LOCUS       NM_001098818            5030 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens phosphodiesterase 4C (PDE4C), transcript variant 3,
            mRNA.
ACCESSION   NM_001098818
VERSION     NM_001098818.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5030)
  AUTHORS   Pan,F., Pan,R., Hu,R., Zhang,H., Lei,S., Zhang,L., Zhou,C.,
            Zeng,Z., Tian,X. and Xie,Q.
  TITLE     Analysis of the effects of M2 macrophage-derived PDE4C on the
            prognosis, metastasis and immunotherapy benefit of osteosarcoma
  JOURNAL   J Cell Mol Med 28 (10), e18395 (2024)
   PUBMED   38774995
  REMARK    GeneRIF: Analysis of the effects of M2 macrophage-derived PDE4C on
            the prognosis, metastasis and immunotherapy benefit of
            osteosarcoma.
REFERENCE   2  (bases 1 to 5030)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5030)
  AUTHORS   Bao,Z., Feng,Y., Wang,H., Zhang,C., Sun,L., Yan,Z., Liu,Q., Guo,T.,
            Li,M., Yang,X., Jiang,C., Zhang,Q. and Jiang,T.
  TITLE     Integrated analysis using methylation and gene expression
            microarrays reveals PDE4C as a prognostic biomarker in human glioma
  JOURNAL   Oncol Rep 32 (1), 250-260 (2014)
   PUBMED   24842301
  REMARK    GeneRIF: Data show that PDE4C is downregulated through promoter
            hypermethylation in glioma.
REFERENCE   4  (bases 1 to 5030)
  AUTHORS   Sullivan,M., Olsen,A.S. and Houslay,M.D.
  TITLE     Genomic organisation of the human cyclic AMP-specific
            phosphodiesterase PDE4C gene and its chromosomal localisation to
            19p13.1, between RAB3A and JUND
  JOURNAL   Cell Signal 11 (10), 735-742 (1999)
   PUBMED   10574328
REFERENCE   5  (bases 1 to 5030)
  AUTHORS   Huston,E., Lumb,S., Russell,A., Catterall,C., Ross,A.H.,
            Steele,M.R., Bolger,G.B., Perry,M.J., Owens,R.J. and Houslay,M.D.
  TITLE     Molecular cloning and transient expression in COS7 cells of a novel
            human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3
  JOURNAL   Biochem J 328 (Pt 2) (Pt 2), 549-558 (1997)
   PUBMED   9371714
REFERENCE   6  (bases 1 to 5030)
  AUTHORS   Owens,R.J., Lumb,S., Rees-Milton,K., Russell,A., Baldock,D.,
            Lang,V., Crabbe,T., Ballesteros,M. and Perry,M.J.
  TITLE     Molecular cloning and expression of a human phosphodiesterase 4C
  JOURNAL   Cell Signal 9 (8), 575-585 (1997)
   PUBMED   9429761
REFERENCE   7  (bases 1 to 5030)
  AUTHORS   Obernolte,R., Ratzliff,J., Baecker,P.A., Daniels,D.V., Zuppan,P.,
            Jarnagin,K. and Shelton,E.R.
  TITLE     Multiple splice variants of phosphodiesterase PDE4C cloned from
            human lung and testis
  JOURNAL   Biochim Biophys Acta 1353 (3), 287-297 (1997)
   PUBMED   9349724
REFERENCE   8  (bases 1 to 5030)
  AUTHORS   Engels,P., Sullivan,M., Muller,T. and Lubbert,H.
  TITLE     Molecular cloning and functional expression in yeast of a human
            cAMP-specific phosphodiesterase subtype (PDE IV-C)
  JOURNAL   FEBS Lett 358 (3), 305-310 (1995)
   PUBMED   7843419
REFERENCE   9  (bases 1 to 5030)
  AUTHORS   Milatovich,A., Bolger,G., Michaeli,T. and Francke,U.
