LOCUS       NM_018945               5385 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens phosphodiesterase 7B (PDE7B), mRNA.
ACCESSION   NM_018945
VERSION     NM_018945.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5385)
  AUTHORS   Du,Y., Xu,Y., Guo,X., Tan,C., Zhu,X., Liu,G., Lyu,X. and Bei,C.
  TITLE     Methylation-regulated tumor suppressor gene PDE7B promotes HCC
            invasion and metastasis through the PI3K/AKT signaling pathway
  JOURNAL   BMC Cancer 24 (1), 624 (2024)
   PUBMED   38778317
  REMARK    GeneRIF: Methylation-regulated tumor suppressor gene PDE7B promotes
            HCC invasion and metastasis through the PI3K/AKT signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5385)
  AUTHORS   Tang,Y. and Li,X.
  TITLE     Role and mechanism of Circ-PDE7B in the formation of keloid
  JOURNAL   Int Wound J 20 (9), 3738-3749 (2023)
   PUBMED   37291755
  REMARK    GeneRIF: Role and mechanism of Circ-PDE7B in the formation of
            keloid.
            Erratum:[Int Wound J. 2024 Apr;21(4):e14869. doi:
            10.1111/iwj.14869.. PMID: 38661319]
REFERENCE   3  (bases 1 to 5385)
  AUTHORS   Cao,L., Zhang,W., Liu,X., Yang,P., Wang,J., Hu,K., Zhang,X.,
            Liu,W., He,X., Jing,H. and Yuan,X.
  TITLE     The Prognostic Significance of PDE7B in Cytogenetically Normal
            Acute Myeloid Leukemia
  JOURNAL   Sci Rep 9 (1), 16991 (2019)
   PUBMED   31740742
  REMARK    GeneRIF: The Prognostic Significance of PDE7B in Cytogenetically
            Normal Acute Myeloid Leukemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5385)
  AUTHORS   Zhang,D.D., Li,Y., Xu,Y., Kim,J. and Huang,S.
  TITLE     Phosphodiesterase 7B/microRNA-200c relationship regulates
            triple-negative breast cancer cell growth
  JOURNAL   Oncogene 38 (7), 1106-1120 (2019)
   PUBMED   30209363
  REMARK    GeneRIF: both low miR-200c and high PDE7B expression were
            correlated with poor survival of breast cancer patients. Our study
            supports a critical role of miR-200c/PDE7B relationship in
            triple-negative breast cancer tumorigenesis.
REFERENCE   5  (bases 1 to 5385)
  AUTHORS   Lee,J.Y., Kim,J., Kim,S.W., Park,S.K., Ahn,S.H., Lee,M.H.,
            Suh,Y.J., Noh,D.Y., Son,B.H., Cho,Y.U., Lee,S.B., Lee,J.W.,
            Hopper,J.L. and Sung,J.
  TITLE     BRCA1/2-negative, high-risk breast cancers (BRCAX) for Asian women:
            genetic susceptibility loci and their potential impacts
  JOURNAL   Sci Rep 8 (1), 15263 (2018)
   PUBMED   30323354
  REMARK    GeneRIF: We have identified three novel loci (PDE7B, UBL3, and a
            new independent marker in CDKN2B-AS1) associated with BRCAX, and
            replicated previously reported SNPs (24 of 92) and
            moderate/high-penetrance (seven of 23) genes for Korean BRCAX. For
            the novel candidate loci, evidence supported their roles in
            regulatory function
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5385)
  AUTHORS   Ikeda,M., Tomita,Y., Mouri,A., Koga,M., Okochi,T., Yoshimura,R.,
            Yamanouchi,Y., Kinoshita,Y., Hashimoto,R., Williams,H.J.,
            Takeda,M., Nakamura,J., Nabeshima,T., Owen,M.J., O'Donovan,M.C.,
            Honda,H., Arinami,T., Ozaki,N. and Iwata,N.
