LOCUS       NM_014976               6477 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens programmed cell death 11 (PDCD11), transcript variant
            2, mRNA.
ACCESSION   NM_014976
VERSION     NM_014976.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6477)
  AUTHORS   Hoya,S., Watanabe,Y., Hishimoto,A., Nunokawa,A., Kaneko,N.,
            Muratake,T., Shinmyo,N., Otsuka,I., Okuda,S., Inoue,E., Igeta,H.,
            Shibuya,M., Egawa,J., Orime,N., Sora,I. and Someya,T.
  TITLE     Rare PDCD11 variations are not associated with risk of
            schizophrenia in Japan
  JOURNAL   Psychiatry Clin Neurosci 71 (11), 780-788 (2017)
   PUBMED   28657695
  REMARK    GeneRIF: data provide no evidence for the contribution of rare
            PDCD11 variations to the risk of schizophrenia in the Japanese
            population.
REFERENCE   2  (bases 1 to 6477)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   3  (bases 1 to 6477)
  AUTHORS   Ripke,S., O'Dushlaine,C., Chambert,K., Moran,J.L., Kahler,A.K.,
            Akterin,S., Bergen,S.E., Collins,A.L., Crowley,J.J., Fromer,M.,
            Kim,Y., Lee,S.H., Magnusson,P.K., Sanchez,N., Stahl,E.A.,
            Williams,S., Wray,N.R., Xia,K., Bettella,F., Borglum,A.D.,
            Bulik-Sullivan,B.K., Cormican,P., Craddock,N., de Leeuw,C.,
            Durmishi,N., Gill,M., Golimbet,V., Hamshere,M.L., Holmans,P.,
            Hougaard,D.M., Kendler,K.S., Lin,K., Morris,D.W., Mors,O.,
            Mortensen,P.B., Neale,B.M., O'Neill,F.A., Owen,M.J.,
            Milovancevic,M.P., Posthuma,D., Powell,J., Richards,A.L.,
            Riley,B.P., Ruderfer,D., Rujescu,D., Sigurdsson,E., Silagadze,T.,
            Smit,A.B., Stefansson,H., Steinberg,S., Suvisaari,J., Tosato,S.,
            Verhage,M., Walters,J.T., Levinson,D.F., Gejman,P.V., Kendler,K.S.,
            Laurent,C., Mowry,B.J., O'Donovan,M.C., Owen,M.J., Pulver,A.E.,
            Riley,B.P., Schwab,S.G., Wildenauer,D.B., Dudbridge,F., Holmans,P.,
            Shi,J., Albus,M., Alexander,M., Campion,D., Cohen,D., Dikeos,D.,
            Duan,J., Eichhammer,P., Godard,S., Hansen,M., Lerer,F.B.,
            Liang,K.Y., Maier,W., Mallet,J., Nertney,D.A., Nestadt,G.,
            Norton,N., O'Neill,F.A., Papadimitriou,G.N., Ribble,R.,
            Sanders,A.R., Silverman,J.M., Walsh,D., Williams,N.M., Wormley,B.,
            Arranz,M.J., Bakker,S., Bender,S., Bramon,E., Collier,D.,
            Crespo-Facorro,B., Hall,J., Iyegbe,C., Jablensky,A., Kahn,R.S.,
            Kalaydjieva,L., Lawrie,S., Lewis,C.M., Lin,K., Linszen,D.H.,
            Mata,I., McIntosh,A., Murray,R.M., Ophoff,R.A., Powell,J.,
            Rujescu,D., Van Os,J., Walshe,M., Weisbrod,M., Wiersma,D.,
            Donnelly,P., Barroso,I., Blackwell,J.M., Bramon,E., Brown,M.A.,
            Casas,J.P., Corvin,A.P., Deloukas,P., Duncanson,A., Jankowski,J.,
            Markus,H.S., Mathew,C.G., Palmer,C.N., Plomin,R., Rautanen,A.,
            Sawcer,S.J., Trembath,R.C., Viswanathan,A.C., Wood,N.W.,
