LOCUS       NM_032346               1157 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens programmed cell death 2 like (PDCD2L), transcript
            variant 1, mRNA.
ACCESSION   NM_032346
VERSION     NM_032346.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1157)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1157)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 1157)
  AUTHORS   Landry-Voyer,A.M., Bilodeau,S., Bergeron,D., Dionne,K.L.,
            Port,S.A., Rouleau,C., Boisvert,F.M., Kehlenbach,R.H. and
            Bachand,F.
  TITLE     Human PDCD2L Is an Export Substrate of CRM1 That Associates with
            40S Ribosomal Subunit Precursors
  JOURNAL   Mol Cell Biol 36 (24), 3019-3032 (2016)
   PUBMED   27697862
  REMARK    GeneRIF: Findings uncover the existence of an extra-ribosomal
            complex consisting of PDCD2L, RPS2, and PRMT3 and support a role
            for PDCD2L in the late maturation of 40S ribosomal subunits.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1157)
  AUTHORS   Burroughs,A.M. and Aravind,L.
  TITLE     Analysis of two domains with novel RNA-processing activities throws
            light on the complex evolution of ribosomal RNA biogenesis
  JOURNAL   Front Genet 5, 424 (2014)
   PUBMED   25566315
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1157)
  AUTHORS   Taipale,M., Tucker,G., Peng,J., Krykbaeva,I., Lin,Z.Y., Larsen,B.,
            Choi,H., Berger,B., Gingras,A.C. and Lindquist,S.
  TITLE     A quantitative chaperone interaction network reveals the
            architecture of cellular protein homeostasis pathways
  JOURNAL   Cell 158 (2), 434-448 (2014)
   PUBMED   25036637
REFERENCE   6  (bases 1 to 1157)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 1157)
  AUTHORS   Chen,Q., Yan,C.Q., Liu,F.J., Tong,J., Miao,S.L. and Chen,J.P.
  TITLE     Overexpression of the PDCD2-like gene results in inhibited
            TNF-alpha production in activated Daudi cells
  JOURNAL   Hum Immunol 69 (4-5), 259-265 (2008)
   PUBMED   18486760
  REMARK    GeneRIF: Overexpression of PDCD2-like gene attenutates TNF-alpha
            release in Daudi cells
REFERENCE   8  (bases 1 to 1157)
  AUTHORS   Chen,Q., Yan,C., Yan,Q., Feng,L., Chen,J. and Qian,K.
  TITLE     The novel MGC13096 protein is correlated with proliferation
  JOURNAL   Cell Biochem Funct 26 (2), 141-145 (2008)
   PUBMED   17393540
  REMARK    GeneRIF: MGC13096 over-expression restrained proliferation of
            HEK293T cells. DNA/flow cytometry analysis showed that the
            over-expression of MGC13096 severely delays cell cycle progression
            at S phase.
REFERENCE   9  (bases 1 to 1157)
  AUTHORS   Chen,Q., Qian,K. and Yan,C.
