LOCUS       NM_001111307            4897 bp    mRNA    linear   PRI 10-DEC-2024
DEFINITION  Homo sapiens phosphodiesterase 4A (PDE4A), transcript variant 1,
            mRNA.
ACCESSION   NM_001111307
VERSION     NM_001111307.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4897)
  AUTHORS   Wang,J., Gu,Q., Liu,Y., Huang,X., Zhang,J., Liu,B., Li,R. and
            Linghu,H.
  TITLE     Low PDE4A expression promoted the progression of ovarian cancer by
            inducing Snail nuclear translocation
  JOURNAL   Exp Cell Res 439 (2), 114100 (2024)
   PUBMED   38797258
  REMARK    GeneRIF: Low PDE4A expression promoted the progression of ovarian
            cancer by inducing Snail nuclear translocation.
REFERENCE   2  (bases 1 to 4897)
  AUTHORS   Zahra,N., Rafique,S., Naveed,Z., Nadeem,J., Waqas,M., Ali,A.,
            Shah,M. and Idrees,M.
  TITLE     Regulatory pathways and therapeutic potential of PDE4 in liver
            pathophysiology
  JOURNAL   Life Sci 345, 122565 (2024)
   PUBMED   38521388
  REMARK    GeneRIF: Regulatory pathways and therapeutic potential of PDE4 in
            liver pathophysiology.
            Review article
REFERENCE   3  (bases 1 to 4897)
  AUTHORS   Louveau,B., Reger De Moura,C., Jouenne,F., Sadoux,A., Allayous,C.,
            Da Meda,L., Bernard-Cacciarella,M., Baroudjian,B., Lebbe,C.,
            Mourah,S. and Dumaz,N.
  TITLE     Combined PDE4+MEK inhibition shows antiproliferative effects in
            NRASQ61 mutated melanoma preclinical models
  JOURNAL   Melanoma Res 34 (2), 186-192 (2024)
   PUBMED   38141200
  REMARK    GeneRIF: Combined PDE4+MEK inhibition shows antiproliferative
            effects in NRASQ61 mutated melanoma preclinical models.
REFERENCE   4  (bases 1 to 4897)
  AUTHORS   Liadaki,K., Zafiriou,E., Giannoulis,T., Alexouda,S., Chaidaki,K.,
            Gidarokosta,P., Roussaki-Schulze,A.V., Tsiogkas,S.G., Daponte,A.,
            Mamuris,Z., Bogdanos,D.P., Moschonas,N.K. and Sarafidou,T.
  TITLE     PDE4 Gene Family Variants Are Associated with Response to
            Apremilast Treatment in Psoriasis
  JOURNAL   Genes (Basel) 15 (3), 369 (2024)
   PUBMED   38540428
  REMARK    GeneRIF: PDE4 Gene Family Variants Are Associated with Response to
            Apremilast Treatment in Psoriasis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4897)
  AUTHORS   Elnagdy,M., Wang,Y., Rodriguez,W., Zhang,J., Bauer,P., Wilkey,D.W.,
            Merchant,M., Pan,J., Farooqui,Z., Cannon,R., Rai,S., Maldonado,C.,
            Barve,S., McClain,C.J. and Gobejishvili,L.
  TITLE     Increased expression of phosphodiesterase 4 in activated hepatic
            stellate cells promotes cytoskeleton remodeling and cell migration
  JOURNAL   J Pathol 261 (3), 361-371 (2023)
   PUBMED   37735782
  REMARK    GeneRIF: Increased expression of phosphodiesterase 4 in activated
            hepatic stellate cells promotes cytoskeleton remodeling and cell
            migration.
REFERENCE   6  (bases 1 to 4897)
  AUTHORS   Horton,Y.M., Sullivan,M. and Houslay,M.D.
  TITLE     Molecular cloning of a novel splice variant of human type IVA
            (PDE-IVA) cyclic AMP phosphodiesterase and localization of the gene
            to the p13.2-q12 region of human chromosome 19 [corrected]
  JOURNAL   Biochem J 308 (Pt 2) (Pt 2), 683-691 (1995)
   PUBMED   7772058
  REMARK    Erratum:[Biochem J 1995 Dec 15;312(Pt 3):991]
REFERENCE   7  (bases 1 to 4897)
  AUTHORS   Sullivan,M., Egerton,M., Shakur,Y., Marquardsen,A. and Houslay,M.D.
