LOCUS       NM_000922               5995 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens phosphodiesterase 3B (PDE3B), transcript variant 2,
            mRNA.
ACCESSION   NM_000922 NM_000753
VERSION     NM_000922.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5995)
  AUTHORS   Feng,Y., Huang,Z., Song,L., Li,N., Li,X., Shi,H., Liu,R., Lu,F.,
            Han,X., Ding,Y., Ding,Y., Wang,J., Yang,J. and Jia,Z.
  TITLE     PDE3B regulates KRT6B and increases the sensitivity of bladder
            cancer cells to copper ionophores
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 397 (7), 4911-4925 (2024)
   PUBMED   38165426
  REMARK    GeneRIF: PDE3B regulates KRT6B and increases the sensitivity of
            bladder cancer cells to copper ionophores.
REFERENCE   2  (bases 1 to 5995)
  AUTHORS   Zhou,P., Wu,Z., Zhang,Q., Wang,L., Zhang,W. and Han,X.
  TITLE     A novel link between circPDE3B and ferroptosis in esophageal
            squamous cell carcinoma progression
  JOURNAL   Genomics 116 (1), 110761 (2024)
   PUBMED   38092323
  REMARK    GeneRIF: A novel link between circPDE3B and ferroptosis in
            esophageal squamous cell carcinoma progression.
REFERENCE   3  (bases 1 to 5995)
  AUTHORS   Dolce,B., Christ,T., Grammatika Pavlidou,N., Yildirim,Y.,
            Reichenspurner,H., Eschenhagen,T., Nikolaev,V.O., Kaumann,A.J. and
            Molina,C.E.
  TITLE     Impact of phosphodiesterases PDE3 and PDE4 on 5-hydroxytryptamine
            receptor4-mediated increase of cAMP in human atrial fibrillation
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 394 (2), 291-298 (2021)
   PUBMED   32949251
  REMARK    GeneRIF: Impact of phosphodiesterases PDE3 and PDE4 on
            5-hydroxytryptamine receptor4-mediated increase of cAMP in human
            atrial fibrillation.
REFERENCE   4  (bases 1 to 5995)
  AUTHORS   Rassi-Cruz,M., Maria,A.G., Faucz,F.R., London,E., Vilela,L.A.P.,
            Santana,L.S., Benedetti,A.F.F., Goldbaum,T.S., Tanno,F.Y.,
            Srougi,V., Chambo,J.L., Pereira,M.A.A., Cavalcante,A.C.B.S.,
            Carnevale,F.C., Pilan,B., Bortolotto,L.A., Drager,L.F.,
            Lerario,A.M., Latronico,A.C., Fragoso,M.C.B.V., Mendonca,B.B.,
            Zerbini,M.C.N., Stratakis,C.A. and Almeida,M.Q.
  TITLE     Phosphodiesterase 2A and 3B variants are associated with primary
            aldosteronism
  JOURNAL   Endocr Relat Cancer 28 (1), 1-13 (2021)
   PUBMED   33112806
  REMARK    GeneRIF: Phosphodiesterase 2A and 3B variants are associated with
            primary aldosteronism.
REFERENCE   5  (bases 1 to 5995)
  AUTHORS   Gottel,C., Niesen,S., Daub,V., Werle,T., Bakuradze,T.,
            Winterhalter,P. and Richling,E.
  TITLE     In Vitro Inhibition of Phosphodiesterase 3B (PDE 3B) by
            Anthocyanin-Rich Fruit Juice Extracts and Selected Anthocyanins
  JOURNAL   Int J Mol Sci 21 (18), 6934 (2020)
   PUBMED   32967310
  REMARK    GeneRIF: In Vitro Inhibition of Phosphodiesterase 3B (PDE 3B) by
            Anthocyanin-Rich Fruit Juice Extracts and Selected Anthocyanins.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5995)
  AUTHORS   Murata,T., Taira,M. and Manganiello,V.C.
