LOCUS       NM_002599               4284 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens phosphodiesterase 2A (PDE2A), transcript variant 1,
            mRNA.
ACCESSION   NM_002599
VERSION     NM_002599.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4284)
  AUTHORS   Carlantoni,C., Liekfeld,L.M.H., Hemkemeyer,S.A., Schreier,D.,
            Saygi,C., Kurelic,R., Cardarelli,S., Kalucka,J., Schulte,C.,
            Beerens,M., Mailer,R.K., Schaffer,T.E., Naro,F., Pellegrini,M.,
            Nikolaev,V.O., Renne,T. and Frye,M.
  TITLE     The phosphodiesterase 2A controls lymphatic junctional maturation
            via cGMP-dependent notch signaling
  JOURNAL   Dev Cell 59 (3), 308-325 (2024)
   PUBMED   38159569
  REMARK    GeneRIF: The phosphodiesterase 2A controls lymphatic junctional
            maturation via cGMP-dependent notch signaling.
REFERENCE   2  (bases 1 to 4284)
  AUTHORS   Metkar,S.K., Yan,Y., Lu,Y., Lu,J., Zhu,X., Du,F. and Xu,Y.
  TITLE     Phosphodiesterase 2 and Its Isoform A as Therapeutic Targets in the
            Central Nervous System Disorders
  JOURNAL   CNS Neurol Disord Drug Targets 23 (8), 941-955 (2024)
   PUBMED   37855295
  REMARK    GeneRIF: Phosphodiesterase 2 and Its Isoform A as Therapeutic
            Targets in the Central Nervous System Disorders.
            Review article
REFERENCE   3  (bases 1 to 4284)
  AUTHORS   Chen,L., Zhou,J., Zhao,Z., Zhu,Y., Xing,J., An,J. and Guo,X.
  TITLE     Low Expression of Phosphodiesterase 2 (PDE2A) Promotes the
            Progression by Regulating Mitochondrial Morphology and ATP Content
            and Predicts Poor Prognosis in Hepatocellular Carcinoma
  JOURNAL   Cells 12 (1), 68 (2022)
   PUBMED   36611861
  REMARK    GeneRIF: Low Expression of Phosphodiesterase 2 (PDE2A) Promotes the
            Progression by Regulating Mitochondrial Morphology and ATP Content
            and Predicts Poor Prognosis in Hepatocellular Carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4284)
  AUTHORS   Li,S.Z., Ren,K.X., Zhao,J., Wu,S., Li,J., Zang,J., Fei,Z. and
            Zhao,J.L.
  TITLE     miR-139/PDE2A-Notch1 feedback circuit represses stemness of gliomas
            by inhibiting Wnt/beta-catenin signaling
  JOURNAL   Int J Biol Sci 17 (13), 3508-3521 (2021)
   PUBMED   34512162
  REMARK    GeneRIF: miR-139/PDE2A-Notch1 feedback circuit represses stemness
            of gliomas by inhibiting Wnt/beta-catenin signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4284)
  AUTHORS   Rassi-Cruz,M., Maria,A.G., Faucz,F.R., London,E., Vilela,L.A.P.,
            Santana,L.S., Benedetti,A.F.F., Goldbaum,T.S., Tanno,F.Y.,
            Srougi,V., Chambo,J.L., Pereira,M.A.A., Cavalcante,A.C.B.S.,
            Carnevale,F.C., Pilan,B., Bortolotto,L.A., Drager,L.F.,
            Lerario,A.M., Latronico,A.C., Fragoso,M.C.B.V., Mendonca,B.B.,
            Zerbini,M.C.N., Stratakis,C.A. and Almeida,M.Q.
  TITLE     Phosphodiesterase 2A and 3B variants are associated with primary
            aldosteronism
  JOURNAL   Endocr Relat Cancer 28 (1), 1-13 (2021)
   PUBMED   33112806
  REMARK    GeneRIF: Phosphodiesterase 2A and 3B variants are associated with
            primary aldosteronism.
REFERENCE   6  (bases 1 to 4284)
  AUTHORS   Manns,J.M., Brenna,K.J., Colman,R.W. and Sheth,S.B.
  TITLE     Differential regulation of human platelet responses by cGMP
            inhibited and stimulated cAMP phosphodiesterases
  JOURNAL   Thromb Haemost 87 (5), 873-879 (2002)
   PUBMED   12038792
  REMARK    GeneRIF: Inhibition of PDE2 resulted in higher levels of
            intracellular cAMP than inhibition of PDE3A suggesting this PDE may
            be the more important regulator of cAMP in human platelets.
REFERENCE   7  (bases 1 to 4284)
  AUTHORS   Zauli,G., Milani,D., Mirandola,P., Mazzoni,M., Secchiero,P.,
            Miscia,S. and Capitani,S.