  TITLE     Molecular cloning and expression, in both COS-1 cells and S.
            cerevisiae, of a human cytosolic type-IVA, cyclic AMP specific
            phosphodiesterase (hPDE-IVA-h6.1)
  JOURNAL   Cell Signal 6 (7), 793-812 (1994)
   PUBMED   7888306
REFERENCE   8  (bases 1 to 4897)
  AUTHORS   Milatovich,A., Bolger,G., Michaeli,T. and Francke,U.
  TITLE     Chromosome localizations of genes for five cAMP-specific
            phosphodiesterases in man and mouse
  JOURNAL   Somat Cell Mol Genet 20 (2), 75-86 (1994)
   PUBMED   8009369
REFERENCE   9  (bases 1 to 4897)
  AUTHORS   Bolger,G., Michaeli,T., Martins,T., St John,T., Steiner,B.,
            Rodgers,L., Riggs,M., Wigler,M. and Ferguson,K.
  TITLE     A family of human phosphodiesterases homologous to the dunce
            learning and memory gene product of Drosophila melanogaster are
            potential targets for antidepressant drugs
  JOURNAL   Mol Cell Biol 13 (10), 6558-6571 (1993)
   PUBMED   8413254
REFERENCE   10 (bases 1 to 4897)
  AUTHORS   Livi,G.P., Kmetz,P., McHale,M.M., Cieslinski,L.B., Sathe,G.M.,
            Taylor,D.P., Davis,R.L., Torphy,T.J. and Balcarek,J.M.
  TITLE     Cloning and expression of cDNA for a human low-Km,
            rolipram-sensitive cyclic AMP phosphodiesterase
  JOURNAL   Mol Cell Biol 10 (6), 2678-2686 (1990)
   PUBMED   2160582
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011548.4, L20965.1,
            BC038234.1, AC011461.5, BE266386.1 and BQ009232.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001111307.1.
            
            Summary: The protein encoded by this gene belongs to the cyclic
            nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This
            PDE hydrolyzes the second messenger, cAMP, which is a regulator and
            mediator of a number of cellular responses to extracellular
            signals. Thus, by regulating the cellular concentration of cAMP,
            this protein plays a key role in many important physiological
            processes. Alternatively spliced transcript variants encoding
            different isoforms have been described for this gene.[provided by
            RefSeq, Jul 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2154665,
                              SAMEA2158188 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380702.7/ ENSP00000370078.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               AC011548.4         11910-12028         c
            120-201             L20965.1           9-90
            202-203             AC011548.4         11826-11827         c
            204-1459            L20965.1           92-1347
            1460-3198           BC038234.1         841-2579
            3199-3555           L20965.1           3086-3442
            3556-3724           AC011461.5         12199-12367
            3725-4147           BE266386.1         28-450
            4148-4279           AC011461.5         12791-12922
            4280-4897           BQ009232.1         18-635              c
FEATURES             Location/Qualifiers
     source          1..4897
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..4897
                     /gene="PDE4A"
                     /gene_synonym="DPDE2; PDE4; PDE46"
                     /note="phosphodiesterase 4A"
                     /db_xref="GeneID:5141"
                     /db_xref="HGNC:HGNC:8780"
                     /db_xref="MIM:600126"
     exon            1..547
                     /gene="PDE4A"
                     /gene_synonym="DPDE2; PDE4; PDE46"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..2888
