LOCUS       NM_004708                603 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens programmed cell death 5 (PDCD5), mRNA.
ACCESSION   NM_004708
VERSION     NM_004708.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 603)
  AUTHORS   Xiao,Z., Si,M., Cao,J., Chen,X., Wang,Z., Zhang,T., Zhou,Y., Li,H.,
            Dai,J., Wang,C., Chen,L. and Xu,J.
  TITLE     Cancer-testis non-coding RNA LEF1-AS1 regulates the nuclear
            translocation of PDCD5 and suppresses its interaction with p53
            signaling: a novel target for immunotherapy in esophageal squamous
            cell carcinoma
  JOURNAL   Carcinogenesis 44 (3), 263-276 (2023)
   PUBMED   36827466
  REMARK    GeneRIF: Cancer-testis non-coding RNA LEF1-AS1 regulates the
            nuclear translocation of PDCD5 and suppresses its interaction with
            p53 signaling: a novel target for immunotherapy in esophageal
            squamous cell carcinoma.
REFERENCE   2  (bases 1 to 603)
  AUTHORS   Liu,S.C., Chen,L.B., Chen,P.F., Huang,M.L., Liu,T.P., Peng,J. and
            Lu,X.S.
  TITLE     PDCD5 inhibits progression of renal cell carcinoma by promoting T
            cell immunity: with the involvement of the
            HDAC3/microRNA-195-5p/SGK1
  JOURNAL   Clin Epigenetics 14 (1), 131 (2022)
   PUBMED   36266728
  REMARK    GeneRIF: PDCD5 inhibits progression of renal cell carcinoma by
            promoting T cell immunity: with the involvement of the
            HDAC3/microRNA-195-5p/SGK1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 603)
  AUTHORS   Park,S.Y., Hong,J.Y., Lee,S.Y., Lee,S.H., Kim,M.J., Kim,S.Y.,
            Kim,K.W., Shim,H.S., Park,M.S., Lee,C.G., Elias,J.A., Sohn,M.H. and
            Yoon,H.G.
  TITLE     Club cell-specific role of programmed cell death 5 in pulmonary
            fibrosis
  JOURNAL   Nat Commun 12 (1), 2923 (2021)
   PUBMED   34011956
  REMARK    GeneRIF: Club cell-specific role of programmed cell death 5 in
            pulmonary fibrosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 603)
  AUTHORS   Zhong,J.H., Zhong,J.J., Shi,Y.N., Hu,X.M., Xu,M.J., Guo,Z.,
            Zhong,T.Y., Li,W.S. and Wang,Y.
  TITLE     Prognostic potentials of miRNA-19a-3p and PDCD5 in nasopharynx
            carcinoma
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (21), 11114-11119 (2020)
   PUBMED   33215428
  REMARK    GeneRIF: Prognostic potentials of miRNA-19a-3p and PDCD5 in
            nasopharynx carcinoma.
REFERENCE   5  (bases 1 to 603)
  AUTHORS   Yao,H., Xu,L., Feng,Y., Liu,D., Chen,Y. and Wang,J.
  TITLE     Structure-function correlation of human programmed cell death 5
            protein
  JOURNAL   Arch Biochem Biophys 486 (2), 141-149 (2009)
   PUBMED   19358820
  REMARK    GeneRIF: Studies of structure-function relationship of PDCD5 by
            multidimensional NMR methods and flow cytometer and fluorescence
            microscopey.
REFERENCE   6  (bases 1 to 603)
  AUTHORS   Xu,L., Chen,Y., Song,Q., Xu,D., Wang,Y. and Ma,D.
  TITLE     PDCD5 interacts with Tip60 and functions as a cooperator in
            acetyltransferase activity and DNA damage-induced apoptosis
  JOURNAL   Neoplasia 11 (4), 345-354 (2009)
   PUBMED   19308289
  REMARK    GeneRIF: PDCD5 contributes to maintaining a basal pool of Tip60 and
            its HAT activity
REFERENCE   7  (bases 1 to 603)
  AUTHORS   Liu,D., Yao,H., Chen,Y., Feng,Y., Chen,Y. and Wang,J.
  TITLE     The N-terminal 26-residue fragment of human programmed cell death 5
            protein can form a stable alpha-helix having unique electrostatic
            potential character
  JOURNAL   Biochem J 392 (Pt 1), 47-54 (2005)
   PUBMED   16083422
  REMARK    GeneRIF: The effects of the secondary structure of PDCD5 on its
            tertiary structure and function are reported.
REFERENCE   8  (bases 1 to 603)
  AUTHORS   Xu,M., Cheng,N., Gui,L., Lai,M., Wang,Y., Xia,D., Rui,M., Zhang,Y.
            and Ma,D.
  TITLE     The 5'-upstream region of human programmed cell death 5 gene
            contains a highly active TATA-less promoter that is up-regulated by
            etoposide
  JOURNAL   Gene 329, 39-49 (2004)
   PUBMED   15033527
  REMARK    GeneRIF: Results imply that the PDCD5 gene may be a target gene
            under the control of some important apoptosis-related
            transcriptional factors during the cell apoptosis.
REFERENCE   9  (bases 1 to 603)
  AUTHORS   Chen,Y., Sun,R., Han,W., Zhang,Y., Song,Q., Di,C. and Ma,D.
