LOCUS       NM_001395426            8617 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens phosphodiesterase 4D interacting protein (PDE4DIP),
            transcript variant 49, mRNA.
ACCESSION   NM_001395426
VERSION     NM_001395426.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8617)
  AUTHORS   Pan,R., Dai,J., Liang,W., Wang,H., Ye,L., Ye,S., Lin,Z., Huang,S.,
            Xiong,Y., Zhang,L., Lu,L., Wang,O., Shen,X., Liao,W. and Lu,X.
  TITLE     PDE4DIP contributes to colorectal cancer growth and chemoresistance
            through modulation of the NF1/RAS signaling axis
  JOURNAL   Cell Death Dis 14 (6), 373 (2023)
   PUBMED   37355626
  REMARK    GeneRIF: PDE4DIP contributes to colorectal cancer growth and
            chemoresistance through modulation of the NF1/RAS signaling axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8617)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   3  (bases 1 to 8617)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 8617)
  AUTHORS   Abou Ziki,M.D., Bhat,N., Neogi,A., Driscoll,T.P., Ugwu,N., Liu,Y.,
            Smith,E., Abboud,J.M., Chouairi,S., Schwartz,M.A., Akar,J.G. and
            Mani,A.
  TITLE     Epistatic interaction of PDE4DIP and DES mutations in familial
            atrial fibrillation with slow conduction
  JOURNAL   Hum Mutat 42 (10), 1279-1293 (2021)
   PUBMED   34289528
  REMARK    GeneRIF: Epistatic interaction of PDE4DIP and DES mutations in
            familial atrial fibrillation with slow conduction.
REFERENCE   5  (bases 1 to 8617)
  AUTHORS   Peng,H., Zhang,J., Ya,A., Ma,W., Villa,S., Sukenik,S. and Ge,X.
  TITLE     Myomegalin regulates Hedgehog pathway by controlling PDE4D at the
            centrosome
  JOURNAL   Mol Biol Cell 32 (19), 1807-1817 (2021)
   PUBMED   34260267
  REMARK    GeneRIF: Myomegalin regulates Hedgehog pathway by controlling PDE4D
            at the centrosome.
REFERENCE   6  (bases 1 to 8617)
  AUTHORS   Shimada,H., Kuboshima,M., Shiratori,T., Nabeya,Y., Takeuchi,A.,
            Takagi,H., Nomura,F., Takiguchi,M., Ochiai,T. and Hiwasa,T.
  TITLE     Serum anti-myomegalin antibodies in patients with esophageal
            squamous cell carcinoma
  JOURNAL   Int J Oncol 30 (1), 97-103 (2007)
   PUBMED   17143517
  REMARK    GeneRIF: MMGL-antibody is significantly with a favorable prognosis.
            Consequently, MMGL-anatibodies may be a useful tumor marker to
            diagnose and establish a prognosis in patients with esophageal
            squamous cell carcinoma.
REFERENCE   7  (bases 1 to 8617)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   8  (bases 1 to 8617)
  AUTHORS   Soejima,H., Kawamoto,S., Akai,J., Miyoshi,O., Arai,Y., Morohka,T.,
            Matsuo,S., Niikawa,N., Kimura,A., Okubo,K. and Mukai,T.
  TITLE     Isolation of novel heart-specific genes using the BodyMap database
  JOURNAL   Genomics 74 (1), 115-120 (2001)
   PUBMED   11374908
REFERENCE   9  (bases 1 to 8617)
  AUTHORS   Verde,I., Pahlke,G., Salanova,M., Zhang,G., Wang,S., Coletti,D.,
            Onuffer,J., Jin,S.L. and Conti,M.
  TITLE     Myomegalin is a novel protein of the golgi/centrosome that
            interacts with a cyclic nucleotide phosphodiesterase
  JOURNAL   J Biol Chem 276 (14), 11189-11198 (2001)
   PUBMED   11134006
REFERENCE   10 (bases 1 to 8617)
  AUTHORS   Lanfranchi,G., Muraro,T., Caldara,F., Pacchioni,B., Pallavicini,A.,
            Pandolfo,D., Toppo,S., Trevisan,S., Scarso,S. and Valle,G.
