LOCUS       NM_014456               3481 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens programmed cell death 4 (PDCD4), transcript variant 1,
            mRNA.
ACCESSION   NM_014456
VERSION     NM_014456.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3481)
  AUTHORS   Brito Querido,J., Sokabe,M., Diaz-Lopez,I., Gordiyenko,Y.,
            Zuber,P., Du,Y., Albacete-Albacete,L., Ramakrishnan,V. and
            Fraser,C.S.
  TITLE     Human tumor suppressor protein Pdcd4 binds at the mRNA entry
            channel in the 40S small ribosomal subunit
  JOURNAL   Nat Commun 15 (1), 6633 (2024)
   PUBMED   39117603
  REMARK    GeneRIF: Human tumor suppressor protein Pdcd4 binds at the mRNA
            entry channel in the 40S small ribosomal subunit.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3481)
  AUTHORS   Liu,L., Feng,X., Fan,C., Kong,D., Feng,X., Sun,C., Xu,Y., Li,B.,
            Jiang,Y. and Zheng,C.
  TITLE     PDCD4 interacting with PIK3CB and CTSZ promotes the apoptosis of
            multiple myeloma cells
  JOURNAL   FASEB J 38 (16), e70024 (2024)
   PUBMED   39190024
  REMARK    GeneRIF: PDCD4 interacting with PIK3CB and CTSZ promotes the
            apoptosis of multiple myeloma cells.
REFERENCE   3  (bases 1 to 3481)
  AUTHORS   Khan,M.T., Almas,M., Malik,N., Jalota,A., Sharma,S., Ali,S.A.,
            Luthra,K., Suri,V., Suri,A., Basak,S., Seth,P., Chosdol,K. and
            Sinha,S.
  TITLE     STAT1 mediated downregulation of the tumor suppressor gene PDCD4,
            is driven by the atypical cadherin FAT1, in glioblastoma
  JOURNAL   Cell Signal 119, 111178 (2024)
   PUBMED   38640981
  REMARK    GeneRIF: STAT1 mediated downregulation of the tumor suppressor gene
            PDCD4, is driven by the atypical cadherin FAT1, in glioblastoma.
REFERENCE   4  (bases 1 to 3481)
  AUTHORS   Li,H. and Wu,G.M.
  TITLE     Progress on the relationship between tumor suppressor PDCD4 and
            diseases based on the analysis of structural characteristics
  JOURNAL   Yi Chuan 46 (4), 290-305 (2024)
   PUBMED   38632092
  REMARK    GeneRIF: Progress on the relationship between tumor suppressor
            PDCD4 and diseases based on the analysis of structural
            characteristics.
            Review article
REFERENCE   5  (bases 1 to 3481)
  AUTHORS   Zhang,J., Qin,M., Kao,C., Shi,Y., Yang,Z., Chen,T., Liu,M.,
            Fang,L., Gao,F., Qin,Y. and Ding,L.
  TITLE     PDCD4 deficiency improved 4-vinylcyclohexene dioxide-induced mouse
            premature ovarian insufficiency
  JOURNAL   Reprod Biomed Online 48 (4), 103685 (2024)
   PUBMED   38324980
  REMARK    GeneRIF: PDCD4 deficiency improved 4-vinylcyclohexene
            dioxide-induced mouse premature ovarian insufficiency.
REFERENCE   6  (bases 1 to 3481)
  AUTHORS   Chen,Y., Knosel,T., Kristiansen,G., Pietas,A., Garber,M.E.,
            Matsuhashi,S., Ozaki,I. and Petersen,I.
  TITLE     Loss of PDCD4 expression in human lung cancer correlates with
            tumour progression and prognosis
  JOURNAL   J Pathol 200 (5), 640-646 (2003)
   PUBMED   12898601
REFERENCE   7  (bases 1 to 3481)
  AUTHORS   Kang,M.J., Ahn,H.S., Lee,J.Y., Matsuhashi,S. and Park,W.Y.
