LOCUS       NM_005707               2823 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens programmed cell death 7 (PDCD7), mRNA.
ACCESSION   NM_005707
VERSION     NM_005707.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2823)
  AUTHORS   Wang,S., Li,N., Jin,S., Zhang,R. and Xu,T.
  TITLE     Polymerase acidic subunit of H9N2 polymerase complex induces cell
            apoptosis by binding to PDCD 7 in A549 cells
  JOURNAL   Virol J 18 (1), 75 (2021)
   PUBMED   33849599
  REMARK    GeneRIF: Polymerase acidic subunit of H9N2 polymerase complex
            induces cell apoptosis by binding to PDCD 7 in A549 cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2823)
  AUTHORS   Abo Elwafa,R., Gamaleldin,M. and Ghallab,O.
  TITLE     The clinical and prognostic significance of FIS1, SPI1, PDCD7 and
            Ang2 expression levels in acute myeloid leukemia
  JOURNAL   Cancer Genet 233-234, 84-95 (2019)
   PUBMED   30555023
  REMARK    GeneRIF: FIS1 and PDCD7 expression are considered independent risk
            factors and should be integrated into the current acute myeloid
            leukemia stratification system
REFERENCE   3  (bases 1 to 2823)
  AUTHORS   Peng,S.Y., Tu,H.F., Yang,C.C., Wu,C.H., Liu,C.J., Chang,K.W. and
            Lin,S.C.
  TITLE     miR-134 targets PDCD7 to reduce E-cadherin expression and enhance
            oral cancer progression
  JOURNAL   Int J Cancer 143 (11), 2892-2904 (2018)
   PUBMED   29971778
  REMARK    GeneRIF: Downregulation of both PDCD7 and E-cad and high levels
            miR-134 expression was observed in OSCC tumor tissues.
REFERENCE   4  (bases 1 to 2823)
  AUTHORS   Tian,Y., Huang,Z., Wang,Z., Yin,C., Zhou,L., Zhang,L., Huang,K.,
            Zhou,H., Jiang,X., Li,J., Liao,L., Yang,M. and Meng,F.
  TITLE     Identification of novel molecular markers for prognosis estimation
            of acute myeloid leukemia: over-expression of PDCD7, FIS1 and Ang2
            may indicate poor prognosis in pretreatment patients with acute
            myeloid leukemia
  JOURNAL   PLoS One 9 (1), e84150 (2014)
   PUBMED   24416201
  REMARK    GeneRIF: PDCD7, Ang2 and FIS1 may indicate a more aggressive form
            and poor prognosis of acute myeloid leukemia.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2823)
  AUTHORS   Turunen,J.J., Will,C.L., Grote,M., Luhrmann,R. and Frilander,M.J.
  TITLE     The U11-48K protein contacts the 5' splice site of U12-type introns
            and the U11-59K protein
  JOURNAL   Mol Cell Biol 28 (10), 3548-3560 (2008)
   PUBMED   18347052
REFERENCE   6  (bases 1 to 2823)
  AUTHORS   Boven,L.A., Noorbakhsh,F., Bouma,G., van der Zee,R., Vargas,D.L.,
            Pardo,C., McArthur,J.C., Nottet,H.S. and Power,C.
  TITLE     Brain-derived human immunodeficiency virus-1 Tat exerts
            differential effects on LTR transactivation and neuroimmune
            activation
  JOURNAL   J Neurovirol 13 (2), 173-184 (2007)
   PUBMED   17505986
REFERENCE   7  (bases 1 to 2823)
  AUTHORS   Will,C.L., Schneider,C., Hossbach,M., Urlaub,H., Rauhut,R.,
            Elbashir,S., Tuschl,T. and Luhrmann,R.
  TITLE     The human 18S U11/U12 snRNP contains a set of novel proteins not
            found in the U2-dependent spliceosome
  JOURNAL   RNA 10 (6), 929-941 (2004)
   PUBMED   15146077
REFERENCE   8  (bases 1 to 2823)
  AUTHORS   Park,E.J., Kim,J.H., Seong,R.H., Kim,C.G., Park,S.D. and Hong,S.H.
  TITLE     Characterization of a novel mouse cDNA, ES18, involved in apoptotic
            cell death of T-cells
  JOURNAL   Nucleic Acids Res 27 (6), 1524-1530 (1999)
   PUBMED   10037816
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK096970.1, AC013553.14 and
            BC016992.2.