            Spencer,C.C., Band,G., Bellenguez,C., Freeman,C., Hellenthal,G.,
            Giannoulatou,E., Pirinen,M., Pearson,R.D., Strange,A., Su,Z.,
            Vukcevic,D., Donnelly,P., Langford,C., Hunt,S.E., Edkins,S.,
            Gwilliam,R., Blackburn,H., Bumpstead,S.J., Dronov,S., Gillman,M.,
            Gray,E., Hammond,N., Jayakumar,A., McCann,O.T., Liddle,J.,
            Potter,S.C., Ravindrarajah,R., Ricketts,M.,
            Tashakkori-Ghanbaria,A., Waller,M.J., Weston,P., Widaa,S.,
            Whittaker,P., Barroso,I., Deloukas,P., Mathew,C.G., Blackwell,J.M.,
            Brown,M.A., Corvin,A.P., McCarthy,M.I., Spencer,C.C., Bramon,E.,
            Corvin,A.P., O'Donovan,M.C., Stefansson,K., Scolnick,E.,
            Purcell,S., McCarroll,S.A., Sklar,P., Hultman,C.M. and
            Sullivan,P.F.
  CONSRTM   Multicenter Genetic Studies of Schizophrenia Consortium; Psychosis
            Endophenotypes International Consortium; Wellcome Trust Case
            Control Consortium 2
  TITLE     Genome-wide association analysis identifies 13 new risk loci for
            schizophrenia
  JOURNAL   Nat Genet 45 (10), 1150-1159 (2013)
   PUBMED   23974872
REFERENCE   4  (bases 1 to 6477)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 6477)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 6477)
  AUTHORS   Turner,A.J., Knox,A.A., Prieto,J.L., McStay,B. and Watkins,N.J.
  TITLE     A novel small-subunit processome assembly intermediate that
            contains the U3 snoRNP, nucleolin, RRP5, and DBP4
  JOURNAL   Mol Cell Biol 29 (11), 3007-3017 (2009)
   PUBMED   19332556
  REMARK    GeneRIF: The 50S U3 snoRNP is an small subunit assembly
            intermediate that is likely recruited to the pre-rRNA through the
            RNA-binding proteins nucleolin and RRP5.[RRP5, DBP4]
REFERENCE   7  (bases 1 to 6477)
  AUTHORS   Sweet,T., Yen,W., Khalili,K. and Amini,S.
  TITLE     Evidence for involvement of NFBP in processing of ribosomal RNA
  JOURNAL   J Cell Physiol 214 (2), 381-388 (2008)
   PUBMED   17654514
  REMARK    GeneRIF: Evidence is presented for involvement of PDCD11 in
            processing of ribosomal RNA.
REFERENCE   8  (bases 1 to 6477)
  AUTHORS   Sweet,T., Khalili,K., Sawaya,B.E. and Amini,S.
  TITLE     Identification of a novel protein from glial cells based on its
            ability to interact with NF-kappaB subunits
  JOURNAL   J Cell Biochem 90 (5), 884-891 (2003)
   PUBMED   14624448
REFERENCE   9  (bases 1 to 6477)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
REFERENCE   10 (bases 1 to 6477)
  AUTHORS   Lacana,E. and D'Adamio,L.
  TITLE     Regulation of Fas ligand expression and cell death by
            apoptosis-linked gene 4
  JOURNAL   Nat Med 5 (5), 542-547 (1999)
   PUBMED   10229231
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591408.19, BC049838.1, D80007.1, BM476302.1 and AL139339.22.
            
            On Nov 22, 2018 this sequence version replaced NM_014976.1.
