LOCUS       NM_005018               2097 bp    mRNA    linear   PRI 15-NOV-2024
DEFINITION  Homo sapiens programmed cell death 1 (PDCD1), mRNA.
ACCESSION   NM_005018
VERSION     NM_005018.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2097)
  AUTHORS   Sun,T., Yang,Y., Qiu,Y., Wang,T., Yang,M., Shen,S. and Wang,W.
  TITLE     High PD-1 and CTLA-4 expression correlates with host immune
            suppression in patients and a mouse model infected with
            Echinococcus multilocularis
  JOURNAL   Parasit Vectors 17 (1), 437 (2024)
   PUBMED   39456030
  REMARK    GeneRIF: High PD-1 and CTLA-4 expression correlates with host
            immune suppression in patients and a mouse model infected with
            Echinococcus multilocularis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2097)
  AUTHORS   Wang,X., Liu,T., Li,Y., Ding,A., Zhang,C., Gu,Y., Zhao,X.,
            Cheng,S., Cheng,T., Wu,S., Duan,L., Zhang,J., Yin,R., Shang,M. and
            Gao,S.
  TITLE     A splicing isoform of PD-1 promotes tumor progression as a
            potential immune checkpoint
  JOURNAL   Nat Commun 15 (1), 9114 (2024)
   PUBMED   39438489
  REMARK    GeneRIF: A splicing isoform of PD-1 promotes tumor progression as a
            potential immune checkpoint.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2097)
  AUTHORS   Mosleh,B., Hammer,B., El-Gazzar,A., Kramer,M., Ayazseven,S.,
            Bernitzky,D., Geleff,S., Idzko,M., Gompelmann,D. and Hoda,M.A.
  TITLE     Evaluation of PD-1 and interleukin-10-receptor expression by T
            lymphocytes in malignant and benign pleural effusions
  JOURNAL   Clin Exp Med 24 (1), 228 (2024)
   PUBMED   39325190
  REMARK    GeneRIF: Evaluation of PD-1 and interleukin-10-receptor expression
            by T lymphocytes in malignant and benign pleural effusions.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2097)
  AUTHORS   Chen,Q., Tan,Z., Tang,Y., Fung,Y.M.E., Chen,S., Chen,Z. and Li,X.
  TITLE     Comprehensive Glycomic and Glycoproteomic Analyses of Human
            Programmed Cell Death Protein 1 Extracellular Domain
  JOURNAL   J Proteome Res 23 (9), 3958-3973 (2024)
   PUBMED   39101792
  REMARK    GeneRIF: Comprehensive Glycomic and Glycoproteomic Analyses of
            Human Programmed Cell Death Protein 1 Extracellular Domain.
REFERENCE   5  (bases 1 to 2097)
  AUTHORS   Perales,O., Jilaveanu,L., Adeniran,A., Su,D.G., Hurwitz,M.,
            Braun,D.A., Kluger,H.M. and Schoenfeld,D.A.
  TITLE     TIGIT expression in renal cell carcinoma infiltrating T cells is
            variable and inversely correlated with PD-1 and LAG3
  JOURNAL   Cancer Immunol Immunother 73 (10), 192 (2024)
   PUBMED   39105820
  REMARK    GeneRIF: TIGIT expression in renal cell carcinoma infiltrating T
            cells is variable and inversely correlated with PD-1 and LAG3.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2097)
  AUTHORS   Moser,K.L., Neas,B.R., Salmon,J.E., Yu,H., Gray-McGuire,C.,
            Asundi,N., Bruner,G.R., Fox,J., Kelly,J., Henshall,S., Bacino,D.,
            Dietz,M., Hogue,R., Koelsch,G., Nightingale,L., Shaver,T.,
            Abdou,N.I., Albert,D.A., Carson,C., Petri,M., Treadwell,E.L.,
            James,J.A. and Harley,J.B.
  TITLE     Genome scan of human systemic lupus erythematosus: evidence for
            linkage on chromosome 1q in African-American pedigrees
  JOURNAL   Proc Natl Acad Sci U S A 95 (25), 14869-14874 (1998)
   PUBMED   9843982
REFERENCE   7  (bases 1 to 2097)
  AUTHORS   Finger,L.R., Pu,J., Wasserman,R., Vibhakar,R., Louie,E.,
            Hardy,R.R., Burrows,P.D. and Billips,L.G.
  TITLE     The human PD-1 gene: complete cDNA, genomic organization, and
            developmentally regulated expression in B cell progenitors
  JOURNAL   Gene 197 (1-2), 177-187 (1997)
   PUBMED   9332365
  REMARK    Erratum:[Gene 1997 Dec 12;203(2):253]
REFERENCE   8  (bases 1 to 2097)
  AUTHORS   Vibhakar,R., Juan,G., Traganos,F., Darzynkiewicz,Z. and Finger,L.R.