                     /gene="PDE4A"
                     /gene_synonym="DPDE2; PDE4; PDE46"
                     /EC_number="3.1.4.53"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phosphodiesterase 4A, cAMP-specific (dunce; cAMP-specific
                     3',5'-cyclic phosphodiesterase 4A; phosphodiesterase E2
                     dunce homolog, Drosophila; phosphodiesterase isozyme 4;
                     cAMP-specific phosphodiesterase 4A; 3',5'-cyclic-AMP
                     phosphodiesterase 4A"
                     /codon_start=1
                     /product="3',5'-cyclic-AMP phosphodiesterase 4A isoform 1"
                     /protein_id="NP_001104777.1"
                     /db_xref="CCDS:CCDS45961.1"
                     /db_xref="GeneID:5141"
                     /db_xref="HGNC:HGNC:8780"
                     /db_xref="MIM:600126"
                     /translation="MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQ
                     QRGYSDSAERAERERQPHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGG
                     GSSRRFEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKT
                     MSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVC
                     KATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEM
                     SRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQ
                     ITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLT
                     CIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLA
                     TPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLA
                     VGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVT
                     SSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERG
                     MEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSA
                     IRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLS
                     GVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSS
                     REEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAK
                     RACSACAGTFGEDTSALPAPGGGGSGGDPT"
     exon            548..739
                     /gene="PDE4A"
                     /gene_synonym="DPDE2; PDE4; PDE46"
                     /inference="alignment:Splign:2.1.0"
     exon            740..776
                     /gene="PDE4A"
                     /gene_synonym="DPDE2; PDE4; PDE46"
                     /inference="alignment:Splign:2.1.0"
     exon            777..847
                     /gene="PDE4A"
                     /gene_synonym="DPDE2; PDE4; PDE46"
                     /inference="alignment:Splign:2.1.0"
     exon            848..897
                     /gene="PDE4A"
                     /gene_synonym="DPDE2; PDE4; PDE46"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1010
                     /gene="PDE4A"
                     /gene_synonym="DPDE2; PDE4; PDE46"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1104
                     /gene="PDE4A"
                     /gene_synonym="DPDE2; PDE4; PDE46"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1328
                     /gene="PDE4A"
                     /gene_synonym="DPDE2; PDE4; PDE46"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1427
                     /gene="PDE4A"
                     /gene_synonym="DPDE2; PDE4; PDE46"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1592
                     /gene="PDE4A"
                     /gene_synonym="DPDE2; PDE4; PDE46"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1692
                     /gene="PDE4A"