  TITLE     Identification of 4370 expressed sequence tags from a
            3'-end-specific cDNA library of human skeletal muscle by DNA
            sequencing and filter hybridization
  JOURNAL   Genome Res 6 (1), 35-42 (1996)
   PUBMED   8681137
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC245389.1, AC239802.3 and
            AC239804.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The protein encoded by this gene serves to anchor
            phosphodiesterase 4D to the Golgi/centrosome region of the cell.
            Defects in this gene may be a cause of myeloproliferative disorder
            (MBD) associated with eosinophilia. Several transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Aug 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000695795.1/ ENSP00000512175.1
            RefSeq Select criteria    :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-367               AC245389.1         223904-224270
            368-423             AC245389.1         242726-242781
            424-575             AC239802.3         161541-161692       c
            576-686             AC239802.3         140269-140379       c
            687-763             AC239802.3         100890-100966       c
            764-887             AC239802.3         98240-98363         c
            888-1063            AC239802.3         97875-98050         c
            1064-1181           AC239802.3         92299-92416         c
            1182-1313           AC239802.3         69378-69509         c
            1314-1433           AC239802.3         68207-68326         c
            1434-1526           AC239802.3         67875-67967         c
            1527-1739           AC239802.3         67523-67735         c
            1740-1898           AC239802.3         64521-64679         c
            1899-2012           AC239802.3         63507-63620         c
            2013-2150           AC239802.3         63187-63324         c
            2151-2330           AC239802.3         62258-62437         c
            2331-2525           AC239802.3         61133-61327         c
            2526-2690           AC239802.3         57819-57983         c
            2691-2772           AC239802.3         57571-57652         c
            2773-2864           AC239802.3         55558-55649         c
            2865-2981           AC239802.3         52110-52226         c
            2982-3119           AC239802.3         51748-51885         c
            3120-3232           AC239802.3         50314-50426         c
            3233-3360           AC239802.3         48766-48893         c
            3361-3449           AC239802.3         38190-38278         c
            3450-3682           AC239802.3         31788-32020         c
            3683-4118           AC239802.3         28137-28572         c
            4119-4311           AC239802.3         27121-27313         c
            4312-4431           AC239802.3         26433-26552         c
            4432-4960           AC239802.3         24726-25254         c
            4961-5196           AC239802.3         22727-22962         c
            5197-5248           AC239802.3         21668-21719         c
            5249-5472           AC239802.3         20372-20595         c
            5473-5625           AC239802.3         19568-19720         c
            5626-5811           AC239802.3         17387-17572         c
            5812-6063           AC239802.3         13613-13864         c
            6064-6195           AC239802.3         12284-12415         c
            6196-6315           AC239802.3         11502-11621         c
            6316-6505           AC239802.3         9827-10016          c
            6506-6630           AC239802.3         9010-9134           c
            6631-6870           AC239802.3         5479-5718           c