  TITLE     Up-regulation of PDCD4 in senescent human diploid fibroblasts
  JOURNAL   Biochem Biophys Res Commun 293 (1), 617-621 (2002)
   PUBMED   12054647
  REMARK    GeneRIF: up-regulated in senescent diploid fibroblasts
REFERENCE   8  (bases 1 to 3481)
  AUTHORS   Yoshinaga,H., Matsuhashi,S., Fujiyama,C. and Masaki,Z.
  TITLE     Novel human PDCD4 (H731) gene expressed in proliferative cells is
            expressed in the small duct epithelial cells of the breast as
            revealed by an anti-H731 antibody
  JOURNAL   Pathol Int 49 (12), 1067-1077 (1999)
   PUBMED   10632927
REFERENCE   9  (bases 1 to 3481)
  AUTHORS   Soejima,H., Miyoshi,O., Yoshinaga,H., Masaki,Z., Ozaki,I.,
            Kajiwara,S., Niikawa,N., Matsuhashi,S. and Mukai,T.
  TITLE     Assignment of the programmed cell death 4 gene (PDCD4) to human
            chromosome band 10q24 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 87 (1-2), 113-114 (1999)
   PUBMED   10640828
REFERENCE   10 (bases 1 to 3481)
  AUTHORS   Azzoni,L., Zatsepina,O., Abebe,B., Bennett,I.M., Kanakaraj,P. and
            Perussia,B.
  TITLE     Differential transcriptional regulation of CD161 and a novel gene,
            197/15a, by IL-2, IL-15, and IL-12 in NK and T cells
  JOURNAL   J Immunol 161 (7), 3493-3500 (1998)
   PUBMED   9759869
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB241608.1, BC026104.2,
            AL136368.24, AL158163.11 and BX647834.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014456.4.
            
            Summary: This gene is a tumor suppressor and encodes a protein that
            binds to the eukaryotic translation initiation factor 4A1 and
            inhibits its function by preventing RNA binding. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Dec 2010].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.186923.1,
                                           SRR1803614.254386.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000280154.12/ ENSP00000280154.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 DB241608.1         134-136
            4-85                BC026104.2         4-85
            86-86               AL136368.24        125389-125389
            87-258              BC026104.2         87-258
            259-296             AL136368.24        134671-134708
            297-1652            BC026104.2         297-1652
            1653-1653           AL158163.11        15706-15706
            1654-2214           BC026104.2         1653-2213
            2215-3231           BX647834.1         2188-3204
            3232-3232           AL158163.11        17285-17285
            3233-3481           BX647834.1         3206-3454
FEATURES             Location/Qualifiers
     source          1..3481
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.2"
     gene            1..3481
                     /gene="PDCD4"
                     /gene_synonym="H731"
                     /note="programmed cell death 4"
                     /db_xref="GeneID:27250"
                     /db_xref="HGNC:HGNC:8763"
                     /db_xref="MIM:608610"
     exon            1..91
                     /gene="PDCD4"
                     /gene_synonym="H731"
                     /inference="alignment:Splign:2.1.0"
     exon            92..196
                     /gene="PDCD4"
                     /gene_synonym="H731"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1563
                     /gene="PDCD4"
                     /gene_synonym="H731"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear antigen H731; programmed cell death protein 4;
                     protein 197/15a; neoplastic transformation inhibitor
                     protein; programmed cell death 4 (neoplastic
                     transformation inhibitor)"
                     /codon_start=1
                     /product="programmed cell death protein 4 isoform 1"