                     /gene_synonym="DPDE2; PDE4; PDE46"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1847
                     /gene="PDE4A"
                     /gene_synonym="DPDE2; PDE4; PDE46"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..1970
                     /gene="PDE4A"
                     /gene_synonym="DPDE2; PDE4; PDE46"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2153
                     /gene="PDE4A"
                     /gene_synonym="DPDE2; PDE4; PDE46"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..4897
                     /gene="PDE4A"
                     /gene_synonym="DPDE2; PDE4; PDE46"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4876..4881
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDE4A"
                     /gene_synonym="DPDE2; PDE4; PDE46"
                     /note="hexamer: ATTAAA"
     polyA_site      4897
                     /gene="PDE4A"
                     /gene_synonym="DPDE2; PDE4; PDE46"
                     /note="major polyA site"
ORIGIN      
        1 gagcgccgcc gggcactgag cagagctcca ggcgccgaaa ggaagctgca gagcccggcc
       61 cgggggcgat tggcccgcag cgcccccggg tctgtccccg gggcgccatg gccctaccgc
      121 ggccgggcgc acccgcgggg ccctgggctc gctggcttgc gcgcagctga gcggggtgta
      181 ggttggaagg gccagggccc cctggggcgc aagtgggggc cggcgccatg gaacccccga
      241 ccgtcccctc ggaaaggagc ctgtctctgt cactgcccgg gccccgggag ggccaggcca
      301 ccctgaagcc tcccccgcag cacctgtggc ggcagcctcg gacccccatc cgtatccagc
      361 agcgcggcta ctccgacagc gcggagcgcg ccgagcggga gcggcagccg caccggccca
      421 tagagcgcgc cgatgccatg gacaccagcg accggcccgg cctgcgcacg acccgcatgt
      481 cctggccctc gtccttccat ggcactggca ccggcagcgg cggcgcgggc ggaggcagca
      541 gcaggcgctt cgaggcagag aatgggccga caccatctcc tggccgcagc cccctggact
      601 cgcaggcgag cccaggactc gtgctgcacg ccggggcggc caccagccag cgccgggagt
      661 ccttcctgta ccgctcagac agcgactatg acatgtcacc caagaccatg tcccggaact
      721 catcggtcac cagcgaggcg cacgctgaag acctcatcgt aacaccattt gctcaggtgc
      781 tggccagcct ccggagcgtc cgtagcaact tctcactcct gaccaatgtg cccgttccca
      841 gtaacaagcg gtccccgctg ggcggcccca cccctgtctg caaggccacg ctgtcagaag
      901 aaacgtgtca gcagttggcc cgggagactc tggaggagct ggactggtgt ctggagcagc
      961 tggagaccat gcagacctat cgctctgtca gcgagatggc ctcgcacaag ttcaaaagga
     1021 tgttgaaccg tgagctcaca cacctgtcag aaatgagcag gtccggaaac caggtctcag
     1081 agtacatttc cacaacattc ctggacaaac agaatgaagt ggagatccca tcacccacga
     1141 tgaaggaacg agaaaaacag caagcgccgc gaccaagacc ctcccagccg cccccgcccc
     1201 ctgtaccaca cttacagccc atgtcccaaa tcacagggtt gaaaaagttg atgcatagta
     1261 acagcctgaa caactctaac attccccgat ttggggtgaa gaccgatcaa gaagagctcc
     1321 tggcccaaga actggagaac ctgaacaagt ggggcctgaa catcttttgc gtgtcggatt
     1381 acgctggagg ccgctcactc acctgcatca tgtacatgat attccaggag cgggacctgc
     1441 tgaagaaatt ccgcatccct gtggacacga tggtgacata catgctgacg ctggaggatc
     1501 actaccacgc tgacgtggcc taccataaca gcctgcacgc agctgacgtg ctgcagtcca
     1561 cccacgtact gctggccacg cctgcactag atgcagtgtt cacggacctg gagattctcg
     1621 ccgccctctt cgcggctgcc atccacgatg tggatcaccc tggggtctcc aaccagttcc
     1681 tcatcaacac caattcggag ctggcgctca tgtacaacga tgagtcggtg ctcgagaatc
     1741 accacctggc cgtgggcttc aagctgctgc aggaggacaa ctgcgacatc ttccagaacc
     1801 tcagcaagcg ccagcggcag agcctacgca agatggtcat cgacatggtg ctggccacgg
     1861 acatgtccaa gcacatgacc ctcctggctg acctgaagac catggtggag accaagaaag
     1921 tgaccagctc aggggtcctc ctgctagata actactccga ccgcatccag gtcctccgga
     1981 acatggtgca ctgtgccgac ctcagcaacc ccaccaagcc gctggagctg taccgccagt
