LOCUS       NP_055791               1871 aa            linear   PRI 03-APR-2025
DEFINITION  protein RRP5 homolog isoform 2 [Homo sapiens].
ACCESSION   NP_055791
VERSION     NP_055791.1
DBSOURCE    REFSEQ: accession NM_014976.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1871)
  AUTHORS   Hoya,S., Watanabe,Y., Hishimoto,A., Nunokawa,A., Kaneko,N.,
            Muratake,T., Shinmyo,N., Otsuka,I., Okuda,S., Inoue,E., Igeta,H.,
            Shibuya,M., Egawa,J., Orime,N., Sora,I. and Someya,T.
  TITLE     Rare PDCD11 variations are not associated with risk of
            schizophrenia in Japan
  JOURNAL   Psychiatry Clin Neurosci 71 (11), 780-788 (2017)
   PUBMED   28657695
  REMARK    GeneRIF: data provide no evidence for the contribution of rare
            PDCD11 variations to the risk of schizophrenia in the Japanese
            population.
REFERENCE   2  (residues 1 to 1871)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   3  (residues 1 to 1871)
  AUTHORS   Ripke,S., O'Dushlaine,C., Chambert,K., Moran,J.L., Kahler,A.K.,
            Akterin,S., Bergen,S.E., Collins,A.L., Crowley,J.J., Fromer,M.,
            Kim,Y., Lee,S.H., Magnusson,P.K., Sanchez,N., Stahl,E.A.,
            Williams,S., Wray,N.R., Xia,K., Bettella,F., Borglum,A.D.,
            Bulik-Sullivan,B.K., Cormican,P., Craddock,N., de Leeuw,C.,
            Durmishi,N., Gill,M., Golimbet,V., Hamshere,M.L., Holmans,P.,
            Hougaard,D.M., Kendler,K.S., Lin,K., Morris,D.W., Mors,O.,
            Mortensen,P.B., Neale,B.M., O'Neill,F.A., Owen,M.J.,
            Milovancevic,M.P., Posthuma,D., Powell,J., Richards,A.L.,
            Riley,B.P., Ruderfer,D., Rujescu,D., Sigurdsson,E., Silagadze,T.,
            Smit,A.B., Stefansson,H., Steinberg,S., Suvisaari,J., Tosato,S.,
            Verhage,M., Walters,J.T., Levinson,D.F., Gejman,P.V., Kendler,K.S.,
            Laurent,C., Mowry,B.J., O'Donovan,M.C., Owen,M.J., Pulver,A.E.,
            Riley,B.P., Schwab,S.G., Wildenauer,D.B., Dudbridge,F., Holmans,P.,
            Shi,J., Albus,M., Alexander,M., Campion,D., Cohen,D., Dikeos,D.,
            Duan,J., Eichhammer,P., Godard,S., Hansen,M., Lerer,F.B.,
            Liang,K.Y., Maier,W., Mallet,J., Nertney,D.A., Nestadt,G.,
            Norton,N., O'Neill,F.A., Papadimitriou,G.N., Ribble,R.,
            Sanders,A.R., Silverman,J.M., Walsh,D., Williams,N.M., Wormley,B.,
            Arranz,M.J., Bakker,S., Bender,S., Bramon,E., Collier,D.,
            Crespo-Facorro,B., Hall,J., Iyegbe,C., Jablensky,A., Kahn,R.S.,
            Kalaydjieva,L., Lawrie,S., Lewis,C.M., Lin,K., Linszen,D.H.,
            Mata,I., McIntosh,A., Murray,R.M., Ophoff,R.A., Powell,J.,
            Rujescu,D., Van Os,J., Walshe,M., Weisbrod,M., Wiersma,D.,
            Donnelly,P., Barroso,I., Blackwell,J.M., Bramon,E., Brown,M.A.,
            Casas,J.P., Corvin,A.P., Deloukas,P., Duncanson,A., Jankowski,J.,
            Markus,H.S., Mathew,C.G., Palmer,C.N., Plomin,R., Rautanen,A.,
            Sawcer,S.J., Trembath,R.C., Viswanathan,A.C., Wood,N.W.,
            Spencer,C.C., Band,G., Bellenguez,C., Freeman,C., Hellenthal,G.,
            Giannoulatou,E., Pirinen,M., Pearson,R.D., Strange,A., Su,Z.,
            Vukcevic,D., Donnelly,P., Langford,C., Hunt,S.E., Edkins,S.,
            Gwilliam,R., Blackburn,H., Bumpstead,S.J., Dronov,S., Gillman,M.,
            Gray,E., Hammond,N., Jayakumar,A., McCann,O.T., Liddle,J.,
            Potter,S.C., Ravindrarajah,R., Ricketts,M.,
            Tashakkori-Ghanbaria,A., Waller,M.J., Weston,P., Widaa,S.,
            Whittaker,P., Barroso,I., Deloukas,P., Mathew,C.G., Blackwell,J.M.,
            Brown,M.A., Corvin,A.P., McCarthy,M.I., Spencer,C.C., Bramon,E.,
            Corvin,A.P., O'Donovan,M.C., Stefansson,K., Scolnick,E.,
            Purcell,S., McCarroll,S.A., Sklar,P., Hultman,C.M. and
            Sullivan,P.F.