            6871-6987           AC239802.3         3332-3448           c
            6988-7214           AC239802.3         2536-2762           c
            7215-7358           AC239802.3         1460-1603           c
            7359-7497           AC239802.3         238-376             c
            7498-7544           AC239804.2         84522-84568
            7545-8617           AC239804.2         86234-87306
FEATURES             Location/Qualifiers
     source          1..8617
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.2"
     gene            1..8617
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /note="phosphodiesterase 4D interacting protein"
                     /db_xref="GeneID:9659"
                     /db_xref="HGNC:HGNC:15580"
                     /db_xref="MIM:608117"
     exon            1..367
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     CDS             348..7586
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /note="isoform 47 is encoded by transcript variant 49;
                     myomegalin; cardiomyopathy-associated protein 2"
                     /codon_start=1
                     /product="myomegalin isoform 47"
                     /protein_id="NP_001382355.1"
                     /db_xref="CCDS:CCDS91043.1"
                     /db_xref="GeneID:9659"
                     /db_xref="HGNC:HGNC:15580"
                     /db_xref="MIM:608117"
                     /translation="MEQTWTRDYFAEDDGEMVPRTSHTAAFLSDTKDRGPPVQSQIWR
                     SGEKVPFVQTYSLRAFEKPPQVQTQALRDFEKHLNDLKKENFSLKLRIYFLEERMQQK
                     YEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEER
                     QQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWE
                     DVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSME
                     VQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYE
                     LKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQL
                     HSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAH
                     ESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHS
                     LSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALE
                     EKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNL
                     QWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEEL
                     CQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERN
                     SELQALRQYLGGRDSLMSQAPISNQQAEVTPTGRLGKQTDQGSMQIPSRDDSTSLTAK
                     EDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEEL
                     QVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQG
                     QEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVE
                     LEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHH
                     SHQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRK
                     AEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWEIEEDKEKG
                     EVMVETVVTKEGLSESSLQAEFRKLQGKLKNAHNIINLLKEQLVLSSKEGNSKLTPEL
                     LVHLTSTIERINTELVGSPGKHQHQEEGNVTVRPFPRPQSLDLGATFTVDAHQLDNQS
                     QPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEATVFAQANELEKYRVM
                     LTGESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNSLKEMVLMEGL
                     CSEQGRRGSTLASSSERKPLENQLGKQEEFRVYGKSENILVLRKDIKDLKAQLQNANK
                     VIQNLKSRVRSLSVTSDYSSSLERPRKLRAVGTLEGSSPHSVPDEDEGWLSDGTGAFY
                     SPGLQAKKDLESLIQRVSQLEAQLPKNGLEEKLAEELRSASWPGKYDSLIQDQARELS
                     YLRQKIREGRGICYLITRHAKDTVKSFEDLLRSNDIDYYLGQSFREQLAQGSQLTERL
                     TSKLSTKDHKSEKDQAGLEPLALRLSRELQEKEKVIEVLQAKLDARSLTPSSSHALSD
                     SHRSPSSTSFLSDELEACSDMDIVSEYTHYEEKKASPSHSDSIHHSSHSAVLSSKPSS
