LOCUS       NM_002600               4531 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens phosphodiesterase 4B (PDE4B), transcript variant a,
            mRNA.
ACCESSION   NM_002600
VERSION     NM_002600.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4531)
  AUTHORS   Scalavino,V., Piccinno,E., Labarile,N., Armentano,R., Giannelli,G.
            and Serino,G.
  TITLE     Anti-Inflammatory Effects of miR-369-3p via PDE4B in Intestinal
            Inflammatory Response
  JOURNAL   Int J Mol Sci 25 (15), 8463 (2024)
   PUBMED   39126032
  REMARK    GeneRIF: Anti-Inflammatory Effects of miR-369-3p via PDE4B in
            Intestinal Inflammatory Response.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4531)
  AUTHORS   Hsu,Y.H., Pintacuda,G., Liu,R., Nacu,E., Kim,A., Tsafou,K.,
            Petrossian,N., Crotty,W., Suh,J.M., Riseman,J., Martin,J.M.,
            Biagini,J.C., Mena,D., Ching,J.K.T., Malolepsza,E., Li,T.,
            Singh,T., Ge,T., Egri,S.B., Tanenbaum,B., Stanclift,C.R.,
            Apffel,A.M., Carr,S.A., Schenone,M., Jaffe,J., Fornelos,N.,
            Huang,H., Eggan,K.C. and Lage,K.
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium;
            Stanley Global Asia Initiatives
  TITLE     Using brain cell-type-specific protein interactomes to interpret
            neurodevelopmental genetic signals in schizophrenia
  JOURNAL   iScience 26 (5), 106701 (2023)
   PUBMED   37207277
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4531)
  AUTHORS   Johnson,K.R., Nicodemus-Johnson,J. and Danziger,R.S.
  TITLE     An evolutionary analysis of cAMP-specific Phosphodiesterase 4
            alternative splicing
  JOURNAL   BMC Evol Biol 10, 247 (2010)
   PUBMED   20701803
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4531)
  AUTHORS   Cheung,Y.F., Kan,Z., Garrett-Engele,P., Gall,I., Murdoch,H.,
            Baillie,G.S., Camargo,L.M., Johnson,J.M., Houslay,M.D. and
            Castle,J.C.
  TITLE     PDE4B5, a novel, super-short, brain-specific cAMP
            phosphodiesterase-4 variant whose isoform-specifying N-terminal
            region is identical to that of cAMP phosphodiesterase-4D6 (PDE4D6)
  JOURNAL   J Pharmacol Exp Ther 322 (2), 600-609 (2007)
   PUBMED   17519386
  REMARK    GeneRIF: A super-short, brain specific isoform of human PDE4B,
            PDE4B5, was identified. It has cAMP hydrolyzing activity and is
            inhibited by PDE4 inhibitors. PDE4B5 bind to DISC1. The 16
            N-terminal residues are identical to the corresponding residues of
            PDE4D6.
REFERENCE   5  (bases 1 to 4531)
  AUTHORS   Shepherd,M., McSorley,T., Olsen,A.E., Johnston,L.A., Thomson,N.C.,
            Baillie,G.S., Houslay,M.D. and Bolger,G.B.
  TITLE     Molecular cloning and subcellular distribution of the novel PDE4B4
            cAMP-specific phosphodiesterase isoform
  JOURNAL   Biochem J 370 (Pt 2), 429-438 (2003)
   PUBMED   12441002
REFERENCE   6  (bases 1 to 4531)
  AUTHORS   Huston,E., Lumb,S., Russell,A., Catterall,C., Ross,A.H.,
            Steele,M.R., Bolger,G.B., Perry,M.J., Owens,R.J. and Houslay,M.D.
  TITLE     Molecular cloning and transient expression in COS7 cells of a novel
            human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3
  JOURNAL   Biochem J 328 (Pt 2) (Pt 2), 549-558 (1997)
   PUBMED   9371714
REFERENCE   7  (bases 1 to 4531)
  AUTHORS   Szpirer,C., Szpirer,J., Riviere,M., Swinnen,J., Vicini,E. and
            Conti,M.
  TITLE     Chromosomal localization of the human and rat genes (PDE4D and
            PDE4B) encoding the cAMP-specific phosphodiesterases 3 and 4
  JOURNAL   Cytogenet Cell Genet 69 (1-2), 11-14 (1995)
   PUBMED   7835077
REFERENCE   8  (bases 1 to 4531)
  AUTHORS   Bolger,G.B., Rodgers,L. and Riggs,M.
