LOCUS       NM_013374               5884 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens programmed cell death 6 interacting protein (PDCD6IP),
            transcript variant 1, mRNA.
ACCESSION   NM_013374
VERSION     NM_013374.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5884)
  AUTHORS   Shen,S., Cai,D., Liang,H., Zeng,G., Liu,W., Yan,R., Yu,X.,
            Zhang,H., Liu,S., Li,W., Deng,R., Lu,X., Liu,Y., Sun,J. and Guo,H.
  TITLE     NEDD4 family ubiquitin ligase AIP4 interacts with Alix to enable
            HBV naked capsid egress in an Alix ubiquitination-independent
            manner
  JOURNAL   PLoS Pathog 20 (9), e1012485 (2024)
   PUBMED   39259704
  REMARK    GeneRIF: NEDD4 family ubiquitin ligase AIP4 interacts with Alix to
            enable HBV naked capsid egress in an Alix
            ubiquitination-independent manner.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5884)
  AUTHORS   Qu,M., Liu,X., Wang,X., Li,Z., Zhou,L. and Li,H.
  TITLE     Palmitoylation of vacuole membrane protein 1 promotes small
            extracellular vesicle secretion via interaction with ALIX and
            influences intercellular communication
  JOURNAL   Cell Commun Signal 22 (1), 150 (2024)
   PUBMED   38403678
  REMARK    GeneRIF: Palmitoylation of vacuole membrane protein 1 promotes
            small extracellular vesicle secretion via interaction with ALIX and
            influences intercellular communication.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5884)
  AUTHORS   Diao,X., Guo,C., Zheng,H., Zhao,K., Luo,Y., An,M., Lin,Y., Chen,J.,
            Li,Y., Li,Y., Gao,X., Zhang,J., Zhou,M., Bai,W., Liu,L., Wang,G.,
            Zhang,L., He,X., Zhang,R., Li,Z., Chen,C. and Li,S.
  TITLE     SUMOylation-triggered ALIX activation modulates extracellular
            vesicles circTLCD4-RWDD3 to promote lymphatic metastasis of
            non-small cell lung cancer
  JOURNAL   Signal Transduct Target Ther 8 (1), 426 (2023)
   PUBMED   37925421
  REMARK    GeneRIF: SUMOylation-triggered ALIX activation modulates
            extracellular vesicles circTLCD4-RWDD3 to promote lymphatic
            metastasis of non-small cell lung cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5884)
  AUTHORS   Kliche,J., Garvanska,D.H., Simonetti,L., Badgujar,D.,
            Dobritzsch,D., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Large-scale phosphomimetic screening identifies phospho-modulated
            motif-based protein interactions
  JOURNAL   Mol Syst Biol 19 (7), e11164 (2023)
   PUBMED   37219487
REFERENCE   5  (bases 1 to 5884)
  AUTHORS   Maki,M., Suzuki,H. and Shibata,H.
  TITLE     Structure and function of ALG-2, a penta-EF-hand calcium-dependent
            adaptor protein
  JOURNAL   Sci China Life Sci 54 (8), 770-779 (2011)
   PUBMED   21786200
  REMARK    Review article
REFERENCE   6  (bases 1 to 5884)
  AUTHORS   Chatellard-Causse,C., Blot,B., Cristina,N., Torch,S., Missotten,M.
            and Sadoul,R.
  TITLE     Alix (ALG-2-interacting protein X), a protein involved in
            apoptosis, binds to endophilins and induces cytoplasmic
            vacuolization
  JOURNAL   J Biol Chem 277 (32), 29108-29115 (2002)
   PUBMED   12034747
REFERENCE   7  (bases 1 to 5884)
  AUTHORS   Wu,Y., Pan,S., Che,S., He,G., Nelman-Gonzalez,M., Weil,M.M. and
            Kuang,J.
  TITLE     Overexpression of Hp95 induces G1 phase arrest in confluent HeLa
            cells
  JOURNAL   Differentiation 67 (4-5), 139-153 (2001)
   PUBMED   11683497
REFERENCE   8  (bases 1 to 5884)
  AUTHORS   Missotten,M., Nichols,A., Rieger,K. and Sadoul,R.