  TITLE     Differential expression of cGMP-inhibited cyclic nucleotide
            phosphodiesterases in human hepatoma cell lines
  JOURNAL   FEBS Lett 390 (1), 29-33 (1996)
   PUBMED   8706823
REFERENCE   7  (bases 1 to 5995)
  AUTHORS   Rahn,T., Ronnstrand,L., Leroy,M.J., Wernstedt,C., Tornqvist,H.,
            Manganiello,V.C., Belfrage,P. and Degerman,E.
  TITLE     Identification of the site in the cGMP-inhibited phosphodiesterase
            phosphorylated in adipocytes in response to insulin and
            isoproterenol
  JOURNAL   J Biol Chem 271 (19), 11575-11580 (1996)
   PUBMED   8626720
REFERENCE   8  (bases 1 to 5995)
  AUTHORS   Loughney,K., Martins,T.J., Harris,E.A., Sadhu,K., Hicks,J.B.,
            Sonnenburg,W.K., Beavo,J.A. and Ferguson,K.
  TITLE     Isolation and characterization of cDNAs corresponding to two human
            calcium, calmodulin-regulated, 3',5'-cyclic nucleotide
            phosphodiesterases
  JOURNAL   J Biol Chem 271 (2), 796-806 (1996)
   PUBMED   8557689
REFERENCE   9  (bases 1 to 5995)
  AUTHORS   Manganiello,V.C., Taira,M., Degerman,E. and Belfrage,P.
  TITLE     Type III cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE3
            gene family)
  JOURNAL   Cell Signal 7 (5), 445-455 (1995)
   PUBMED   8562305
  REMARK    Review article
REFERENCE   10 (bases 1 to 5995)
  AUTHORS   Rascon,A., Degerman,E., Taira,M., Meacci,E., Smith,C.J.,
            Manganiello,V., Belfrage,P. and Tornqvist,H.
  TITLE     Identification of the phosphorylation site in vitro for
            cAMP-dependent protein kinase on the rat adipocyte cGMP-inhibited
            cAMP phosphodiesterase
  JOURNAL   J Biol Chem 269 (16), 11962-11966 (1994)
   PUBMED   8163498
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC150307.1, BC136565.1 and AC090835.7.
            
            On Nov 22, 2018 this sequence version replaced NM_000922.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.52394.1,
                                           SRR1660803.66885.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282096.9/ ENSP00000282096.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                BC150307.1         82-108
            28-3845             BC136565.1         2-3819
            3846-5995           AC090835.7         147818-149967       c
FEATURES             Location/Qualifiers
     source          1..5995
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.2"
     gene            1..5995
                     /gene="PDE3B"
                     /gene_synonym="cGIPDE1; HcGIP1"
                     /note="phosphodiesterase 3B"
                     /db_xref="GeneID:5140"
                     /db_xref="HGNC:HGNC:8779"
                     /db_xref="MIM:602047"
     exon            1..1250
                     /gene="PDE3B"
                     /gene_synonym="cGIPDE1; HcGIP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..3611
                     /gene="PDE3B"
                     /gene_synonym="cGIPDE1; HcGIP1"
                     /EC_number="3.1.4.17"
                     /note="isoform 2 is encoded by transcript variant 2;
                     cGMP-inhibited 3',5'-cyclic phosphodiesterase B; cyclic