            
            Summary: PDCD11 is a NF-kappa-B (NFKB1; 164011)-binding protein
            that colocalizes with U3 RNA (MIM 180710) in the nucleolus and is
            required for rRNA maturation and generation of 18S rRNA (Sweet et
            al., 2003 [PubMed 14624448]; Sweet et al., 2008 [PubMed
            17654514]).[supplied by OMIM, Oct 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.69102.1,
                                           SRR1803613.113397.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369797.8/ ENSP00000358812.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AL591408.19        148555-148583
            30-76               BC049838.1         2-48
            77-3761             D80007.1           1-3685
            3762-4407           BC049838.1         3734-4379
            4408-5899           D80007.1           4332-5823
            5900-6445           BM476302.1         98-643
            6446-6477           AL139339.22        23724-23755
FEATURES             Location/Qualifiers
     source          1..6477
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.33"
     gene            1..6477
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /note="programmed cell death 11"
                     /db_xref="GeneID:22984"
                     /db_xref="HGNC:HGNC:13408"
                     /db_xref="MIM:612333"
     exon            1..105
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            106..218
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..5732
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein RRP5 homolog; apoptosis-linked gene 4;
                     NF-kappa-B-binding protein; programmed cell death protein
                     11"
                     /codon_start=1
                     /product="protein RRP5 homolog isoform 2"
                     /protein_id="NP_055791.1"
                     /db_xref="CCDS:CCDS31276.1"
                     /db_xref="GeneID:22984"
                     /db_xref="HGNC:HGNC:13408"
                     /db_xref="MIM:612333"
                     /translation="MANLEESFPRGGTRKIHKPEKAFQQSVEQDNLFDISTEEGSTKR
                     KKSQKGPAKTKKLKIEKRESSKSAREKFEILSVESLCEGMRILGCVKEVNELELVISL
                     PNGLQGFVQVTEICDAYTKKLNEQVTQEQPLKDLLHLPELFSPGMLVRCVVSSLGITD
                     RGKKSVKLSLNPKNVNRVLSAEALKPGMLLTGTVSSLEDHGYLVDIGVDGTRAFLPLL
                     KAQEYIRQKNKGAKLKVGQYLNCIVEKVKGNGGVVSLSVGHSEVSTAIATEQQSWNLN
                     NLLPGLVVKAQVQKVTPFGLTLNFLTFFTGVVDFMHLDPKKAGTYFSNQAVRACILCV
                     HPRTRVVHLSLRPIFLQPGRPLTRLSCQNLGAVLDDVPVQGFFKKAGATFRLKDGVLA
                     YARLSHLSDSKNVFNPEAFKPGNTHKCRIIDYSQMDELALLSLRTSIIEAQYLRYHDI
                     EPGAVVKGTVLTIKSYGMLVKVGEQMRGLVPPMHLADILMKNPEKKYHIGDEVKCRVL
                     LCDPEAKKLMMTLKKTLIESKLPVITCYADAKPGLQTHGFIIRVKDYGCIVKFYNNVQ
                     GLVPKHELSTEYIPDPERVFYTGQVVKVVVLNCEPSKERMLLSFKLSSDPEPKKEPAG
                     HSQKKGKAINIGQLVDVKVLEKTKDGLEVAVLPHNIRAFLPTSHLSDHVANGPLLHHW
                     LQAGDILHRVLCLSQSEGRVLLCRKPALVSTVEGGQDPKNFSEIHPGMLLIGFVKSIK