  TITLE     Alix, a novel mouse protein undergoing calcium-dependent
            interaction with the apoptosis-linked-gene 2 (ALG-2) protein
  JOURNAL   Cell Death Differ 6 (2), 124-129 (1999)
   PUBMED   10200558
REFERENCE   9  (bases 1 to 5884)
  AUTHORS   Vito,P., Pellegrini,L., Guiet,C. and D'Adamio,L.
  TITLE     Cloning of AIP1, a novel protein that associates with the
            apoptosis-linked gene ALG-2 in a Ca2+-dependent reaction
  JOURNAL   J Biol Chem 274 (3), 1533-1540 (1999)
   PUBMED   9880530
REFERENCE   10 (bases 1 to 5884)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF349951.1, BC020066.1,
            AB037796.1, DA149360.1, AL695629.1 and CR739098.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_013374.5.
            
            Summary: This gene encodes a protein that functions within the
            ESCRT pathway in the abscission stage of cytokinesis, in
            intralumenal endosomal vesicle formation, and in enveloped virus
            budding. Studies using mouse cells have shown that overexpression
            of this protein can block apoptosis. In addition, the product of
            this gene binds to the product of the PDCD6 gene, a protein
            required for apoptosis, in a calcium-dependent manner. This gene
            product also binds to endophilins, proteins that regulate membrane
            shape during endocytosis. Overexpression of this gene product and
            endophilins results in cytoplasmic vacuolization, which may be
            partly responsible for the protection against cell death. Several
            alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. Related pseudogenes have
            been identified on chromosome 15. [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (1) uses an alternate in-frame
            splice site in the central coding region, compared to variant 2,
            resulting in an isoform (1) that is shorter than isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.15843.1,
                                           SRR1803615.183829.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307296.8/ ENSP00000307387.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1747              AF349951.1         33-1779
            1748-3451           BC020066.1         1757-3460
            3452-3736           AB037796.1         2387-2671
            3737-4164           DA149360.1         147-574
            4165-4797           AL695629.1         96-728
            4798-5397           AB037796.1         3733-4332
            5398-5884           CR739098.1         14-500              c
FEATURES             Location/Qualifiers
     source          1..5884
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.3"
     gene            1..5884
                     /gene="PDCD6IP"
                     /gene_synonym="AIP1; ALIX; DRIP4; HP95; MCPH29"
                     /note="programmed cell death 6 interacting protein"
                     /db_xref="GeneID:10015"
                     /db_xref="HGNC:HGNC:8766"
                     /db_xref="MIM:608074"
     exon            1..308
                     /gene="PDCD6IP"
                     /gene_synonym="AIP1; ALIX; DRIP4; HP95; MCPH29"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..2706