  TITLE     Chromosome localizations of genes for five cAMP-specific
            phosphodiesterases in man and mouse
  JOURNAL   Somat Cell Mol Genet 20 (2), 75-86 (1994)
   PUBMED   8009369
REFERENCE   10 (bases 1 to 5030)
  AUTHORS   Bolger,G., Michaeli,T., Martins,T., St John,T., Steiner,B.,
            Rodgers,L., Riggs,M., Wigler,M. and Ferguson,K.
  TITLE     A family of human phosphodiesterases homologous to the dunce
            learning and memory gene product of Drosophila melanogaster are
            potential targets for antidepressant drugs
  JOURNAL   Mol Cell Biol 13 (10), 6558-6571 (1993)
   PUBMED   8413254
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U88713.1, BC109067.1, L20968.1,
            DB313915.1, Z46632.1 and AC068499.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001098818.3.
            
            Summary: The protein encoded by this gene belongs to the cyclic
            nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This
            PDE hydrolyzes the second messenger, cAMP, which is a regulator and
            mediator of a number of cellular responses to extracellular
            signals. Thus, by regulating the cellular concentration of cAMP,
            this protein plays a key role in many important physiological
            processes. Alternatively spliced transcript variants encoding
            different isoforms have been described for this gene.[provided by
            RefSeq, Jul 2011].
            
            Transcript Variant: This variant (3) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at an
            alternate start codon, compared to variant 1. The encoded isoform
            (3) has a shorter, distinct N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK300983.1, SRR14038195.996735.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262805.17/ ENSP00000262805.10
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-957               U88713.1           38-994
            958-2164            BC109067.1         493-1699
            2165-2451           L20968.1           862-1148
            2452-2531           DB313915.1         265-344             c
            2532-3261           Z46632.1           2716-3445
            3262-5030           AC068499.1         32783-34551         c
FEATURES             Location/Qualifiers
     source          1..5030
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..5030
                     /gene="PDE4C"
                     /gene_synonym="DPDE1; PDE21"
                     /note="phosphodiesterase 4C"
                     /db_xref="GeneID:5143"
                     /db_xref="HGNC:HGNC:8782"
                     /db_xref="MIM:600128"
     exon            1..169
                     /gene="PDE4C"
                     /gene_synonym="DPDE1; PDE21"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..2066
                     /gene="PDE4C"
                     /gene_synonym="DPDE1; PDE21"
                     /EC_number="3.1.4.53"
                     /note="isoform 3 is encoded by transcript variant 3;
                     phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1
                     dunce homolog, Drosophila); cAMP-specific
                     phosphodiesterase 4C; cAMP-specific 3',5'-cyclic
                     phosphodiesterase 4C; dunce-like phosphodiesterase E1;
                     3',5'-cyclic-AMP phosphodiesterase 4C"
                     /codon_start=1
                     /product="3',5'-cyclic-AMP phosphodiesterase 4C isoform 3"