                     DYGVFIQFPSGLSGLAPKAIMSDKFVTSTSDHFVEGQTVAAKVTNVDEEKQRMLLSLR
                     LSDCGLGDLAITSLLLLNQCLEELQGVRSLMSNRDSVLIQTLAEMTPGMFLDLVVQEV
                     LEDGSVVFSGGPVPDLVLKASRYHRAGQEVESGQKKKVVILNVDLLKLEVHVSLHQDL
                     VNRKARKLRKGSEHQAIVQHLEKSFAIASLVETGHLAAFSLTSHLNDTFRFDSEKLQV
                     GQGVSLTLKTTEPGVTGLLLAVEGPAAKRTMRPTQKDSETVDEDEEVDPALTVGTIKK
                     HTLSIGDMVTGTVKSIKPTHVVVTLEDGIIGCIHASHILDDVPEGTSPTTKLKVGKTV
                     TARVIGGRDMKTFKYLPISHPRFVRTIPELSVRPSELEDGHTALNTHSVSPMEKIKQY
                     QAGQTVTCFLKKYNVVKKWLEVEIAPDIRGRIPLLLTSLSFKVLKHPDKKFRVGQALR
                     ATVVGPDSSKTLLCLSLTGPHKLEEGEVAMGRVVKVTPNEGLTVSFPFGKIGTVSIFH
                     MSDSYSETPLEDFVPQKVVRCYILSTADNVLTLSLRSSRTNPETKSKVEDPEINSIQD
                     IKEGQLLRGYVGSIQPHGVFFRLGPSVVGLARYSHVSQHSPSKKALYNKHLPEGKLLT
                     ARVLRLNHQKNLVELSFLPGDTGKPDVLSASLEGQLTKQEERKTEAEERDQKGEKKNQ
                     KRNEKKNQKGQEEVEMPSKEKQQPQKPQAQKRGGRECRESGSEQERVSKKPKKAGLSE
                     EDDSLVDVYYREGKEEAEETNVLPKEKQTKPAEAPRLQLSSGFAWNVGLDSLTPALPP
                     LAESSDSEEDEKPHQATIKKSKKERELEKQKAEKELSRIEEALMDPGRQPESADDFDR
                     LVLSSPNSSILWLQYMAFHLQATEIEKARAVAERALKTISFREEQEKLNVWVALLNLE
                     NMYGSQESLTKVFERAVQYNEPLKVFLHLADIYAKSEKFQEAGELYNRMLKRFRQEKA
                     VWIKYGAFLLRRSQAAASHRVLQRALECLPSKEHVDVIAKFAQLEFQLGDAERAKAIF
                     ENTLSTYPKRTDVWSVYIDMTIKHGSQKDVRDIFERVIHLSLAPKRMKFFFKRYLDYE
                     KQHGTEKDVQAVKAKALEYVEAKSSVLED"
     exon            219..350
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            351..518
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            519..680
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            681..804
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            805..986
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1094
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1301
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1426
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1487
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1634
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1886
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2027
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2222
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2393
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2613
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2614..2763
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2764..2879
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2880..3421
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            3422..3484
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            3485..3590
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            3591..3680
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            3681..3783
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            3784..3961
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            3962..4018