  TITLE     Cloning of cDNAs with PDCD2(C) domain and their expressions during
            apoptosis of HEK293T cells
  JOURNAL   Mol Cell Biochem 280 (1-2), 185-191 (2005)
   PUBMED   16311922
  REMARK    GeneRIF: To study the role of PDCD2_C domain in apoptosis, the
            cDNAs of two isoforms of PDCD2 and MGC13096 were cloned. PDCD2
            (NM_002598) was over expressed when endothelial cells treated with
            leukotriene D4 or natural killer cells were activated by IL-2.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC006146.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032346.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006146.1, SRR1163658.556297.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000246535.4/ ENSP00000246535.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1157              BC006146.1         2-1158
FEATURES             Location/Qualifiers
     source          1..1157
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.11"
     gene            1..1157
                     /gene="PDCD2L"
                     /note="programmed cell death 2 like"
                     /db_xref="GeneID:84306"
                     /db_xref="HGNC:HGNC:28194"
                     /db_xref="MIM:615661"
     exon            1..140
                     /gene="PDCD2L"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1109
                     /gene="PDCD2L"
                     /note="isoform 1 is encoded by transcript variant 1;
                     programmed cell death protein 2-like"
                     /codon_start=1
                     /product="programmed cell death protein 2-like isoform 1"
                     /protein_id="NP_115722.1"
                     /db_xref="CCDS:CCDS12438.1"
                     /db_xref="GeneID:84306"
                     /db_xref="HGNC:HGNC:28194"
                     /db_xref="MIM:615661"
                     /translation="MAAVLKPVLLGLRDAPVHGSPTGPGAWTASKLGGIPDALPTVAA
                     PRPVCQRCGQPLALVVQVYCPLEGSPFHRLLHVFACACPGCSTGGARSWKVFRSQCLQ
                     VPEREAQDAQKQGNSLAAEDWCEGADDWGSDTEEGPSPQFTLDFGNDASSAKDVDWTA
                     RLQDLRLQDAVLGAAHPVPPGLPLFLPYYICVADEDDYRDFVNLDHAHSLLRDYQQRE
                     GIAMDQLLSQSLPNDGDEKYEKTIIKSGDQTFYKFMKRIAACQEQILRYSWSGEPLFL
                     TCPTSEVTELPACSQCGGQRIFEFQLMPALVSMLKSANLGLSVEFGTILVYTCEKSCW
                     PPNHQTPMEEFCIIQEDPDELLFK"
     exon            141..307
                     /gene="PDCD2L"
                     /inference="alignment:Splign:2.1.0"
     exon            308..368
                     /gene="PDCD2L"
                     /inference="alignment:Splign:2.1.0"
     exon            369..718
                     /gene="PDCD2L"
                     /inference="alignment:Splign:2.1.0"
     exon            719..829
                     /gene="PDCD2L"
                     /inference="alignment:Splign:2.1.0"
     exon            830..978
                     /gene="PDCD2L"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1157
                     /gene="PDCD2L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1138..1143
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDCD2L"
                     /note="hexamer: AACAAA"
     polyA_site      1157
                     /gene="PDCD2L"
                     /note="major polyA site"
ORIGIN      
        1 agtttgcgtt ttcacctggt cgcccggcgg ccatggcggc cgttctgaag ccggtgctgc
       61 tgggccttcg agatgcgccg gtgcacggca gccccacagg gccgggtgcc tggactgcta
      121 gcaagctggg cggcattccg gatgctctgc ccaccgtggc tgcgcccagg cccgtgtgtc
      181 agcgctgcgg gcagccgctc gctctggtcg tgcaggtgta ttgcccgctg gaaggctccc
      241 cgtttcaccg tctgctgcac gtgttcgcgt gcgcctgccc cggctgtagc accggcggtg
      301 cgcgcagctg gaaggtgttc cgctcccagt gcctgcaggt gccagagaga gaggcgcagg
      361 acgctcagaa acagggaaac agccttgcag ctgaggactg gtgtgaaggt gctgatgact
      421 ggggaagtga tactgaggag gggccttcac cacagtttac cttggatttt gggaatgatg
      481 ccagcagtgc caaagacgta gactggactg ctcggctcca agacctccgc ctgcaggatg
      541 ctgtcctggg tgctgcccat cctgtgcctc ctgggctgcc gctcttcctg ccctactaca
      601 tctgtgttgc agatgaggat gattacaggg actttgtcaa cctggatcat gcccacagcc
      661 ttctgaggga ctatcagcag agagaaggca ttgccatgga tcagttgctt tcccaaagcc
      721 ttcctaatga tggtgatgaa aaatatgaga agaccataat taaaagtgga gatcagacgt
      781 tttacaaatt catgaagcga attgctgctt gtcaggagca gattttgagg tattcctgga
      841 gtggagagcc actctttttg acctgcccta catcagaagt caccgagctc ccagcctgca
      901 gccagtgtgg aggccaaagg atatttgagt ttcagcttat gccagcactg gtcagcatgc
      961 tcaagagtgc taatttaggt ctttctgtgg aatttggaac aattctagtt tacacatgtg
     1021 agaagagttg ctggccccca aatcatcaga ctcccatgga agaattttgt attatacaag
     1081 aagacccaga tgaattattg tttaagtaga gcatttcctt ttattaatat aaattaaaac
     1141 aaatgtttac atccaaa
//