  TITLE     Activation-induced expression of human programmed death-1 gene in
            T-lymphocytes
  JOURNAL   Exp Cell Res 232 (1), 25-28 (1997)
   PUBMED   9141617
REFERENCE   9  (bases 1 to 2097)
  AUTHORS   Shinohara,T., Taniwaki,M., Ishida,Y., Kawaichi,M. and Honjo,T.
  TITLE     Structure and chromosomal localization of the human PD-1 gene
            (PDCD1)
  JOURNAL   Genomics 23 (3), 704-706 (1994)
   PUBMED   7851902
REFERENCE   10 (bases 1 to 2097)
  AUTHORS   Ishida,Y., Agata,Y., Shibahara,K. and Honjo,T.
  TITLE     Induced expression of PD-1, a novel member of the immunoglobulin
            gene superfamily, upon programmed cell death
  JOURNAL   EMBO J 11 (11), 3887-3895 (1992)
   PUBMED   1396582
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U64863.1, AY238517.1,
            CR988122.1 and AI928135.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005018.2.
            
            Summary: Programmed cell death protein 1 (PDCD1) is an
            immune-inhibitory receptor expressed in activated T cells; it is
            involved in the regulation of T-cell functions, including those of
            effector CD8+ T cells. In addition, this protein can also promote
            the differentiation of CD4+ T cells into T regulatory cells. PDCD1
            is expressed in many types of tumors including melanomas, and has
            demonstrated to play a role in anti-tumor immunity. Moreover, this
            protein has been shown to be involved in safeguarding against
            autoimmunity, however, it can also contribute to the inhibition of
            effective anti-tumor and anti-microbial immunity. [provided by
            RefSeq, Aug 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U64863.1, SRR1163657.360434.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2158800 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334409.10/ ENSP00000335062.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                U64863.1           13-68
            57-923              AY238517.1         1-867
            924-1537            U64863.1           936-1549
            1538-1632           U64863.1           1551-1645
            1633-1999           CR988122.1         113-479
            2000-2095           U64863.1           2011-2106
            2096-2097           AI928135.1         7-8                 c
FEATURES             Location/Qualifiers
     source          1..2097
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..2097
                     /gene="PDCD1"
                     /gene_synonym="AIMTBS; CD279; hPD-1; hPD-l; hSLE1; PD-1;
                     PD1; SLEB2"
                     /note="programmed cell death 1"
                     /db_xref="GeneID:5133"
                     /db_xref="HGNC:HGNC:8760"
                     /db_xref="MIM:600244"
     exon            1..132
                     /gene="PDCD1"
                     /gene_synonym="AIMTBS; CD279; hPD-1; hPD-l; hSLE1; PD-1;
                     PD1; SLEB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..923
                     /gene="PDCD1"
                     /gene_synonym="AIMTBS; CD279; hPD-1; hPD-l; hSLE1; PD-1;
                     PD1; SLEB2"
                     /note="programmed cell death protein 1; protein PD-1;
                     systemic lupus erythematosus susceptibility 2; programmed
                     cell death 1 protein"
                     /codon_start=1
                     /product="programmed cell death protein 1 precursor"
                     /protein_id="NP_005009.2"
                     /db_xref="CCDS:CCDS33428.1"
                     /db_xref="GeneID:5133"
                     /db_xref="HGNC:HGNC:8760"
                     /db_xref="MIM:600244"
                     /translation="MQIPQAPWPVVWAVLQLGWRPGWFLDSPDRPWNPPTFSPALLVV
                     TEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPN
                     GRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSP
                     RPAGQFQTLVVGVVGGLLGSLVLLVWVLAVICSRAARGTIGARRTGQPLKEDPSAVPV