                     nucleotide phosphodiesterase; CGIP1; CGI-PDE B; cyclic
                     GMP-inhibited phosphodiesterase B; phosphodiesterase 3B,
                     cGMP-inhibited; cGMP-inhibited 3',5'-cyclic
                     phosphodiesterase 3B"
                     /codon_start=1
                     /product="cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B
                     isoform 2"
                     /protein_id="NP_000913.2"
                     /db_xref="CCDS:CCDS7817.1"
                     /db_xref="GeneID:5140"
                     /db_xref="HGNC:HGNC:8779"
                     /db_xref="MIM:602047"
                     /translation="MRRDERDAKAMRSLQPPDGAGSPPESLRNGYVKSCVSPLRQDPP
                     RGFFFHLCRFCNVELRPPPASPQQPRRCSPFCRARLSLGALAAFVLALLLGAEPESWA
                     AGAAWLRTLLSVCSHSLSPLFSIACAFFFLTCFLTRTKRGPGPGRSCGSWWLLALPAC
                     CYLGDFLVWQWWSWPWGDGDAGSAAPHTPPEAAAGRLLLVLSCVGLLLTLAHPLRLRH
                     CVLVLLLASFVWWVSFTSLGSLPSALRPLLSGLVGGAGCLLALGLDHFFQIREAPLHP
                     RLSSAAEEKVPVIRPRRRSSCVSLGETAASYYGSCKIFRRPSLPCISREQMILWDWDL
                     KQWYKPHYQNSGGGNGVDLSVLNEARNMVSDLLTDPSLPPQVISSLRSISSLMGAFSG
                     SCRPKINPLTPFPGFYPCSEIEDPAEKGDRKLNKGLNRNSLPTPQLRRSSGTSGLLPV
                     EQSSRWDRNNGKRPHQEFGISSQGCYLNGPFNSNLLTIPKQRSSSVSLTHHVGLRRAG
                     VLSSLSPVNSSNHGPVSTGSLTNRSPIEFPDTADFLNKPSVILQRSLGNAPNTPDFYQ
                     QLRNSDSNLCNSCGHQMLKYVSTSESDGTDCCSGKSGEEENIFSKESFKLMETQQEEE
                     TEKKDSRKLFQEGDKWLTEEAQSEQQTNIEQEVSLDLILVEEYDSLIEKMSNWNFPIF
                     ELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENGYRDIPYHNRI
                     HATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYISSKSCSNPDES
                     YGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAA
                     SAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNS
                     NGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGLP
                     ISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWLEAEEDNDTESGDDEDG
                     EELDTEDEEMENNLNPKPPRRKSRRRIFCQLMHHLTENHKIWKEIVEEEEKCKADGNK
                     LQVENSSLPQADEIQVIEEADEEE"
     exon            1251..1301
                     /gene="PDE3B"
                     /gene_synonym="cGIPDE1; HcGIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1550
                     /gene="PDE3B"
                     /gene_synonym="cGIPDE1; HcGIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1687
                     /gene="PDE3B"
                     /gene_synonym="cGIPDE1; HcGIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1794
                     /gene="PDE3B"
                     /gene_synonym="cGIPDE1; HcGIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..2005
                     /gene="PDE3B"
                     /gene_synonym="cGIPDE1; HcGIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2079
                     /gene="PDE3B"
                     /gene_synonym="cGIPDE1; HcGIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2228
                     /gene="PDE3B"