                     TSASQGAKAESNSNPISLPTPQNTPKEANQAHSGFHFHSIPKLASLPQAPLPSAPSSF
                     LPFSPTGPLLLGCCETPVVSLAEAQQELQMLQKQLGESASTVPPASTATLLSNDLEAD
                     SSYYLNSAQPHSPPRGTIELGRILEPGYLGSSGKWDVMRPQKGSVSGDLSSGSSVYQL
                     NSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQ
                     GLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKEL
                     EHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFES
                     LQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNN
                     CLRLQLQQQLESGAGKASLSPSSINQNFPASTDPGNKQLLLQDSAVSPPVRDVGMNSP
                     ALVFPSSASSTPGSETPIINRANGLGLDTSPVMKTPPKLEGDATDGSFANKHGRHVIG
                     HIDDYSALRQQIAEGKLLVKKIVSLVRSACSFPGLEAQGTEVLGSKGIHELRSSTSAL
                     HHALEESASLLTMFWRAALPSTHIPVLPGKVGESTERELLELRTKVSKQERLLQSTTE
                     HLKNANQQKESMEQFIVSQLTRTHDVLKKARTNLEVKSLRALPCTPAL"
     exon            368..423
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            424..575
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            576..686
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            687..763
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            764..887
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1063
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1181
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1313
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1433
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1526
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1739
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1898
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2012
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2150
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..2330
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2525
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..2690
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..2772
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..2864
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            2865..2981
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            2982..3119
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            3120..3232
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            3233..3360
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            3361..3449
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            3450..3682
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            3683..4118
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            4119..4311
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            4312..4431
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            4432..4960
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            4961..5196
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            5197..5248
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            5249..5472
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            5473..5625
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            5626..5811
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            5812..6063
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            6064..6195
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            6196..6315
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            6316..6505
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            6506..6630
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            6631..6870
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            6871..6987
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            6988..7214