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            4019..4141
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            4142..4264
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            4265..4556
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            4557..4673
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            4674..4823
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            4824..5071
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            5072..5240
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            5241..5394
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            5395..5560
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            5561..6477
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5902
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
     regulatory      6456..6461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /note="hexamer: ATTAAA"
     polyA_site      6477
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /note="major polyA site"
ORIGIN      
        1 acacttccgg aagaattgca ctggactgtg ggtatcctgg tctccgcgtg tgtgagtacc
       61 gcggcgcgag gttagtggta gctgggtgca gacgccgtgg cgctggagac ccaaacatgg
      121 caaacctgga agaaagcttc ccccgaggag gtacaagaaa gatccacaaa ccagagaaag
      181 ctttccagca gtcagttgaa caagacaact tatttgatat ttctactgaa gagggatcca
      241 ccaaaagaaa aaagagccag aaggggccag caaaaacaaa aaagttgaaa atcgaaaaga
      301 gagaaagcag caagtccgca agagagaagt ttgaaatcct tagtgttgag tccctgtgtg
      361 agggaatgcg tattttgggt tgcgtgaaag aggtgaatga actggaactg gtgattagtc
      421 tccccaatgg cctccagggc tttgtgcaag tcactgaaat ctgtgatgcc tacaccaaaa
      481 agctgaatga gcaggtgaca caagaacaac ctctgaagga cctacttcac ttgcctgaac
      541 ttttctcacc tggaatgctg gtaagatgtg tggtgagcag tctgggcatc acagacaggg
      601 gcaagaagag tgtcaagctg tctctgaacc ccaaaaatgt caacagagtg ctgagtgctg
      661 aggccctgaa gcctggcatg ctacttacag gtaccgtatc cagcctggaa gaccatggct
      721 acctagtgga cattggtgtt gatgggacca gagcttttct gccactgctg aaagcccagg
      781 agtacatcag acagaagaac aaaggtgcta aactaaaggt gggtcagtac ctgaactgca
      841 ttgttgaaaa ggtgaaaggc aacggaggag ttgttagtct gtctgttggt cactcagagg
      901 tttctacggc cattgctact gaacagcaga gctggaacct taataacttg ctaccaggac
      961 tggtggtcaa agctcaggta cagaaggtga ctccatttgg ccttacgcta aacttcctca
     1021 cattcttcac gggcgtggtt gactttatgc acctggatcc caagaaagct ggaacatatt
     1081 tctcaaatca ggcagtgagg gcctgcatcc tttgcgtcca tcctcgaacc agagttgtgc
     1141 acctgagcct gcgccccatc ttcctacagc ctggacgccc actcacccga ctctcttgcc
     1201 agaaccttgg agcagtgctg gatgatgttc ctgtccaggg ttttttcaaa aaggctgggg
     1261 ccacctttag gctgaaggat ggggttctgg cctatgcccg gctcagccat ctctctgatt
     1321 ctaagaacgt cttcaatcct gaggccttca agccagggaa cactcacaag tgtagaatta
     1381 ttgactacag ccaaatggat gaactggcct tgctctctct acgaacgtct attattgaag
     1441 ctcagtacct tagatatcat gacatcgaac ctggggcagt ggtaaagggc acagtgctaa
     1501 ccataaagtc atatgggatg ctggtgaagg tgggcgagca gatgaggggc ctggtacctc