                     /gene_synonym="cGIPDE1; HcGIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2366
                     /gene="PDE3B"
                     /gene_synonym="cGIPDE1; HcGIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2367..2478
                     /gene="PDE3B"
                     /gene_synonym="cGIPDE1; HcGIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2479..2592
                     /gene="PDE3B"
                     /gene_synonym="cGIPDE1; HcGIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..2792
                     /gene="PDE3B"
                     /gene_synonym="cGIPDE1; HcGIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2793..2996
                     /gene="PDE3B"
                     /gene_synonym="cGIPDE1; HcGIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2997..3158
                     /gene="PDE3B"
                     /gene_synonym="cGIPDE1; HcGIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3159..3411
                     /gene="PDE3B"
                     /gene_synonym="cGIPDE1; HcGIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3412..5995
                     /gene="PDE3B"
                     /gene_synonym="cGIPDE1; HcGIP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5297..5302
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDE3B"
                     /gene_synonym="cGIPDE1; HcGIP1"
                     /note="hexamer: AATAAA"
     polyA_site      5320
                     /gene="PDE3B"
                     /gene_synonym="cGIPDE1; HcGIP1"
                     /note="major polyA site"
     regulatory      5973..5978
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDE3B"
                     /gene_synonym="cGIPDE1; HcGIP1"
                     /note="hexamer: CATAAA"
     polyA_site      5986
                     /gene="PDE3B"
                     /gene_synonym="cGIPDE1; HcGIP1"
     polyA_site      5995
                     /gene="PDE3B"
                     /gene_synonym="cGIPDE1; HcGIP1"
                     /note="major polyA site"
ORIGIN      
        1 agtcccgaga ggtgcccgag ggaaaaggag gcggcagcta aactggtcct ggagagaagc
       61 cccttccgcc cctctcctca gccagcatgt cccggactcc gccgctcctc agtccgcgcg
      121 gtggggaccc cgggccgtgg cggccggcgc agccctgacg ggttgcgaac cagggggcgc
      181 cccgaacgcg ggggttgggg tctgggagcg cgagcggccg ctacggtacg agcggggtgt
      241 gctgagtccc gtggccaccc ccggccccag ccatgaggag ggacgagcga gacgccaaag
      301 ccatgcggtc cctgcagccg ccggatgggg ccggctcgcc ccccgagagt ctgaggaacg
      361 gctacgtgaa gagctgcgtg agccccttgc ggcaggaccc tccgcgcggc ttcttcttcc
      421 acctctgccg cttctgcaac gtggagctgc ggccgccgcc ggcctctccc cagcagccgc
      481 ggcgctgctc ccccttctgc cgggcgcgcc tctcgctggg cgccctggct gcctttgtcc
      541 tcgccctgct gctgggcgcg gaacccgaga gctgggctgc cggggccgcc tggctgcgga
      601 cgctgctgag cgtgtgttcg cacagcttga gccccctctt cagcatcgcc tgtgccttct
      661 tcttcctcac ctgcttcctc acccggacca agcggggacc cggcccgggc cggagctgcg
      721 gctcctggtg gctgctggcg ctgcccgcct gctgttacct gggggacttc ttggtgtggc
      781 agtggtggtc ttggccttgg ggggatggcg acgcagggtc cgcggccccg cacacgcccc
      841 cggaggcggc agcgggcagg ttgctgctgg tgctgagctg cgtagggctg ctgctgacgc