  TITLE     HIV-1 Tat protein down-regulates CREB transcription factor
            expression in PC12 neuronal cells through a phosphatidylinositol
            3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway
  JOURNAL   FASEB J 15 (2), 483-491 (2001)
   PUBMED   11156964
REFERENCE   8  (bases 1 to 4284)
  AUTHORS   Sadhu,K., Hensley,K., Florio,V.A. and Wolda,S.L.
  TITLE     Differential expression of the cyclic GMP-stimulated
            phosphodiesterase PDE2A in human venous and capillary endothelial
            cells
  JOURNAL   J Histochem Cytochem 47 (7), 895-906 (1999)
   PUBMED   10375378
REFERENCE   9  (bases 1 to 4284)
  AUTHORS   Rosman,G.J., Martins,T.J., Sonnenburg,W.K., Beavo,J.A., Ferguson,K.
            and Loughney,K.
  TITLE     Isolation and characterization of human cDNAs encoding a
            cGMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase
  JOURNAL   Gene 191 (1), 89-95 (1997)
   PUBMED   9210593
REFERENCE   10 (bases 1 to 4284)
  AUTHORS   Loughney,K., Martins,T.J., Harris,E.A., Sadhu,K., Hicks,J.B.,
            Sonnenburg,W.K., Beavo,J.A. and Ferguson,K.
  TITLE     Isolation and characterization of cDNAs corresponding to two human
            calcium, calmodulin-regulated, 3',5'-cyclic nucleotide
            phosphodiesterases
  JOURNAL   J Biol Chem 271 (2), 796-806 (1996)
   PUBMED   8557689
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP003065.2 and AP005019.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002599.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform, PDE2A3 (see
            PMID:9210593).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040974.1, SRR1660809.137939.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334456.10/ ENSP00000334910.5
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-286               AP003065.2         70176-70461         c
            287-359             AP003065.2         38293-38365         c
            360-449             AP005019.1         94818-94907         c
            450-538             AP005019.1         91294-91382         c
            539-648             AP005019.1         83666-83775         c
            649-704             AP005019.1         82749-82804         c
            705-764             AP005019.1         77453-77512         c
            765-918             AP005019.1         76583-76736         c
            919-971             AP005019.1         76348-76400         c
            972-1046            AP005019.1         76063-76137         c
            1047-1088           AP005019.1         75907-75948         c
            1089-1154           AP005019.1         75331-75396         c
            1155-1285           AP005019.1         74940-75070         c
            1286-1397           AP005019.1         72226-72337         c
            1398-1437           AP005019.1         71710-71749         c
            1438-1501           AP005019.1         71527-71590         c
            1502-1574           AP005019.1         71028-71100         c
            1575-1752           AP005019.1         70707-70884         c
            1753-1865           AP005019.1         70357-70469         c
            1866-1943           AP005019.1         69594-69671         c
            1944-2066           AP005019.1         68600-68722         c
            2067-2137           AP005019.1         68033-68103         c
            2138-2260           AP005019.1         67513-67635         c
            2261-2348           AP005019.1         67042-67129         c
            2349-2396           AP005019.1         66733-66780         c
            2397-2471           AP005019.1         65690-65764         c
            2472-2571           AP005019.1         65440-65539         c
            2572-2684           AP005019.1         65053-65165         c
            2685-2723           AP005019.1         64632-64670         c
            2724-2830           AP005019.1         64389-64495         c
            2831-4284           AP005019.1         62297-63750         c
FEATURES             Location/Qualifiers
     source          1..4284
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..4284
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /note="phosphodiesterase 2A"
                     /db_xref="GeneID:5138"
                     /db_xref="HGNC:HGNC:8777"
                     /db_xref="MIM:602658"
     exon            1..286
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..3041
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /EC_number="3.1.4.17"
                     /note="isoform PDE2A3 is encoded by transcript variant 1;
                     cGMP-dependent 3',5'-cyclic phosphodiesterase;
                     cGMP-stimulated phosphodiesterase 1; cGMP-stimulated
                     phosphodiesterase 4; cyclic GMP-stimulated
                     phosphodiesterase; cGMP-stimulated phosphodiesterase 2;