  TITLE     Differential CNS expression of alternative mRNA isoforms of the
            mammalian genes encoding cAMP-specific phosphodiesterases
  JOURNAL   Gene 149 (2), 237-244 (1994)
   PUBMED   7958996
REFERENCE   9  (bases 1 to 4531)
  AUTHORS   Obernolte,R., Bhakta,S., Alvarez,R., Bach,C., Zuppan,P.,
            Mulkins,M., Jarnagin,K. and Shelton,E.R.
  TITLE     The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE
            IV) reveals a multigene family
  JOURNAL   Gene 129 (2), 239-247 (1993)
   PUBMED   8392015
REFERENCE   10 (bases 1 to 4531)
  AUTHORS   McLaughlin,M.M., Cieslinski,L.B., Burman,M., Torphy,T.J. and
            Livi,G.P.
  TITLE     A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from
            human brain. Cloning and expression of cDNA, biochemical
            characterization of recombinant protein, and tissue distribution of
            mRNA
  JOURNAL   J Biol Chem 268 (9), 6470-6476 (1993)
   PUBMED   8384210
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL513493.11, DA126733.1,
            L20966.1, AA453531.1, AA206316.1, CN268011.1 and BC046161.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002600.3.
            
            Summary: This gene is a member of the type IV, cyclic AMP
            (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family.
            The encoded protein regulates the cellular concentrations of cyclic
            nucleotides and thereby play a role in signal transduction. Altered
            activity of this protein has been associated with schizophrenia and
            bipolar affective disorder. Alternative splicing and the use of
            alternative promoters results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (a) encodes the longest isoform
            (1, also referred to as PDE4B1 or Tm72). Both variants a and d
            encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.182919.1,
                                           SRR1803613.142398.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341517.9/ ENSP00000342637.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-278               AL513493.11        99056-99333
            279-286             DA126733.1         1-8
            287-3461            L20966.1           1-3175
            3462-3831           AA453531.1         60-429
            3832-4108           AA206316.1         89-365
            4109-4380           CN268011.1         121-392
            4381-4531           BC046161.1         1196-1346
FEATURES             Location/Qualifiers
     source          1..4531
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.3"
     gene            1..4531
                     /gene="PDE4B"
                     /gene_synonym="DPDE4; PDEIVB"
                     /note="phosphodiesterase 4B"
                     /db_xref="GeneID:5142"
                     /db_xref="HGNC:HGNC:8781"
                     /db_xref="MIM:600127"
     exon            1..354
                     /gene="PDE4B"
                     /gene_synonym="DPDE4; PDEIVB"
                     /inference="alignment:Splign:2.1.0"
     exon            355..466
                     /gene="PDE4B"
                     /gene_synonym="DPDE4; PDEIVB"
                     /inference="alignment:Splign:2.1.0"
     CDS             425..2635
                     /gene="PDE4B"
                     /gene_synonym="DPDE4; PDEIVB"
                     /EC_number="3.1.4.53"
                     /note="isoform 1 is encoded by transcript variant a;
                     phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4
                     dunce homolog, Drosophila); dunce-like phosphodiesterase
                     E4; cAMP-specific 3',5'-cyclic phosphodiesterase 4B;
                     cAMP-specific phosphodiesterase 4B; 3',5'-cyclic-AMP
                     phosphodiesterase 4B"
                     /codon_start=1
                     /product="3',5'-cyclic-AMP phosphodiesterase 4B isoform 1"
                     /protein_id="NP_002591.2"
                     /db_xref="CCDS:CCDS632.1"
                     /db_xref="GeneID:5142"
                     /db_xref="HGNC:HGNC:8781"
                     /db_xref="MIM:600127"
                     /translation="MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRR
                     CCSGNLQLPPLSQRQSERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPS
                     PGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQH
                     GDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKL
