LOCUS       NM_016205               4570 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens platelet derived growth factor C (PDGFC), transcript
            variant 1, mRNA.
ACCESSION   NM_016205
VERSION     NM_016205.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4570)
  AUTHORS   Shi,Y.H., Liu,Z.D., Ma,M.J., Zhao,G.Y., Zhu,Y.Q., Wang,J.Q.,
            Yu,Y.Y., Huang,X.T., Ye,J.Y., Li,F.X., Wang,X.Y., Xu,Q.C. and
            Yin,X.Y.
  TITLE     Platelet-Derived Growth Factor C Facilitates Malignant Behavior of
            Pancreatic Ductal Adenocarcinoma by Regulating SREBP1 Mediated
            Lipid Metabolism
  JOURNAL   Adv Sci (Weinh) 11 (40), e2407069 (2024)
   PUBMED   39225567
  REMARK    GeneRIF: Platelet-Derived Growth Factor C Facilitates Malignant
            Behavior of Pancreatic Ductal Adenocarcinoma by Regulating SREBP1
            Mediated Lipid Metabolism.
REFERENCE   2  (bases 1 to 4570)
  AUTHORS   Li,J., Hu,W., Zhang,R., Chen,W., Li,X. and Tang,Z.
  TITLE     PDGF-C promotes cell proliferation partially via downregulating
            BOP1
  JOURNAL   Cell Biol Int 47 (12), 1942-1949 (2023)
   PUBMED   37615370
  REMARK    GeneRIF: PDGF-C promotes cell proliferation partially via
            downregulating BOP1.
REFERENCE   3  (bases 1 to 4570)
  AUTHORS   Rodriguez,A.G., Rodriguez,J.Z., Barreto,A., Sanabria-Barrera,S.,
            Iglesias,J. and Morales,L.
  TITLE     Impact of Acute High Glucose on Mitochondrial Function in a Model
            of Endothelial Cells: Role of PDGF-C
  JOURNAL   Int J Mol Sci 24 (5), 4394 (2023)
   PUBMED   36901825
  REMARK    GeneRIF: Impact of Acute High Glucose on Mitochondrial Function in
            a Model of Endothelial Cells: Role of PDGF-C.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4570)
  AUTHORS   Salokas,K., Liu,X., Ohman,T., Chowdhury,I., Gawriyski,L.,
            Keskitalo,S. and Varjosalo,M.
  TITLE     Physical and functional interactome atlas of human receptor
            tyrosine kinases
  JOURNAL   EMBO Rep 23 (6), e54041 (2022)
   PUBMED   35384245
REFERENCE   5  (bases 1 to 4570)
  AUTHORS   Tan,Z., Shi,S., Xu,J., Liu,X., Lei,Y., Zhang,B., Hua,J., Meng,Q.,
            Wang,W., Yu,X. and Liang,C.
  TITLE     RNA N6-methyladenosine demethylase FTO promotes pancreatic cancer
            progression by inducing the autocrine activity of PDGFC in an
            m6A-YTHDF2-dependent manner
  JOURNAL   Oncogene 41 (20), 2860-2872 (2022)
   PUBMED   35422475
  REMARK    GeneRIF: RNA N6-methyladenosine demethylase FTO promotes pancreatic
            cancer progression by inducing the autocrine activity of PDGFC in
            an m(6)A-YTHDF2-dependent manner.
REFERENCE   6  (bases 1 to 4570)
  AUTHORS   Gilbertson,D.G., Duff,M.E., West,J.W., Kelly,J.D., Sheppard,P.O.,
            Hofstrand,P.D., Gao,Z., Shoemaker,K., Bukowski,T.R., Moore,M.,
            Feldhaus,A.L., Humes,J.M., Palmer,T.E. and Hart,C.E.
  TITLE     Platelet-derived growth factor C (PDGF-C), a novel growth factor
            that binds to PDGF alpha and beta receptor
  JOURNAL   J Biol Chem 276 (29), 27406-27414 (2001)
   PUBMED   11297552
REFERENCE   7  (bases 1 to 4570)
  AUTHORS   Zwerner,J.P. and May,W.A.
  TITLE     PDGF-C is an EWS/FLI induced transforming growth factor in Ewing
            family tumors
  JOURNAL   Oncogene 20 (5), 626-633 (2001)
   PUBMED   11313995
  REMARK    GeneRIF: PDGFC was identified as target of EWS/ETS
            transcriptionalderegulation specific to EWS/FLI-1 chimeras in the
            Ewing Family Tumors suggesting that it may be a significant
            mediator of EWS/FLI driven oncogenesis.
