LOCUS       NP_000913               1112 aa            linear   PRI 28-APR-2025
DEFINITION  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2 [Homo
            sapiens].
ACCESSION   NP_000913 NP_000744
VERSION     NP_000913.2
DBSOURCE    REFSEQ: accession NM_000922.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1112)
  AUTHORS   Feng,Y., Huang,Z., Song,L., Li,N., Li,X., Shi,H., Liu,R., Lu,F.,
            Han,X., Ding,Y., Ding,Y., Wang,J., Yang,J. and Jia,Z.
  TITLE     PDE3B regulates KRT6B and increases the sensitivity of bladder
            cancer cells to copper ionophores
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 397 (7), 4911-4925 (2024)
   PUBMED   38165426
  REMARK    GeneRIF: PDE3B regulates KRT6B and increases the sensitivity of
            bladder cancer cells to copper ionophores.
REFERENCE   2  (residues 1 to 1112)
  AUTHORS   Zhou,P., Wu,Z., Zhang,Q., Wang,L., Zhang,W. and Han,X.
  TITLE     A novel link between circPDE3B and ferroptosis in esophageal
            squamous cell carcinoma progression
  JOURNAL   Genomics 116 (1), 110761 (2024)
   PUBMED   38092323
  REMARK    GeneRIF: A novel link between circPDE3B and ferroptosis in
            esophageal squamous cell carcinoma progression.
REFERENCE   3  (residues 1 to 1112)
  AUTHORS   Dolce,B., Christ,T., Grammatika Pavlidou,N., Yildirim,Y.,
            Reichenspurner,H., Eschenhagen,T., Nikolaev,V.O., Kaumann,A.J. and
            Molina,C.E.
  TITLE     Impact of phosphodiesterases PDE3 and PDE4 on 5-hydroxytryptamine
            receptor4-mediated increase of cAMP in human atrial fibrillation
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 394 (2), 291-298 (2021)
   PUBMED   32949251
  REMARK    GeneRIF: Impact of phosphodiesterases PDE3 and PDE4 on
            5-hydroxytryptamine receptor4-mediated increase of cAMP in human
            atrial fibrillation.
REFERENCE   4  (residues 1 to 1112)
  AUTHORS   Rassi-Cruz,M., Maria,A.G., Faucz,F.R., London,E., Vilela,L.A.P.,
            Santana,L.S., Benedetti,A.F.F., Goldbaum,T.S., Tanno,F.Y.,
            Srougi,V., Chambo,J.L., Pereira,M.A.A., Cavalcante,A.C.B.S.,
            Carnevale,F.C., Pilan,B., Bortolotto,L.A., Drager,L.F.,
            Lerario,A.M., Latronico,A.C., Fragoso,M.C.B.V., Mendonca,B.B.,
            Zerbini,M.C.N., Stratakis,C.A. and Almeida,M.Q.
  TITLE     Phosphodiesterase 2A and 3B variants are associated with primary
            aldosteronism
  JOURNAL   Endocr Relat Cancer 28 (1), 1-13 (2021)
   PUBMED   33112806
  REMARK    GeneRIF: Phosphodiesterase 2A and 3B variants are associated with
            primary aldosteronism.
REFERENCE   5  (residues 1 to 1112)
  AUTHORS   Gottel,C., Niesen,S., Daub,V., Werle,T., Bakuradze,T.,
            Winterhalter,P. and Richling,E.
  TITLE     In Vitro Inhibition of Phosphodiesterase 3B (PDE 3B) by
            Anthocyanin-Rich Fruit Juice Extracts and Selected Anthocyanins
  JOURNAL   Int J Mol Sci 21 (18), 6934 (2020)
   PUBMED   32967310
  REMARK    GeneRIF: In Vitro Inhibition of Phosphodiesterase 3B (PDE 3B) by
            Anthocyanin-Rich Fruit Juice Extracts and Selected Anthocyanins.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1112)
  AUTHORS   Murata,T., Taira,M. and Manganiello,V.C.
  TITLE     Differential expression of cGMP-inhibited cyclic nucleotide
            phosphodiesterases in human hepatoma cell lines
  JOURNAL   FEBS Lett 390 (1), 29-33 (1996)
   PUBMED   8706823
REFERENCE   7  (residues 1 to 1112)
  AUTHORS   Rahn,T., Ronnstrand,L., Leroy,M.J., Wernstedt,C., Tornqvist,H.,
            Manganiello,V.C., Belfrage,P. and Degerman,E.
  TITLE     Identification of the site in the cGMP-inhibited phosphodiesterase
            phosphorylated in adipocytes in response to insulin and
            isoproterenol
  JOURNAL   J Biol Chem 271 (19), 11575-11580 (1996)
   PUBMED   8626720
REFERENCE   8  (residues 1 to 1112)
  AUTHORS   Loughney,K., Martins,T.J., Harris,E.A., Sadhu,K., Hicks,J.B.,
            Sonnenburg,W.K., Beavo,J.A. and Ferguson,K.
  TITLE     Isolation and characterization of cDNAs corresponding to two human
            calcium, calmodulin-regulated, 3',5'-cyclic nucleotide
            phosphodiesterases
  JOURNAL   J Biol Chem 271 (2), 796-806 (1996)
   PUBMED   8557689
REFERENCE   9  (residues 1 to 1112)
  AUTHORS   Manganiello,V.C., Taira,M., Degerman,E. and Belfrage,P.
  TITLE     Type III cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE3
            gene family)
  JOURNAL   Cell Signal 7 (5), 445-455 (1995)
   PUBMED   8562305
  REMARK    Review article
REFERENCE   10 (residues 1 to 1112)
  AUTHORS   Rascon,A., Degerman,E., Taira,M., Meacci,E., Smith,C.J.,
            Manganiello,V., Belfrage,P. and Tornqvist,H.