                     /gene="PDCD6IP"
                     /gene_synonym="AIP1; ALIX; DRIP4; HP95; MCPH29"
                     /note="isoform 1 is encoded by transcript variant 1; ALG-2
                     interacting protein 1; dopamine receptor interacting
                     protein 4; apoptosis-linked gene 2-interacting protein X;
                     PDCD6-interacting protein; ALG-2-interacting protein X"
                     /codon_start=1
                     /product="programmed cell death 6-interacting protein
                     isoform 1"
                     /protein_id="NP_037506.2"
                     /db_xref="CCDS:CCDS2660.1"
                     /db_xref="GeneID:10015"
                     /db_xref="HGNC:HGNC:8766"
                     /db_xref="MIM:608074"
                     /translation="MATFISVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQAQYCRAAE
                     ELSKLRRAAVGRPLDKHEGALETLLRYYDQICSIEPKFPFSENQICLTFTWKDAFDKG
                     SLFGGSVKLALASLGYEKSCVLFNCAALASQIAAEQNLDNDEGLKIAAKHYQFASGAF
                     LHIKETVLSALSREPTVDISPDTVGTLSLIMLAQAQEVFFLKATRDKMKDAIIAKLAN
                     QAADYFGDAFKQCQYKDTLPKEVFPVLAAKHCIMQANAEYHQSILAKQQKKFGEEIAR
                     LQHAAELIKTVASRYDEYVNVKDFSDKINRALAAAKKDNDFIYHDRVPDLKDLDPIGK
                     ATLVKSTPVNVPISQKFTDLFEKMVPVSVQQSLAAYNQRKADLVNRSIAQMREATTLA
                     NGVLASLNLPAAIEDVSGDTVPQSILTKSRSVIEQGGIQTVDQLIKELPELLQRNREI
                     LDESLRLLDEEEATDNDLRAKFKERWQRTPSNELYKPLRAEGTNFRTVLDKAVQADGQ
                     VKECYQSHRDTIVLLCKPEPELNAAIPSANPAKTMQGSEVVNVLKSLLSNLDEVKKER
                     EGLENDLKSVNFDMTSKFLTALAQDGVINEEALSVTELDRVYGGLTTKVQESLKKQEG
                     LLKNIQVSHQEFSKMKQSNNEANLREEVLKNLATAYDNFVELVANLKEGTKFYNELTE
                     ILVRFQNKCSDIVFARKTERDELLKDLQQSIAREPSAPSIPTPAYQSSPAGGHAPTPP
                     TPAPRTMPPTKPQPPARPPPPVLPANRAPSATAPSPVGAGTAAPAPSQTPGSAPPPQA
                     QGPPYPTYPGYPGYCQMPMPMGYNPYAYGQYNMPYPPVYHQSPGQAPYPGPQQPSYPF
                     PQPPQQSYYPQQ"
     exon            309..363
                     /gene="PDCD6IP"
                     /gene_synonym="AIP1; ALIX; DRIP4; HP95; MCPH29"
                     /inference="alignment:Splign:2.1.0"
     exon            364..433
                     /gene="PDCD6IP"
                     /gene_synonym="AIP1; ALIX; DRIP4; HP95; MCPH29"
                     /inference="alignment:Splign:2.1.0"
     exon            434..561
                     /gene="PDCD6IP"
                     /gene_synonym="AIP1; ALIX; DRIP4; HP95; MCPH29"
                     /inference="alignment:Splign:2.1.0"
     exon            562..715
                     /gene="PDCD6IP"
                     /gene_synonym="AIP1; ALIX; DRIP4; HP95; MCPH29"
                     /inference="alignment:Splign:2.1.0"
     exon            716..816
                     /gene="PDCD6IP"
                     /gene_synonym="AIP1; ALIX; DRIP4; HP95; MCPH29"
                     /inference="alignment:Splign:2.1.0"
     exon            817..933
                     /gene="PDCD6IP"
                     /gene_synonym="AIP1; ALIX; DRIP4; HP95; MCPH29"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1156
                     /gene="PDCD6IP"