     2041 ggacagaccg catcatggcc gagttcttcc agcagggtga ccgagagcgc gagcgtggca
     2101 tggaaatcag ccccatgtgt gacaagcaca ctgcctccgt ggagaagtct caggtgggtt
     2161 ttattgacta cattgtgcac ccattgtggg agacctgggc ggaccttgtc cacccagatg
     2221 cccaggagat cttggacact ttggaggaca accgggactg gtactacagc gccatccggc
     2281 agagcccatc tccgccaccc gaggaggagt caagggggcc aggccaccca cccctgcctg
     2341 acaagttcca gtttgagctg acgctggagg aggaagagga ggaagaaata tcaatggccc
     2401 agataccgtg cacagcccaa gaggcattga ctgcgcaggg attgtcagga gtcgaggaag
     2461 ctctggatgc aaccatagcc tgggaggcat ccccggccca ggagtcgttg gaagttatgg
     2521 cacaggaagc atccctggag gccgagctgg aggcagtgta tttgacacag caggcacagt
     2581 ccacaggcag tgcacctgtg gctccggatg agttctcgtc ccgggaggaa ttcgtggttg
     2641 ctgtaagcca cagcagcccc tctgccctgg ctcttcaaag cccccttctc cctgcttgga
     2701 ggaccctgtc tgtttcagag catgccccgg gcctcccggg cctcccctcc acggcggccg
     2761 aggtggaggc ccaacgagag caccaggctg ccaagagggc ttgcagtgcc tgcgcaggga
     2821 catttgggga ggacacatcc gcactcccag ctcctggtgg cggggggtca ggtggagacc
     2881 ctacctgatc cccagacctc tgtccctgtt cccctccact cctcccctca ctcccctgct
     2941 cccccgacca cctcctcctc tgcctcaaag actcttgtcc tcttgtccct cctgagaaaa
     3001 aagaaaacga aaagtggggt ttttttctgt tttctttttt tcccctttcc ccctgccccc
     3061 acccacgggg cctttttttg gaggtggggg ctggggaatg aggggctgag gtcccggaag
     3121 ggattttatt tttttgaatt ttaattgtaa catttttaga aaaagaacaa aaaaagaaaa
     3181 aaaaaagaaa gaaacacagc aactgtagat gctcctgttc ctggttcccg ctttccactt
     3241 ccaaatccct cccctcacct tcccccactg ccccccaagt tccaggctca gtcttccagc
     3301 cgcctgggga gtctctacct gggcccaagc aggtgtgggg cctccttctg ggcttttctt
     3361 ctgaatttag aggatttcta gaacgtggtc aggaatagcc attctaggcg gggctggggc
     3421 cagggtgggg ggcagtcact gtgggaggtc ccagctccag cccccctctg gtttgctgcc
     3481 tcctctcccc tctaaaaaag tcttccgctt gattttgcac aatcccggcg atactcctgg
     3541 cgatactgac tagaaagtca gggagctggg ggagctgttc actttaggat acgggggtgg
     3601 tatggaaggg agcgttcaca ccgccagcct cgggcctggg atttgaggag ggccctagac
     3661 ctcctccact ctccatcccc tttcccttcc actttgggtt cactttgaat tttctccgtt
     3721 ttttggggca gtggctctga tccactcacc cccccgcccc ccgccccact tctagctgct
     3781 tctcctcttg tttctgcctt aataattccc acggccacag gcaagggggt tgcagtggcc
     3841 gcctgcacct tggatgaggc agggccaggc gcccagaacc cccatcctgg ccgcaccccc
     3901 ctttccaggg tcctccggac cccaccttcc acactctgat cacagccccc ctaccttttg
     3961 ccctaggagg aagcaataat ggtgtatacc ctcattctca ttcctgggca gcccttcctt
     4021 ccaccctggc accaaaataa tttctcctcc atccgtacct tgcctagcct ctccctctcc
     4081 cccagctagt ccctgagcaa tacggcagac agatgcaaga ccatttttct ccaagccatg
     4141 ggggactgtt tggaaggaaa gccccctctc tccctcctcc cctcgccctc ggcctggttc
     4201 tgcagctgga ccgacctcat tcatcgcctg ccccctaccc aattctgagc acacggtact
     4261 gtagccccca gttcctccct agccttccat ccctctgtcc accccagggg gaggtaaccc
     4321 cgcactcaca ctcccttgat gctgtctgta cagggttcat attttgtagc gaaagtcgtt
     4381 tttgtcccag ccggcgatcg gagtgggcct tttctttctt tttgttcatt ctttaccttt
     4441 ttttcttttc tttctttctt ttttgtacat actgtaaggt tggtttgtaa attattctac
     4501 ggaggcaaaa agggaaaata aaaacttgcc cttccctggc tgacccagtc gggaaggtag
     4561 ggaaggaggt ctcccgttgg gagagtctct gttcctgctg tattatacaa actgtaccat
     4621 agtcctggga aaagggtgga ctcaccgctg ttgttttatg ggaagtcgtg tcatcctagg
     4681 ggttggggct gggcagagcc tgtcccctcc ccccttctcc aggagccagg gggtgactgg
     4741 agagacagac ccacccccaa gcagggctcc tctccccagg gtgagcacag gacctctgta
     4801 agctgcttgt gtattgtcca ctttgacgat cagtcattcg gtccgttgat caataatcct
     4861 tcgatcttgt ctccaattaa accgaggctt tcaccga
//