      901 tcgcgcaccc gctgcggctc cggcactgcg ttctggtgct gctcctggcc agcttcgtct
      961 ggtgggtctc cttcaccagc ctcgggtcgc tgccctccgc cctcaggccg ctgctctccg
     1021 gcctggtggg gggcgctggc tgcctgctgg ccctggggtt ggatcacttc tttcaaatca
     1081 gggaagcgcc tcttcatcct cgactgtcca gtgccgccga agaaaaagtg cctgtgatcc
     1141 gaccccggag gaggtccagc tgcgtgtcgt taggagaaac tgcagccagt tactatggca
     1201 gttgcaaaat attcaggaga ccgtcgttgc cttgtatttc cagagaacag atgattcttt
     1261 gggattggga cttaaaacaa tggtataagc ctcattatca aaattctgga ggtggaaatg
     1321 gagttgatct ttcagtgcta aatgaggctc gcaatatggt gtcagatctt ctgactgatc
     1381 caagccttcc accacaagtc atttcctctc tacggagtat tagtagctta atgggtgctt
     1441 tctcaggttc ctgtaggcca aagattaatc ctctcacacc atttcctgga ttttacccct
     1501 gttctgaaat agaggaccca gctgagaaag gggatagaaa acttaacaag ggactaaata
     1561 ggaatagttt gccaactcca cagctgagga gaagctcagg aacttcagga ttgctacctg
     1621 ttgaacagtc ttcaaggtgg gatcgtaata atggcaaaag acctcaccaa gaatttggca
     1681 tttcaagtca aggatgctat ctaaatgggc cttttaattc aaatctactg actatcccga
     1741 agcaaaggtc atcttctgta tcactgactc accatgtagg tctcagaaga gctggtgttt
     1801 tgtccagtct gagtcctgtg aattcttcca accatggacc agtgtctact ggctctctaa
     1861 ctaatcgatc acccatagaa tttcctgata ctgctgattt tcttaataag ccaagcgtta
     1921 tcttgcagag atctctgggc aatgcaccta atactccaga tttttatcag caacttagaa
     1981 attctgatag caatctgtgt aacagctgtg gacatcaaat gctgaaatat gtttcaacat
     2041 ctgaatcaga tggtacagat tgctgcagtg gaaaatcagg tgaagaagaa aacattttct
     2101 cgaaagaatc attcaaactt atggaaactc aacaagaaga ggaaacagag aagaaagaca
     2161 gcagaaaatt atttcaggaa ggtgataagt ggctaacaga agaggcacag agtgaacagc
     2221 aaacaaatat tgaacaggaa gtatcactgg acctgatttt agtagaagag tatgactcat
     2281 taatagaaaa gatgagcaac tggaattttc caatttttga acttgtagaa aagatgggag
     2341 agaaatcagg aaggattctc agtcaggtta tgtatacctt atttcaagac actggtttat
     2401 tggaaatatt taaaattccc actcaacaat ttatgaacta ttttcgtgca ttagaaaatg
     2461 gctatcgaga cattccttat cacaatcgta tacatgccac agatgtgcta catgcagttt
     2521 ggtatctgac aacacggcca gttcctggct tacagcagat ccacaatggt tgtggaacag
     2581 gaaatgaaac agattctgat ggtagaatta accatgggcg aattgcttat atttcttcga
     2641 agagctgctc taatcctgat gagagttatg gctgcctgtc ttcaaacatt cctgcattag
     2701 aattgatggc tctatacgtg gcagctgcca tgcatgatta tgatcaccca gggaggacaa
     2761 atgcatttct agtggctaca aatgcccctc aggcagtttt atacaatgac agatctgttc
     2821 tggaaaatca tcatgctgcg tcagcttgga atctatatct ttctcgccca gaatacaact
     2881 tccttcttca tcttgatcat gtggaattca agcgctttcg ttttttagtc attgaagcaa
     2941 tccttgctac ggatcttaaa aagcattttg attttctcgc agaattcaat gccaaggcaa
     3001 atgatgtaaa tagtaatggc atagaatgga gtaatgaaaa tgatcgcctc ttggtatgcc
     3061 aggtgtgcat caaactggca gatataaatg gcccagcaaa agttcgagac ttgcatttga
     3121 aatggacaga aggcattgtc aatgaatttt atgagcaggg agatgaagaa gcaaatcttg
     3181 gtctgcccat cagtccattc atggatcgtt cttctcctca actagcaaaa ctccaagaat
     3241 cttttatcac ccacatagtg ggtcccctgt gtaactccta tgatgctgct ggtttgctac
     3301 caggtcagtg gttagaagca gaagaggata atgatactga aagtggtgat gatgaagacg
     3361 gtgaagaatt agatacagaa gatgaagaaa tggaaaacaa tctaaatcca aaaccaccaa
     3421 gaaggaaaag cagacggcga atattttgtc agctaatgca ccacctcact gaaaaccaca