                     /protein_id="NP_001092288.1"
                     /db_xref="CCDS:CCDS42523.1"
                     /db_xref="GeneID:5143"
                     /db_xref="HGNC:HGNC:8782"
                     /db_xref="MIM:600128"
                     /translation="MQGPPAPAPVPGPGSPRGSPRGSPGLFRKLLVNQSIRLQRRFTV
                     AHPLCFDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKA
                     MSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSS
                     NQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSE
                     TSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVP
                     RFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIP
                     ADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFA
                     SAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSA
                     KQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQN
                     LVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQV
                     GFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRF
                     QFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLPLDNQRT"
     exon            170..361
                     /gene="PDE4C"
                     /gene_synonym="DPDE1; PDE21"
                     /inference="alignment:Splign:2.1.0"
     exon            362..398
                     /gene="PDE4C"
                     /gene_synonym="DPDE1; PDE21"
                     /inference="alignment:Splign:2.1.0"
     exon            399..472
                     /gene="PDE4C"
                     /gene_synonym="DPDE1; PDE21"
                     /inference="alignment:Splign:2.1.0"
     exon            473..522
                     /gene="PDE4C"
                     /gene_synonym="DPDE1; PDE21"
                     /inference="alignment:Splign:2.1.0"
     exon            523..635
                     /gene="PDE4C"
                     /gene_synonym="DPDE1; PDE21"
                     /inference="alignment:Splign:2.1.0"
     exon            636..729
                     /gene="PDE4C"
                     /gene_synonym="DPDE1; PDE21"
                     /inference="alignment:Splign:2.1.0"
     exon            730..893
                     /gene="PDE4C"
                     /gene_synonym="DPDE1; PDE21"
                     /inference="alignment:Splign:2.1.0"
     exon            894..992
                     /gene="PDE4C"
                     /gene_synonym="DPDE1; PDE21"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1157
                     /gene="PDE4C"
                     /gene_synonym="DPDE1; PDE21"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1257
                     /gene="PDE4C"
                     /gene_synonym="DPDE1; PDE21"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1412
                     /gene="PDE4C"
                     /gene_synonym="DPDE1; PDE21"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1535
                     /gene="PDE4C"
                     /gene_synonym="DPDE1; PDE21"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1718
                     /gene="PDE4C"
                     /gene_synonym="DPDE1; PDE21"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..5030
                     /gene="PDE4C"
                     /gene_synonym="DPDE1; PDE21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4322..4327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDE4C"