                     /protein_id="NP_055271.2"
                     /db_xref="CCDS:CCDS7567.1"
                     /db_xref="GeneID:27250"
                     /db_xref="HGNC:HGNC:8763"
                     /db_xref="MIM:608610"
                     /translation="MDVENEQILNVNPADPDNLSDSLFSGDEENAGTEEIKNEINGNW
                     ISASSINEARINAKAKRRLRKNSSRDSGRGDSVSDSGSDALRSGLTVPTSPKGRLLDR
                     RSRSGKGRGLPKKGGAGGKGVWGTPGQVYDVEEVDVKDPNYDDDQENCVYETVVLPLD
                     ERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREM
                     TSKLLSDLCGTVMSTTDVEKSFDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCN
                     TYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQSVNHLVKEIDML
                     LKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWK
                     SSTITVDQMKRGYERIYNEIPDINLDVPHSYSVLERFVEECFQAGIISKQLRDLCPSR
                     GRKRFVSEGDGGRLKPESY"
     exon            197..499
                     /gene="PDCD4"
                     /gene_synonym="H731"
                     /inference="alignment:Splign:2.1.0"
     exon            500..594
                     /gene="PDCD4"
                     /gene_synonym="H731"
                     /inference="alignment:Splign:2.1.0"
     exon            595..708
                     /gene="PDCD4"
                     /gene_synonym="H731"
                     /inference="alignment:Splign:2.1.0"
     exon            709..930
                     /gene="PDCD4"
                     /gene_synonym="H731"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1028
                     /gene="PDCD4"
                     /gene_synonym="H731"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1143
                     /gene="PDCD4"
                     /gene_synonym="H731"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1251
                     /gene="PDCD4"
                     /gene_synonym="H731"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1362
                     /gene="PDCD4"
                     /gene_synonym="H731"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1502
                     /gene="PDCD4"
                     /gene_synonym="H731"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..3481
                     /gene="PDCD4"
                     /gene_synonym="H731"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2194..2199
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDCD4"
                     /gene_synonym="H731"
                     /note="hexamer: AATAAA"
     polyA_site      2214
                     /gene="PDCD4"
                     /gene_synonym="H731"
                     /note="major polyA site"
     regulatory      2599..2604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDCD4"
                     /gene_synonym="H731"
                     /note="hexamer: AATAAA"
     polyA_site      2622
                     /gene="PDCD4"
                     /gene_synonym="H731"
     regulatory      3457..3462
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDCD4"
                     /gene_synonym="H731"
                     /note="hexamer: AATAAA"
     polyA_site      3481
                     /gene="PDCD4"
                     /gene_synonym="H731"
                     /note="major polyA site"
ORIGIN      
        1 agagactctc cgaggcggcg gcagagacag aagagcgggg tcggggccgg ctgaccagga
       61 acctgggcga gcagcggcgg gggcccgagg gattctgaag gaagatttcc attaggtaat
      121 ttgtttaatc agtgcaagcg aaattaaggg aaaatggatg tagaaaatga gcagatactg
      181 aatgtaaacc ctgcagatcc tgataactta agtgactctc tcttttccgg tgatgaagaa
      241 aatgctggga ctgaggaaat aaagaatgaa ataaatggaa attggatttc agcatcctcc
      301 attaacgaag ctagaattaa tgccaaggca aaaaggcgac taaggaaaaa ctcatcccgg
      361 gactctggca gaggcgattc ggtcagcgac agtgggagtg acgcccttag aagtggatta
