LOCUS       NM_005388               3017 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens phosducin like (PDCL), mRNA.
ACCESSION   NM_005388
VERSION     NM_005388.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3017)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3017)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3017)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3017)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   5  (bases 1 to 3017)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 3017)
  AUTHORS   Ruiz-Gomez,A., Humrich,J., Murga,C., Quitterer,U., Lohse,M.J. and
            Mayor,F. Jr.
  TITLE     Phosphorylation of phosducin and phosducin-like protein by G
            protein-coupled receptor kinase 2
  JOURNAL   J Biol Chem 275 (38), 29724-29730 (2000)
   PUBMED   10884381
REFERENCE   7  (bases 1 to 3017)
  AUTHORS   Lazarov,M.E., Martin,M.M., Willardson,B.M. and Elton,T.S.
  TITLE     Molecular cloning and characterization of the human phosducin-like
            protein (hPhLP) promoter
  JOURNAL   Biochim Biophys Acta 1492 (2-3), 460-464 (2000)
   PUBMED   10899582
REFERENCE   8  (bases 1 to 3017)
  AUTHORS   Lazarov,M.E., Martin,M.M., Willardson,B.M. and Elton,T.S.
  TITLE     Human phosducin-like protein (hPhLP) messenger RNA stability is
            regulated by cis-acting instability elements present in the
            3'-untranslated region
  JOURNAL   Biochim Biophys Acta 1446 (3), 253-264 (1999)
   PUBMED   10524200
REFERENCE   9  (bases 1 to 3017)
  AUTHORS   Thibault,C., Feng Wang,J., Charnas,R., Mirel,D., Barhite,S. and
            Miles,M.F.
  TITLE     Cloning and characterization of the rat and human phosducin-like
            protein genes: structure, expression and chromosomal localization
  JOURNAL   Biochim Biophys Acta 1444 (3), 346-354 (1999)
   PUBMED   10095058
REFERENCE   10 (bases 1 to 3017)
  AUTHORS   Miles,M.F., Barhite,S., Sganga,M. and Elliott,M.
  TITLE     Phosducin-like protein: an ethanol-responsive potential modulator
            of guanine nucleotide-binding protein function
  JOURNAL   Proc Natl Acad Sci U S A 90 (22), 10831-10835 (1993)
   PUBMED   8248177
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313429.1 and AL359512.15.
            
            On May 17, 2019 this sequence version replaced NM_005388.4.
            
            Summary: Phosducin-like protein is a putative modulator of
            heterotrimeric G proteins. The protein shares extensive amino acid
            sequence homology with phosducin, a phosphoprotein expressed in
            retina and pineal gland. Both phosducin-like protein and
            phosphoducin have been shown to regulate G-protein signaling by
            binding to the beta-gamma subunits of G proteins. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.86814.1,
                                           SRR7410570.437364.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144, SAMEA2467146
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259467.9/ ENSP00000259467.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1029              AK313429.1         69-1097
            1030-3017           AL359512.15        20963-22950         c
FEATURES             Location/Qualifiers
     source          1..3017
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.2"
     gene            1..3017
                     /gene="PDCL"
                     /gene_synonym="PhLP"
                     /note="phosducin like"
                     /db_xref="GeneID:5082"
                     /db_xref="HGNC:HGNC:8770"
                     /db_xref="MIM:604421"
     exon            1..118
                     /gene="PDCL"
                     /gene_synonym="PhLP"
                     /inference="alignment:Splign:2.1.0"
     exon            119..295
                     /gene="PDCL"
                     /gene_synonym="PhLP"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1029
                     /gene="PDCL"
                     /gene_synonym="PhLP"
                     /EC_number="1.14.99.1"
                     /codon_start=1
                     /product="phosducin-like protein"
                     /protein_id="NP_005379.3"
                     /db_xref="CCDS:CCDS6845.1"
                     /db_xref="GeneID:5082"
                     /db_xref="HGNC:HGNC:8770"
                     /db_xref="MIM:604421"
                     /translation="MTTLDDKLLGEKLQYYYSSSEDEDSDHEDKDRGRCAPASSSVPA
                     EAELAGEGISVNTGPKGVINDWRRFKQLETEQREEQCREMERLIKKLSMTCRSHLDEE
                     EEQQKQKDLQEKISGKMTLKEFAIMNEDQDDEEFLQQYRKQRMEEMRQQLHKGPQFKQ
                     VFEISSGEGFLDMIDKEQKSIVIMVHIYEDGIPGTEAMNGCMICLAAEYPAVKFCKVK
                     SSVIGASSQFTRNALPALLIYKGGELIGNFVRVTDQLGDDFFAVDLEAFLQEFGLLPE
                     KEVLVLTSVRNSATCHSEDSDLEID"
     exon            296..477
                     /gene="PDCL"
                     /gene_synonym="PhLP"