                     /gene_synonym="DPDE1; PDE21"
                     /note="hexamer: AATAAA"
     polyA_site      4360
                     /gene="PDE4C"
                     /gene_synonym="DPDE1; PDE21"
                     /note="major polyA site"
     regulatory      5008..5013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDE4C"
                     /gene_synonym="DPDE1; PDE21"
                     /note="hexamer: AATAAA"
     polyA_site      5030
                     /gene="PDE4C"
                     /gene_synonym="DPDE1; PDE21"
                     /note="major polyA site"
ORIGIN      
        1 ccagcctcca cgcagtcctg gcgatgcagg gcccccccgc gcccgccccg gtccccgggc
       61 ccggctcccc tcggggatcc ccgcgcggct cccccgggct cttcaggaag cttttggtga
      121 atcagagcat ccgcctgcag cggcgcttca cggtggccca tccgctgtgc tttgacctgg
      181 aaaatgggct ctcgtgtggg aggagggccc tggaccctca gtccagccct ggcctgggcc
      241 ggattatgca ggctccagtc ccgcacagcc agcggcgcga gtccttcctg taccgctcag
      301 atagcgacta tgaactctcg cccaaggcca tgtctcggaa ctcctctgtg gccagcgacc
      361 tacatggaga ggacatgatt gtgacgccct ttgcccaggt cctggccagt ctgcggaccg
      421 ttcggagcaa cgtggcggcc cttgcccgcc agcaatgcct aggagcagcc aagcagggac
      481 ccgtcggaaa cccttcatcc agcaatcagc tccctcctgc agaggacacg gggcagaagc
      541 tggcattgga gacgctagac gagctggact ggtgcctgga tcagttggag acgctgcaga
      601 cccggcactc ggtgggggag atggcctcca acaagttcaa gcggatcctg aaccgggagt
      661 tgacccacct gtccgaaacc agccgctccg ggaaccaggt gtccgagtac atctcccgga
      721 ccttcctgga ccagcagacc gaggtggagc tgcccaaggt gaccgctgag gaggccccac
      781 agcccatgtc ccggatcagt ggcctacatg ggctctgcca cagtgccagc ctctcctcag
      841 ccactgtccc acgctttggg gtccagactg accaggagga gcaactggcc aaggagctag
      901 aagacaccaa caagtgggga cttgatgtgt tcaaggtggc ggagctaagt gggaaccggc
      961 ccctcacagc tatcatattc agcatttttc aggagcggga cctgctgaag acattccaga
     1021 tcccagcaga cacactggcc acctacctgc tgatgctgga aggtcactac cacgccaatg
     1081 tggcctacca caacagccta catgccgccg acgtggccca gtccacgcat gtgctgctgg
     1141 ctacgcccgc cctcgaggct gtgttcacag acttggaaat cctggctgcc ctctttgcaa
     1201 gcgccatcca cgacgtggac catcctgggg tctccaacca gtttctgatt aacaccaact
     1261 cagagctggc gcttatgtac aacgacgcct cggtgctgga gaaccatcac ctggctgtgg
     1321 gcttcaagct gctgcaggca gagaactgcg atatcttcca gaacctcagc gccaagcagc
     1381 gactgagtct gcgcaggatg gtcattgaca tggtgctggc cacagacatg tccaaacaca
     1441 tgaacctcct ggccgacctc aagaccatgg tggagaccaa gaaggtgaca agcctcggtg
     1501 tcctcctcct ggacaactat tccgaccgaa tccaggtctt gcagaacctg gtgcactgtg
     1561 ctgatctgag caaccccacc aagccgctgc ccctgtaccg ccagtggacg gaccgcatca
     1621 tggccgagtt cttccagcag ggagaccgcg agcgtgagtc gggcctggac atcagtccca
     1681 tgtgtgacaa gcatacggcc tcagtggaga agtcccaggt gggtttcatt gactacattg
     1741 ctcacccact gtgggagact tgggctgacc tggtccaccc agatgcacag gacctgctgg
     1801 acacgctgga ggacaatcga gagtggtacc agagcaagat cccccgaagt ccctcagacc
     1861 tcaccaaccc cgagcgggac gggcctgaca gattccagtt tgaactgact ctggaggagg
     1921 cagaggaaga ggatgaggag gaagaagagg agggggaaga gacagcttta gccaaagagg
     1981 ccttggagtt gcctgacact gaactcctgt cccctgaagc cggcccagac cctggggact
     2041 tacccctcga caaccagagg acttagggcc agccctgcgt gaactgcagg ggcaatggat
     2101 ggtaaagccc tttggctctt ggcaggcaga ctttccagga agaggctcca tgtggctcct
     2161 gcttcacttt cccacccatt tagggagaca atcaagctct tagttatagg tggctcccag
     2221 ggtctaattg gaggcacctg gctggggtcc actctgaccc tagacttgcc taaaagagct