REFERENCE   8  (bases 1 to 4570)
  AUTHORS   Tsai,Y.J., Lee,R.K., Lin,S.P. and Chen,Y.H.
  TITLE     Identification of a novel platelet-derived growth factor-like gene,
            fallotein, in the human reproductive tract
  JOURNAL   Biochim Biophys Acta 1492 (1), 196-202 (2000)
   PUBMED   11004490
REFERENCE   9  (bases 1 to 4570)
  AUTHORS   Hamada,T., Ui-Tei,K. and Miyata,Y.
  TITLE     A novel gene derived from developing spinal cords, SCDGF, is a
            unique member of the PDGF/VEGF family
  JOURNAL   FEBS Lett 475 (2), 97-102 (2000)
   PUBMED   10858496
REFERENCE   10 (bases 1 to 4570)
  AUTHORS   Li,X., Ponten,A., Aase,K., Karlsson,L., Abramsson,A., Uutela,M.,
            Backstrom,G., Hellstrom,M., Bostrom,H., Li,H., Soriano,P.,
            Betsholtz,C., Heldin,C.H., Alitalo,K., Ostman,A. and Eriksson,U.
  TITLE     PDGF-C is a new protease-activated ligand for the PDGF
            alpha-receptor
  JOURNAL   Nat Cell Biol 2 (5), 302-309 (2000)
   PUBMED   10806482
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093325.3, AF091434.1,
            AI446155.1 and AC092608.2.
            
            On Nov 23, 2018 this sequence version replaced NM_016205.2.
            
            Summary: The protein encoded by this gene is a member of the
            platelet-derived growth factor family. The four members of this
            family are mitogenic factors for cells of mesenchymal origin and
            are characterized by a core motif of eight cysteines. This gene
            product appears to form only homodimers. It differs from the
            platelet-derived growth factor alpha and beta polypeptides in
            having an unusual N-terminal domain, the CUB domain. Alternatively
            spliced transcript variants have been found for this gene.
            [provided by RefSeq, Sep 2010].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF091434.1, AY358493.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000502773.6/ ENSP00000422464.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-405               AC093325.3         80703-81107         c
            406-3412            AF091434.1         1-3007
            3413-3413           AI446155.1         31-31               c
            3414-4570           AC092608.2         64714-65870         c
FEATURES             Location/Qualifiers
     source          1..4570
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.1"
     gene            1..4570
                     /gene="PDGFC"
                     /gene_synonym="FALLOTEIN; SCDGF"
                     /note="platelet derived growth factor C"
                     /db_xref="GeneID:56034"
                     /db_xref="HGNC:HGNC:8801"
                     /db_xref="MIM:608452"
     exon            1..1014
                     /gene="PDGFC"
                     /gene_synonym="FALLOTEIN; SCDGF"
                     /inference="alignment:Splign:2.1.0"
     CDS             897..1934
                     /gene="PDGFC"
                     /gene_synonym="FALLOTEIN; SCDGF"
                     /note="secretory growth factor-like protein; spinal
                     cord-derived growth factor; PDGF-C; VEGF-E"
                     /codon_start=1
                     /product="platelet-derived growth factor C precursor"
                     /protein_id="NP_057289.1"
                     /db_xref="CCDS:CCDS3795.1"
                     /db_xref="GeneID:56034"
                     /db_xref="HGNC:HGNC:8801"
                     /db_xref="MIM:608452"
                     /translation="MSLFGLLLLTSALAGQRQGTQAESNLSSKFQFSSNKEQNGVQDP
                     QHERIITVSTNGSIHSPRFPHTYPRNTVLVWRLVAVEENVWIQLTFDERFGLEDPEDD
                     ICKYDFVEVEEPSDGTILGRWCGSGTVPGKQISKGNQIRIRFVSDEYFPSEPGFCIHY
