LOCUS       NM_025239               2432 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens programmed cell death 1 ligand 2 (PDCD1LG2), mRNA.
ACCESSION   NM_025239
VERSION     NM_025239.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2432)
  AUTHORS   Wang,S., Su,D., Chen,H., Lai,J.C., Tang,C., Li,Y., Wang,Y.,
            Yang,Y., Qin,M., Jia,L., Cui,W., Yang,J., Wang,L. and Wu,C.
  TITLE     PD-L2 drives resistance to EGFR-TKIs: dynamic changes of the tumor
            immune environment and targeted therapy
  JOURNAL   Cell Death Differ 31 (9), 1140-1156 (2024)
   PUBMED   38816578
  REMARK    GeneRIF: PD-L2 drives resistance to EGFR-TKIs: dynamic changes of
            the tumor immune environment and targeted therapy.
REFERENCE   2  (bases 1 to 2432)
  AUTHORS   Tsuneyoshi,N., Hosoya,T., Takeno,Y., Saitoh,K., Murai,H.,
            Amimoto,N., Tatsumi,R., Watanabe,S., Hasegawa,Y., Kikkawa,E.,
            Goto,K., Nishigaki,F., Tamura,K. and Kimura,H.
  TITLE     Hypoimmunogenic human iPSCs expressing HLA-G, PD-L1, and PD-L2
            evade innate and adaptive immunity
  JOURNAL   Stem Cell Res Ther 15 (1), 193 (2024)
   PUBMED   38956724
  REMARK    GeneRIF: Hypoimmunogenic human iPSCs expressing HLA-G, PD-L1, and
            PD-L2 evade innate and adaptive immunity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2432)
  AUTHORS   Dioken,D.N., Ozgul,I., Yilmazbilek,I., Yakicier,M.C., Karaca,E. and
            Erson-Bensan,A.E.
  TITLE     An alternatively spliced PD-L1 isoform PD-L13, and PD-L2 expression
            in breast cancers: implications for eligibility scoring and
            immunotherapy response
  JOURNAL   Cancer Immunol Immunother 72 (12), 4065-4075 (2023)
   PUBMED   37768345
  REMARK    GeneRIF: An alternatively spliced PD-L1 isoform PD-L13, and PD-L2
            expression in breast cancers: implications for eligibility scoring
            and immunotherapy response.
REFERENCE   4  (bases 1 to 2432)
  AUTHORS   Matsubara,E., Shinchi,Y., Komohara,Y., Yano,H., Pan,C.,
            Fujiwara,Y., Ikeda,K. and Suzuki,M.
  TITLE     PD-L2 overexpression on tumor-associated macrophages is one of the
            predictors for better prognosis in lung adenocarcinoma
  JOURNAL   Med Mol Morphol 56 (4), 250-256 (2023)
   PUBMED   37402054
  REMARK    GeneRIF: PD-L2 overexpression on tumor-associated macrophages is
            one of the predictors for better prognosis in lung adenocarcinoma.
REFERENCE   5  (bases 1 to 2432)
  AUTHORS   Kuol,N., Godlewski,J., Kmiec,Z., Vogrin,S., Fraser,S.,
            Apostolopoulos,V. and Nurgali,K.
  TITLE     Cholinergic signaling influences the expression of immune
            checkpoint inhibitors, PD-L1 and PD-L2, and tumor hallmarks in
            human colorectal cancer tissues and cell lines
  JOURNAL   BMC Cancer 23 (1), 971 (2023)
   PUBMED   37828429
  REMARK    GeneRIF: Cholinergic signaling influences the expression of immune
            checkpoint inhibitors, PD-L1 and PD-L2, and tumor hallmarks in
            human colorectal cancer tissues and cell lines.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2432)
  AUTHORS   Tsushima,F., Iwai,H., Otsuki,N., Abe,M., Hirose,S., Yamazaki,T.,
            Akiba,H., Yagita,H., Takahashi,Y., Omura,K., Okumura,K. and
            Azuma,M.