  CONSRTM   Multicenter Genetic Studies of Schizophrenia Consortium; Psychosis
            Endophenotypes International Consortium; Wellcome Trust Case
            Control Consortium 2
  TITLE     Genome-wide association analysis identifies 13 new risk loci for
            schizophrenia
  JOURNAL   Nat Genet 45 (10), 1150-1159 (2013)
   PUBMED   23974872
REFERENCE   4  (residues 1 to 1871)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (residues 1 to 1871)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (residues 1 to 1871)
  AUTHORS   Turner,A.J., Knox,A.A., Prieto,J.L., McStay,B. and Watkins,N.J.
  TITLE     A novel small-subunit processome assembly intermediate that
            contains the U3 snoRNP, nucleolin, RRP5, and DBP4
  JOURNAL   Mol Cell Biol 29 (11), 3007-3017 (2009)
   PUBMED   19332556
  REMARK    GeneRIF: The 50S U3 snoRNP is an small subunit assembly
            intermediate that is likely recruited to the pre-rRNA through the
            RNA-binding proteins nucleolin and RRP5.[RRP5, DBP4]
REFERENCE   7  (residues 1 to 1871)
  AUTHORS   Sweet,T., Yen,W., Khalili,K. and Amini,S.
  TITLE     Evidence for involvement of NFBP in processing of ribosomal RNA
  JOURNAL   J Cell Physiol 214 (2), 381-388 (2008)
   PUBMED   17654514
  REMARK    GeneRIF: Evidence is presented for involvement of PDCD11 in
            processing of ribosomal RNA.
REFERENCE   8  (residues 1 to 1871)
  AUTHORS   Sweet,T., Khalili,K., Sawaya,B.E. and Amini,S.
  TITLE     Identification of a novel protein from glial cells based on its
            ability to interact with NF-kappaB subunits
  JOURNAL   J Cell Biochem 90 (5), 884-891 (2003)
   PUBMED   14624448
REFERENCE   9  (residues 1 to 1871)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
REFERENCE   10 (residues 1 to 1871)
  AUTHORS   Lacana,E. and D'Adamio,L.
  TITLE     Regulation of Fas ligand expression and cell death by
            apoptosis-linked gene 4
  JOURNAL   Nat Med 5 (5), 542-547 (1999)
   PUBMED   10229231
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591408.19, BC049838.1, D80007.1, BM476302.1 and AL139339.22.