     1561 ccatgcacct ggctgacatc ctgatgaaga atccggagaa gaagtaccac atcggggatg
     1621 aggtcaagtg ccgggttttg ctttgtgacc ctgaagccaa gaagctgatg atgaccctga
     1681 aaaaaaccct gattgagtcc aaactacctg tcattacctg ctatgccgat gccaagcctg
     1741 gtctgcagac acatggcttc atcatcaggg tcaaggacta tggctgcatt gtgaagttct
     1801 acaacaatgt gcagggactg gtgcccaagc atgagctcag tactgagtat atccctgacc
     1861 cggagagagt tttttacact ggccaggtgg tgaaggttgt cgtattgaac tgtgagccat
     1921 ccaaagagag gatgctctta tccttcaagc tgtcgagtga tccagagcca aagaaagagc
     1981 ctgcaggaca cagtcagaag aaaggaaaag ccattaacat tgggcagttg gtagatgtga
     2041 aggttttaga gaagaccaaa gatgggctgg aggtggctgt cctgccccac aacatccgtg
     2101 ctttcctccc cacatctcat ctgtcggacc acgttgccaa cggcccattg ttacatcatt
     2161 ggctccaggc aggtgacatc cttcaccgag tcctgtgtct gagccagagc gaggggcgtg
     2221 ttcttctttg caggaagcca gccttggtct ccacagtaga aggtggccag gatcccaaga
     2281 acttctcaga aatccatcct ggaatgctgc tcattggttt tgtgaagagc atcaaggact
     2341 atggcgtgtt catccagttc ccctcaggtc ttagcggact ggccccaaaa gctatcatga
     2401 gtgacaaatt tgtgacctcc acaagtgacc actttgttga gggccagaca gtagcggcaa
     2461 aggtgaccaa tgtggatgag gagaagcagc ggatgctgct gtcactgcgg ctgtcggact
     2521 gtggtctggg ggacttggct atcaccagcc tcctcctcct gaatcagtgc ctggaggagc
     2581 tgcagggcgt gcgcagcctt atgagcaacc gagactctgt gttgatccag acgctggccg
     2641 agatgacccc aggaatgttc cttgacctag tggtgcagga ggtgttggaa gatggctctg
     2701 tggtattcag tgggggtcca gtgcccgacc tggtcctgaa agccagcaga taccatcgcg
     2761 cagggcagga ggtggaatct gggcagaaaa agaaggttgt tatcttaaat gttgatcttt
     2821 tgaagttgga agtgcacgtt tcccttcacc aggacttggt gaatagaaaa gctagaaagc
     2881 tgaggaaagg cagcgaacac caggcgattg tgcagcactt ggagaagtcc tttgccattg
     2941 cctccttggt agagacgggc cacctggcag ctttctccct gacctctcac ctcaacgaca
     3001 ccttccgctt tgactcagag aaattgcagg tgggacaggg tgtctcccta accctcaaga
     3061 ccacagaacc aggagtgact ggccttcttt tggctgtgga ggggccggct gccaagagga
     3121 ccatgaggcc gacccagaag gactctgaga cagttgatga ggatgaagaa gtggatccag
     3181 ctctgactgt agggaccata aagaagcaca ccctctccat cggggacatg gtcacaggga
     3241 ctgtcaagtc cattaagcct acccatgtgg ttgtgactct ggaagatggc attattggct
     3301 gtatccatgc ctcccacatt ctagatgatg ttccagaggg cacctctcct actaccaagc
     3361 tgaaggttgg gaagacggtc actgcccgag tgattggcgg gcgagacatg aagacattca
     3421 agtatctccc aataagtcac cccagattcg ttcgaaccat cccggagctg agtgttcggc
     3481 caagtgagct ggaggatggc cacactgctc ttaacactca ctctgttagc cccatggaga
     3541 agattaaaca gtaccaggcc ggccagactg ttacttgctt cttaaagaaa tacaatgtgg
     3601 tgaagaaatg gcttgaggtg gagattgccc cagacatccg ggggagaatt cccttattgc
     3661 tcacttctct gagcttcaag gttctgaagc atccagataa gaagttccgg gttggccagg
     3721 ccctgagggc caccgttgtt ggcccagatt cctccaagac cctcttatgt ctgtccctca
     3781 caggtcctca caagcttgag gaaggggaag tggccatggg ccgagtggtg aaggtgactc
     3841 ccaacgaggg gctgaccgtc tccttcccct ttgggaagat aggaacagtc agtatatttc
     3901 acatgagtga ctcctactcc gagacgcccc tggaagactt cgtcccccag aaggttgtca
     3961 gatgttacat cctgtccact gcagacaacg tattgacttt gtcgctgcga tcatccagaa