                     NIVMPQFTEAVSPSVLPPSALPLDLLNNAITAFSTLEDLIRYLEPERWQLDLEDLYRP
                     TWQLLGKAFVFGRKSRVVDLNLLTEEVRLYSCTPRNFSVSIREELKRTDTIFWPGCLL
                     VKRCGGNCACCLHNCNECQCVPSKVTKKYHEVLQLRPKTGVRGLHKSLTDVALEHHEE
                     CDCVCRGSTGG"
     exon            1015..1210
                     /gene="PDGFC"
                     /gene_synonym="FALLOTEIN; SCDGF"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1391
                     /gene="PDGFC"
                     /gene_synonym="FALLOTEIN; SCDGF"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1599
                     /gene="PDGFC"
                     /gene_synonym="FALLOTEIN; SCDGF"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1817
                     /gene="PDGFC"
                     /gene_synonym="FALLOTEIN; SCDGF"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..4570
                     /gene="PDGFC"
                     /gene_synonym="FALLOTEIN; SCDGF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3379..3384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDGFC"
                     /gene_synonym="FALLOTEIN; SCDGF"
                     /note="hexamer: AATAAA"
     polyA_site      3413
                     /gene="PDGFC"
                     /gene_synonym="FALLOTEIN; SCDGF"
                     /note="major polyA site"
     regulatory      4547..4552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDGFC"
                     /gene_synonym="FALLOTEIN; SCDGF"
                     /note="hexamer: AATAAA"
     polyA_site      4570
                     /gene="PDGFC"
                     /gene_synonym="FALLOTEIN; SCDGF"
ORIGIN      
        1 accccgtgcg gagacgccgc gcgtagcccc gaggttagcg cggagcccga ggcgtggggg
       61 gaggggacgg ggaacaaccg gagccccgcg gtgaccccga gcggccgaat tgccccaggc
      121 tttgaggagc gggggacgag cccgaacaag gtgaactttg gtcgcggaaa actcaagcca
      181 ggtgccggaa tccgtgctgc ggcgctccga acccggggcc aactgcgctc cgggctgagg
      241 agcgggagcc ccgcggcctc tctccgcctg cgcccgggcc gccgtcggcc cggagccccc
      301 cggccccgct ccggcgcccc ggcccgtggg acccgccgcg gcgccctcgc cttgtttctt
      361 ccccctcccc cttcgggggt ggggggtggg gcgggggaga ggggcgcccg gagagccgca
      421 tctattggca gctttgttat tgatcagaaa ctgctcgccg ccgacttggc ttccagtctg
      481 gctgcgggca acccttgagt tttcgcctct gtcctgtccc ccgaactgac aggtgctccc
      541 agcaacttgc tggggacttc tcgccgctcc cccgcgtccc caccccctca ttcctccctc
      601 gccttcaccc ccacccccac cacttcgcca cagctcagga tttgtttaaa ccttgggaaa
      661 ctggttcagg tccaggtttt gctttgatcc ttttcaaaaa ctggagacac agaagagggc
      721 tctaggaaaa agttttggat gggattatgt ggaaactacc ctgcgattct ctgctgccag
      781 agcaggctcg gcgcttccac cccagtgcag ccttcccctg gcggtggtga aagagactcg
      841 ggagtcgctg cttccaaagt gcccgccgtg agtgagctct caccccagtc agccaaatga
      901 gcctcttcgg gcttctcctg ctgacatctg ccctggccgg ccagagacag gggactcagg
      961 cggaatccaa cctgagtagt aaattccagt tttccagcaa caaggaacag aacggagtac
     1021 aagatcctca gcatgagaga attattactg tgtctactaa tggaagtatt cacagcccaa
     1081 ggtttcctca tacttatcca agaaatacgg tcttggtatg gagattagta gcagtagagg
     1141 aaaatgtatg gatacaactt acgtttgatg aaagatttgg gcttgaagac ccagaagatg
     1201 acatatgcaa gtatgatttt gtagaagttg aggaacccag tgatggaact atattagggc
     1261 gctggtgtgg ttctggtact gtaccaggaa aacagatttc taaaggaaat caaattagga
     1321 taagatttgt atctgatgaa tattttcctt ctgaaccagg gttctgcatc cactacaaca
     1381 ttgtcatgcc acaattcaca gaagctgtga gtccttcagt gctaccccct tcagctttgc
     1441 cactggacct gcttaataat gctataactg cctttagtac cttggaagac cttattcgat
     1501 atcttgaacc agagagatgg cagttggact tagaagatct atataggcca acttggcaac
     1561 ttcttggcaa ggcttttgtt tttggaagaa aatccagagt ggtggatctg aaccttctaa
