LOCUS       NM_152401                900 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens phosducin like 2 (PDCL2), mRNA.
ACCESSION   NM_152401
VERSION     NM_152401.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 900)
  AUTHORS   Lou,X., Bao,R., Zhou,C.Z. and Chen,Y.
  TITLE     Structure of the thioredoxin-fold domain of human phosducin-like
            protein 2
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 65 (Pt 2), 67-70
            (2009)
   PUBMED   19193988
  REMARK    GeneRIF: The X-ray crystal structure of the thioredoxin (Trx)-fold
            domain of PDCL2 has been solved and resembles the Trx-fold domain
            of rat; the presence of two molecules in an asymmetric unit is
            suggested.
REFERENCE   2  (bases 1 to 900)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC024243.8, BC034431.1,
            AW629089.1 and BG198696.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152401.2.
            
            Summary: This gene encodes a member of the phosducin-like protein
            family and is a putative modulator of heterotrimeric G proteins.
            The protein shares extensive amino acid sequence homology with
            phosducin. Members of the phosducin-like protein family have been
            shown to bind to the beta-gamma subunits of G proteins. [provided
            by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.47724.1,
                                           SRR5189667.26283.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2147975 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295645.9/ ENSP00000295645.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AC024243.8         75976-76008         c
            34-319              BC034431.1         1-286
            320-398             AW629089.1         501-579             c
            399-852             BC034431.1         366-819
            853-894             BG198696.1         182-223
            895-900             AC024243.8         40282-40287         c
FEATURES             Location/Qualifiers
     source          1..900
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q12"
     gene            1..900
                     /gene="PDCL2"
                     /gene_synonym="GCPHLP"
                     /note="phosducin like 2"
                     /db_xref="GeneID:132954"
                     /db_xref="HGNC:HGNC:29524"
                     /db_xref="MIM:611676"
     exon            1..142
                     /gene="PDCL2"
                     /gene_synonym="GCPHLP"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..862
                     /gene="PDCL2"
                     /gene_synonym="GCPHLP"
                     /codon_start=1
                     /product="phosducin-like protein 2"
                     /protein_id="NP_689614.2"
                     /db_xref="CCDS:CCDS47059.1"
                     /db_xref="GeneID:132954"
                     /db_xref="HGNC:HGNC:29524"
                     /db_xref="MIM:611676"
                     /translation="MQDPNEDTEWNDILRDFGILPPKEESKDEIEEMVLRLQKEAMVK
                     PFEKMTLAQLKEAEDEFDEEDMQAVETYRKKRLQEWKALKKKQKFGELREISGNQYVN
                     EVTNAEEDVWVIIHLYRSSIPMCLLVNQHLSLLARKFPETKFVKAIVNSCIQHYHDNC
                     LPTIFVYKNGQIEAKFIGIIECGGINLKLEELEWKLAEVGAIQTDLEENPRKDMVDMM
                     VSSIRNTSIHDDSDSSNSDNDTK"
     exon            143..263
                     /gene="PDCL2"
                     /gene_synonym="GCPHLP"
                     /inference="alignment:Splign:2.1.0"
     exon            264..354
                     /gene="PDCL2"
                     /gene_synonym="GCPHLP"
                     /inference="alignment:Splign:2.1.0"
     exon            355..498
                     /gene="PDCL2"
                     /gene_synonym="GCPHLP"
                     /inference="alignment:Splign:2.1.0"
     exon            499..707
                     /gene="PDCL2"
                     /gene_synonym="GCPHLP"
                     /inference="alignment:Splign:2.1.0"
     exon            708..900
                     /gene="PDCL2"
                     /gene_synonym="GCPHLP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      875..880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDCL2"
                     /gene_synonym="GCPHLP"
                     /note="hexamer: AATAAA"
     polyA_site      900
                     /gene="PDCL2"
                     /gene_synonym="GCPHLP"
                     /note="major polyA site"
ORIGIN      
        1 ctcttctggc ggtcactcga aaccgccggg cctgaagcgg gcgctcttcc agcctggaga
       61 aggctgcggg tctccatccg tggcgcctcg ccagctgcag gacgacgcgg gctcttgagg
      121 ggcagagcag cgcatcatgc aggatcccaa tgaagataca gaatggaatg acattttaag
      181 agatttcggc attcttcctc ctaaagaaga gtcaaaagat gaaattgaag aaatggtttt
      241 acgtttacag aaagaagcaa tggtgaaacc atttgaaaag atgactcttg cacagctaaa
      301 ggaagctgaa gatgaatttg atgaagaaga tatgcaggct gttgaaacat atagaaagaa
      361 gcggttacag gaatggaaag ctcttaagaa aaaacaaaaa tttggagaat taagagaaat
      421 ttctggaaat cagtatgtga atgaagtcac aaatgcagaa gaagatgtgt gggttataat
      481 tcatctatac agatcaagca tcccaatgtg tttgttggtt aaccagcatc ttagtcttct
      541 agcaagaaag tttccagaaa ctaaatttgt taaagccatc gtgaatagct gtattcaaca
      601 ctaccatgac aattgtttac caacaatttt tgtgtataaa aatggtcaga tagaagccaa
      661 attcattgga attatagaat gtggagggat aaatctcaag ctggaagaac ttgaatggaa
      721 gctagcagaa gttggagcaa tacagactga tttggaagaa aaccccagaa aagacatggt
      781 agatatgatg gtatcttcaa ttagaaacac ttctattcat gatgacagtg atagctccaa
      841 cagtgataat gataccaaat agagagaaat attcaataaa tagcttttag tatatgtgta
//