            
            Summary: PDCD11 is a NF-kappa-B (NFKB1; 164011)-binding protein
            that colocalizes with U3 RNA (MIM 180710) in the nucleolus and is
            required for rRNA maturation and generation of 18S rRNA (Sweet et
            al., 2003 [PubMed 14624448]; Sweet et al., 2008 [PubMed
            17654514]).[supplied by OMIM, Oct 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.69102.1,
                                           SRR1803613.113397.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369797.8/ ENSP00000358812.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1871
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.33"
     Protein         1..1871
                     /product="protein RRP5 homolog isoform 2"
                     /note="protein RRP5 homolog; apoptosis-linked gene 4;
                     NF-kappa-B-binding protein; programmed cell death protein
                     11"
                     /calculated_mol_wt=208571
     Region          1..62
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14690.3)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine. /evidence=ECO:0000269|Ref.5,
                     ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895;
                     propagated from UniProtKB/Swiss-Prot (Q14690.3)"
     Site            7
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q14690.3)"
     Region          80..176
                     /region_name="S1_Rrp5_repeat_hs1_sc1"
                     /note="Rrp5 is a trans-acting factor important for
                     biogenesis of both the 40S and 60S eukaryotic ribosomal
                     subunits. Rrp5 has two distinct regions, an N-terminal
                     region containing tandemly repeated S1 RNA-binding domains
                     (12 S1 repeats in Saccharomyces...; cd05693"
                     /db_xref="CDD:240198"
     Site            order(91,99,109,111)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:240198"
     Region          183..263
                     /region_name="S1_Rrp5_repeat_hs2_sc2"
                     /note="Rrp5 is a trans-acting factor important for
                     biogenesis of both the 40S and 60S eukaryotic ribosomal
                     subunits. Rrp5 has two distinct regions, an N-terminal
                     region containing tandemly repeated S1 RNA-binding domains
                     (12 S1 repeats in Saccharomyces...; cd05694"
                     /db_xref="CDD:240199"
     Site            order(195,203,214,216)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:240199"
     Region          281..344
                     /region_name="S1_Rrp5_repeat_hs3"
                     /note="Rrp5 is a trans-acting factor important for
                     biogenesis of both the 40S and 60S eukaryotic ribosomal
                     subunits. Rrp5 has two distinct regions, an N-terminal
                     region containing tandemly repeated S1 RNA-binding domains
                     (12 S1 repeats in Saccharomyces...; cd05695"
                     /db_xref="CDD:240200"
     Site            order(289,297,307,309)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:240200"
     Region          365..435
                     /region_name="S1_Rrp5_repeat_hs4"
                     /note="Rrp5 is a trans-acting factor important for
                     biogenesis of both the 40S and 60S eukaryotic ribosomal
                     subunits. Rrp5 has two distinct regions, an N-terminal
                     region containing tandemly repeated S1 RNA-binding domains
                     (12 S1 repeats in Saccharomyces...; cd05696"
                     /db_xref="CDD:240201"
     Site            order(373,383,393,395)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:240201"
     Site            438
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q14690.3)"
     Region          453..521
                     /region_name="S1_Rrp5_repeat_hs5"
                     /note="Rrp5 is a trans-acting factor important for
                     biogenesis of both the 40S and 60S eukaryotic ribosomal
                     subunits. Rrp5 has two distinct regions, an N-terminal
                     region containing tandemly repeated S1 RNA-binding domains
                     (12 S1 repeats in Saccharomyces...; cd05697"
                     /db_xref="CDD:240202"
     Site            order(461,469,479,481)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:240202"
     Region          542..611
                     /region_name="S1_Rrp5_repeat_hs6_sc5"
                     /note="Rrp5 is a trans-acting factor important for
                     biogenesis of both the 40S and 60S eukaryotic ribosomal
                     subunits. Rrp5 has two distinct regions, an N-terminal
                     region containing tandemly repeated S1 RNA-binding domains
                     (12 S1 repeats in Saccharomyces...; cd05698"
                     /db_xref="CDD:240203"
     Site            order(550,558,568,570)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:240203"
     Region          636..707
                     /region_name="S1_Rrp5_repeat_hs7"
                     /note="Rrp5 is a trans-acting factor important for
                     biogenesis of both the 40S and 60S eukaryotic ribosomal
                     subunits. Rrp5 has two distinct regions, an N-terminal
                     region containing tandemly repeated S1 RNA-binding domains
                     (12 S1 repeats in Saccharomyces...; cd05699"
                     /db_xref="CDD:240204"
     Site            order(644,652,663,665)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:240204"
     Region          715..797
                     /region_name="S1_Rrp5_repeat_hs8_sc7"
                     /note="Rrp5 Homo sapiens S1 repeat 8 (hs8) and
                     Saccharomyces cerevisiae S1 repeat 7 (sc7)-like domains.