  TITLE     Preferential contribution of B7-H1 to programmed death-1-mediated
            regulation of hapten-specific allergic inflammatory responses
  JOURNAL   Eur J Immunol 33 (10), 2773-2782 (2003)
   PUBMED   14515261
  REMARK    GeneRIF: regulatory role of PD-1 and the differential roles of
            B7-H1 and B7-DC in hapten-induced immune responses.
REFERENCE   7  (bases 1 to 2432)
  AUTHORS   Youngnak,P., Kozono,Y., Kozono,H., Iwai,H., Otsuki,N., Jin,H.,
            Omura,K., Yagita,H., Pardoll,D.M., Chen,L. and Azuma,M.
  TITLE     Differential binding properties of B7-H1 and B7-DC to programmed
            death-1
  JOURNAL   Biochem Biophys Res Commun 307 (3), 672-677 (2003)
   PUBMED   12893276
  REMARK    GeneRIF: Binding properties of B7-DC to programmed death-1.
REFERENCE   8  (bases 1 to 2432)
  AUTHORS   Brown,J.A., Dorfman,D.M., Ma,F.R., Sullivan,E.L., Munoz,O.,
            Wood,C.R., Greenfield,E.A. and Freeman,G.J.
  TITLE     Blockade of programmed death-1 ligands on dendritic cells enhances
            T cell activation and cytokine production
  JOURNAL   J Immunol 170 (3), 1257-1266 (2003)
   PUBMED   12538684
  REMARK    GeneRIF: Blockade of PD-L2 during T cell responses initiated by
            allogenic dendritic cells increases T cell proliferation and
            cytokine production, showing that PD-L2 functions to inhibit T cell
            activation.
REFERENCE   9  (bases 1 to 2432)
  AUTHORS   Tseng,S.Y., Otsuji,M., Gorski,K., Huang,X., Slansky,J.E., Pai,S.I.,
            Shalabi,A., Shin,T., Pardoll,D.M. and Tsuchiya,H.
  TITLE     B7-DC, a new dendritic cell molecule with potent costimulatory
            properties for T cells
  JOURNAL   J Exp Med 193 (7), 839-846 (2001)
   PUBMED   11283156
REFERENCE   10 (bases 1 to 2432)
  AUTHORS   Latchman,Y., Wood,C.R., Chernova,T., Chaudhary,D., Borde,M.,
            Chernova,I., Iwai,Y., Long,A.J., Brown,J.A., Nunes,R.,
            Greenfield,E.A., Bourque,K., Boussiotis,V.A., Carter,L.L.,
            Carreno,B.M., Malenkovich,N., Nishimura,H., Okazaki,T., Honjo,T.,
            Sharpe,A.H. and Freeman,G.J.
  TITLE     PD-L2 is a second ligand for PD-1 and inhibits T cell activation
  JOURNAL   Nat Immunol 2 (3), 261-268 (2001)
   PUBMED   11224527
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL162253.17, AF344424.1, AF329193.1, BX951459.1, AK001872.1 and
            CA442083.1.
