LOCUS       NM_024065               1038 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens phosducin like 3 (PDCL3), mRNA.
ACCESSION   NM_024065
VERSION     NM_024065.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1038)
  AUTHORS   Yang,B., Zheng,G. and Lu,F.
  TITLE     PDCL3 as a prognostic factor and associated with the VEGF signaling
            pathway in glioma
  JOURNAL   J Gene Med 26 (8), e3724 (2024)
   PUBMED   39107869
  REMARK    GeneRIF: PDCL3 as a prognostic factor and associated with the VEGF
            signaling pathway in glioma.
REFERENCE   2  (bases 1 to 1038)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1038)
  AUTHORS   Billon,C., Molin,A., Poirsier,C., Clemenson,A., Dauge,C.,
            Grelet,M., Sigaudy,S., Patrier,S., Goldenberg,A., Layet,V.,
            Tantau,J., Fleury,C., Liard,A., Diguet,A., Fritih,R., Verspyck,E.,
            Rendu,J., Boutaud,L., Tessier,A., Thomas,S., Razavi,F., Achaiaa,A.,
            Elkhartoufi,N., Hakkakian,L., Magnin,E., Bole-Feysot,C., Masson,C.,
            Ville,Y., Roth,P., Prieur,F., Bessieres,B., Bonniere,M. and
            Attie-Bitach,T.
  TITLE     Fetal megacystis-microcolon: Genetic mutational spectrum and
            identification of PDCL3 as a novel candidate gene
  JOURNAL   Clin Genet 98 (3), 261-273 (2020)
   PUBMED   32621347
  REMARK    GeneRIF: Fetal megacystis-microcolon: Genetic mutational spectrum
            and identification of PDCL3 as a novel candidate gene.
REFERENCE   4  (bases 1 to 1038)
  AUTHORS   Krzemien-Ojak,L., Goral,A., Joachimiak,E., Filipek,A. and
            Fabczak,H.
  TITLE     Interaction of a Novel Chaperone PhLP2A With the Heat Shock Protein
            Hsp90
  JOURNAL   J Cell Biochem 118 (2), 420-429 (2017)
   PUBMED   27496612
  REMARK    GeneRIF: results have shown that PhLP2A interacts with Hsp90 and
            exhibits molecular chaperone activity toward denatured proteins.
REFERENCE   5  (bases 1 to 1038)
  AUTHORS   Herold,C., Hooli,B.V., Mullin,K., Liu,T., Roehr,J.T.,
            Mattheisen,M., Parrado,A.R., Bertram,L., Lange,C. and Tanzi,R.E.
  TITLE     Family-based association analyses of imputed genotypes reveal
            genome-wide significant association of Alzheimer's disease with
            OSBPL6, PTPRG, and PDCL3
  JOURNAL   Mol Psychiatry 21 (11), 1608-1612 (2016)
   PUBMED   26830138
  REMARK    GeneRIF: family-based GWAS of imputed SNPs revealed novel genomic
            variants in (or near) PTPRG, OSBPL6, and PDCL3 that influence risk
            for Alzheimer's Disease. rs7609954 in the gene PTPRG, rs1347297 in
            the gene OSBPL6, and rs1513625 near PDCL3.  In addition, rs72953347
            in OSBPL6 and two SNPs in the gene CDKAL1 showed marginally
            significant association with LOAD (rs10456232, P-value=4.76 x 10-7;
            rs62400067, P-value=3.54 x 10-7).
REFERENCE   6  (bases 1 to 1038)
  AUTHORS   Srinivasan,S., Meyer,R.D., Lugo,R. and Rahimi,N.
  TITLE     Identification of PDCL3 as a novel chaperone protein involved in
            the generation of functional VEGF receptor 2
  JOURNAL   J Biol Chem 288 (32), 23171-23181 (2013)
   PUBMED   23792958
  REMARK    GeneRIF: data provide strong evidence for the role of PDCL3 in
            angiogenesis and establishes the molecular mechanism by which it
            regulates VEGFR-2 expression and function.
REFERENCE   7  (bases 1 to 1038)
  AUTHORS   Bisson,W.H., Zhang,Z., Welsh,K., Huang,J.W., Ryan,J., Reed,J.C. and
            Pellecchia,M.
  TITLE     Binding properties of the C-terminal domain of VIAF
  JOURNAL   Chem Biol Drug Des 72 (5), 331-336 (2008)
   PUBMED   19012568
REFERENCE   8  (bases 1 to 1038)
  AUTHORS   Stirling,P.C., Srayko,M., Takhar,K.S., Pozniakovsky,A., Hyman,A.A.
            and Leroux,M.R.
  TITLE     Functional interaction between phosducin-like protein 2 and
            cytosolic chaperonin is essential for cytoskeletal protein function
            and cell cycle progression
  JOURNAL   Mol Biol Cell 18 (6), 2336-2345 (2007)
   PUBMED   17429077
  REMARK    GeneRIF: Data support a model in which Plp2p modulates the
            biogenesis of several CCT substrates relating to cell cycle and
            cytoskeletal function, which together contribute to the essential
            function of PLP2.
            GeneRIF: Data support a model in which Plp2p modulates the
            biogenesis of several CCT substrates relating to cell cycle and
            cytoskeletal function, which together contribute to the essential
            function of PLP2.
REFERENCE   9  (bases 1 to 1038)
  AUTHORS   Wilkinson,J.C., Richter,B.W., Wilkinson,A.S., Burstein,E.,
            Rumble,J.M., Balliu,B. and Duckett,C.S.
