for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF113216.1, SRR1660803.54696.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393158.7/ ENSP00000376865.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               BC030645.2         233-346
            115-2858            AF113216.1         1-2744
            2859-3834           BC030645.2         3073-4048
            3835-3838           AI962915.1         8-11                c
FEATURES             Location/Qualifiers
     source          1..3838
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.3"
     gene            1..3838
                     /gene="PDGFD"
                     /gene_synonym="IEGF; MSTP036; SCDGF-B; SCDGFB"
                     /note="platelet derived growth factor D"
                     /db_xref="GeneID:80310"
                     /db_xref="HGNC:HGNC:30620"
                     /db_xref="MIM:609673"
     exon            1..344
                     /gene="PDGFD"
                     /gene_synonym="IEGF; MSTP036; SCDGF-B; SCDGFB"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..1333
                     /gene="PDGFD"
                     /gene_synonym="IEGF; MSTP036; SCDGF-B; SCDGFB"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; iris-expressed growth factor; PDGF-D; spinal
                     cord-derived growth factor B"
                     /codon_start=1
                     /product="platelet-derived growth factor D isoform 1
                     precursor"
                     /protein_id="NP_079484.1"
                     /db_xref="CCDS:CCDS41703.1"
                     /db_xref="GeneID:80310"
                     /db_xref="HGNC:HGNC:30620"
                     /db_xref="MIM:609673"
                     /translation="MHRLIFVYTLICANFCSCRDTSATPQSASIKALRNANLRRDESN
                     HLTDLYRRDETIQVKGNGYVQSPRFPNSYPRNLLLTWRLHSQENTRIQLVFDNQFGLE
                     EAENDICRYDFVEVEDISETSTIIRGRWCGHKEVPPRIKSRTNQIKITFKSDDYFVAK
                     PGFKIYYSLLEDFQPAAASETNWESVTSSISGVSYNSPSVTDPTLIADALDKKIAEFD
                     TVEDLLKYFNPESWQEDLENMYLDTPRYRGRSYHDRKSKVDLDRLNDDAKRYSCTPRN
                     YSVNIREELKLANVVFFPRCLLVQRCGGNCGCGTVNWRSCTCNSGKTVKKYHEVLQFE
                     PGHIKRRGRAKTMALVDIQLDHHERCDCICSSRPPR"
     exon            345..549
                     /gene="PDGFD"
                     /gene_synonym="IEGF; MSTP036; SCDGF-B; SCDGFB"
                     /inference="alignment:Splign:2.1.0"
     exon            550..730
                     /gene="PDGFD"
                     /gene_synonym="IEGF; MSTP036; SCDGF-B; SCDGFB"
                     /inference="alignment:Splign:2.1.0"
     exon            731..793
                     /gene="PDGFD"
                     /gene_synonym="IEGF; MSTP036; SCDGF-B; SCDGFB"
                     /inference="alignment:Splign:2.1.0"
     exon            794..992
                     /gene="PDGFD"
                     /gene_synonym="IEGF; MSTP036; SCDGF-B; SCDGFB"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1207
                     /gene="PDGFD"
                     /gene_synonym="IEGF; MSTP036; SCDGF-B; SCDGFB"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..3838
                     /gene="PDGFD"
                     /gene_synonym="IEGF; MSTP036; SCDGF-B; SCDGFB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3815..3820
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDGFD"
                     /gene_synonym="IEGF; MSTP036; SCDGF-B; SCDGFB"
                     /note="hexamer: AATAAA"
     polyA_site      3838
                     /gene="PDGFD"
                     /gene_synonym="IEGF; MSTP036; SCDGF-B; SCDGFB"
                     /note="major polyA site"
ORIGIN      
        1 accatttatc agctcagcac cacaaggaag tgcggcaccc acacgcgctc ggaaagttca
       61 gcatgcagga agtttgggga gagctcggcg attagcacag cgacccgggc cagcgcaggg
      121 cgagcgcagg cggcgagagc gcagggcggc gcggcgtcgg tcccgggagc agaacccggc
      181 tttttcttgg agcgacgctg tctctagtcg ctgatcccaa atgcaccggc tcatctttgt
      241 ctacactcta atctgcgcaa acttttgcag ctgtcgggac acttctgcaa ccccgcagag
      301 cgcatccatc aaagctttgc gcaacgccaa cctcaggcga gatgagagca atcacctcac
      361 agacttgtac cgaagagatg agaccatcca ggtgaaagga aacggctacg tgcagagtcc
      421 tagattcccg aacagctacc ccaggaacct gctcctgaca tggcggcttc actctcagga