            
            On May 17, 2019 this sequence version replaced NM_025239.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.433334.1,
                                           SRR1803612.136662.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397747.5/ ENSP00000380855.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AL162253.17        56119-56132
            15-113              AF344424.1         1-99
            114-972             AF329193.1         85-943
            973-973             BX951459.1         596-596
            974-1512            AF329193.1         945-1483
            1513-2402           AK001872.1         930-1819
            2403-2432           CA442083.1         610-639
FEATURES             Location/Qualifiers
     source          1..2432
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p24.1"
     gene            1..2432
                     /gene="PDCD1LG2"
                     /gene_synonym="B7DC; bA574F11.2; Btdc; CD273; PD-L2;
                     PDCD1L2; PDL2"
                     /note="programmed cell death 1 ligand 2"
                     /db_xref="GeneID:80380"
                     /db_xref="HGNC:HGNC:18731"
                     /db_xref="MIM:605723"
     exon            1..273
                     /gene="PDCD1LG2"
                     /gene_synonym="B7DC; bA574F11.2; Btdc; CD273; PD-L2;
                     PDCD1L2; PDL2"
                     /inference="alignment:Splign:2.1.0"
     exon            274..342
                     /gene="PDCD1LG2"
                     /gene_synonym="B7DC; bA574F11.2; Btdc; CD273; PD-L2;
                     PDCD1L2; PDL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..1109
                     /gene="PDCD1LG2"
                     /gene_synonym="B7DC; bA574F11.2; Btdc; CD273; PD-L2;
                     PDCD1L2; PDL2"
                     /note="programmed death ligand 2; B7 dendritic cell
                     molecule; PD-1-ligand 2; B7-DC; PDCD1 ligand 2;
                     butyrophilin B7-DC"
                     /codon_start=1
                     /product="programmed cell death 1 ligand 2 precursor"
                     /protein_id="NP_079515.2"
                     /db_xref="CCDS:CCDS6465.1"
                     /db_xref="GeneID:80380"
                     /db_xref="HGNC:HGNC:18731"
                     /db_xref="MIM:605723"
                     /translation="MIFLLLMLSLELQLHQIAALFTVTVPKELYIIEHGSNVTLECNF
                     DTGSHVNLGAITASLQKVENDTSPHRERATLLEEQLPLGKASFHIPQVQVRDEGQYQC
                     IIIYGVAWDYKYLTLKVKASYRKINTHILKVPETDEVELTCQATGYPLAEVSWPNVSV
                     PANTSHSRTPEGLYQVTSVLRLKPPPGRNFSCVFWNTHVRELTLASIDLQSQMEPRTH
                     PTWLLHIFIPFCIIAFIFIATVIALRKQLCQKLYSSKDTTKRPVTTTKREVNSAI"
     exon            343..648
                     /gene="PDCD1LG2"
                     /gene_synonym="B7DC; bA574F11.2; Btdc; CD273; PD-L2;
                     PDCD1L2; PDL2"
                     /inference="alignment:Splign:2.1.0"
     exon            649..918
                     /gene="PDCD1LG2"
                     /gene_synonym="B7DC; bA574F11.2; Btdc; CD273; PD-L2;
                     PDCD1L2; PDL2"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1053
                     /gene="PDCD1LG2"
                     /gene_synonym="B7DC; bA574F11.2; Btdc; CD273; PD-L2;
                     PDCD1L2; PDL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1103
                     /gene="PDCD1LG2"
                     /gene_synonym="B7DC; bA574F11.2; Btdc; CD273; PD-L2;
                     PDCD1L2; PDL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..2432
                     /gene="PDCD1LG2"