                     AMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYIS
                     NTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTEN
                     EDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYM
                     MTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDH
                     PGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRK
                     MVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLS
                     NPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVH
                     PLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFEL
                     TLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT"
     exon            467..705
                     /gene="PDE4B"
                     /gene_synonym="DPDE4; PDEIVB"
                     /inference="alignment:Splign:2.1.0"
     exon            706..900
                     /gene="PDE4B"
                     /gene_synonym="DPDE4; PDEIVB"
                     /inference="alignment:Splign:2.1.0"
     exon            901..937
                     /gene="PDE4B"
                     /gene_synonym="DPDE4; PDEIVB"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1008
                     /gene="PDE4B"
                     /gene_synonym="DPDE4; PDEIVB"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1058
                     /gene="PDE4B"
                     /gene_synonym="DPDE4; PDEIVB"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1171
                     /gene="PDE4B"
                     /gene_synonym="DPDE4; PDEIVB"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1265
                     /gene="PDE4B"
                     /gene_synonym="DPDE4; PDEIVB"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1444
                     /gene="PDE4B"
                     /gene_synonym="DPDE4; PDEIVB"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1543
                     /gene="PDE4B"
                     /gene_synonym="DPDE4; PDEIVB"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1708
                     /gene="PDE4B"
                     /gene_synonym="DPDE4; PDEIVB"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1808
                     /gene="PDE4B"
                     /gene_synonym="DPDE4; PDEIVB"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1963
                     /gene="PDE4B"
                     /gene_synonym="DPDE4; PDEIVB"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2086
                     /gene="PDE4B"
                     /gene_synonym="DPDE4; PDEIVB"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2269
                     /gene="PDE4B"
                     /gene_synonym="DPDE4; PDEIVB"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..4531
                     /gene="PDE4B"
                     /gene_synonym="DPDE4; PDEIVB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4512..4517
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDE4B"
                     /gene_synonym="DPDE4; PDEIVB"
                     /note="hexamer: AATAAA"
     polyA_site      4531
                     /gene="PDE4B"
                     /gene_synonym="DPDE4; PDEIVB"
                     /note="major polyA site"
ORIGIN      
        1 agaggacgag agaagagctg aggggcgcgt cgccagcgcc tgtgtctccc tggcgcgggt
       61 tccccaggct agcccgctgg cccgtccgcg cgcgcgcccc cggcccgcgc gccccttccc
      121 ggggctcctg gcctcgcctc agcggctgca ggctcttcgt cgcgggccgg gctgcacgcg
      181 agcgccctcc gggcagactt tcgtccccca cccccgggag cgcggaaggc tcactcgcag
      241 cgcatggtct acccgcgccg ggcggagccc cggcgtccag agcgctgcgg ccgcggcggt
      301 gcagcagagg cgcctcgggc aggaggaggg cggcttctgc gagggcagcc tgaggtatta
      361 aaaagtgtca gcaaactgca ttgaataaca gacatcctaa gaggggatat tttccacctc
      421 tataatgaag aaaagcagga gtgtgatgac ggtgatggct gatgataatg ttaaagatta
      481 ttttgaatgt agcttgagta aatcctacag ttcttccagt aacacacttg ggatcgacct
      541 ctggagaggg agaaggtgtt gctcaggaaa cttacagtta ccaccactgt ctcaaagaca
      601 gagtgaaagg gcaaggactc ctgagggaga tggtatttcc aggccgacca cactgccttt
      661 gacaacgctt ccaagcattg ctattacaac tgtaagccag gagtgctttg atgtggaaaa
      721 tggcccttcc ccaggtcgga gtccactgga tccccaggcc agctcttccg ctgggctggt
      781 acttcacgcc acctttcctg ggcacagcca gcgcagagag tcatttctct acagatcaga
      841 cagcgactat gacttgtcac caaaggcgat gtcgagaaac tcttctcttc caagcgagca
      901 acacggcgat gacttgattg taactccttt tgcccaggtc cttgccagct tgcgaagtgt