  TITLE     Identification of the phosphorylation site in vitro for
            cAMP-dependent protein kinase on the rat adipocyte cGMP-inhibited
            cAMP phosphodiesterase
  JOURNAL   J Biol Chem 269 (16), 11962-11966 (1994)
   PUBMED   8163498
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC150307.1, BC136565.1 and AC090835.7.
            
            On Dec 20, 2003 this sequence version replaced NP_000913.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.52394.1,
                                           SRR1660803.66885.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282096.9/ ENSP00000282096.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1112
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.2"
     Protein         1..1112
                     /product="cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B
                     isoform 2"
                     /EC_number="3.1.4.17"
                     /note="cGMP-inhibited 3',5'-cyclic phosphodiesterase B;
                     cyclic nucleotide phosphodiesterase; CGIP1; CGI-PDE B;
                     cyclic GMP-inhibited phosphodiesterase B;
                     phosphodiesterase 3B, cGMP-inhibited; cGMP-inhibited
                     3',5'-cyclic phosphodiesterase 3B"
                     /calculated_mol_wt=124203
     Region          1..26
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13370.2)"
     Region          1..25
                     /region_name="Interaction with RAPGEF3.
                     /evidence=ECO:0000269|PubMed:21393242"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13370.2)"
     Site            13
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q61409; propagated from
                     UniProtKB/Swiss-Prot (Q13370.2)"
     Site            88..108
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13370.2)"
     Region          <102..>282
                     /region_name="COG5373"
                     /note="Uncharacterized membrane protein [Function
                     unknown]"
                     /db_xref="CDD:444140"
     Site            117..137
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13370.2)"
     Site            152..172
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13370.2)"
     Region          <190..263
                     /region_name="CynX"
                     /note="Cyanate permease [Inorganic ion transport and
                     metabolism]; COG2807"
                     /db_xref="CDD:442057"
     Site            192..212
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13370.2)"
     Site            220..240
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13370.2)"
     Site            247..267
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13370.2)"
     Site            295
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKB/AKT1 or PKB/AKT2.
                     /evidence=ECO:0000250|UniProtKB:Q61409; propagated from
                     UniProtKB/Swiss-Prot (Q13370.2)"
     Site            296
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q61409; propagated from
                     UniProtKB/Swiss-Prot (Q13370.2)"
     Region          418..471
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13370.2)"
     Region          436..460
                     /region_name="Interaction with PIK3R6.
                     /evidence=ECO:0000269|PubMed:21393242"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13370.2)"
     Site            442
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q13370.2)"
     Region          736..1010
                     /region_name="PDEase_I"
                     /note="3'5'-cyclic nucleotide phosphodiesterase;
                     pfam00233"
                     /db_xref="CDD:459723"
     Region          1017..1051
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13370.2)"
     Region          1092..1112
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13370.2)"
     CDS             1..1112
                     /gene="PDE3B"
                     /gene_synonym="cGIPDE1; HcGIP1"
                     /coded_by="NM_000922.4:273..3611"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS7817.1"
                     /db_xref="GeneID:5140"
                     /db_xref="HGNC:HGNC:8779"
                     /db_xref="MIM:602047"
ORIGIN      
        1 mrrderdaka mrslqppdga gsppeslrng yvkscvsplr qdpprgfffh lcrfcnvelr
       61 pppaspqqpr rcspfcrarl slgalaafvl alllgaepes waagaawlrt llsvcshsls
      121 plfsiacaff fltcfltrtk rgpgpgrscg swwllalpac cylgdflvwq wwswpwgdgd
      181 agsaaphtpp eaaagrlllv lscvgllltl ahplrlrhcv lvlllasfvw wvsftslgsl
      241 psalrpllsg lvggagclla lgldhffqir eaplhprlss aaeekvpvir prrrsscvsl
      301 getaasyygs ckifrrpslp cisreqmilw dwdlkqwykp hyqnsgggng vdlsvlnear
      361 nmvsdlltdp slppqvissl rsisslmgaf sgscrpkinp ltpfpgfypc seiedpaekg
      421 drklnkglnr nslptpqlrr ssgtsgllpv eqssrwdrnn gkrphqefgi ssqgcylngp
      481 fnsnlltipk qrsssvslth hvglrragvl sslspvnssn hgpvstgslt nrspiefpdt
      541 adflnkpsvi lqrslgnapn tpdfyqqlrn sdsnlcnscg hqmlkyvsts esdgtdccsg
      601 ksgeeenifs kesfklmetq qeeetekkds rklfqegdkw lteeaqseqq tnieqevsld
      661 lilveeydsl iekmsnwnfp ifelvekmge ksgrilsqvm ytlfqdtgll eifkiptqqf
      721 mnyfraleng yrdipyhnri hatdvlhavw ylttrpvpgl qqihngcgtg netdsdgrin
      781 hgriayissk scsnpdesyg clssnipale lmalyvaaam hdydhpgrtn aflvatnapq
      841 avlyndrsvl enhhaasawn lylsrpeynf llhldhvefk rfrflvieai latdlkkhfd
      901 flaefnakan dvnsngiews nendrllvcq vciklading pakvrdlhlk wtegivnefy
      961 eqgdeeanlg lpispfmdrs spqlaklqes fithivgplc nsydaagllp gqwleaeedn
     1021 dtesgddedg eeldtedeem ennlnpkppr rksrrrifcq lmhhltenhk iwkeiveeee
     1081 kckadgnklq vensslpqad eiqvieeade ee
//