  TITLE     Identification of novel candidate genes for treatment response to
            risperidone and susceptibility for schizophrenia: integrated
            analysis among pharmacogenomics, mouse expression, and genetic
            case-control association approaches
  JOURNAL   Biol Psychiatry 67 (3), 263-269 (2010)
   PUBMED   19850283
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association, gene-environment interaction, and
            pharmacogenomic / toxicogenomic. (HuGE Navigator)
REFERENCE   7  (bases 1 to 5385)
  AUTHORS   Zhang,L., Murray,F., Zahno,A., Kanter,J.R., Chou,D., Suda,R.,
            Fenlon,M., Rassenti,L., Cottam,H., Kipps,T.J. and Insel,P.A.
  TITLE     Cyclic nucleotide phosphodiesterase profiling reveals increased
            expression of phosphodiesterase 7B in chronic lymphocytic leukemia
  JOURNAL   Proc Natl Acad Sci U S A 105 (49), 19532-19537 (2008)
   PUBMED   19033455
  REMARK    GeneRIF: higher levels than in normal B-cell of PDE7B are found in
            chronic lymphocytic leukemia
REFERENCE   8  (bases 1 to 5385)
  AUTHORS   Gardner,C., Robas,N., Cawkill,D. and Fidock,M.
  TITLE     Cloning and characterization of the human and mouse PDE7B, a novel
            cAMP-specific cyclic nucleotide phosphodiesterase
  JOURNAL   Biochem Biophys Res Commun 272 (1), 186-192 (2000)
   PUBMED   10872825
REFERENCE   9  (bases 1 to 5385)
  AUTHORS   Sasaki,T., Kotera,J., Yuasa,K. and Omori,K.
  TITLE     Identification of human PDE7B, a cAMP-specific phosphodiesterase
  JOURNAL   Biochem Biophys Res Commun 271 (3), 575-583 (2000)
   PUBMED   10814504
REFERENCE   10 (bases 1 to 5385)
  AUTHORS   Hetman,J.M., Soderling,S.H., Glavas,N.A. and Beavo,J.A.
  TITLE     Cloning and characterization of PDE7B, a cAMP-specific
            phosphodiesterase
  JOURNAL   Proc Natl Acad Sci U S A 97 (1), 472-476 (2000)
   PUBMED   10618442
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB038040.1, AJ251860.1 and
            AL138828.15.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_018945.3.
            
            Summary: The 3',5'-cyclic nucleotides cAMP and cGMP function as
            second messengers in a wide variety of signal transduction
            pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs)
            catalyze the hydrolysis of cAMP and cGMP to the corresponding
            5'-monophosphates and provide a mechanism to downregulate cAMP and
            cGMP signaling. This gene encodes a cAMP-specific
            phosphodiesterase, a member of the cyclic nucleotide
            phosphodiesterase family.[provided by RefSeq, Apr 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.74193.1,
                                           SRR1803615.124067.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308191.11/ ENSP00000310661.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               AB038040.1         7-177
            172-1678            AJ251860.1         171-1677
            1679-5382           AL138828.15        90502-94205
            5383-5385           AL138828.15        94206-94208
FEATURES             Location/Qualifiers
     source          1..5385
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.3"
     gene            1..5385
                     /gene="PDE7B"
                     /gene_synonym="bA472E5.1"
                     /note="phosphodiesterase 7B"
                     /db_xref="GeneID:27115"
                     /db_xref="HGNC:HGNC:8792"
                     /db_xref="MIM:604645"
     exon            1..319
                     /gene="PDE7B"
