LOCUS       NM_014891               2604 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens PDGFA associated protein 1 (PDAP1), mRNA.
ACCESSION   NM_014891
VERSION     NM_014891.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2604)
  AUTHORS   Chirichella,M., Bianchi,N., Dzafo,E., Foli,E., Gualdrini,F.,
            Kenyon,A., Natoli,G. and Monticelli,S.
  TITLE     RFX transcription factors control a miR-150/PDAP1 axis that
            restrains the proliferation of human T cells
  JOURNAL   PLoS Biol 20 (2), e3001538 (2022)
   PUBMED   35143476
  REMARK    GeneRIF: RFX transcription factors control a miR-150/PDAP1 axis
            that restrains the proliferation of human T cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2604)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2604)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2604)
  AUTHORS   Weston,V.J., Wei,W., Stankovic,T. and Kearns,P.
  TITLE     Synergistic action of dual IGF1/R and MEK inhibition sensitizes
            childhood acute lymphoblastic leukemia (ALL) cells to cytotoxic
            agents and involves downregulation of STAT6 and PDAP1
  JOURNAL   Exp Hematol 63, 52-63 (2018)
   PUBMED   29656114
  REMARK    GeneRIF: AG1024+U0126 acted synergistically to downregulate
            'synergy' genes, especially STAT6 and PDAP1, which displayed
            significant expression codependency and a common expression pattern
            linked with other key 'synergy' genes, supporting their predicted
            role in an STAT6-ERK-nuclear factor kappa beta (NF-kappaB) network.
            Daunorubicin and PDAP1 loss were synergistic, so PDAP1 is important
            for the response to this anthracycline.
REFERENCE   5  (bases 1 to 2604)
  AUTHORS   Sharma,V.K., Singh,A., Srivastava,S.K., Kumar,V., Gardi,N.L.,
            Nalwa,A., Dinda,A.K., Chattopadhyay,P. and Yadav,S.
  TITLE     Increased expression of platelet-derived growth factor associated
            protein-1 is associated with PDGF-B mediated glioma progression
  JOURNAL   Int J Biochem Cell Biol 78, 194-205 (2016)
   PUBMED   27448842
  REMARK    GeneRIF: PDAP-1 as an effecter of PDGF signaling in glioma cells
REFERENCE   6  (bases 1 to 2604)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   7  (bases 1 to 2604)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   8  (bases 1 to 2604)
  AUTHORS   LaRochelle,W.J., Jeffers,M., McDonald,W.F., Chillakuru,R.A.,
            Giese,N.A., Lokker,N.A., Sullivan,C., Boldog,F.L., Yang,M.,
            Vernet,C., Burgess,C.E., Fernandes,E., Deegler,L.L., Rittman,B.,
            Shimkets,J., Shimkets,R.A., Rothberg,J.M. and Lichenstein,H.S.
  TITLE     PDGF-D, a new protease-activated growth factor
  JOURNAL   Nat Cell Biol 3 (5), 517-521 (2001)
   PUBMED   11331882
REFERENCE   9  (bases 1 to 2604)
  AUTHORS   Fischer,W.H. and Schubert,D.
  TITLE     Characterization of a novel platelet-derived growth
            factor-associated protein
  JOURNAL   J Neurochem 66 (5), 2213-2216 (1996)
   PUBMED   8780057
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI460344.1, BC000684.2,
            AC004922.2 and BC001578.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_014891.6.
            
            Summary: The protein encoded by this gene is a phosphoprotein that
            may upregulate the PDGFA-stimulated growth of fibroblasts and also
            downregulate the mitogenicity of PDGFB. The encoded protein in
            rodents has been shown to bind PDGFA with a low affinity. [provided
            by RefSeq, Dec 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.482920.1,
                                           SRR3476690.121608.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2155751
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000350498.8/ ENSP00000222968.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BI460344.1         78-80
            4-1292              BC000684.2         1-1289
            1293-2497           AC004922.2         35794-36998
            2498-2604           BC001578.1         936-1042
FEATURES             Location/Qualifiers
     source          1..2604
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..2604
                     /gene="PDAP1"
                     /gene_synonym="HASPP28; PAP; PAP1"
                     /note="PDGFA associated protein 1"
                     /db_xref="GeneID:11333"
                     /db_xref="HGNC:HGNC:14634"
                     /db_xref="MIM:607075"
     exon            1..62
                     /gene="PDAP1"
                     /gene_synonym="HASPP28; PAP; PAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..595
                     /gene="PDAP1"
                     /gene_synonym="HASPP28; PAP; PAP1"
                     /note="PDGF-associated protein"
                     /codon_start=1
                     /product="28 kDa heat- and acid-stable phosphoprotein"
                     /protein_id="NP_055706.1"
                     /db_xref="CCDS:CCDS5662.1"
                     /db_xref="GeneID:11333"
                     /db_xref="HGNC:HGNC:14634"