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            7215..7358
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            7359..7497
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            7498..7544
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            7545..8617
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8598..8603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /note="hexamer: AATAAA"
     polyA_site      8617
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /note="major polyA site"
ORIGIN      
        1 agtcgtgtct cagcctggag agtgcgcgca ccgcggcccg ggcagccgct ggctccagct
       61 cacgaaacag ccccgggcgc cgcgccgctc tgagtccagc ctcctactga gaacagtccc
      121 tcccttgtgc gggtcgcacg gctagccgca ggttcggcca cgtcaaatcc attttctaaa
      181 aaagcaggga gcagagctct ctcttcgccg ccgacgcaga aaggagctgg ggaggaaaaa
      241 gctgctgcct tttgcgctgg agattcgtgg gcaaggcttc tcattttccc aggctgcttc
      301 ccctcccggg tgaggagcgt cctgagacta aggaaagagc ctggaaaatg gagcagacct
      361 ggacgagaga ttattttgca gaggatgatg gggagatggt acccagaacg agtcacacag
      421 cagcttttct tagtgacact aaagatcgag gccctccagt gcagtcacag atctggagaa
      481 gtggtgaaaa ggtcccgttt gtgcagacat attccttgag agcatttgag aaaccccctc
      541 aggtacagac ccaggctctt cgagactttg agaagcacct caatgacctg aagaaggaga
      601 acttcagcct caagctgcgc atctacttcc tggaggagcg catgcaacag aagtatgagg
      661 ccagccggga ggacatctac aagcggaaca ttgagctgaa ggttgaagtg gagagcttga
      721 aacgagaact ccaggacaag aaacagcatc tggataaaac atgggctgat gtggagaatc
      781 tcaacagtca gaatgaagct gagctccgac gccagtttga ggagcgacag caggagacgg
      841 agcatgttta tgagctcttg gagaataaga tccagcttct gcaggaggaa tccaggctag
      901 caaagaatga agctgcgcgg atggcagctc tggtggaagc agagaaggag tgtaacctgg
      961 agctctcaga gaaactgaag ggagtcacca aaaactggga agatgtacca ggagaccagg
     1021 tcaagcccga ccaatacact gaggccctgg cccagaggga caagagaatt gaagaactga
     1081 atcagagcct ggctgcccag gagaggcttg tagaacagct atctcgggag aaacaacaac
     1141 tgctacatct gttggaggag ccaactagca tggaagtgca gcccatgact gaagagttgc
     1201 tgaaacaaca aaagctgaat tcacatgaga ccactataac tcagcagtct gtatctgatt
     1261 cccacttggc agaactccag gaaaaaatcc agcaaacaga ggccaccaac aagattcttc
     1321 aagagaaact taatgaaatg agctatgaac taaagtgtgc tcaggagtcg tctcaaaagc
     1381 aagatggtac aattcagaac ctcaaggaaa ctctgaaaag cagggaacgt gagactgagg
     1441 agttgtacca ggtaattgaa ggtcaaaatg acacaatggc aaagcttcga gaaatgctgc
     1501 accaaagcca gcttggacaa cttcacagct cagagggtac ttctccagct cagcaacagg
     1561 tagctctgct tgatcttcag agtgctttat tctgcagcca acttgaaata cagaagctcc
     1621 agagggtggt acgacagaaa gagcgccaac tggctgatgc caaacaatgt gtgcaatttg
     1681 tagaggctgc agcacacgag agtgaacagc agaaagaggc ttcttggaaa cataaccagg
     1741 aattgcgaaa agccttgcag cagctacaag aagaattgca gaataagagc caacagcttc
     1801 gtgcctggga ggctgaaaaa tacaatgaga ttcgaaccca ggaacaaaac atccagcacc
     1861 taaaccatag tctgagtcac aaggagcagt tgcttcagga atttcgggag ctcctacagt
     1921 atcgagataa ctcagacaaa acccttgaag caaatgaaat gttgcttgag aaacttcgcc
     1981 agcgaataca tgataaagct gttgctctgg agcgggctat agatgaaaaa ttctctgctc
     2041 tagaagagaa agaaaaagaa ctgcgccagc ttcgtcttgc tgtgagagag cgagatcatg
     2101 acttagagag actgcgcgat gtcctctcct ccaatgaagc tactatgcaa agtatggaga
     2161 gtctcctgag ggccaaaggc ctggaagtgg aacagttatc tactacctgt caaaacctcc
     2221 agtggctgaa agaagaaatg gaaaccaaat ttagccgttg gcagaaggaa caagagagta
     2281 tcattcagca gttacagacg tctcttcatg ataggaacaa agaagtggag gatcttagtg
     2341 caacactgct ctgcaaactt ggaccagggc agagtgagat agcagaggag ctgtgccagc
     2401 gtctacagcg aaaggaaagg atgctgcagg accttctaag tgatcgaaat aaacaagtgc
     2461 tggaacatga aatggagatt caaggcctgc ttcagtctgt gagcaccagg gagcaggaaa
     2521 gccaagctgc tgcagagaag ttggtgcaag ccttaatgga aagaaattca gaattacagg