  TITLE     VIAF, a conserved inhibitor of apoptosis (IAP)-interacting factor
            that modulates caspase activation
  JOURNAL   J Biol Chem 279 (49), 51091-51099 (2004)
   PUBMED   15371430
REFERENCE   10 (bases 1 to 1038)
  AUTHORS   Ambartsumyan,L.
  TITLE     Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   31070878
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC001021.2 and AI741007.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024065.4.
            
            Summary: This gene encodes a member of the phosducin-like protein
            family and is a putative modulator of heterotrimeric G proteins.
            The protein shares extensive amino acid sequence homology with
            phosducin. Members of the phosducin-like protein family have been
            shown to bind to the beta-gamma subunits of G proteins. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.215273.1,
                                           SRR3476690.166917.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264254.11/ ENSP00000264254.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1008              BC001021.2         17-1024
            1009-1038           AI741007.1         12-41               c
FEATURES             Location/Qualifiers
     source          1..1038
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..1038
                     /gene="PDCL3"
                     /gene_synonym="HTPHLP; PHLP2A; PHLP3; VIAF; VIAF1"
                     /note="phosducin like 3"
                     /db_xref="GeneID:79031"
                     /db_xref="HGNC:HGNC:28860"
                     /db_xref="MIM:611678"
     exon            1..81
                     /gene="PDCL3"
                     /gene_synonym="HTPHLP; PHLP2A; PHLP3; VIAF; VIAF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..795
                     /gene="PDCL3"
                     /gene_synonym="HTPHLP; PHLP2A; PHLP3; VIAF; VIAF1"
                     /note="IAP-associated factor VIAF1; phPL3; VIAF-1; viral
                     IAP-associated factor 1"
                     /codon_start=1
                     /product="phosducin-like protein 3"
                     /protein_id="NP_076970.1"
                     /db_xref="CCDS:CCDS33261.1"
                     /db_xref="GeneID:79031"
                     /db_xref="HGNC:HGNC:28860"
                     /db_xref="MIM:611678"
                     /translation="MQDPNADTEWNDILRKKGILPPKESLKELEEEAEEEQRILQQSV
                     VKTYEDMTLEELEDHEDEFNEEDERAIEMYRRRRLAEWKATKLKNKFGEVLEISGKDY
                     VQEVTKAGEGLWVILHLYKQGIPLCALINQHLSGLARKFPDVKFIKAISTTCIPNYPD
                     RNLPTIFVYLEGDIKAQFIGPLVFGGMNLTRDELEWKLSESGAIMTDLEENPKKPIED
                     VLLSSVRRSVLMKRDSDSEGD"
     exon            82..208
                     /gene="PDCL3"
                     /gene_synonym="HTPHLP; PHLP2A; PHLP3; VIAF; VIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            209..299
                     /gene="PDCL3"
                     /gene_synonym="HTPHLP; PHLP2A; PHLP3; VIAF; VIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            300..443
                     /gene="PDCL3"
                     /gene_synonym="HTPHLP; PHLP2A; PHLP3; VIAF; VIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            444..652
                     /gene="PDCL3"
                     /gene_synonym="HTPHLP; PHLP2A; PHLP3; VIAF; VIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            653..1038
                     /gene="PDCL3"
                     /gene_synonym="HTPHLP; PHLP2A; PHLP3; VIAF; VIAF1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      980
                     /gene="PDCL3"
                     /gene_synonym="HTPHLP; PHLP2A; PHLP3; VIAF; VIAF1"
     regulatory      1008..1013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDCL3"
                     /gene_synonym="HTPHLP; PHLP2A; PHLP3; VIAF; VIAF1"
                     /note="hexamer: ATTAAA"
     polyA_site      1038
                     /gene="PDCL3"
                     /gene_synonym="HTPHLP; PHLP2A; PHLP3; VIAF; VIAF1"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgtgcac aaaagagagc tgaggggcgg gggcgctgcg gcacagctgg tttgagcaac
       61 tgaactggaa acaagatgca ggaccccaac gcagacactg aatggaatga catcttacgc
      121 aaaaagggta tcttaccccc caaggaaagt ctgaaagaat tggaagagga ggcagaagag
      181 gagcagcgca tcctccagca gtcagtggtg aaaacatatg aagatatgac tttggaagag
      241 ctggaggatc atgaagacga gtttaatgag gaggatgaac gtgctattga aatgtacaga
      301 cggcggagac tggctgagtg gaaagcaact aaactgaaga ataaattcgg agaagttttg
      361 gagatctcag ggaaggatta tgttcaagaa gttaccaaag ctggcgaggg cttgtgggtc
      421 atcttgcacc tttacaaaca aggaattccc ctctgtgccc tgataaatca gcacctcagt
      481 ggacttgcca ggaagtttcc tgatgtcaaa tttatcaaag ccatttcaac aacctgcata
      541 cccaattatc ctgataggaa tctgcccacg atatttgttt acctggaagg agatatcaag
      601 gctcagttta ttggtcctct ggtgtttggc ggcatgaacc tgacaagaga tgagttggaa
      661 tggaaactgt ctgaatctgg agcaattatg acagacctgg aggaaaaccc taagaagccg
      721 attgaagacg tgttgctgtc ctcagtgcgg cgctctgtcc tcatgaagag ggacagcgat
      781 tccgagggtg actgaggcta cagcttctat cacatgccga actttcttgt gacaaattgt
      841 ctggattttt taaaaaagga aaaagcaaga atgaatcctt gtggttttta gttttgtata
      901 aattatgttt caaatcttta cattttggaa ataatcattg ctggagattc tgttaaatat
      961 tttggaactc tttttttttt taaattatag tatttcctct aaaaaaaatt aaaaccagcc
     1021 atttgtatgg caaatgtc
//