      481 gaatacacgg atacagctag tgtttgacaa tcagtttgga ttagaggaag cagaaaatga
      541 tatctgtagg tatgattttg tggaagttga agatatatcc gaaaccagta ccattattag
      601 aggacgatgg tgtggacaca aggaagttcc tccaaggata aaatcaagaa cgaaccaaat
      661 taaaatcaca ttcaagtccg atgactactt tgtggctaaa cctggattca agatttatta
      721 ttctttgctg gaagatttcc aacccgcagc agcttcagag accaactggg aatctgtcac
      781 aagctctatt tcaggggtat cctataactc tccatcagta acggatccca ctctgattgc
      841 ggatgctctg gacaaaaaaa ttgcagaatt tgatacagtg gaagatctgc tcaagtactt
      901 caatccagag tcatggcaag aagatcttga gaatatgtat ctggacaccc ctcggtatcg
      961 aggcaggtca taccatgacc ggaagtcaaa agttgacctg gataggctca atgatgatgc
     1021 caagcgttac agttgcactc ccaggaatta ctcggtcaat ataagagaag agctgaagtt
     1081 ggccaatgtg gtcttctttc cacgttgcct cctcgtgcag cgctgtggag gaaattgtgg
     1141 ctgtggaact gtcaactgga ggtcctgcac atgcaattca gggaaaaccg tgaaaaagta
     1201 tcatgaggta ttacagtttg agcctggcca catcaagagg aggggtagag ctaagaccat
     1261 ggctctagtt gacatccagt tggatcacca tgaacgatgt gattgtatct gcagctcaag
     1321 accacctcga taagagaatg tgcacatcct tacattaagc ctgaaagaac ctttagttta
     1381 aggagggtga gataagagac ccttttccta ccagcaacca aacttactac tagcctgcaa
     1441 tgcaatgaac acaagtggtt gctgagtctc agccttgctt tgttaatgcc atggcaagta
     1501 gaaaggtata tcatcaactt ctatacctaa gaatatagga ttgcatttaa taatagtgtt
     1561 tgaggttata tatgcacaaa cacacacaga aatatattca tgtctatgtg tatatagatc
     1621 aaatgttttt tttggtatat ataaccaggt acaccagagc ttacatatgt ttgagttaga
     1681 ctcttaaaat cctttgccaa aataagggat ggtcaaatat atgaaacatg tctttagaaa
     1741 atttaggaga taaatttatt tttaaatttt gaaacacaaa acaattttga atcttgctct
     1801 cttaaagaaa gcatcttgta tattaaaaat caaaagatga ggctttctta catatacatc
     1861 ttagttgatt attaaaaaag gaaaaatatg gtttccagag aaaaggccaa tacctaagca
     1921 ttttttccat gagaagcact gcatacttac ctatgtggac tataataacc tgtctccaaa
     1981 accatgccat aataatataa gtgctttaga aattaaatca ttgtgttttt tatgcatttt
     2041 gctgaggcat gcttattcat ttaacaccta tctcaaaaac ttacttagaa ggttttttat
     2101 tatagtccta caaaagacaa tgtataagct gtaacagaat tttgaattgt ttttctttgc
     2161 aaaacccctc cacaaaagca aatcctttca agaatggcat gggcattctg tatgaacctt
     2221 tccagatggt gttcagtgaa agatgtgggt agttgagaac ttaaaaagtg aacattgaaa
     2281 catcgacgta actggaaatt aggtgggata tttgatagga tccatatcta ataatggatt
     2341 cgaactctcc aaactacacc aattaattta atgtatcttg cttttgtgtt cccgtctttt
     2401 tgaaatatag acatggattt ataatggcat tttatatttg gcaggccatc atagattatt
     2461 tacaacctaa aagcttttgt gtatcaaaaa aatcacattt tattaatgta aatttctaat
     2521 cgtatacttg ctcactgttc tgatttcctg tttctgaacc aagtaaaatc agtcctagag
     2581 gctatggttc ttaatctatg gagcttgctt taagaagcca gttgtcaatt gtggtaacac
     2641 aagtttggcc ctgctgtcct actgtttaat agaaaactgt tttacattgg ttaatggtat
     2701 ttagagtaat tttttctctc tgcctccttt gtgtctgttt taaaggagac taactccagg
     2761 agtaggaaat gattcatcat cctccaaagc aagaggctta agagagaaac accgaaattc
     2821 agatagctca gggactgcta acagagaact acatttttct tattgccttg aaagttaaaa
     2881 ggaaagcaga tttcttcagt gactttgtgg tcctactaac tacaaccagt ttgggtgaca
     2941 gggctggtaa agtcccagtg ttagatgagt gacctaaata tacttagatt tctaagtatg
     3001 gtgctctcag gtccaagttc aactattctt aagcagtgca attcttccca gttatttgag
     3061 atgaaagatc tctgcttatt gaagatgtac cttctaaaac tttcctaaaa gtgtctgatg
     3121 tttttactca agaggggagt ggtaaaatta aatactctat tgttcaattc tctaaaatcc
     3181 cagaacacaa tcagaaatag ctcaggcaga cactaataat taagaacgct cttcctcttc
     3241 ataactgctt tgcaagtttc ctgtgaaaac atcagtttcc tgtaccaaag tcaaaatgaa
     3301 cgttacatca ctctaacctg aacagctcac aatgtagctg taaatataaa aaatgagagt
     3361 gttctaccca gttttcaata aaccttccag gctgcaataa ccagcaaggt tttcagttaa
     3421 agccctatct gcacttttta tttattagct gaaatgtaag caggcatatt cactcacttt
     3481 tctttgcctt tcctgagagt tttattaaaa cttctccctt ggttacctgt tatcttttgc
     3541 acttctaaca tgtagccaat aaatctattt gatagccatc aaaggaataa aaagctggcc
     3601 gtacaaatta catttcaaaa caaaccctaa taaatccaca tttccgcatg gctcattcac
     3661 ctggaataat gccttttatt gaatatgttc ttatagggca aaacactttc ataagtagag
     3721 ttttttatgt tttttgtcat atcggtaaca tgcagctttt tcctctcata gcattttcta
     3781 tagcgaatgt aatatgcctc ttatcttcat gaaaaataaa tattgctttt gaacaaaa
//