  TITLE     Nuclear translocation of PDCD5 (TFAR19): an early signal for
            apoptosis?
  JOURNAL   FEBS Lett 509 (2), 191-196 (2001)
   PUBMED   11741587
REFERENCE   10 (bases 1 to 603)
  AUTHORS   Liu,H., Wang,Y., Zhang,Y., Song,Q., Di,C., Chen,G., Tang,J. and
            Ma,D.
  TITLE     TFAR19, a novel apoptosis-related gene cloned from human leukemia
            cell line TF-1, could enhance apoptosis of some tumor cells induced
            by growth factor withdrawal
  JOURNAL   Biochem Biophys Res Commun 254 (1), 203-210 (1999)
   PUBMED   9920759
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DN915905.1, BC015519.2,
            N40187.1 and AC008474.9.
            
            On Nov 22, 2018 this sequence version replaced NM_004708.3.
            
            Summary: This gene encodes a protein that is upregulated during
            apoptosis where it translocates rapidly from the cytoplasm to the
            nucleus. The encoded protein may be an important regulator of
            K(lysine) acetyltransferase 5 (a protein involved in transcription,
            DNA damage response and cell cycle control) by inhibiting its
            proteasome-dependent degradation. Pseudogenes have been identified
            on chromosomes 5 and 12 [provided by RefSeq, Dec 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.26537.1,
                                           SRR1163657.173575.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000590247.7/ ENSP00000466214.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                DN915905.1         3-34
            33-575              BC015519.2         1-543
            576-602             N40187.1           1-27                c
            603-603             AC008474.9         92703-92703
FEATURES             Location/Qualifiers
     source          1..603
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.11"
     gene            1..603
                     /gene="PDCD5"
                     /gene_synonym="TFAR19"
                     /note="programmed cell death 5"
                     /db_xref="GeneID:9141"
                     /db_xref="HGNC:HGNC:8764"
                     /db_xref="MIM:604583"
     exon            1..138
                     /gene="PDCD5"
                     /gene_synonym="TFAR19"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..450
                     /gene="PDCD5"
                     /gene_synonym="TFAR19"
                     /note="TFAR19 novel apoptosis-related; TF1 cell
                     apoptosis-related gene 19; TF-1 cell apoptosis-related
                     protein 19"
                     /codon_start=1
                     /product="programmed cell death protein 5"
                     /protein_id="NP_004699.1"
                     /db_xref="CCDS:CCDS12423.1"
                     /db_xref="GeneID:9141"
                     /db_xref="HGNC:HGNC:8764"
                     /db_xref="MIM:604583"
                     /translation="MADEELEALRRQRLAELQAKHGDPGDAAQQEAKHREAEMRNSIL
                     AQVLDQSARARLSNLALVKPEKTKAVENYLIQMARYGQLSEKVSEQGLIEILKKVSQQ
                     TEKTTTVKFNRRKVMDSDEDDDY"
     exon            139..176
                     /gene="PDCD5"
                     /gene_synonym="TFAR19"
                     /inference="alignment:Splign:2.1.0"
     exon            177..238
                     /gene="PDCD5"
                     /gene_synonym="TFAR19"
                     /inference="alignment:Splign:2.1.0"
     exon            239..330
                     /gene="PDCD5"
                     /gene_synonym="TFAR19"
                     /inference="alignment:Splign:2.1.0"
     exon            331..402
                     /gene="PDCD5"
                     /gene_synonym="TFAR19"
                     /inference="alignment:Splign:2.1.0"
     exon            403..603
                     /gene="PDCD5"
                     /gene_synonym="TFAR19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      551..556
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDCD5"
                     /gene_synonym="TFAR19"
                     /note="hexamer: AATAAA"
     regulatory      569..574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDCD5"
                     /gene_synonym="TFAR19"
                     /note="hexamer: AATAAA"
     polyA_site      575
                     /gene="PDCD5"
                     /gene_synonym="TFAR19"
                     /note="major polyA site"
     polyA_site      603
                     /gene="PDCD5"
                     /gene_synonym="TFAR19"
ORIGIN      
        1 agtggtcaag gccgcgctcg cgccgagggg ctgcgagagt gaccgcggct gctccagcgc
       61 tgacgccgag ccatggcgga cgaggagctt gaggcgctga ggagacagag gctggccgag
      121 ctgcaggcca aacacgggga tcctggtgat gcggcccaac aggaagcaaa gcacagggaa
      181 gcagaaatga gaaacagtat cttagcccaa gttctggatc agtcggcccg ggccaggtta
      241 agtaacttag cacttgtaaa gcctgaaaaa actaaagcag tagagaatta ccttatacag
      301 atggcaagat atggacaact aagtgagaag gtatcagaac aaggtttaat agaaatcctt
      361 aaaaaagtaa gccaacaaac agaaaagaca acaacagtga aattcaacag aagaaaagta
      421 atggactctg atgaagatga cgattattga actacaagtg ctcacagact agaacttaac
      481 ggaacaagtc taggacagaa gttaagatct gattatttac tttgtttatt gtctatatgc
      541 cttttaaaaa aataaacttg ttatgcaaaa taaaacattt gggtaagttg ttttagtatc
      601 ata
//