                     phosphodiesterase 2A, cGMP-stimulated"
                     /codon_start=1
                     /product="cGMP-dependent 3',5'-cyclic phosphodiesterase
                     isoform PDE2A3"
                     /protein_id="NP_002590.1"
                     /db_xref="CCDS:CCDS8216.1"
                     /db_xref="GeneID:5138"
                     /db_xref="HGNC:HGNC:8777"
                     /db_xref="MIM:602658"
                     /translation="MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCA
                     DSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELP
                     QEGKVREAIISQKRLGCNGLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAA
                     VILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQK
                     GGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSC
                     KVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVP
                     VISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCE
                     CQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVV
                     DDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIK
                     NENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHL
                     ANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQ
                     DMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLE
                     DIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNT
                     HGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRL
                     LLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIP
                     ELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLD
                     FLDEEYEVPDLDGTRAPINGCCSLDAE"
     exon            287..359
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /inference="alignment:Splign:2.1.0"
     exon            360..449
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /inference="alignment:Splign:2.1.0"
     exon            450..538
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /inference="alignment:Splign:2.1.0"
     exon            539..648
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /inference="alignment:Splign:2.1.0"
     exon            649..704
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /inference="alignment:Splign:2.1.0"
     exon            705..764
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /inference="alignment:Splign:2.1.0"
     exon            765..918
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /inference="alignment:Splign:2.1.0"
     exon            919..971
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1046
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1088
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1154
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1285
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1397
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1437
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1501
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1574
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1752
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1865
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1943
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2066
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2137
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2260
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2348
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2396
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..2471
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..2571
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /inference="alignment:Splign:2.1.0"
     exon            2572..2684
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..2723
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /inference="alignment:Splign:2.1.0"
     exon            2724..2830
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /inference="alignment:Splign:2.1.0"
     exon            2831..4284
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4262..4267
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /note="hexamer: AATAAA"
     polyA_site      4284
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /note="major polyA site"
ORIGIN      
        1 agagccagcc gagcagcaga ggcagtggca gcgggagagg cgggagcagc ggggcagcag
       61 agctggattg gggtgttgag tccaggctga gtagggggca gcccactgct cttggtccct
      121 gtgcctgctg ggggtgccct gccctgaact ccaggcagcg gggacagggc gaggtgccac
      181 cttagtctgg ctggggaggc ggacgatgag gagtgatggg gcaggcatgc ggccactcca
      241 tcctctgcag gagccagcag tacccggcag cgcgaccggc tgagccgcgg ggccagcagg
      301 tcttcctcaa gccggacgag ccgccgccgc cgccgcagcc atgcgccgac agcctgcagg
      361 acgccttgct gagtctgggc tctgtcatcg acatttcagg cctgcaacgt gctgtcaagg