     2281 ctctaagggg cagcctctta cgatgccctg gtgtctttct cctgggcttc tatccctgtg
     2341 aggagaggtg ctgtctgctg gagcctctag tccaccctct ccagtggtca ctcttgagtc
     2401 acatctgtca cttaattatt tccttcttta tcaaatattt attgctcatc tacttcgtgc
     2461 cagctttctg cctctgtagt agccctgcac aaagggtggg gagtcaggag accatcccaa
     2521 aggcatctcc ctgtcttcct ctaccaagcg gctctctgca agagcatgga aatgtgagtg
     2581 gggaaaattt tcagcaccaa agcttcactc atacccagtt ttgtttctga aactacggta
     2641 gggggcagga agaggagcag aaaagaaggg ctgggcaagg catagtggct tatgcctgta
     2701 atcccggtac tttgggaggc tgaggtggga ggactgctta agctcaggag tttgagacca
     2761 gcctgggcaa catagcaaga cccccaccat ctctgaaaaa aaaaattagc caggcatggt
     2821 ggtgtgcacc tgagaatccc agctactcag aaggttgaga caaaggggat cgcttgagcc
     2881 caggagttgg aggctgaaga gagctatgac tgcatcactg cactccagcc tgggcaacac
     2941 agcaagatcc tgtctaaaaa taaaaagaaa agagaaggaa aggaaagaga cggggctctg
     3001 aggccgagca cagtggccca tgcctataat cccagcactt tgggaggctg aggcaggtgg
     3061 atcacctgag gttaggagtt cgagaccagc ctggccaaca tggtgaaacc ccatctctac
     3121 taaaaataca aaaattggct gggcatggtg gcgggtgcct gtaatcccag ctactgggga
     3181 ggctgaggca ggagaatcac ttgaattcag gaggtggagg ttgcagtgag ccgacatcat
     3241 gccactgcac tccagcctgg gcgacagagc aagacactgt ctcaaaaaag aaaagaaaaa
     3301 aaaaaaagcc gggccaggtg gctcacgcct gtaatcctag cactttggga ggctgagtgg
     3361 gggtggatcg cctgagatca ggagttcaaa atcagcctgg ccaacatagt gaaaccctgt
     3421 ctctactaaa aatacaaaaa attagaggct gggtgcggcg gctcacacct gtaatcccag
     3481 aactttggga ggccgaggcg ggtggatcac gaggtcagga gttcaagacc agcctggcca
     3541 acacggtgaa accccatctc tactaaaaat acacaaatta gctgggcatg gtgttgggtg
     3601 cctgaatccc agctactcgg gaggctgagg caggagaatc gcttgaatcc gggaggcggg
     3661 gcttgcagtg agccgagatc gtgccattgc actccagcct gggtgacaga gcaagactcc
     3721 gtctcaaaaa gaaaaaaaaa aaattagcca ggcatggtgg caggtgcctg taatcccagc
     3781 tacttgagag gctgaggcag gagaatcgct tgaacccggg aggtggaggt tgtggtgagc
     3841 cgaggtcgcg ccactgcact ccagcctggg caacgacaac aacaataaaa agagggggct
     3901 ctgtgcccgg catgtctctg aagactgatt gaacctatgc accagttgtt gctttaagtc
     3961 gctttatttt ctgtctttgg tgtctctgga tgtaggagcc ccctgctttc tctgtccgca
     4021 gaactccata ctgggtcccc tacgtgttcc tccttcccta ggacagcaac aaaaacacac
     4081 aattttccct ctctagcagg tctctaagtc tcctgattcc tgaaactgcc tcagactccc
     4141 cctagaggga gggaggcccc tgaggctttc ttgccatcat agcctcttct gggcctcagt
     4201 ttcccctctg taacctgatc ctagtacttg gataaactcc gacgaggtgt ggggggttgt
     4261 tgtctgtgac ctccctgaaa tatcttagac atttggggta ctgagcattt atctggggtt
     4321 aaataaaatc tttacatctt aagacattcg attgaccaaa ttgagtgtcc tggccatttc
     4381 actgatgagg aaactgaggc gcagagaggt cctcttgcca gctcaaagtc aagcatctgg
     4441 gcgcccaatg ttagccagcg gcaccccctg gtggcgggcg tgggagacac ggcggggcgc
     4501 gcttgtcggg ggttgggggg tgggtcggag gggtggcatc ctccagccct gatggtccca
     4561 cttaccgcac ctcgccggga agagctcgtc ctgctggtcg ggcctccgag cggactgggc
     4621 agcaccatgc tcaagcctag ggttcgatcc ccgcctccgg aagcctcagt atccatccct
     4681 cccctctgcc tccctcttcg cgtgcctgaa tatttataca agatacaggc gtcatcacag
     4741 ccgccctcgg cttccagagc agctggcttc gttcataaat attataacca ctcagaattc
     4801 atcatcatca cagttaatga taaaattcca cagtgccaga actaaaagtc atccgggttc
     4861 acgaacttgg tgcatttcct tccagacttt taaaaagaag atatttaggg aatttttttt
     4921 tcaagatttt tccccccagt ccgcttacaa agtaatacca tgttcgctgt aaaaaatttg
     4981 gaaataatgg aaatgtataa agaaggaaat aaaattctgc tgtatctcca
//