     4021 caaacccgga gacgaaaagc aaagtagaag atccagagat taactccatc caggacatta
     4081 aggaagggca gcttctgagg ggctatgtag ggtccatcca gccacacggt gtgttctttc
     4141 gccttggccc ctccgttgtg ggtttggctc ggtactccca tgtctcccag cacagcccgt
     4201 ccaagaaagc cctttataac aaacacctcc ctgaagggaa gctgctcaca gccagggtcc
     4261 tacgccttaa ccaccagaag aacctggtag agctgtcttt cctccccgga gacactggga
     4321 agccagacgt gctttctgct tccttggaag ggcaacttac aaagcaagag gagaggaaaa
     4381 cagaggctga ggagagagac caaaaagggg aaaagaaaaa tcagaaaagg aacgagaaga
     4441 agaaccagaa ggggcaggag gaggtggaga tgcccagcaa ggagaagcaa cagccccaga
     4501 agccacaggc gcagaagcgg ggcgggcggg agtgccggga gtctgggagt gagcaggaaa
     4561 gagtgagcaa gaagccaaag aaagccggcc tgtcagagga ggacgacagc cttgtggacg
     4621 tgtactatcg ggagggaaaa gaggaggcag aagagacgaa tgtgctgccc aaggagaagc
     4681 aaaccaagcc agcagaagcg ccccggctgc agctgtcttc aggcttcgct tggaatgtgg
     4741 gactagactc tctgaccccg gccttgccac ctctagcaga gagctcagac agcgaggagg
     4801 atgagaagcc acaccaagcc acgataaaga aaagcaagaa agaaagggag ttggagaagc
     4861 agaaggcaga gaaggaactg tcccgcattg aggaggcgct gatggatcct gggcggcagc
     4921 cagagtccgc ggatgatttt gaccgactgg tgctgagctc ccccaacagc tccattctgt
     4981 ggctgcagta catggctttc cacctgcagg ccacggagat cgagaaggcc cgtgccgtgg
     5041 ctgagagggc ccttaagacc atctccttca gagaggagca ggagaagctg aacgtgtggg
     5101 tggctctgct gaacctggag aacatgtacg gctctcagga gtccctgacc aaggtctttg
     5161 agcgagccgt gcagtacaac gagcctctca aagtctttct ccacctggct gacatctacg
     5221 ccaagtcaga gaaattccag gaagctggtg aactctacaa ccggatgctg aagcgtttcc
     5281 ggcaggagaa agctgtgtgg atcaaatacg gcgccttcct tctgcggagg agccaggctg
     5341 cagccagtca ccgcgtgctg cagcgagccc tggagtgcct gcctagcaag gagcatgtgg
     5401 atgtcattgc caagtttgcc cagcttgagt ttcagctggg ggatgcagag cgggccaaag
     5461 ccatttttga gaacacgctg agcacctacc caaagcgcac agatgtctgg tcggtctata
     5521 tcgacatgac catcaagcac ggcagccaga aggacgtccg ggacatcttt gagcgggtca
     5581 ttcatctgag cttggccccc aagagaatga agttcttctt caagcgctac ctggactacg
     5641 agaagcagca tggcactgag aaggatgtgc aggcagtcaa ggccaaggcc ctggagtatg
     5701 tggaggccaa gagctcagtg ctagaggact agtggcaggc tggctctgtg ggacactgtc
     5761 aacaatgggc cagcccggcc ccgcctcgag tgcctgggca ctcggaaaac tgttacctca
     5821 ggactctatt taaatgctgc tttttctgca gcacgcttgg ggaaatcctg tcaggatgaa
     5881 aaggaagttg agatttttta aatccctctt cgcttgcttt attttcagta ccaacttgtt
     5941 atctttttcc ttatctgagg ctacctgggg attgtgggca gcaggcccct ggactcccag
     6001 aaatgctgag ggtccctctt ccaggggagt tccctgggga gcaagagtag aggggctatt
     6061 cccgagggtc ctgtggtcag ggtcctgctt tgtccctggc aggctgtcag tccagctgga
     6121 gggggtcagt aggctccagg gagtgggccc tcccctccga tcttggagtc tctgggtgtt
     6181 ccttcagcct cagcctcact ggtaccttct gccctttagg ggaggctatg agtctgggac
     6241 aggaggacaa attcagagcc cagaggggga aatggagaaa cctgggctgc tgaggaaagc
     6301 cacgggtgtt ggcgtgaact gatgatgtct catcccacgc ccactatggc cacattacct
     6361 aacctctcca tatctgggct attcaaggtc ttggaggcca gcacagaccc agctagttgt
     6421 tgaagccagt tcttttttgt cttggtcatg agggaattaa acgttttctc tggcaga
//