                     /db_xref="MIM:607075"
                     /translation="MPKGGRKGGHKGRARQYTSPEEIDAQLQAEKQKAREEEEQKEGG
                     DGAAGDPKKEKKSLDSDESEDEEDDYQQKRKGVEGLIDIENPNRVAQTTKKVTQLDLD
                     GPKELSRREREEIEKQKAKERYMKMHLAGKTEQAKADLARLAIIRKQREEAARKKEEE
                     RKAKDDATLSGKRMQSLSLNK"
     exon            63..154
                     /gene="PDAP1"
                     /gene_synonym="HASPP28; PAP; PAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            155..262
                     /gene="PDAP1"
                     /gene_synonym="HASPP28; PAP; PAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            263..384
                     /gene="PDAP1"
                     /gene_synonym="HASPP28; PAP; PAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            385..536
                     /gene="PDAP1"
                     /gene_synonym="HASPP28; PAP; PAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            537..2604
                     /gene="PDAP1"
                     /gene_synonym="HASPP28; PAP; PAP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1271..1276
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDAP1"
                     /gene_synonym="HASPP28; PAP; PAP1"
                     /note="hexamer: ATTAAA"
     polyA_site      1292
                     /gene="PDAP1"
                     /gene_synonym="HASPP28; PAP; PAP1"
                     /note="major polyA site"
     regulatory      2584..2589
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDAP1"
                     /gene_synonym="HASPP28; PAP; PAP1"
                     /note="hexamer: AATGAA"
     polyA_site      2604
                     /gene="PDAP1"
                     /gene_synonym="HASPP28; PAP; PAP1"
ORIGIN      
        1 ggtgtcagtt cgaggcgccg ccgccgccgc cgcagccgcc ggagccgcaa tgcctaaagg
       61 aggaagaaag ggaggccaca aaggccgggc gaggcagtat acaagccctg aggagatcga
      121 cgcgcagctg caggctgaga agcagaaggc cagggaagaa gaggagcaaa aagaaggtgg
      181 agatggggct gcaggtgacc ccaaaaagga gaagaaatct ctagactcag atgagagtga
      241 ggatgaagaa gatgactacc agcaaaagcg caaaggcgtt gaagggctca tcgacatcga
      301 gaaccccaac cgggtggcac agacaaccaa aaaggtcaca caactggatc tggacgggcc
      361 aaaggagctt tcgaggagag aacgagaaga gattgagaag cagaaggcaa aagagcgtta
      421 catgaaaatg cacttggccg ggaagacaga gcaagccaag gctgacctgg cccggctggc
      481 catcatccgg aaacagcggg aggaggctgc ccggaagaag gaagaggaaa ggaaagcaaa
      541 agacgatgcc acattgtcag gaaaacgaat gcagtcactc tccctgaata agtaactgcg
      601 acccgtggga ggagatgccg gggacctggg ccgcgctgcc aggacctctg ctgtgtctcg
      661 cccaccctgt gccctggcgc cgctgcaaca gcccctcatg gccaggagcc ccccatggcc
      721 tggggcctcc tcttcatctt ggcacagaaa ttgtttgggg gatggggggg gggactgggg
      781 gaggggtagc tgctatcttt gagacagaaa gatgcaggac agcatttcat atgtaaccat
      841 ttgaatgttt ttgctgtttt tagaattcag agcccttgct ggggggtgcc tgggagatgg
      901 ggtaagaaga gctttcattt gtctggtaga tagatagcat gtaagggggt ggttgtccca
      961 ggaggcagct gctgacaggt ttgctacaca cagccccgga ctgtgttgcc tgggtgctca
     1021 ttcagagagg ggctatcatc tgggagcctg tgcccctggg tcctcgaggg tcatggcttg
     1081 tccctggtca gtcctgtctg actgacctca gggcctcacc tctctgccct tccctgcccg
     1141 gttcctactc acctggctag ggccagtgcc cattttcagc cctacccatt gatcatttca
     1201 agaaacctct gtttactgtg tggcacccag gcaaaacatg ctccacaaat tcaacttgta
     1261 tatttggcag attaaacttg acattatcgt aatctttgtt ttggcaatcc atcctttggc
     1321 ttccgtgctc gagccgtttt tacccagctg ggtacggtgc cacgttcagg cacgtgcacc
     1381 cggcaaggtt cagggcacat acctacctgg ggcatgacat ctgtcaggtg gcaccgagca
     1441 ggatgcgggg atggacccta gataccacag cctgccccct cccctccttt agccaagtca
     1501 ggatcttagg cctcagcagg cagggaccct tccaggccac agtaggctga agcagcacca
     1561 ggatcctggc ctggcctggc ctgtaggtgt cccctggtgg ttataattct gtaactctag
     1621 gggagaaggg gaatagcact agcattggat gtcgccaagg cccacatttt cctgagagaa
     1681 gccacaaaag atgtgcaaat gcccttcagc acaggacctg gtgacatgac ataaactcca
     1741 agacagaacc tcagtttaca gcacacgaaa aaaatatctt gccaacattg taatgacaaa
     1801 ataaattccc gtgaagttcc acaaccaggc cgggcatggt ggctcatgcc tgtaatccca
     1861 gcactttggg aggtgaggtg ggtggatcat ctgaggtcag gagttcaaga ccagcctggc
     1921 caacatggag aaactccgtc tctactaaaa atacaaaaat taaccaggct tggtggtgta
     1981 tgcctgtaat cccagctact tgggaggctg aggcaggaga atcgcttgat cccaggaagg
     2041 cagaggtggc agtgagctga gaacgcacaa ctgcactcca gcctgggtga cgagcaaaac
     2101 tccatctcaa aacaaaagtt ccacaaccag cctggagtgt gtagcccctt tgtccaggaa
     2161 tttgactagt caatcagtga cacctggtac tggcagtttt gggagtggca gcccaggatg
     2221 gacagcagtg gggagggaac catttggcat aaggccgttg ggcttcagga tcaattttgt
     2281 tggcaagcag taaaaataag ctatctacct atggccgtgc aaacaccaat ctctccctgg
     2341 agtcccagct acttgggagg ctgaggcaga aggattgctc ccacgagttc tagtgcagcc
     2401 tggaaaactt agcaagaccc caaggaaata acaaaaaacc tctccttcca cataggcaag
     2461 catgtccata attacttttt tttttttttt tttttttaca cagttgcatt ttattacctc
     2521 cacattttga agcagttcat gaccagcata gtgctttggg ggcatttttt ttttttttca
     2581 ataaatgaaa gcatttaaga aaaa
//