     1621 cagaggaggt aagattatac agctgcacac ctcgtaactt ctcagtgtcc ataagggaag
     1681 aactaaagag aaccgatacc attttctggc caggttgtct cctggttaaa cgctgtggtg
     1741 ggaactgtgc ctgttgtctc cacaattgca atgaatgtca atgtgtccca agcaaagtta
     1801 ctaaaaaata ccacgaggtc cttcagttga gaccaaagac cggtgtcagg ggattgcaca
     1861 aatcactcac cgacgtggcc ctggagcacc atgaggagtg tgactgtgtg tgcagaggga
     1921 gcacaggagg atagccgcat caccaccagc agctcttgcc cagagctgtg cagtgcagtg
     1981 gctgattcta ttagagaacg tatgcgttat ctccatcctt aatctcagtt gtttgcttca
     2041 aggacctttc atcttcagga tttacagtgc attctgaaag aggagacatc aaacagaatt
     2101 aggagttgtg caacagctct tttgagagga ggcctaaagg acaggagaaa aggtcttcaa
     2161 tcgtggaaag aaaattaaat gttgtattaa atagatcacc agctagtttc agagttacca
     2221 tgtacgtatt ccactagctg ggttctgtat ttcagttctt tcgatacggc ttagggtaat
     2281 gtcagtacag gaaaaaaact gtgcaagtga gcacctgatt ccgttgcctt gcttaactct
     2341 aaagctccat gtcctgggcc taaaatcgta taaaatctgg attttttttt ttttttttgc
     2401 tcatattcac atatgtaaac cagaacattc tatgtactac aaacctggtt tttaaaaagg
     2461 aactatgttg ctatgaatta aacttgtgtc gtgctgatag gacagactgg atttttcata
     2521 tttcttatta aaatttctgc catttagaag aagagaacta cattcatggt ttggaagaga
     2581 taaacctgaa aagaagagtg gccttatctt cactttatcg ataagtcagt ttatttgttt
     2641 cattgtgtac atttttatat tctccttttg acattataac tgttggcttt tctaatcttg
     2701 ttaaatatat ctatttttac caaaggtatt taatattctt ttttatgaca acttagatca
     2761 actattttta gcttggtaaa tttttctaaa cacaattgtt atagccagag gaacaaagat
     2821 gatataaaat attgttgctc tgacaaaaat acatgtattt cattctcgta tggtgctaga
     2881 gttagattaa tctgcatttt aaaaaactga attggaatag aattggtaag ttgcaaagac
     2941 tttttgaaaa taattaaatt atcatatctt ccattcctgt tattggagat gaaaataaaa
     3001 agcaacttat gaaagtagac attcagatcc agccattact aacctattcc ttttttgggg
     3061 aaatctgagc ctagctcaga aaaacataaa gcaccttgaa aaagacttgg cagcttcctg
     3121 ataaagcgtg ctgtgctgtg cagtaggaac acatcctatt tattgtgatg ttgtggtttt
     3181 attatcttaa actctgttcc atacacttgt ataaatacat ggatattttt atgtacagaa
     3241 gtatgtctct taaccagttc acttattgta ctctggcaat ttaaaagaaa atcagtaaaa
     3301 tattttgctt gtaaaatgct taatatcgtg cctaggttat gtggtgacta tttgaatcaa
     3361 aaatgtattg aatcatcaaa taaaagaatg tggctatttt ggggagaaaa ttatgtgtgt
     3421 gtgtgctcaa gatttatttc ttggactctg agaaaatgaa agataaaatt ttctgttatg
     3481 attttcattt agcaaaagca tatgtcaatt caaaagacaa aaaaagggaa gatacctgtg
     3541 agccttctct gcctcttgtt tccaatgcct ttgagcaatg gttttatttt tcttactggt
     3601 cttaatacag atttctggta atttaagttt cacctgactt gaaagttgta tggtttatga
     3661 aatgcttggt gataggtggt atggtagtat gaaactggaa aaaaacttgc aggtttccac
     3721 tcatgtcttc attgtcactg gcaactacta aatggggtga gcataaattg atttggtgca
     3781 tggattattg tacattgcac acttcaagat atggttcctc agttccagac atagattcct
     3841 attcagggct ggtatcttca gcatcctttc ctcagccttt caacttggca gagatgtcta
     3901 gtgtccaggg ccttctgtct tcagactgct cttcaggcaa gcaccctttt cctgtgcttt
     3961 gacacctgca gttctgccct gcctccaact atgtggaaaa caaagaaaca aaatgagcct
     4021 atgtgttctg tcttacttcc ttaccttttc ctggttttgt cctatccata tagaggccaa
     4081 ctagatatat ggaatatgca acgtagtaag tagttggcag tttacaactt tcattagtat
     4141 agtaaagact actaagtctt agtaaatagc ctgtttaact gtgtttaatc cattgtttcc
     4201 catctttgaa cgaaatatat tttccctttt ttaatattta ttttttgttt acttataaaa
     4261 tcttgacagc cagaagagat cataagggta gcagtcctca gttgccagtc ggtgagtggt
     4321 taccatgtga ggactaacca ctttataatc acttactcat agatcgtcct gtgtatttta
     4381 ctaaacacac acacacacac acacacacat aaatagcaca tgaccctaat ttctgagaag
     4441 tacagtaagt attgactgta ttgaccacac accgttttgt gtatgatatc tgtttcaagc
     4501 ctttgtcctt gagacatggg ctgttttgcc cagtgatgtt tactaaaata aaagcaagcc
     4561 ttaaatgtca
//