                     Rrp5 is a trans-acting factor important for biogenesis of
                     both the 40S and 60S eukaryotic ribosomal subunits. Rrp5
                     has two distinct regions, an N-terminal...; cd04461"
                     /db_xref="CDD:239908"
     Site            755
                     /site_type="other"
                     /note="oligonucleotide binding site [chemical binding]"
                     /db_xref="CDD:239908"
     Region          846..910
                     /region_name="S1_like"
                     /note="Ribosomal protein S1-like RNA-binding domain. Found
                     in a wide variety of RNA-associated proteins. Originally
                     identified in S1 ribosomal protein. This superfamily also
                     contains the Cold Shock Domain (CSD), which is a homolog
                     of the S1 domain. Both domains...; cl09927"
                     /db_xref="CDD:471952"
     Site            order(854,862,872,874)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:238094"
     Region          925..993
                     /region_name="S1_Rrp5_repeat_hs10"
                     /note="Rrp5 is a trans-acting factor important for
                     biogenesis of both the 40S and 60S eukaryotic ribosomal
                     subunits. Rrp5 has two distinct regions, an N-terminal
                     region containing tandemly repeated S1 RNA-binding domains
                     (12 S1 repeats in Saccharomyces...; cd05701"
                     /db_xref="CDD:240206"
     Site            order(933,944,953,955)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:240206"
     Region          998..1018
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14690.3)"
     Region          1036..1105
                     /region_name="S1_Rrp5_repeat_hs11_sc8"
                     /note="Rrp5 is a trans-acting factor important for
                     biogenesis of both the 40S and 60S eukaryotic ribosomal
                     subunits. Rrp5 has two distinct regions, an N-terminal
                     region containing tandemly repeated S1 RNA-binding domains
                     (12 S1 repeats in Saccharomyces...; cd05702"
                     /db_xref="CDD:240207"
     Site            order(1044,1052,1062,1064)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:240207"
     Region          1149..1223
                     /region_name="S1_Rrp5_repeat_hs12_sc9"
                     /note="Rrp5 is a trans-acting factor important for
                     biogenesis of both the 40S and 60S eukaryotic ribosomal
                     subunits. Rrp5 has two distinct regions, an N-terminal
                     region containing tandemly repeated S1 RNA-binding domains
                     (12 S1 repeats in Saccharomyces...; cd05703"
                     /db_xref="CDD:240208"
     Site            order(1157,1165,1177,1179)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:240208"
     Region          1227..1298
                     /region_name="S1_Rrp5_repeat_hs13"
                     /note="Rrp5 is a trans-acting factor important for
                     biogenesis of both the 40S and 60S eukaryotic ribosomal
                     subunits. Rrp5 has two distinct regions, an N-terminal
                     region containing tandemly repeated S1 RNA-binding domains
                     (12 S1 repeats in Saccharomyces...; cd05704"
                     /db_xref="CDD:240209"
     Site            order(1238,1247,1257,1259)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:240209"
     Region          1321..1394
                     /region_name="S1_Rrp5_repeat_hs14"
                     /note="Rrp5 is a trans-acting factor important for
                     biogenesis of both the 40S and 60S eukaryotic ribosomal
                     subunits. Rrp5 has two distinct regions, an N-terminal
                     region containing tandemly repeated S1 RNA-binding domains
                     (12 S1 repeats in Saccharomyces...; cd05705"
                     /db_xref="CDD:240210"
     Site            order(1332,1340,1350,1352)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:240210"
     Site            1360
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21406692; propagated from
                     UniProtKB/Swiss-Prot (Q14690.3)"
     Site            1362
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21406692; propagated from
                     UniProtKB/Swiss-Prot (Q14690.3)"