                     /inference="alignment:Splign:2.1.0"
     exon            478..3017
                     /gene="PDCL"
                     /gene_synonym="PhLP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1156..1161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDCL"
                     /gene_synonym="PhLP"
                     /note="hexamer: AAGAAA"
     polyA_site      1174
                     /gene="PDCL"
                     /gene_synonym="PhLP"
                     /note="major polyA site"
     regulatory      2742..2747
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDCL"
                     /gene_synonym="PhLP"
                     /note="hexamer: AATAAA"
     regulatory      2746..2751
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDCL"
                     /gene_synonym="PhLP"
                     /note="hexamer: AATAAT"
     polyA_site      2765
                     /gene="PDCL"
                     /gene_synonym="PhLP"
                     /note="major polyA site"
     polyA_site      2770
                     /gene="PDCL"
                     /gene_synonym="PhLP"
                     /note="major polyA site"
ORIGIN      
        1 ggcttttctc tttagcgctc agggcgctga cccactgctc ttcctcttaa gaaagtgctc
       61 cattccttcc ggcgcccgga gctgctggcc caaagggatc cggagcgagc tagggcagac
      121 accatgacca cccttgatga taagttgctg ggggagaaac tgcagtacta ctatagcagc
      181 agtgaggatg aggacagtga ccacgaggac aaggaccgag gcagatgtgc cccagccagc
      241 agttctgtgc ctgcagaggc tgagctggca ggcgaaggca tctcagttaa cacaggccca
      301 aaaggtgtga tcaatgactg gcgccgcttc aagcagttgg agacagagca gagggaggag
      361 cagtgccggg agatggaaag gctgatcaag aagctgtcaa tgacttgcag gtcccatctg
      421 gatgaagagg aggagcaaca gaaacagaaa gacctccagg agaagatcag tgggaagatg
      481 actctgaagg agtttgccat aatgaatgag gaccaagatg atgaagagtt tctgcagcag
      541 taccggaagc agcgaatgga agagatgcgg cagcagcttc acaaggggcc ccaattcaag
      601 caggtttttg agatctccag tggagaaggg tttttagaca tgattgataa agaacagaaa
      661 agcattgtca tcatggttca tatttatgag gatggcattc cagggaccga agccatgaat
      721 ggttgcatga tctgccttgc cgcagagtac ccagctgtca agttctgcaa ggtgaagagc
      781 tcagttattg gcgccagcag tcagttcacc aggaatgccc ttcctgccct gctgatctat
      841 aaggggggtg aattgatcgg caattttgtt cgtgttactg accagctggg ggatgatttc
      901 tttgctgtgg accttgaagc ttttctccag gaatttggat tactcccaga aaaggaagtc
      961 ttggtgctga catctgtgcg taactctgcc acgtgtcaca gtgaggatag cgacctggaa
     1021 atagattgaa ctgatagtct agttgcatag atttctcatt gtttgggttg gaatacacgt
     1081 cattgtttat ttttgttcct ttgtcttctg gcttttcagc tgttctttgt agtccctttt
     1141 attatgcata aaataaagaa attcttagat taaatcagaa tgctgaataa ccttgtagct
     1201 agcaataagg tgacttacag ttgtataaac aggaagccag gcttttgaac tgtttactta
     1261 agattctgtg gtgtgacatc tctgttattg tttccagtca atatttacaa agcatcctaa
     1321 agacagggtc ttggaaattg tcttcagatg atcttagagg tctctgccaa gtctgagagt
     1381 ataattctgt aggtattgtg ttatttgcaa cgtaaatagt gcattttctt aatcaaatga
     1441 ttgtaaatta tatttacttg taatcagttc catagcttta gacggtggtt agattttttt
     1501 tttccccacc agggtcttgt ttaaaggggt gagccaccgc acccagtcct gaggggtggc
     1561 ctctgctgct ggatttcatg tcttcctcca gcatgactaa gtctggaaca gcaggaaggg
     1621 ttgatgctta ctgacctggt gatgttagaa gacaagtagt ttatggattt aaacattaga
     1681 gctggagtgg ggctggaaat ctttgtaaag gaagttcttt cagtaagatg cccctgcttg
     1741 tctttgtctc ttttttgttt aacaaggtaa ctttttgttt aacaaggtaa ctttttgttt
     1801 aacctagatt ttttttaaaa cttttttttt ttttcatatt ggaaaagtaa ttcatattca
     1861 gtagaggaaa actgaccaaa acagaagcaa aaataagaaa attaaaataa tctctaatcc
     1921 tactacctag aataaaacac tattaatatt ttggtctgtt tcctgccaag gtgttttctg
     1981 tgtatacatg gatattttgt ttgtttttaa acaaaacgat gggatcattc tgaacatact
     2041 gttctatagt atggtcagct aataatatat cagacctttt tttatattat taaatattct
     2101 acaacttttt aaaaatgtct attaatattc catcgtatag atgtgatata atttgcttga
     2161 tggttgtctc ttaaaaagaa agatagcaaa tacttttttt aaattacaaa agtgatagat
     2221 gttcattgta gaaaatgtaa taaacactgt taagacttaa aagccatata attccaccaa
     2281 ccaaaattaa tcccttttgt catatttcta gtcattttta tagccttttt ttctatgtat
     2341 ttataataat tatcatttgc gtttttttcc tttttttaac tttaaaaatg tatattctag
     2401 ggtcagggga aatgtaatct ggaattaaat attagcctta aaattcacaa ttttgatttt
     2461 cctggctttt caggaattga ctaactgtaa aagagtcttg aaagtattta gtcaacaaac
     2521 agagtgcatt tttttttttt ttgactaaga aagctcgttg tagtagaaag ggtggaatgt
     2581 attgaaaatt attagaagca gggaagtatt gttagtctag cttatttcct ttcagtcttt
     2641 tttcaatatt tttataaaca ttgagtactt actgaattta gttctgtgct cttccttatt
     2701 tagtgttgta tcataaatac tttgatgttt caaacattct aaataaataa ttttcagtgg
     2761 cttcataata tttcatcatt tggatatata ataatttatt taaccagtct ctttattttt
     2821 atttatttat tttgtttgtt ttctttgaga tggagtctcg ctctgtcacc caggctggag
     2881 tacaatagcg tgatctcggc tcactgcaac ctccacctcc tgggttcaag cagttctcct
     2941 gcctcagcct cctgagtagc tgggactaca ggcacatgcc atcacgcctg gctaattttt
     3001 gtatttttac tagagac
//