                     /gene_synonym="B7DC; bA574F11.2; Btdc; CD273; PD-L2;
                     PDCD1L2; PDL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2379..2384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDCD1LG2"
                     /gene_synonym="B7DC; bA574F11.2; Btdc; CD273; PD-L2;
                     PDCD1L2; PDL2"
                     /note="hexamer: AATAAA"
     polyA_site      2404
                     /gene="PDCD1LG2"
                     /gene_synonym="B7DC; bA574F11.2; Btdc; CD273; PD-L2;
                     PDCD1L2; PDL2"
                     /note="major polyA site"
ORIGIN      
        1 actctcatgt tacggcaaac cttaagctga atgaacaact tttcttctct tgaatatatc
       61 ttaacgccaa attttgagtg cttttttgtt acccatcctc atatgtccca gctagaaaga
      121 atcctgggtt ggagctactg catgttgatt gttttgtttt tccttttggc tgttcatttt
      181 ggtggctact ataaggaaat ctaacacaaa cagcaactgt tttttgttgt ttacttttgc
      241 atctttactt gtggagctgt ggcaagtcct catatcaaat acagaacatg atcttcctcc
      301 tgctaatgtt gagcctggaa ttgcagcttc accagatagc agctttattc acagtgacag
      361 tccctaagga actgtacata atagagcatg gcagcaatgt gaccctggaa tgcaactttg
      421 acactggaag tcatgtgaac cttggagcaa taacagccag tttgcaaaag gtggaaaatg
      481 atacatcccc acaccgtgaa agagccactt tgctggagga gcagctgccc ctagggaagg
      541 cctcgttcca catacctcaa gtccaagtga gggacgaagg acagtaccaa tgcataatca
      601 tctatggggt cgcctgggac tacaagtacc tgactctgaa agtcaaagct tcctacagga
      661 aaataaacac tcacatccta aaggttccag aaacagatga ggtagagctc acctgccagg
      721 ctacaggtta tcctctggca gaagtatcct ggccaaacgt cagcgttcct gccaacacca
      781 gccactccag gacccctgaa ggcctctacc aggtcaccag tgttctgcgc ctaaagccac
      841 cccctggcag aaacttcagc tgtgtgttct ggaatactca cgtgagggaa cttactttgg
      901 ccagcattga ccttcaaagt cagatggaac ccaggaccca tccaacttgg ctgcttcaca
      961 ttttcatccc cttctgcatc attgctttca ttttcatagc cacagtgata gccctaagaa
     1021 aacaactctg tcaaaagctg tattcttcaa aagacacaac aaaaagacct gtcaccacaa
     1081 caaagaggga agtgaacagt gctatctgaa cctgtggtct tgggagccag ggtgacctga
     1141 tatgacatct aaagaagctt ctggactctg aacaagaatt cggtggcctg cagagcttgc
     1201 catttgcact tttcaaatgc ctttggatga cccagcactt taatctgaaa cctgcaacaa
     1261 gactagccaa cacctggcca tgaaacttgc cccttcactg atctggactc acctctggag
     1321 cctatggctt taagcaagca ctactgcact ttacagaatt accccactgg atcctggacc
     1381 cacagaattc cttcaggatc cttcttgctg ccagactgaa agcaaaagga attatttccc
     1441 ctcaagtttt ctaagtgatt tccaaaagca gaggtgtgtg gaaatttcca gtaacagaaa
     1501 cagatgggtt gccaatagag ttatttttta tctatagctt cctctgggta ctagaagagg
     1561 ctattgagac tatgagctca cagacagggc ttcgcacaaa ctcaaatcat aattgacatg
     1621 ttttatggat tactggaatc ttgatagcat aatgaagttg ttctaattaa cagagagcat
     1681 ttaaatatac actaagtgca caaattgtgg agtaaagtca tcaagctctg tttttgaggt
     1741 ctaagtcaca aagcatttgt tttaacctgt aatggcacca tgtttaatgg tggttttttt
     1801 tttgaactac atctttcctt taaaaattat tggtttcttt ttatttgttt ttaccttaga
     1861 aatcaattat atacagtcaa aaatatttga tatgctcata cgttgtatct gcagcaattt
     1921 cagataagta gctaaaatgg ccaaagcccc aaactaagcc tccttttctg gccctcaata
     1981 tgactttaaa tttgactttt cagtgcctca gtttgcacat ctgtaataca gcaatgctaa
     2041 gtagtcaagg cctttgataa ttggcactat ggaaatcctg caagatccca ctacatatgt
     2101 gtggagcaga agggtaactc ggctacagta acagcttaat tttgttaaat ttgttcttta
     2161 tactggagcc atgaagctca gagcattagc tgacccttga actattcaaa tgggcacatt
     2221 agctagtata acagacttac ataggtgggc ctaaagcaag ctccttaact gagcaaaatt
     2281 tggggcttat gagaatgaaa gggtgtgaaa ttgactaaca gacaaatcat acatctcagt
     2341 ttctcaattc tcatgtaaat cagagaatgc ctttaaagaa taaaactcaa ttgttattct
     2401 tcaacgttct ttatatattc tacttttggg ta
//