      961 gagaaacaac ttcactatac tgacaaacct tcatggtaca tctaacaaga ggtccccagc
     1021 tgctagtcag cctcctgtct ccagagtcaa cccacaagaa gaatcttatc aaaaattagc
     1081 aatggaaacg ctggaggaat tagactggtg tttagaccag ctagagacca tacagaccta
     1141 ccggtctgtc agtgagatgg cttctaacaa gttcaaaaga atgctgaacc gggagctgac
     1201 acacctctca gagatgagcc gatcagggaa ccaggtgtct gaatacattt caaatacttt
     1261 cttagacaag cagaatgatg tggagatccc atctcctacc cagaaagaca gggagaaaaa
     1321 gaaaaagcag cagctcatga cccagataag tggagtgaag aaattaatgc atagttcaag
     1381 cctaaacaat acaagcatct cacgctttgg agtcaacact gaaaatgaag atcacctggc
     1441 caaggagctg gaagacctga acaaatgggg tcttaacatc tttaatgtgg ctggatattc
     1501 tcacaataga cccctaacat gcatcatgta tgctatattc caggaaagag acctcctaaa
     1561 gacattcaga atctcatctg acacatttat aacctacatg atgactttag aagaccatta
     1621 ccattctgac gtggcatatc acaacagcct gcacgctgct gatgtagccc agtcgaccca
     1681 tgttctcctt tctacaccag cattagacgc tgtcttcaca gatttggaga tcctggctgc
     1741 catttttgca gctgccatcc atgacgttga tcatcctgga gtctccaatc agtttctcat
     1801 caacacaaat tcagaacttg ctttgatgta taatgatgaa tctgtgttgg aaaatcatca
     1861 ccttgctgtg ggtttcaaac tgctgcaaga agaacactgt gacatcttca tgaatctcac
     1921 caagaagcag cgtcagacac tcaggaagat ggttattgac atggtgttag caactgatat
     1981 gtctaaacat atgagcctgc tggcagacct gaagacaatg gtagaaacga agaaagttac
     2041 aagttcaggc gttcttctcc tagacaacta taccgatcgc attcaggtcc ttcgcaacat
     2101 ggtacactgt gcagacctga gcaaccccac caagtccttg gaattgtatc ggcaatggac
     2161 agaccgcatc atggaggaat ttttccagca gggagacaaa gagcgggaga ggggaatgga
     2221 aattagccca atgtgtgata aacacacagc ttctgtggaa aaatcccagg ttggtttcat
     2281 cgactacatt gtccatccat tgtgggagac atgggcagat ttggtacagc ctgatgctca
     2341 ggacattctc gataccttag aagataacag gaactggtat cagagcatga tacctcaaag
     2401 tccctcacca ccactggacg agcagaacag ggactgccag ggtctgatgg agaagtttca
     2461 gtttgaactg actctcgatg aggaagattc tgaaggacct gagaaggagg gagagggaca
     2521 cagctatttc agcagcacaa agacgctttg tgtgattgat ccagaaaaca gagattccct
     2581 gggagagact gacatagaca ttgcaacaga agacaagtcc cccgtggata cataatcccc
     2641 ctctccctgt ggagatgaac attctatcct tgatgagcat gccagctatg tggtagggcc
     2701 agcccaccat gggggccaag acctgcacag gacaagggcc acctggcctt tcagttactt
     2761 gagtttggag tcagaaagca agaccaggaa gcaaatagca gctcaggaaa tcccacggtt
     2821 gacttgcctt gatggcaagc ttggtggaga gggctgaagc tgttgctggg ggccgattct
     2881 gatcaagaca catggcttga aaatggaaga cacaaaactg agagatcatt ctgcactaag
     2941 tttcgggaac ttatccccga cagtgactga actcactgac taataacttc atttatgaat
     3001 cttctcactt gtccctttgt ctgccaacct gtgtgccttt tttgtaaaac attttcatgt
     3061 ctttaaaatg cctgttgaat acctggagtt tagtatcaac ttctacacag ataagctttc
     3121 aaagttgaca aacttttttg actctttctg gaaaagggaa agaaaatagt cttccttctt
     3181 tcttgggcaa tatccttcac tttactacag ttacttttgc aaacagacag aaaggataca
     3241 cttctaacca cattttactt ccttcccctg ttgtccagtc caactccaca gtcactctta
     3301 aaacttctct ctgtttgcct gcctccaaca gtacttttaa ctttttgctg taaacagaat
     3361 aaaattgaac aaattagggg gtagaaagga gcagtggtgt cgttcaccgt gagagtctgc
     3421 atagaactca gcagtgtgcc ctgctgtgtc ttggaccctg ccccccacag gagttgtaca
     3481 gtccctggcc ctgttcccta cctcctctct tcaccccgtt aggctgtttt caatgtaatg
     3541 ctgccgtcct tctcttgcac tgccttctgc gctaacacct ccattcctgt ttataaccgt
     3601 gtatttatta cttaatgtat ataatgtaat gttttgtaag ttattaattt atatatctaa
     3661 cattgcctgc caatggtggt gttaaatttg tgtagaaaac tctgcctaag agttacgact
     3721 ttttcttgta atgttttgta ttgtgtatta tataacccaa acgtcactta gtagagacat
     3781 atggccccct tggcagagag gacaggggtg ggcttttgtt caaagggtct gccctttccc
     3841 tgcctgagtt gctacttctg cacaacccct ttatgaacca gttttggaaa caatattctc
     3901 acattagata ctaaatggtt tatactgagc ttttactttt gtatagcttg ataggggcag
     3961 ggggcaatgg gatgtagttt ttacccaggt tctatccaaa tctatgtggg catgagttgg
     4021 gttataactg gatcctacta tcattgtggc tttggttcaa aaggaaacac tacatttgct
     4081 cacagatgat tcttctgaat gctcccgaac tactgacttt gaagaggtag cctcctgcct
     4141 gccattaagc aggaatgtca tgttccagtt cattacaaaa gaaaacaata aaacaatgtg
     4201 aatttttata ataaaatgtg aactgatgta gcaaattacg caaatgtgaa gcctcttctg
     4261 ataacacttg ttaggcctct tactgatgtc agtttcagtt tgtaaaatat gtttcatgct
     4321 ttcagttcag cattgtgact cagtaattac agaaaatggc acaaatgtgc atgaccaatg
     4381 tatgtctatg aacactgcat tgtttcaggt ggacatttta tcattttcaa atgtttctca
     4441 caatgtatgt tatagtatta ttattatata ttgtgttcaa atgcattcta aagagacttt
     4501 tatatgaggt gaataaagaa aagcatgatt a
//