      421 aggccctgtc agctgtgctc ccccgagtgg aaactgtcta cacctaccta ctggatggtg
      481 agtcccagct ggtgtgtgag gaccccccac atgagctgcc ccaggagggg aaagtccggg
      541 aggctatcat ctcccagaag cggctgggct gcaatgggct gggcttctca gacctgccag
      601 ggaagccctt ggccaggctg gtggctccac tggctcctga tacccaagtg ctggtcatgc
      661 cgctagcgga caaggaggct ggggccgtgg cagctgtcat cttggtgcac tgtggccagc
      721 tgagtgataa tgaggaatgg agcctgcagg cggtggagaa gcataccctg gtcgccctgc
      781 ggagggtgca ggtcctgcag cagcgcgggc ccagggaggc tccccgagcc gtccagaacc
      841 ccccggaggg gacggcggaa gaccagaagg gcggggcggc gtacaccgac cgcgaccgca
      901 agatcctcca actgtgcggg gaactctacg acctggatgc ctcttccctg cagctcaaag
      961 tgctccaata cctgcagcag gagacccggg catcccgctg ctgcctcctg ctggtgtcgg
     1021 aggacaatct ccagctttct tgcaaggtca tcggagacaa agtgctcggg gaagaggtca
     1081 gctttccctt gacaggatgc ctgggccagg tggtggaaga caagaagtcc atccagctga
     1141 aggacctcac ctccgaggat gtacaacagc tgcagagcat gttgggctgt gagctgcagg
     1201 ccatgctctg tgtccctgtc atcagccggg ccactgacca ggtggtggcc ttggcctgcg
     1261 ccttcaacaa gctagaagga gacttgttca ccgacgagga cgagcatgtg atccagcact
     1321 gcttccacta caccagcacc gtgctcacca gcaccctggc cttccagaag gaacagaaac
     1381 tcaagtgtga gtgccaggct cttctccaag tggcaaagaa cctcttcacc cacctggatg
     1441 acgtctctgt cctgctccag gagatcatca cggaggccag aaacctcagc aacgcagaga
     1501 tctgctctgt gttcctgctg gatcagaatg agctggtggc caaggtgttc gacgggggcg
     1561 tggtggatga tgagagctat gagatccgca tcccggccga tcagggcatc gcgggacacg
     1621 tggcgaccac gggccagatc ctgaacatcc ctgacgcata tgcccatccg cttttctacc
     1681 gcggcgtgga cgacagcacc ggcttccgca cgcgcaacat cctctgcttc cccatcaaga
     1741 acgagaacca ggaggtcatc ggtgtggccg agctggtgaa caagatcaat gggccatggt
     1801 tcagcaagtt cgacgaggac ctggcgacgg ccttctccat ctactgcggc atcagcatcg
     1861 cccattctct cctatacaaa aaagtgaatg aggctcagta tcgcagccac ctggccaatg
     1921 agatgatgat gtaccacatg aaggtctccg atgatgagta taccaaactt ctccatgatg
     1981 ggatccagcc tgtggctgcc attgactcca attttgcaag tttcacctat acccctcgtt
     2041 ccctgcccga ggatgacacg tccatggcca tcctgagcat gctgcaggac atgaatttca
     2101 tcaacaacta caaaattgac tgcccgaccc tggcccggtt ctgtttgatg gtgaagaagg
     2161 gctaccggga tcccccctac cacaactgga tgcacgcctt ttctgtctcc cacttctgct
     2221 acctgctcta caagaacctg gagctcacca actacctcga ggacatcgag atctttgcct
     2281 tgtttatttc ctgcatgtgt catgacctgg accacagagg cacaaacaac tctttccagg
     2341 tggcctcgaa atctgtgctg gctgcgctct acagctctga gggctccgtc atggagaggc
     2401 accactttgc tcaggccatc gccatcctca acacccacgg ctgcaacatc tttgatcatt
     2461 tctcccggaa ggactatcag cgcatgctgg atctgatgcg ggacatcatc ttggccacag
     2521 acctggccca ccatctccgc atcttcaagg acctccagaa gatggctgag gtgggctacg
     2581 accgaaacaa caagcagcac cacagacttc tcctctgcct cctcatgacc tcctgtgacc
     2641 tctctgacca gaccaagggc tggaagacta cgagaaagat cgcggagctg atctacaaag
     2701 aattcttctc ccagggagac ctggagaagg ccatgggcaa caggccgatg gagatgatgg
     2761 accgggagaa ggcctatatc cctgagctgc aaatcagctt catggagcac attgcaatgc
     2821 ccatctacaa gctgttgcag gacctgttcc ccaaagcggc agagctgtac gagcgcgtgg
     2881 cctccaaccg tgagcactgg accaaggtgt cccacaagtt caccatccgc ggcctcccaa
     2941 gtaacaactc gctggacttc ctggatgagg agtacgaggt gcctgatctg gatggcacta
     3001 gggcccccat caatggctgc tgcagccttg atgctgagtg atcccctcca gggacacttc
     3061 cctgcccagg ccacctccca cagccctcca ctggtctggc cagatgcact gggaacagag
     3121 ccacgggtcc tgggtcctag accaggactt cctgtgtgac cctggacaag tactaccttc
     3181 ctgggcctca gctttctcgt ctgtataatg gaagcaagac ttccaacctc acggagactt
     3241 tgtaatttgt tttctgagag cacaggggtg accaatgagc agtgggccct actctgcacc
     3301 tctgaccaca ccttggcaag tctttcccaa gccattcttt gtctgagcag cttgatggtt
     3361 tctccttgcc ccatttctgc cccaccagat ctttgctcct ttccctttga ggactcccac
     3421 cctttggggt ctccaggatc ctcatggaag gggaaggtga gacatctgag tgagcagagt
     3481 gtggcatctt ggaaacagtc cttagttctg tgggaggact agaaacagcc gcggggcgaa
     3541 ggccccctga ggaccactac tatactgatg gtgggattgg gacctggggg atacaggggc
     3601 cccaggaaga agctgccaga ggggcagctc agtgctctgc agagaggggc cctggggaga
     3661 agcaggatgg gattgatggg caggagggat ccccgcactg ggagacaggc ccaggtatga
     3721 atgagccagc catgcttcct cctgcctgtg tgacgctggg cgagtctctt cccctgtctg
     3781 ggccaaacag ggagcgggta agacaatcca tgctctaaga tccattttag atcaatgtct
     3841 aaaatagctc tatcgctctg cggagtccca gcagaggcta tggaatgttt ctgcaaccct
     3901 aaggcacaga gagcccaacc ctgagtgtct cagaggcccc ctgagtgttc cccttggcct
     3961 gagcccctta cccattcctg cagccagtga gagacctggc ctcagccctg gcagggctct
     4021 ctcttcaagg ccatatccac ctgtgccctg gggcttggga gaccccatag ggccgggact
     4081 cttgggtcag cccggccact ggcttctctc tttttctctg tttcattctg tgtgcgttgt
     4141 ggggtggggg agggggtcca cctgccttac ctttctgagt tgcctttaga gagatgcgtt
     4201 tttctaggac tctgtgcaac tgtcgtatat ggtcccgtgg gctgaccgct ttgtacatga
     4261 gaataaatct atttctttct acca
//