            
            On Nov 22, 2018 this sequence version replaced NM_005707.1.
            
            Summary: This gene encodes a 59 kDa protein that is associated with
            the U11 small nuclear ribonucleoprotein (snRNP), which is a
            component of the minor U12-type spliceosome responsible for
            catalyzing pre-mRNA splicing of U12-type introns. [provided by
            RefSeq, Dec 2010].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK096970.1, SRR1803613.51790.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2159764, SAMN03267755
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000204549.9/ ENSP00000204549.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1151              AK096970.1         29-1179
            1152-1152           AC013553.14        128974-128974       c
            1153-1956           AK096970.1         1181-1984
            1957-2823           BC016992.2         915-1781
FEATURES             Location/Qualifiers
     source          1..2823
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.31"
     gene            1..2823
                     /gene="PDCD7"
                     /gene_synonym="59K; ES18; HES18"
                     /note="programmed cell death 7"
                     /db_xref="GeneID:10081"
                     /db_xref="HGNC:HGNC:8767"
                     /db_xref="MIM:608138"
     exon            1..897
                     /gene="PDCD7"
                     /gene_synonym="59K; ES18; HES18"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1485
                     /gene="PDCD7"
                     /gene_synonym="59K; ES18; HES18"
                     /note="apoptosis-related protein ES18; U11/U12 snRNP 59K"
                     /codon_start=1
                     /product="programmed cell death protein 7"
                     /protein_id="NP_005698.1"
                     /db_xref="CCDS:CCDS10201.1"
                     /db_xref="GeneID:10081"
                     /db_xref="HGNC:HGNC:8767"
                     /db_xref="MIM:608138"
                     /translation="MALPPFFGQGRPGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQR
                     PGPFPGASAPFLQPPLALQPRASAEASRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTD
                     AGERPRPPPPGPGPPWSPRWPEAPPPPADVLGDAALQRLRDRQWLEAVFGTPRRAGCP
                     VPQRTHAGPSLGEVRARLLRALRLVRRLRGLSQALREAEADGAAWVLLYSQTAPLRAE
                     LAERLQPLTQAAYVGEARRRLERVRRRRLRLRERAREREAEREAEAARAVEREQEIDR
                     WRVKCVQEVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAA
                     RKGVCPPASADETFTHHLQRLRKLIKKRSELYEAEERALRVMLEGEQEEERKRELEKK
                     QRKEKEKILLQKREIESKLFGDPDEFPLAHLLEPFRQYYLQAEHSLPALIQIRHDWDQ
                     YLVPSDHPKGNFVPQGWVLPPLPSNDIWATAVKLH"
     exon            898..1036
                     /gene="PDCD7"
                     /gene_synonym="59K; ES18; HES18"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1273
                     /gene="PDCD7"
                     /gene_synonym="59K; ES18; HES18"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1361
                     /gene="PDCD7"
                     /gene_synonym="59K; ES18; HES18"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..2823
                     /gene="PDCD7"
                     /gene_synonym="59K; ES18; HES18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2800..2805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDCD7"
                     /gene_synonym="59K; ES18; HES18"
                     /note="hexamer: AATAAA"
     polyA_site      2823
                     /gene="PDCD7"