                     /gene_synonym="AIP1; ALIX; DRIP4; HP95; MCPH29"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1280
                     /gene="PDCD6IP"
                     /gene_synonym="AIP1; ALIX; DRIP4; HP95; MCPH29"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1458
                     /gene="PDCD6IP"
                     /gene_synonym="AIP1; ALIX; DRIP4; HP95; MCPH29"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1570
                     /gene="PDCD6IP"
                     /gene_synonym="AIP1; ALIX; DRIP4; HP95; MCPH29"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1740
                     /gene="PDCD6IP"
                     /gene_synonym="AIP1; ALIX; DRIP4; HP95; MCPH29"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1989
                     /gene="PDCD6IP"
                     /gene_synonym="AIP1; ALIX; DRIP4; HP95; MCPH29"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2124
                     /gene="PDCD6IP"
                     /gene_synonym="AIP1; ALIX; DRIP4; HP95; MCPH29"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2219
                     /gene="PDCD6IP"
                     /gene_synonym="AIP1; ALIX; DRIP4; HP95; MCPH29"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2343
                     /gene="PDCD6IP"
                     /gene_synonym="AIP1; ALIX; DRIP4; HP95; MCPH29"
                     /inference="alignment:Splign:2.1.0"
     exon            2344..2531
                     /gene="PDCD6IP"
                     /gene_synonym="AIP1; ALIX; DRIP4; HP95; MCPH29"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..5884
                     /gene="PDCD6IP"
                     /gene_synonym="AIP1; ALIX; DRIP4; HP95; MCPH29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3169..3174
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDCD6IP"
                     /gene_synonym="AIP1; ALIX; DRIP4; HP95; MCPH29"
                     /note="hexamer: AATAAA"
     polyA_site      3187
                     /gene="PDCD6IP"
                     /gene_synonym="AIP1; ALIX; DRIP4; HP95; MCPH29"
                     /note="major polyA site"
     regulatory      5863..5868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDCD6IP"
                     /gene_synonym="AIP1; ALIX; DRIP4; HP95; MCPH29"
                     /note="hexamer: AATAAA"
     polyA_site      5884
                     /gene="PDCD6IP"
                     /gene_synonym="AIP1; ALIX; DRIP4; HP95; MCPH29"
ORIGIN      
        1 agtcagtccg ccagtccgcc agcccagtac ctctctctcc tcggccctcg taagctgtcc
       61 gcggtctgtt tggcccgaac ggcggcggag gcgctgatca tggcgacatt catctcggtg
      121 cagctgaaaa agacctcaga ggtggacctg gccaagccgc tggtgaagtt catccagcag
      181 acttacccaa gcggcgggga agagcaggcc cagtactgcc gcgcggcgga ggagctcagc
      241 aagctgcgcc gcgccgcagt cggtcgtccg ctggacaagc acgagggcgc gctcgagacg
      301 ctcctgagat attatgatca gatttgttct attgaaccca aattcccatt ttctgaaaat
      361 cagatctgct tgacatttac ctggaaggat gctttcgata aaggttcact ttttggaggc
      421 tctgtaaaac tggctcttgc aagcttagga tatgaaaaga gctgtgtgtt gttcaattgt
      481 gcagccttag ctagccaaat tgcagcagaa cagaacctgg ataatgatga aggattgaaa
      541 atcgctgcta aacattacca gtttgctagt ggtgcctttt tacatattaa agagacggtt
      601 ttatctgcct taagtcgaga gccgaccgtg gacatatctc cagatactgt tgggaccctc