     Region          1395..1531
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14690.3)"
     Region          <1402..>1593
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Site            1476
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6NS46; propagated from
                     UniProtKB/Swiss-Prot (Q14690.3)"
     Site            1493
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (Q14690.3)"
     Site            1498
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:23186163;
                     propagated from UniProtKB/Swiss-Prot (Q14690.3)"
     Region          1549..1586
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14690.3)"
     Region          1599..1631
                     /region_name="HAT 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14690.3)"
     Region          1600..1860
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          1621..1647
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1663..1686
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1692,1695..1696,1699..1700,1702,1726,1729..1730,
                     1733..1734,1736..1737,1762,1765..1766,1769..1770,1773)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1692..1719
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1705..1737
                     /region_name="HAT 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14690.3)"
     Region          1724..1754
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1761..1789
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1775..1807
                     /region_name="HAT 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14690.3)"
     Region          1809..1844
                     /region_name="HAT 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14690.3)"
     CDS             1..1871
                     /gene="PDCD11"
                     /gene_synonym="ALG-4; ALG4; NFBP; RRP5"
                     /coded_by="NM_014976.2:117..5732"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS31276.1"
                     /db_xref="GeneID:22984"
                     /db_xref="HGNC:HGNC:13408"
                     /db_xref="MIM:612333"
ORIGIN      
        1 manleesfpr ggtrkihkpe kafqqsveqd nlfdisteeg stkrkksqkg paktkklkie
       61 kressksare kfeilsvesl cegmrilgcv kevnelelvi slpnglqgfv qvteicdayt
      121 kklneqvtqe qplkdllhlp elfspgmlvr cvvsslgitd rgkksvklsl npknvnrvls
      181 aealkpgmll tgtvssledh gylvdigvdg traflpllka qeyirqknkg aklkvgqyln
      241 civekvkgng gvvslsvghs evstaiateq qswnlnnllp glvvkaqvqk vtpfgltlnf
      301 ltfftgvvdf mhldpkkagt yfsnqavrac ilcvhprtrv vhlslrpifl qpgrpltrls
      361 cqnlgavldd vpvqgffkka gatfrlkdgv layarlshls dsknvfnpea fkpgnthkcr
      421 iidysqmdel allslrtsii eaqylryhdi epgavvkgtv ltiksygmlv kvgeqmrglv
      481 ppmhladilm knpekkyhig devkcrvllc dpeakklmmt lkktlieskl pvitcyadak
      541 pglqthgfii rvkdygcivk fynnvqglvp khelsteyip dpervfytgq vvkvvvlnce
      601 pskermllsf klssdpepkk epaghsqkkg kainigqlvd vkvlektkdg levavlphni
      661 raflptshls dhvangpllh hwlqagdilh rvlclsqseg rvllcrkpal vstveggqdp
      721 knfseihpgm lligfvksik dygvfiqfps glsglapkai msdkfvtsts dhfvegqtva
      781 akvtnvdeek qrmllslrls dcglgdlait sllllnqcle elqgvrslms nrdsvliqtl
      841 aemtpgmfld lvvqevledg svvfsggpvp dlvlkasryh ragqevesgq kkkvvilnvd
      901 llklevhvsl hqdlvnrkar klrkgsehqa ivqhleksfa iaslvetghl aafsltshln
      961 dtfrfdsekl qvgqgvsltl kttepgvtgl llavegpaak rtmrptqkds etvdedeevd
     1021 paltvgtikk htlsigdmvt gtvksikpth vvvtledgii gcihashild dvpegtsptt
     1081 klkvgktvta rviggrdmkt fkylpishpr fvrtipelsv rpseledght alnthsvspm
     1141 ekikqyqagq tvtcflkkyn vvkkwlevei apdirgripl lltslsfkvl khpdkkfrvg
     1201 qalratvvgp dssktllcls ltgphkleeg evamgrvvkv tpnegltvsf pfgkigtvsi
     1261 fhmsdsyset pledfvpqkv vrcyilstad nvltlslrss rtnpetkskv edpeinsiqd
     1321 ikegqllrgy vgsiqphgvf frlgpsvvgl aryshvsqhs pskkalynkh lpegklltar
     1381 vlrlnhqknl velsflpgdt gkpdvlsasl egqltkqeer kteaeerdqk gekknqkrne
     1441 kknqkgqeev empskekqqp qkpqaqkrgg recresgseq ervskkpkka glseeddslv
     1501 dvyyregkee aeetnvlpke kqtkpaeapr lqlssgfawn vgldsltpal pplaessdse
     1561 edekphqati kkskkerele kqkaekelsr ieealmdpgr qpesaddfdr lvlsspnssi
     1621 lwlqymafhl qateiekara vaeralktis freeqeklnv wvallnlenm ygsqesltkv
     1681 feravqynep lkvflhladi yaksekfqea gelynrmlkr frqekavwik ygafllrrsq
     1741 aaashrvlqr aleclpskeh vdviakfaql efqlgdaera kaifentlst ypkrtdvwsv
     1801 yidmtikhgs qkdvrdifer vihlslapkr mkfffkryld yekqhgtekd vqavkakale
     1861 yveakssvle d
//