                     /gene_synonym="bA472E5.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             299..1651
                     /gene="PDE7B"
                     /gene_synonym="bA472E5.1"
                     /EC_number="3.1.4.53"
                     /note="cAMP-specific 3',5'-cyclic phosphodiesterase 7B;
                     high-affinity cAMP-specific 3',5'-cyclic
                     phosphodiesterase; rolipram-insensitive phosphodiesterase
                     type 7; cAMP-specific phosphodiesterase 7B"
                     /codon_start=1
                     /product="3',5'-cyclic-AMP phosphodiesterase 7B"
                     /protein_id="NP_061818.1"
                     /db_xref="CCDS:CCDS5175.1"
                     /db_xref="GeneID:27115"
                     /db_xref="HGNC:HGNC:8792"
                     /db_xref="MIM:604645"
                     /translation="MSCLMVERCGEILFENPDQNAKCVCMLGDIRLRGQTGVRAERRG
                     SYPFIDFRLLNSTTYSGEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYL
                     GQARHMLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLV
                     MVQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHP
                     GVNQPFLIKTNHHLANLYQNMSVLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLG
                     SLILATDINRQNEFLTRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMS
                     KQWSERVCEEFYRQGELEQKFELEISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHF
                     TGNSTLSENMLGHLAHNKAQWKSLLPRQHRSRGSSGSGPDHDHAGQGTESEEQEGDSP
                     "
     exon            320..380
                     /gene="PDE7B"
                     /gene_synonym="bA472E5.1"
                     /inference="alignment:Splign:2.1.0"
     exon            381..464
                     /gene="PDE7B"
                     /gene_synonym="bA472E5.1"
                     /inference="alignment:Splign:2.1.0"
     exon            465..616
                     /gene="PDE7B"
                     /gene_synonym="bA472E5.1"
                     /inference="alignment:Splign:2.1.0"
     exon            617..680
                     /gene="PDE7B"
                     /gene_synonym="bA472E5.1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..776
                     /gene="PDE7B"
                     /gene_synonym="bA472E5.1"
                     /inference="alignment:Splign:2.1.0"
     exon            777..877
                     /gene="PDE7B"
                     /gene_synonym="bA472E5.1"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1009
                     /gene="PDE7B"
                     /gene_synonym="bA472E5.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1101
                     /gene="PDE7B"
                     /gene_synonym="bA472E5.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1246
                     /gene="PDE7B"
                     /gene_synonym="bA472E5.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1343
                     /gene="PDE7B"
                     /gene_synonym="bA472E5.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1424
                     /gene="PDE7B"
                     /gene_synonym="bA472E5.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..5385
                     /gene="PDE7B"
                     /gene_synonym="bA472E5.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2736..2741
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDE7B"
                     /gene_synonym="bA472E5.1"
                     /note="hexamer: AATAAA"
     polyA_site      2754
                     /gene="PDE7B"