     3481 agatatggaa ggaaatcgta gaggaagaag aaaaatgtaa agctgatggg aataaactgc
     3541 aggtggagaa ttcctcctta cctcaagcag atgagattca ggtaattgaa gaggcagatg
     3601 aagaggaata gcgacagttt gagtaaaaga aaagtcatat tgaagaagcc cagagggttg
     3661 tgcccagggg cagaaatcat tgcctagtgt tcaccggctg actctcaact gaccattccc
     3721 atgtggacag gccttaatac tgtgagagga tccttgctct gctggcagtt tcccactcct
     3781 atgcactttc acaggaacta gaaaactatt cttaaaccaa aaataccatc cgtgttgacc
     3841 catgttgcag agcccttact taaatccttc actggtgtat gaatactttg tcataatgct
     3901 gctttgctgg gtagtgagct cttatttttc actgggggtc agctataact aaaaactcaa
     3961 gtgacatatt tcagttacca aagtggccag gaactttttg cttttatgaa aatagattca
     4021 tattgtattt cccagtgtgt cttttatgtc tttgaatgtt ttggagaaaa gtctatgcct
     4081 gtctaaaaat gaatccagtg ttgcctttct gagggatttc tgctcaatgc aatacactgt
     4141 tcagtgctat tctcccagct aggtttatcc atgaaggact gagtgacctt tgttgtattt
     4201 aacaaaatcc aggtgcatca atttctgatg ctttttacta ttgtgtatta tctactatgt
     4261 gtgttttatt tctgctgaga gtattcaggt ttgccatgga catcagaagt ttgaattcca
     4321 gtcttatctt atgttccatg gctgaatttt aaagctgttt aggtttaaca atgaagggat
     4381 ttattcttta gtcaaaattg ttgtttttac tctagctcag gattcgtatt tttaaagatt
     4441 tagttaatat gaacacagca cagatttgtt agaagaaaaa aaatttgctg taataccaaa
     4501 actaacctca tcaaagatac agaaaaaaag aaatatagtg agccctaaag gacacataca
     4561 ttgaataaat aattggaaca tgtggttatc tttagatcca catcttagct gtcatttgtt
     4621 cactctaaaa ctgatgttca tctttctgtt aatttccctc tgcctaaaga ctacatgaca
     4681 gaaatgacct atcactactt attatttctg aagcctaact gcaagactga tttctgagaa
     4741 caagtaaaga actggaatac ttatttttca tataaaaatc taaatgtgtt aataaatcat
     4801 ttcatacaaa agtacattat taaataacca cattattaaa ataattgcaa gaaaatggac
     4861 catatttaca atgttttgta aacttgctag tgtgtggata tgtaccctac ttgtgaaata
     4921 catttgaaga tataaagagc agccaaaatg atggcaaaat ggtaggctaa tattttctat
     4981 tattattgga gaacatatca tattttggaa tcatgcaatt ttgcacacag tgaaaccatt
     5041 aattttccaa ggtaattcct ttagaatatg gtattggcat gcagtttctt acttatctag
     5101 aatatttggc ttatctgaaa gatatcaatt taagatctct ggaagtgtta gaatttttga
     5161 tccttcacag tgtcaatatt taatgaatca ctaagcttta tttattagac gtgttgagtg
     5221 agtgctgagt tccttgctgc cacttttgtt accattgtca cacactatgt gtaaaccagt
     5281 cccaccactt attactaata aaattttgac tgataattta tatttgcact tacaatatat
     5341 atatcctgtc cttatatttc tctagagtac attttccatc atgtttaagt gtatttctgc
     5401 tattatttcc tctcctgcag aatacataca agtgtatgtg tataaagtca tacatgtaca
     5461 agcatgcata ttgagattga atcacatttc catactgtct gttattttat tgggttttat
     5521 attgggtttc tttagtttat gttgttttct caaaagcagc attttaaatt acgaatactg
     5581 gacttattgg atttaattat aaatccaatt actactggaa actcattttt acataatata
     5641 gtccttaaat tatttaaccc ttgctaagta attgacatat gtaacaataa ctagcctaaa
     5701 gaaacccaaa aaagtatctc tcccgagctg aaacttaaaa attcgtaagt gtaagaaaga
     5761 atgtgagaat atattaaatg cacactgtac cattagatga aatcttactt gagaaattgc
     5821 cataagccat attacagatc ttactttgtt actgaatcag attaatttct tgttataata
     5881 attttcatca taaattttct atttttaaag ccgctggtac tagaaatatt cttttaatgc
     5941 tatatctatg tacctactga cacatttttc tccataaaag tacttttaaa aatta
//