                     /gene_synonym="59K; ES18; HES18"
                     /note="major polyA site"
ORIGIN      
        1 acttctcaaa gcatctccgt cgtgaacatg gccctgccac cattcttcgg ccagggtcgc
       61 ccaggcccac cgcccccgca gccgccgcct cctgctcctt tcggctgtcc gccaccgccg
      121 ctgccctccc cggctttccc gccgcctctc ccccagcggc ccggcccttt tccgggggcc
      181 tccgccccct tccttcagcc tccgctggct ctgcagcccc gagcctccgc ggaggcctcc
      241 cgcggcggag gcggcgctgg cgccttctac ccggtgccac caccgccgct gcctcctccg
      301 ccgccccagt gtcggccctt cccggggacc gacgccggcg agcggccgcg gccaccgcct
      361 cccggcccgg ggccgccctg gagcccgcgg tggcctgagg cgccgccgcc gccggccgac
      421 gtgctcgggg atgcggccct ccaacgcctg cgcgaccggc agtggctgga ggcggtgttc
      481 gggaccccgc ggcgggcagg ctgtccggtg ccccagcgca cgcatgccgg gcccagcctt
      541 ggcgaagtgc gcgcgcgatt gctccgggct ctgcgcctgg tgcggcggct gcgcggcctg
      601 agccaggccc tgcgcgaggc cgaagccgac ggcgcggcct gggtcctgct gtactcccag
      661 accgcgccgc tgcgcgcgga actggccgag cggctacagc cgttgaccca ggctgcctat
      721 gtgggcgagg cgcggaggag gctggagagg gtccggcgcc gccggctgcg gcttcgcgag
      781 agggcccggg aacgcgaggc cgagcgggag gcagaggccg cgcgggcagt ggaacgcgag
      841 caggagattg accgctggag ggtgaagtgt gtgcaggagg tggaggagaa gaagcgggag
      901 caggaactca aagcagccgc tgatggcgta ctatctgaag tgaggaaaaa acaagcagat
      961 accaaaagaa tggtggacat tctacgggct ttggagaaat tgaggaaact gaggaaagag
     1021 gctgcagcga ggaaaggggt ctgtcctcca gcctcagcag atgagacttt tacgcatcat
     1081 cttcagcgac tgagaaaact cattaaaaag cgctctgaac tgtatgaagc tgaagagaga
     1141 gccctcagag ttatgctaga aggagaacaa gaggaagaga ggaaaagaga attagaaaag
     1201 aaacaaagaa aagaaaaaga gaaaatttta cttcagaaac gtgaaattga gtccaagttg
     1261 tttggggatc cagatgagtt cccacttgct cacctcttgg agcctttccg acagtattat
     1321 ctccaagccg agcactccct gccagcgctc atccagatca ggcatgattg ggatcagtac
     1381 ctggtgccat ccgatcatcc caaaggcaac ttcgttcccc aaggatgggt ccttcccccg
     1441 ctccccagca acgacatctg ggcaactgct gttaagctgc attagtaaag atgctccagg
     1501 agtgtggtcc agccagcgct ctttccagct gtaaatatta gcgatggtgc catcttttgc
     1561 tgtagactaa actgcaactt ctaaattcca tgtggcattc ccctaccctg aagttatgct
     1621 ttccttctgt gctctgtgct ggccagaggt gcctcttgaa tcagattaat gtggtttttc
     1681 aggaaaggac ttaggtgaac tgaggttttt accacaggca gtgaatgacc ttggttcacc
     1741 aaatttgcct ctgttttgag gggcttggtc cagagtgact tgttaattta ctctaacttc
     1801 cttgtgtgtt gatgggtaag tacactcaaa cactgaatac aggtgtgtga tgggtagatt
     1861 tcacagccct tctactaata gtgagtgtga aggcaagctt gatgcaaaac ctcctgacct
     1921 ttcctacctg aagagccctt tgacttctag gaagaaaggt caaaaatgtt atcttcagtt
     1981 gtgttaatcc cagttttagt gcagcttagg aggctgctag ttaggaagat ggcagtggct
     2041 gtaggctggg ttgccagaaa agatggtggc ctagtcttat tattcagatg gagaacttag
     2101 aaaacctgaa gagtacccaa attggattgt attttaatgg acaatggctg tattttttcc
     2161 atgttagaag gatcctaatg aaagcacctg ttatttttaa gtttctaagg gtctagttgt
     2221 tcagaatccc caaggatatt tccctaacct cactcagtca cattgtagga gccagtgtag
     2281 ctatggaatt atcttaggaa ctcaagcttc taaaactatc catgtagtca aatctagggg
     2341 aaaaagcaaa taaaaatagt aaaatttggc cgggcacagt ggctcacgcc tgtaatccca
     2401 acactttggg aggccgaggc gggccgatca cgaggtcagg agatcaaggc catcctggct
     2461 aacacggtga aaccctgtct ctactaaaaa tacaaaaaaa tattagctgg gcgtaggtgg
     2521 tgcacacctg tagtcccagc tactggggag gctgaggcag gagaatggtg taaaacccag
     2581 gaggcagagc ttgcagtgag ccgagatcgc gccacggcac tccagcctgg gagacagagc
     2641 aagactccgt ctcaaaaaaa aaaaaagtaa aatttatttt ttatattcat taataaatgc
     2701 tgttgtgctt ggagatgatc actcatataa catgtcattt ttttggttct gttttggttt
     2761 ggtttttgcc aattattttg ttatatttcc aaaaaactaa ataaaaatca tttttatttt
     2821 tta
//