     2581 ccctgcgcca atatttagga gggagagact ccctgatgtc ccaagcaccc atctctaacc
     2641 aacaagctga agttaccccc actggccgtc ttggaaaaca gactgatcaa ggttcaatgc
     2701 agataccttc cagagatgat agcacttcat tgactgccaa agaggatgtc agcataccca
     2761 gatccacatt aggagacttg gacacagttg cagggctgga aaaagaactg agtaatgcca
     2821 aagaggaact tgaactcatg gctaaaaaag aaagagaaag tcagatggaa ctttctgctc
     2881 tacagtccat gatggctgtg caggaagaag agctgcaggt gcaggctgct gatatggagt
     2941 ctctgaccag gaacatacag attaaagaag atctcataaa ggacctgcaa atgcaactgg
     3001 ttgatcctga agacatacca gctatggaac gcctgaccca ggaagtctta cttcttcggg
     3061 aaaaagttgc ttcagtagaa tcccagggtc aagaaatttc aggaaaccga agacaacagt
     3121 tgctgctgat gctagaagga ctagtagatg aacggagtcg gctcaatgag gccttacaag
     3181 cagagagaca gctctatagc agtctggtga agttccatgc ccatccagag agctctgaga
     3241 gagaccgaac tctgcaggtg gaactggaag gggctcaggt gttacgcagt cggctagaag
     3301 aagttcttgg aagaagcttg gagcgcttaa acaggctgga gaccctggcc gccattggag
     3361 gtgcagctgc aggggatgac accgaagata caagcactga gttcactgac agtattgagg
     3421 aggaggctgc acaccatagt caccagcaac ttgtcaaggt ggctttggag aaaagtctgg
     3481 caactgtgga gacccagaac ccatcttttt cccctccttc tccgatggga ggggacagta
     3541 acaggtgtct tcaggaagaa atgctccacc tgagggctga gttccaccag cacttagaag
     3601 agaagaggaa agctgaggag gaactgaagg agctaaaggc tcaaattgag gaagcaggat
     3661 tctcctcagt gtcccacatc aggaacacca tgctgagcct ttgccttgag aatgcggagc
     3721 tgaaagagca gatgggagaa gcaatgtctg atggatggga gatcgaggaa gacaaggaga
     3781 agggcgaggt gatggttgag actgtggtaa ccaaagaggg tctgagtgag agtagccttc
     3841 aggctgagtt cagaaagctc cagggaaaac tgaagaatgc ccacaatatc atcaacctcc
     3901 tcaaagaaca acttgtgctg agtagcaagg aagggaatag taaacttact ccagagctcc
     3961 ttgtgcatct gaccagcacc attgaaagaa taaacacaga actggttggt tcccctggga
     4021 agcaccaaca ccaagaggag gggaatgtga ctgtgaggcc tttccccaga ccccagagcc
     4081 ttgaccttgg ggctaccttc acagtggatg cccaccaatt ggataaccag tcccagcctc
     4141 gtgaccctgg gcctcagtca gcgtttagcc taccagggtc cacccagcac ctgcgctccc
     4201 agctgtcaca atgcaaacaa cgctatcaag atctccagga gaagctgctg ctatcagaag
     4261 ccactgtctt tgctcaggct aacgagctgg agaaatacag agttatgctt acaggtgaat
     4321 ccttggtgaa gcaggacagc aagcagatcc aggtggacct ccaggacctg ggctatgaga
     4381 cttgtggccg aagcgagaat gaggctgaac gggaggaaac caccagtcct gagtgtgagg
     4441 agcacaacag cctcaaggaa atggtcctga tggaggggct gtgctctgag cagggacgcc
     4501 ggggctcaac actggctagt tcctctgaga ggaagccctt ggagaaccag ctagggaagc
     4561 aggaagagtt ccgggtatat ggaaagtcag aaaacatctt ggtcctacga aaggacatca
     4621 aagatctgaa ggcccagctg cagaatgcca acaaggtcat tcaaaacctc aagagccggg
     4681 tccggtccct ctcagttaca agtgattatt cgtctagtct ggaaagaccc cggaagctga
     4741 gagctgttgg caccttggag gggtcttcac ctcatagtgt ccctgatgag gatgaggggt
     4801 ggctgtctga tggcactggg gctttctact ctccagggct tcaggccaaa aaggacctgg
     4861 agagtctcat ccagagagta tcccagctgg aggcccagct cccaaaaaat ggactagaag
     4921 agaagctggc tgaggagctg agatcagcct cgtggcctgg gaaatatgat tccctgattc
     4981 aggatcaggc ccgggaactg tcttacctac ggcaaaaaat acgagaaggg agaggtattt
     5041 gttatcttat cacccggcat gcaaaagata cagtaaaatc ttttgaggat ctcctaagga
     5101 gcaatgacat tgactactac ctgggacaga gcttccggga gcaactcgcc cagggaagcc
     5161 agctgacaga gaggctcacc agcaaactca gcaccaagga tcataaaagt gagaaagatc
     5221 aagctggact tgagccactg gccctcaggc tcagcaggga gctgcaggag aaggagaaag
     5281 tgattgaagt cctgcaggcc aagctggatg ctcggtccct cacaccctcc agcagccatg
     5341 ccttgtctga ctcccaccgc tctcccagca gcacctcttt cctgtctgat gaactggaag
     5401 cctgctctga catggacata gtcagcgagt acacacacta tgaagagaag aaagcttctc
     5461 ccagtcactc agattccatc catcattcga gtcattctgc tgtgttgtct tctaaaccat
     5521 catcaaccag tgcatctcag ggggctaagg ccgaatccaa cagcaacccc atcagcttgc