                     FSVDYGELDFQWREKTPEPPVPCVPEQTEYATIVFPSGMGTSSPARRGSADGPRSAQP
                     LRPEDGHCSWPL"
     exon            133..492
                     /gene="PDCD1"
                     /gene_synonym="AIMTBS; CD279; hPD-1; hPD-l; hSLE1; PD-1;
                     PD1; SLEB2"
                     /inference="alignment:Splign:2.1.0"
     exon            493..648
                     /gene="PDCD1"
                     /gene_synonym="AIMTBS; CD279; hPD-1; hPD-l; hSLE1; PD-1;
                     PD1; SLEB2"
                     /inference="alignment:Splign:2.1.0"
     exon            649..683
                     /gene="PDCD1"
                     /gene_synonym="AIMTBS; CD279; hPD-1; hPD-l; hSLE1; PD-1;
                     PD1; SLEB2"
                     /inference="alignment:Splign:2.1.0"
     exon            684..2097
                     /gene="PDCD1"
                     /gene_synonym="AIMTBS; CD279; hPD-1; hPD-l; hSLE1; PD-1;
                     PD1; SLEB2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2076..2081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDCD1"
                     /gene_synonym="AIMTBS; CD279; hPD-1; hPD-l; hSLE1; PD-1;
                     PD1; SLEB2"
                     /note="hexamer: ATTAAA"
     polyA_site      2097
                     /gene="PDCD1"
                     /gene_synonym="AIMTBS; CD279; hPD-1; hPD-l; hSLE1; PD-1;
                     PD1; SLEB2"
                     /note="major polyA site"
ORIGIN      
        1 gctcacctcc gcctgagcag tggagaaggc ggcactctgg tggggctgct ccaggcatgc
       61 agatcccaca ggcgccctgg ccagtcgtct gggcggtgct acaactgggc tggcggccag
      121 gatggttctt agactcccca gacaggccct ggaacccccc caccttctcc ccagccctgc
      181 tcgtggtgac cgaaggggac aacgccacct tcacctgcag cttctccaac acatcggaga
      241 gcttcgtgct aaactggtac cgcatgagcc ccagcaacca gacggacaag ctggccgcct
      301 tccccgagga ccgcagccag cccggccagg actgccgctt ccgtgtcaca caactgccca
      361 acgggcgtga cttccacatg agcgtggtca gggcccggcg caatgacagc ggcacctacc
      421 tctgtggggc catctccctg gcccccaagg cgcagatcaa agagagcctg cgggcagagc
      481 tcagggtgac agagagaagg gcagaagtgc ccacagccca ccccagcccc tcacccaggc
      541 cagccggcca gttccaaacc ctggtggttg gtgtcgtggg cggcctgctg ggcagcctgg
      601 tgctgctagt ctgggtcctg gccgtcatct gctcccgggc cgcacgaggg acaataggag
      661 ccaggcgcac cggccagccc ctgaaggagg acccctcagc cgtgcctgtg ttctctgtgg
      721 actatgggga gctggatttc cagtggcgag agaagacccc ggagcccccc gtgccctgtg
      781 tccctgagca gacggagtat gccaccattg tctttcctag cggaatgggc acctcatccc
      841 ccgcccgcag gggctcagct gacggccctc ggagtgccca gccactgagg cctgaggatg
      901 gacactgctc ttggcccctc tgaccggctt ccttggccac cagtgttctg cagaccctcc
      961 accatgagcc cgggtcagcg catttcctca ggagaagcag gcagggtgca ggccattgca
     1021 ggccgtccag gggctgagct gcctgggggc gaccggggct ccagcctgca cctgcaccag
     1081 gcacagcccc accacaggac tcatgtctca atgcccacag tgagcccagg cagcaggtgt
     1141 caccgtcccc tacagggagg gccagatgca gtcactgctt caggtcctgc cagcacagag
     1201 ctgcctgcgt ccagctccct gaatctctgc tgctgctgct gctgctgctg ctgctgcctg
     1261 cggcccgggg ctgaaggcgc cgtggccctg cctgacgccc cggagcctcc tgcctgaact
     1321 tgggggctgg ttggagatgg ccttggagca gccaaggtgc ccctggcagt ggcatcccga
     1381 aacgccctgg acgcagggcc caagactggg cacaggagtg ggaggtacat ggggctgggg
     1441 actccccagg agttatctgc tccctgcagg cctagagaag tttcagggaa ggtcagaaga
     1501 gctcctggct gtggtgggca gggcaggaaa cccctccacc tttacacatg cccaggcagc
     1561 acctcaggcc ctttgtgggg cagggaagct gaggcagtaa gcgggcaggc agagctggag
     1621 gcctttcagg cccagccagc actctggcct cctgccgccg cattccaccc cagcccctca
     1681 caccactcgg gagagggaca tcctacggtc ccaaggtcag gagggcaggg ctggggttga
     1741 ctcaggcccc tcccagctgt ggccacctgg gtgttgggag ggcagaagtg caggcaccta
     1801 gggcccccca tgtgcccacc ctgggagctc tccttggaac ccattcctga aattatttaa
     1861 aggggttggc cgggctccca ccagggcctg ggtgggaagg tacaggcgtt cccccggggc
     1921 ctagtacccc cgccgtggcc tatccactcc tcacatccac acactgcacc cccactcctg
     1981 gggcagggcc accagcatcc aggcggccag caggcacctg agtggctggg acaagggatc
     2041 ccccttccct gtggttctat tatattataa ttataattaa atatgagagc atgctaa
//