      661 agtcttatta tgctggcaca ggctcaagaa gtattttttt taaaagccac aagagataaa
      721 atgaaagatg ccatcatagc taaattggct aatcaggctg cagattattt tggtgatgct
      781 ttcaaacagt gtcaatacaa agatactctc cccaaggagg tgttccctgt cttggctgca
      841 aagcactgta tcatgcaggc caatgctgag taccatcagt ctatcctggc aaaacagcag
      901 aagaaatttg gagaagaaat tgcaaggtta cagcatgcag cagaactgat taaaacagtg
      961 gcatctcgct atgatgaata tgttaatgtg aaggattttt ctgacaaaat caatcgtgcc
     1021 cttgctgcag caaagaagga taatgacttc atttatcatg atcgagttcc agaccttaaa
     1081 gatctagatc ctattggcaa agccacactt gtgaaatcta ccccggtcaa tgtacccatc
     1141 agtcagaaat ttactgatct gtttgagaag atggttcccg tgtcagtaca gcagtctttg
     1201 gctgcctata atcagaggaa agccgatttg gttaacagat caattgctca gatgagagaa
     1261 gccaccactt tggcaaatgg ggtgctagct tcccttaatc ttccagcagc aattgaagat
     1321 gtgtctggag acactgtacc tcagtctata ttgactaaat ccagatctgt gattgaacag
     1381 ggaggcatcc agactgttga tcagttgatt aaagaactgc ctgaattact gcaacgaaat
     1441 agagaaatcc tagatgagtc attaaggttg ttggatgaag aagaagcaac cgataatgat
     1501 ttaagagcaa aatttaagga acgttggcaa aggacaccat ccaatgaact gtataagcct
     1561 ttaagagcag agggaaccaa cttcagaaca gttttagata aagctgtgca ggcagatgga
     1621 caagtgaaag aatgttacca gtctcatcgt gacaccatcg tgcttttgtg taagccagag
     1681 cctgagctga atgctgccat cccttctgct aatccagcaa agaccatgca gggcagtgag
     1741 gttgtaaatg tcttaaaatc cttattgtca aatcttgatg aagtaaagaa ggaaagagag
     1801 ggtctggaga atgacttgaa atctgtgaat tttgacatga caagcaagtt tttgacagcc
     1861 ctggctcaag atggtgtgat aaatgaagaa gctctttctg ttactgaact agatcgagtc
     1921 tatggaggtc ttacaactaa agtccaagaa tctctaaaga aacaggaggg acttcttaaa
     1981 aatattcagg tctcacatca ggaattttca aaaatgaaac aatctaataa tgaagctaac
     2041 ttaagagaag aagttttgaa gaatttagct actgcatatg acaactttgt tgaacttgta
     2101 gctaatttga aggaaggcac aaagttttac aatgagttga ctgaaatcct ggtcaggttc
     2161 cagaacaaat gcagtgatat agtttttgca cggaagacag aaagagatga actcttaaag
     2221 gacttgcaac aaagcattgc cagagaacct agtgctcctt caattcctac acctgcgtat
     2281 cagtcctcac cagcaggagg acatgcacca actcctccaa ctccagcgcc aagaaccatg
     2341 ccgcctacta agccccagcc cccagccagg cctccaccac ctgtgcttcc agcaaatcga
     2401 gctccttctg ctactgctcc atctccagtg ggggctggga ctgctgcgcc agctccatca
     2461 caaacgcctg gctcagctcc tcctccacag gcgcagggac caccctatcc cacctatcca
     2521 ggatatcctg ggtattgcca aatgcccatg cccatgggct ataatcctta tgcgtatggc
     2581 cagtataata tgccatatcc accagtgtat caccagagtc ctggacaggc tccatacccg
     2641 ggaccccagc agccttcata ccccttccct cagcccccac agcagtctta ctatccacag
     2701 cagtaatatg tctgctcagc agctcagctg attcagatca gagggaaaga aataccaacc
     2761 ctgcaataag tgtactaaac tctacgctct ggttaatgta atgtactctc ctggactgaa
     2821 tgcagtgtat aatttctgtc tacagctaga agctgtgccc cagttccaca tttgattaca
     2881 catgtgagat ttgctgctgt tgcagtataa acactaggta taataggatt tgaaattgca
     2941 ttacagttca taaaaattga aaatgagaaa ttaaacctgc aagtgaaaca tttgaaacga
     3001 ttatactttc tacataagac atggttggga catcagatac ttacaaagat ggtttaagta
     3061 tggatactag agaaaattaa gttttctttc tctttggttt attgatttgg tttaatttcc
     3121 attatgctat tttgcataat caaggcactg taaatcttat aattttaaaa taaattactt
     3181 aagaacagtt gtcattgtta tgttttgtta ttgattctca ttactgtcta attttttttc
     3241 tggtattagt ctcattttgt atgtatataa gttaaacaga tactgttttt aagtgcatga