                     /gene_synonym="bA472E5.1"
                     /note="major polyA site"
     regulatory      5359..5364
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDE7B"
                     /gene_synonym="bA472E5.1"
                     /note="hexamer: AATAAA"
     polyA_site      5385
                     /gene="PDE7B"
                     /gene_synonym="bA472E5.1"
                     /note="major polyA site"
ORIGIN      
        1 agttggtctg ggcactgcag caggctcggc tctgtcccag cacttgtctg ggagaaaagt
       61 ggtgttactc acccagggag agtctctctt tctaccttcc ttctttctcg atctccttgt
      121 gtgcttttgt gtttctttat ttcttttcct tttttttctt tttttttttt tgttacttaa
      181 ttatattcct aatcctggat gaagttgctg gattctgcag cacaagtctt catgaacaag
      241 cagcaccgct cagagatttc acggcattca aaggtcacag aactgccact atggttaaat
      301 gtcttgttta atggttgaga ggtgtggcga aatcttgttt gagaaccccg atcagaatgc
      361 caaatgtgtt tgcatgctgg gagatatacg actaaggggt cagacggggg ttcgtgctga
      421 acgccgtggc tcctacccat tcattgactt ccgcctactt aacagtacaa catactcagg
      481 ggagattggc accaagaaaa aggtgaaaag actattaagc tttcaaagat acttccatgc
      541 atcaaggctg cttcgtggaa ttataccaca agcccctctg cacctgctgg atgaagacta
      601 ccttggacaa gcaaggcata tgctctccaa agtgggaatg tgggattttg acattttctt
      661 gtttgatcgc ttgacaaatg gaaacagcct ggtaacactg ttgtgccacc tcttcaatac
      721 ccatggactc attcaccatt tcaagttaga tatggtgacc ttacaccgat ttttagtcat
      781 ggttcaagaa gattaccaca gccaaaaccc gtatcacaat gctgttcacg cagccgacgt
      841 cacccaggcc atgcactgct acctgaaaga gccaaagctt gccagcttcc tcacgcctct
      901 ggacatcatg cttggactgc tggctgcagc agcacacgat gtggaccacc caggggtgaa
      961 ccagccattt ttgataaaaa ctaaccacca tcttgcaaac ctatatcaga atatgtctgt
     1021 gctggagaat catcactggc gatctacaat tggcatgctt cgagaatcaa ggcttcttgc
     1081 tcatttgcca aaggaaatga cacaggatat tgaacagcag ctgggctcct tgatcttggc
     1141 aacagacatc aacaggcaga atgaattttt gaccagattg aaagctcacc tccacaataa
     1201 agacttaaga ctggaggatg cacaggacag gcactttatg cttcagatcg ccttgaagtg
     1261 tgctgacatt tgcaatcctt gtagaatctg ggagatgagc aagcagtgga gtgaaagggt
     1321 ctgtgaagaa ttctacaggc aaggtgaact tgaacagaaa tttgaactgg aaatcagtcc
     1381 tctttgtaat caacagaaag attccatccc tagtatacaa attggtttca tgagctacat
     1441 cgtggagccg ctcttccggg aatgggccca tttcacgggt aacagcaccc tgtcggagaa
     1501 catgctgggc cacctcgcac acaacaaggc ccagtggaag agcctgttgc ccaggcagca
     1561 cagaagcagg ggcagcagtg gcagcgggcc tgaccacgac cacgcaggcc aagggactga
     1621 gagcgaggag caggaaggcg acagccccta ggggccggcc caacttagac gcggctctcc
     1681 tccggcaggg cccccagagg gcagaagcag cgtggagggg ccctcacgca gcagcccagc
     1741 cactttctga gtgttgtcct ggggctcttt ggaacgccat cttcctccca cttacctgcc
     1801 tcccctcctt ttcgcaaatg tacagaagcc atttgtcacc tcagcattcg ctgccgaaat
     1861 gagcaactcc attcagtaac gtgggagctg atcccacggg caggctctcc ctgctccagg
     1921 agaagactag gaggaagaat gaggtgctcc tgccgtgtcc gccttgttcc gggtcgcact
     1981 ggaacaggca gcaattccta agtccggagc gtttgagcgt ttgctatctg actgctgatc
     2041 tgcgtgacag aaacaccagc atatttgcaa cgccaaggat attggtctta agtgcaagag
     2101 cacaaatgag agtgtgagag aaagtacctt ctattttaat aataatatta ttataaaaat
     2161 aataaatctt tttaactttt atattttatg cactagacaa tggatctgca actttggact
     2221 aaggtcattc aatgtaccca aacttgaaca gggggttcat tgttttgcta ttgactttat
     2281 tatgccactt tggggcagag acttggcatc ttcgcagttt aagaaaccac gtttcctatc
     2341 caatccgaag ggaaggtgct gtacagttca ttcctttgca ccattagcca atctgtcttt
     2401 tatggattct gtgacatgtt tatattcacc catgtacatt ttctgtaaat accaaacgct
     2461 actgattccc atgccaaaat acatgagtat tatgggattg ctacctgtat aaacaatggc