      421 actgtgccaa ccagtccaaa gggaaggttg ctggataggc gatccagatc tgggaaagga
      481 aggggactac caaagaaagg tggtgcagga ggcaaaggtg tctggggtac acctggacag
      541 gtgtatgatg tggaggaggt ggatgtgaaa gatcctaact atgatgatga ccaggagaac
      601 tgtgtttatg aaactgtagt tttgcctttg gatgaaaggg catttgagaa gactttaaca
      661 ccaatcatac aggaatattt tgagcatgga gatactaatg aagttgcgga aatgttaaga
      721 gatttaaatc ttggtgaaat gaaaagtgga gtaccagtgt tggcagtatc cttagcattg
      781 gaggggaagg ctagtcatag agagatgaca tctaagcttc tttctgacct ttgtgggaca
      841 gtaatgagca caactgatgt ggaaaaatca tttgataaat tgttgaaaga tctacctgaa
      901 ttagcactgg atactcctag agcaccacag ttggtgggcc agtttattgc tagagctgtt
      961 ggagatggaa ttttatgtaa tacctatatt gatagttaca aaggaactgt agattgtgtg
     1021 caggctagag ctgctctgga taaggctacc gtgcttctga gtatgtctaa aggtggaaag
     1081 cgtaaagata gtgtgtgggg ctctggaggt gggcagcaat ctgtcaatca ccttgttaaa
     1141 gagattgata tgctgctgaa agaatattta ctctctggag acatatctga agctgaacat
     1201 tgccttaagg aactggaagt acctcatttt caccatgagc ttgtatatga agctattata
     1261 atggttttag agtcaactgg agaaagtaca tttaagatga ttttggattt attaaagtcc
     1321 ctttggaagt cttctaccat tactgtagac caaatgaaaa gaggttatga gagaatttac
     1381 aatgaaattc cggacattaa tctggatgtc ccacattcat actctgtgct ggagcggttt
     1441 gtagaagaat gttttcaggc tggaataatt tccaaacaac tcagagatct ttgtccttca
     1501 aggggcagaa agcgttttgt aagcgaagga gatggaggtc gtcttaaacc agagagctac
     1561 tgaatataag aactcttgca gtcttagatg ttataaaaat atatatctga attgtaagag
     1621 ttgttagcac aagttttttt tttttttttt tttaagcact tgttttgggt acaaggcatt
     1681 tctgacattt tataaaccta catttaaggg gaatttttaa aggaaatgtt ttttcttttt
     1741 tttttgtttt tcgagggggc aaggagggac agaaaagtaa cctcttctta agtggaatat
     1801 tctaataagc taccttttgt aagtgccatg tttattatct aatcattcca agttttgcat
     1861 tgatgtctga ctgccactcc tttctttcaa ggacagtgtt ttttgtagta aaatcactgg
     1921 tttatacaaa gctttattta gggggtaaag ttaagctgct aaaaccccat gttggctgct
     1981 gctgttgaga tactgtgctt tgggagtaaa aaaagaaagt tatttctttg tcttaaagaa
     2041 tttttaaaaa attagtcatg agacttattc atctttccag ggaacatact gattggtctt
     2101 aaaagactag acagttaagt aaaaggtggc tggaacatct atttttctac aaaactggaa
     2161 aaatgaacct ggttctagaa gaatgtacac caaaataaaa catgtgaagc agtattgatt
     2221 ctttattggg agtacatttt tttaggtctc ttaaacttta atttcacaca gtaaattttg
     2281 aatctcataa ggaagcatat ttgaacctag tcaatttaat cttagtgttc ccttgaaaac
     2341 tttttttccc tacaaaattt taagtgaaaa atacaatagt aaattaagat tacactgggg
     2401 aaaaaaatgc aggtatcact ttactccatt gttatctgac ctagagctta attaagtttt
     2461 agaaatatgt aataccttcc atcattccat catccttaaa ttctgttacc aaataatggc
     2521 taatgttaca aaaagttata ctccagagac ccaaagcttg acatttacct aatgtatgag
     2581 aaaatattac caattaacaa taaagaatga tcatattttt aacctctttt acatagccta
     2641 ataactcagc aaggcctcaa cgtctgtgct aatttaaact gccaaatatt gactgcagca
     2701 aacaagaatt atattcagaa tttatgaggg tactgttagg agtatactgc ttacaggttt
     2761 agatatagtc tgttagaatt aaaaccaagt ttagtgttca tatttacctc atgggcttta
     2821 tcaagcccat attacctcag cttatatata gttaccattt ttaggttttt aattgtttga
     2881 cacttggatg ataaatgcag tcattttatt ctcaagtgct taaaattaat gtaattaaaa
     2941 gcttagctga ctacagaata ggtgagggtt tcttaaaaat gagatttaag ggctgggcac
     3001 ggtggctcat gcctgtaatc ccagcacttt gggaggccga ggtgggcgga tcacttgagg
     3061 ttgggagttc atgaccagct tgaccaacat gaagaaaccc tgtctctatt aaaaatacaa
     3121 aagtagccag gcatggtggc gcatgcgtgt aatcccagct acttgggagg ctgaggcagg
     3181 agaattgctt gaacctggga ggcagaggtt gcagtgagtc gagatggtgc cattgctctc
     3241 gtttgggcaa caagagtgaa actcttgtct caaaaaaaaa aaaaaatgag gtttaagaca
     3301 gttttgtcat tactggtggg atctggtcac acaagatagc attaaacgtg acatggcaca
     3361 taaaattggt taaaaaattt tgttttttaa ttacgtaatg taaaagccca acaaacactt
     3421 tatgcaagat tggaatgtat cttcaaattc agatttaata aacatgtaaa gatcctctgt
     3481 a
//