     3301 atagtacaag ttattatcaa ggatgtttta cagggaaatc aaaagaatat tatcatactt
     3361 tatctttcgt atgctgatta gtaaacgatt tttgacattt attttagaaa gtcctataat
     3421 gtggaagaaa caaacagttg ctaccaaaga ttcttcaaat aaacatacaa ataaatgtgt
     3481 atatttaatg ttttattgtt agcttctcca gaaaattgat gcaaattctg gtaataattc
     3541 ttgcattttt tccccataac ctggttaaaa taaatacgcc attggcaata cttcataatg
     3601 taatggaatt gtttggggaa cacttactgt accctctcat cctttttcca ccttactgtg
     3661 ttaacttagt gacatttaat gcccaatatg tatgaataga tctaagccat ttaatttttt
     3721 ttccttaaag attggagtat tttataattc aaggagcata caaaacaatg gttgggaaca
     3781 tatgccaatt atggaatagg ctatgtattt aatattaatc tctgccatta ggatatctac
     3841 tcactgtata aacctcagta aaaatagtga agacatgcat catggaatga gaaaatgaga
     3901 aaggaatgag ttgtctaaca tcacagtggg atctgttttt tgtgaggttc atttctgaac
     3961 acattaggca tatgagcaga tttccagtga atctatttat gtttattttc tgagtttcaa
     4021 cgctgacctt ttcttgcatt attgtttcat tttaatgata gtgttacttg tcccactgtt
     4081 gttttcattg agtttggatt tatattttaa atgttcgaat gaaagtatga ttgtaaaagg
     4141 gagtgaattg gtttaaaaat atatgtatat tttaaacttt gttgtgtgta ggaaacatga
     4201 aggcatgtta attcaatata aatgaccttt gatttcatgg aatattaaag ttggtttaaa
     4261 gtccaatagt taaaccttag caaaaatagc tttttacttc atcagttgct aagatttaat
     4321 actttggatt catcaaagtg tgacatgggc ttgtttgact tctgtaagtg gcatttaagt
     4381 tccacattct tattacttga ggtactttat actaacataa gacagtgaga gttagaggta
     4441 ttacaagttg ctagtttata atgtcttact aatgcagaaa caaggaaaaa agcaaaattg
     4501 gcctgaatat tctcttgggg aaagagggca ccaaagaaaa gggtaagtgc atctgagggc
     4561 caaaagagat gtataagcct tttagcccat tccccatgct gggcctgctc acagagccac
     4621 aggaagatca ttcagaaact aggaaaggag gcccccacag ctgatcctgc cacagcacac
     4681 ctgactcact cggctctgtt agtgtaacct tttaaatgta gcaacacaaa ccctttccct
     4741 cttgtcagtt cactcatcct ttggtttctt tttaatcacc tgtgtctggg cacagacaat
     4801 cacaataaat gcagcccttt attactgtta aggatcatac tgttggtttg gagttggaag
     4861 ggtactactc tgtgattcag gtgtgttgta cccatattta taattaggct ttattatctt
     4921 cctaaatcaa ggaaaggaaa tcatccccag accatttatg ctgagctttg gaatactatt
     4981 ttaaactgga ttgtacttaa ataatgaagc tctgcataga ggaactagtc agaagtgggg
     5041 aaaacactgt ctaattttta tcagtctggt ataaagtatt gatctaagag aactctccct
     5101 gtgccccttg gtctttattc tcaattaaga aaaacagtca catgtcacga caaaccaatc
     5161 aatctttatg agatattcct gtatccatac cccagcttgt ttgcaattta taaacctccc
     5221 cttcaaaact aaggagttgc agaaaaaaat ggatttcaca gagccttgtg tccctaaagt
     5281 tctgtcccag tcagcagtct ttatagtcca aacagattat aaaaaatgtt ttccatttga
     5341 actttacagt ttgcaaaagt gcttttatac attttctaat ttcagaaaca ggataatttg
     5401 ttaagtgggt ttcagtttgc taatagggat tttttgtgtt ttgtttttta attttcagca
     5461 tctcttgaag aatcttgcta cagccaaatg gcatctcact ttttaaagac gtttgcaatt
     5521 attagttgat tcacagtaca gaacaaggta taaaggaaaa aaccctgcta ggtagtgtta
     5581 taattgctag attaaaaata gactagaaca ggttcatttt aagatttact tggaagagca
     5641 aagaaggaaa aattatattt ttaaagaaag agaatattca ggctttattt ctggtatgaa
     5701 gtttatattt tttaaaaaaa tcctatatta tcacaccaga gattttagat tcttttctgg
     5761 ttagaaacat tgctggtagt tggattatat ttttattgta ttcatttatc ttagggggaa
     5821 cattgtaaag aaacaaaaag gtccagatga atgtatgcta gaaataaaag ttgaaagatt
     5881 ctta
//