     2521 actgtgaaaa tactgttagt tttaatacaa gagaatgcat ttgtaaatat ggtatagagt
     2581 ttattaatat actattgttt gcagataaag gccttaactt taaacatctt tcatcttctg
     2641 aaagctgccc aacttaaatc ctcatagatg tctttctcaa ctgccttccc atgttcatct
     2701 gtatgttttc cagctaaggt cacaaaccaa aactgaataa agtctttgag gaaacatttt
     2761 ggaaacttca catgcattcc gcttgagacc atagtgttta atctatggca ccaagcatcg
     2821 tttcctcaga ttaatgagac ccttcaacaa gcctgaatca gtcacttttc aacacagcga
     2881 tgttttaaca agccagctgc taagcttgtg tttatgtgac tcttgttaca gatcatggcg
     2941 gtgcgtcagc ctcacaggag acatagcagg tctcagaaac cttctatgac cctgtcatct
     3001 aaccatcagg gaattccctg ctcccatgcc acacatttgt ctattatggc tatagtacca
     3061 aagtactttt ggtgtttggt tggtgtgcat ttctttagtg tcgatagtaa ctggattttt
     3121 ctttttcctt aatctcatgt gaacaactac ccaactgttt agctgaagtt catattattt
     3181 aagtaaagaa aatatttcag ttttataaca gactttacct tcctggcagg tcattgtagt
     3241 taattatgtc tctagcttgg agtgtcacct tggaatttcg ttgccatttt ttctcagaca
     3301 cctggccgta aaatcagttt gttacagcat tcttctctag gctgctaaac gctgtgcatt
     3361 gaaccttttc tttagaagtt tcagcgtaac taatgttaga tgaaaattgt tgatgcccct
     3421 ttctttttac tttaaacaat gtggtagtgg gagaatgact gtttctgcca ctatcaacct
     3481 gatcctcatg ctgatagaat gacagctagc acttatttcc taagtgcaac tgttttagag
     3541 atttttctcc taacatgcaa aggaaatact gattggccta taataagttc ctatagggag
     3601 actgaggctt gcagaattaa ggttcagggg aaattttgga aagttggttg tattttcatt
     3661 gaagtaggag agattatcag atggtgctaa agaaagtgtg aagatcttat gaaataggtg
     3721 gatggtaagt tgaaattatt gatgtgggta agaagggagg ttgtggaaag ttaacactag
     3781 ctttgtattt ttttttctgt aaaactgtga actgatatat tttcctttat cactttagta
     3841 ttctgcagtt ctcagcttgg tgaggctcca aaagagaata tgtcagatgt attcctactt
     3901 ccaaacctgt cttactttgg tttgatggta cacatagggc ttttgaacag tctattttta
     3961 atgtatatga ggtcaaatca aggaaggcaa ttgctgggga caagaaaagt agaggtagga
     4021 aagaagacac tattttagct aatggggttt cttgggacta aaaaatggct ttgtttaaat
     4081 tataattata taataattta aataaatgag attggaggta ttcttagtag ttctgagttg
     4141 atagtttaca ttacaattag gtcttgaaga agagctcaca gagaaaaaac taccaaatat
     4201 ccaatgggta agcccatgat gtagccacta gtacaataaa aatctgaagt aaaatgaggc
     4261 ataaacttga tgcagctgcc tccctcattc aactggggag ttcttgagtt cctcatttgt
     4321 tggtaaaaag aaaaagaatg tgaaaatgtc tctttttttc ttggctatta gtggctgtct
     4381 tgcaatattt caataggagt ccaattacta gttaaaacac tggcggggtg cggtggctca
     4441 cgcctgtaat cctagcactt tgggaggcca agttgggcag atcacaagtt caagagatcg
     4501 agaccattct ggccaacatg gtgaaacccc gtctctacta aaaatacaaa aattagctgg
     4561 gcatggcagt gcgtgcctgc aatcccagct actcaggaag ctgaggcagg agaatcgctt
     4621 gaacctggga ggtggaagtt gtagtgaact gagatcgcac cactgcactc cagcctggca
     4681 acagagctag aatccgtctc aaacaaacaa acaaaaaatc ccacagctat tggatcatcc
     4741 acagattttt tctttacaat cttgttctcc ttgtccatgg accatcaata gttgacttgc
     4801 caggtttaat tctttcattg cttgagaaga aaggaatcaa aggactgtgt gtagtaagct
     4861 gacggtaaag ttaagattaa attaagacag agagagaata catatcactg ccaggcctga
     4921 taggaaaaat ctgctcttcc ttttaataac agtgatgaat tgtcaggacc ttatttagga
     4981 aaccctgacc tacccataac tccctgctag gctaagtaga aaccaggtta tttctccctg
     5041 cttatggctc cccgcaaagg gacttgcagc gtgtcctgca actttgtctt cagatagtgc
     5101 ttcctacaaa actaggtctt gttttgtaat cttttctcgt gttgaatcag atctgcttac
     5161 ttatttaggt ttggttatga gcttgtatct cactgtattt ctcatgcttt gttcttttaa
     5221 acaaatcctt taaactgtgt cattttgtat acacatgtga ggtttgaaaa aaaaaaaaaa
     5281 aaaaaaaaga actaccttgt gagttttgct caaaatgtgg cctaagtagc cattggcatg
     5341 tctagatgaa caaataaaaa taaagataat ttctttaaaa tatca
//