     5581 caactcccca gaataccccc aaggaggcca accaggccca ttcaggcttt cattttcact
     5641 ccatacccaa gctggctagc cttcctcagg caccattgcc ctcagctcca tccagcttcc
     5701 tgcctttcag ccccactggc cctctcctcc ttggctgctg tgagacacca gtggtctcct
     5761 tggctgaggc tcagcaggag ctacagatgc tgcagaagca gttgggagaa agtgccagca
     5821 ctgttcctcc tgcttccaca gctacattgc tgagcaacga cttggaagcc gactcttcct
     5881 actacctcaa ctctgcccag cctcactctc ctccaagggg caccatagaa ctgggaagaa
     5941 tcctagagcc tgggtacctg ggcagcagtg gcaagtggga tgtgatgagg cctcagaaag
     6001 ggagtgtatc tggggaccta tcctcaggct cctctgtgta ccagcttaac tccaaaccca
     6061 caggggctga cctgctggaa gagcatcttg gtgaaatccg gaacctgcgc cagcgcctgg
     6121 aggaatccat ctgcatcaat gaccgcctac gggagcaact ggaacaccgg ctgacctcta
     6181 ctgctcgtgg aaggggatcc acttctaact tctacagtca gggcctggag tccatacctc
     6241 agctctgcaa tgagaacaga gtcctcaggg aagacaatcg aagacttcag gctcaactga
     6301 gtcatgtttc cagagagcac tcccaggaaa cagaaagcct gagggaggct ctgctgtcct
     6361 ctcgatccca ccttcaagag ctggaaaagg agctggagca ccagaaggtg gaaaggcagc
     6421 agcttttgga agacttgagg gagaagcagc aagaggtctt gcatttcagg gaggaacgtc
     6481 tttccctcca ggaaaacgac tccagactgc agcacaagct ggttctcctg cagcaacagt
     6541 gtgaagagaa acagcagctc tttgagtccc tccagtcaga gctacaaatc tacgaggcac
     6601 tttatggcaa ttccaagaag gggctgaaag cttacagcct ggatgcctgt caccaaatcc
     6661 ctttgagcag tgacctgagc cacctggtgg cagaggtacg agctctgaga gggcagctgg
     6721 agcagagcat tcaggggaac aattgtctgc gactgcagct gcaacagcag ctggagagcg
     6781 gtgctggcaa agccagcctc agcccctcct ccattaacca gaacttccca gccagcactg
     6841 accctggaaa caagcagctg ctcctccaag attcagctgt gtcccctcca gtccgggatg
     6901 ttggtatgaa ttccccagct ctggtcttcc ccagctctgc ttcctctact cctggctcag
     6961 aaacgcccat aatcaacaga gcaaatggct tgggtttgga tacttctcca gtaatgaaga
     7021 cccctcccaa gctagagggt gatgctactg atggctcctt tgccaataag catggccgcc
     7081 atgtcattgg ccacattgat gactacagtg ccctaagaca gcagattgcg gagggcaagc
     7141 tgctggtcaa aaagatagtg tctcttgtga gatcagcgtg cagcttccct ggccttgaag
     7201 cccaaggcac agaggtgcta ggcagcaaag gtattcatga gcttcggagc agcaccagtg
     7261 ccctgcacca tgccctagag gagtcagctt ccctcctcac catgttctgg agagcggccc
     7321 tgccaagcac ccacatccct gtgctgcctg gcaaagtggg agaatcaaca gaaagggaac
     7381 ttctggaact gagaaccaaa gtatccaaac aggagcgact ccttcagagc acaactgagc
     7441 atctgaagaa cgccaaccag cagaaggaga gcatggagca gttcatcgtc agccagctaa
     7501 ccagaacaca tgatgtttta aagaaggcaa ggactaactt agaggtgaaa tccctaaggg
     7561 ctctgccatg tactccagcc ttgtgaccct tgccttccag gaaccatgca agaagcgcag
     7621 ccaccagaag tccttaaaac agcaggaaag gtgggcctgt cccccttttg tgcagctacc
     7681 tatctgctga ggagcatctg ggcctcattc ctccaagtcc acgggagggt ccagaagagg
     7741 gagtcagaga tgtatcctgg tggagctggg agaaaggcag aaagcctttc tgacggctat
     7801 ggaatacgat tagccaaggt ccacttggcc cagcactaag aaaaagatgc gtagtttgca
     7861 cagaaggttt tgtgatcctg cctctcaaca gccccagcag cttgggaact agcaagagca
     7921 catttcttgc ctcatcagct gtcctgagat ggaaaactca gtgaatatag gaccctgatt
     7981 ccgatgaaag gggcacgtgg tcccaatgct ggagctcctc tggcaggttc taaaagcaca
     8041 ctactgagca gcggtgccct gccggacact gctggcgggg gctcagtgag cactactcac
     8101 agatccacac ctgaccctgt tgggtcgagt caggctgggc cttggtctgc actgtagcac
     8161 ctgtgttctt tgagttcaca tcatgaatgt ggtgacttcc cagataccat ctcaggctta
     8221 acctagcaca tcctatttct tttcttctat gatatccaaa ttggactgac ctcacttcaa
     8281 agttgctgtc ccattttgtc accctatctt atctcgggga aattgcagac tgatggccag
     8341 accaactctg ttgaaattct tgcatagagc aaacctgtgc tcatttttaa gtggcatggg
     8401 agaggcccca agcctagtaa agcctagtct gtgtcttcac agtgctggta gaatgtgttt
     8461 gtgtgtataa atatatgata tagatttata tatgttgcta acgccatata ttgaaggcca
     8521 acataactgg tggacagggt gggtgacaga aaatgaaagt ctttttggtg attgttaaag
     8581 caaaatgtgt ataaagaaat aaatagtttt tctttca
//
