LOCUS       NM_004845               5558 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens phosphate cytidylyltransferase 1B, choline (PCYT1B),
            transcript variant 1, mRNA.
ACCESSION   NM_004845
VERSION     NM_004845.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5558)
  AUTHORS   Shen,W., Kuang,P., Wang,B., Zeng,Q., Chen,C. and Lin,X.
  TITLE     Genetic Polymorphisms of LPCAT1, CHPT1 and PCYT1B and Risk of
            Neonatal Respiratory Distress Syndrome among a Chinese Han
            Population
  JOURNAL   Pediatr Neonatol 61 (3), 318-324 (2020)
   PUBMED   31964590
  REMARK    GeneRIF: Genetic Polymorphisms of LPCAT1, CHPT1 and PCYT1B and Risk
            of Neonatal Respiratory Distress Syndrome among a Chinese Han
            Population.
REFERENCE   2  (bases 1 to 5558)
  AUTHORS   Yue,L., McPhee,M.J., Gonzalez,K., Charman,M., Lee,J., Thompson,J.,
            Winkler,D.F.H., Cornell,R.B., Pelech,S. and Ridgway,N.D.
  TITLE     Differential dephosphorylation of CTP:phosphocholine
            cytidylyltransferase upon translocation to nuclear membranes and
            lipid droplets
  JOURNAL   Mol Biol Cell 31 (10), 1047-1059 (2020)
   PUBMED   32186954
  REMARK    GeneRIF: Differential dephosphorylation of CTP:phosphocholine
            cytidylyltransferase upon translocation to nuclear membranes and
            lipid droplets.
REFERENCE   3  (bases 1 to 5558)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5558)
  AUTHORS   Cornell,R.B. and Ridgway,N.D.
  TITLE     CTP:phosphocholine cytidylyltransferase: Function, regulation, and
            structure of an amphitropic enzyme required for membrane biogenesis
  JOURNAL   Prog Lipid Res 59, 147-171 (2015)
   PUBMED   26165797
  REMARK    GeneRIF: CCT contributes to phospholipid compositional homeostasis.
            [Review]
            Review article
REFERENCE   5  (bases 1 to 5558)
  AUTHORS   Parchim,N.F., Wang,W., Iriyama,T., Ashimi,O.A., Siddiqui,A.H.,
            Blackwell,S., Sibai,B., Kellems,R.E. and Xia,Y.
  TITLE     Neurokinin 3 receptor and phosphocholine transferase: missing
            factors for pathogenesis of C-reactive protein in preeclampsia
  JOURNAL   Hypertension 65 (2), 430-439 (2015)
   PUBMED   25452470
  REMARK    GeneRIF: PCYT1B, a placental-specific enzyme post-translationally
            modifying neurokinin B, is essential for the pathogenic role of CRP
            in preeclampsia through activation of the neurokinin 3 receptor.
REFERENCE   6  (bases 1 to 5558)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   7  (bases 1 to 5558)
  AUTHORS   Llorca,O., Martin-Benito,J., Gomez-Puertas,P., Ritco-Vonsovici,M.,
            Willison,K.R., Carrascosa,J.L. and Valpuesta,J.M.
  TITLE     Analysis of the interaction between the eukaryotic chaperonin CCT
            and its substrates actin and tubulin
  JOURNAL   J Struct Biol 135 (2), 205-218 (2001)
   PUBMED   11580270
REFERENCE   8  (bases 1 to 5558)
  AUTHORS   Lykidis,A., Baburina,I. and Jackowski,S.
  TITLE     Distribution of CTP:phosphocholine cytidylyltransferase (CCT)
            isoforms. Identification of a new CCTbeta splice variant
  JOURNAL   J Biol Chem 274 (38), 26992-27001 (1999)
   PUBMED   10480912
REFERENCE   9  (bases 1 to 5558)
  AUTHORS   Gubin,A.N., Njoroge,J.M., Bouffard,G.G. and Miller,J.L.
  TITLE     Gene expression in proliferating human erythroid cells
  JOURNAL   Genomics 59 (2), 168-177 (1999)
   PUBMED   10409428
REFERENCE   10 (bases 1 to 5558)
  AUTHORS   Lykidis,A., Murti,K.G. and Jackowski,S.
  TITLE     Cloning and characterization of a second human CTP:phosphocholine
            cytidylyltransferase
  JOURNAL   J Biol Chem 273 (22), 14022-14029 (1998)
   PUBMED   9593753
  REMARK    Erratum:[J Biol Chem 1998 Jul 24;273(30):19357]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC079168.22, AK315323.1,
            AK226121.1 and BC045634.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_004845.4.
            
            Summary: The protein encoded by this gene belongs to the
            cytidylyltransferase family. It is involved in the regulation of
            phosphatidylcholine biosynthesis. Several alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Sep 2009].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.59370.1,
                                           SRR1660805.104310.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379144.7/ ENSP00000368439.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC079168.22        37858-37866
            10-1352             AK315323.1         1-1343
            1353-3491           AK226121.1         1287-3425
            3492-4170           BC045634.1         3241-3919
            4171-4203           AK226121.1         4105-4137
            4204-5557           AK226121.1         4142-5495
            5558-5558           BC045634.1         5314-5314
FEATURES             Location/Qualifiers
     source          1..5558
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.11"
     gene            1..5558
                     /gene="PCYT1B"
                     /gene_synonym="CCTB; CTB"
                     /note="phosphate cytidylyltransferase 1B, choline"
                     /db_xref="GeneID:9468"
                     /db_xref="HGNC:HGNC:8755"
                     /db_xref="MIM:300948"
     exon            1..359
                     /gene="PCYT1B"
                     /gene_synonym="CCTB; CTB"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..1352
                     /gene="PCYT1B"
                     /gene_synonym="CCTB; CTB"
                     /EC_number="2.7.7.15"
                     /note="isoform 1 is encoded by transcript variant 1;
                     CTP:phosphocholine cytidylyltransferase b; CCT-beta;
                     phosphorylcholine transferase B; choline-phosphate
                     cytidylyltransferase B; CT B; CCT B; CTP:phosphocholine
                     cytidylyltransferase-beta; choline-phosphate
                     cytidylyltransferase beta; phosphorylcholine transferase
                     beta; phosphate cytidylyltransferase 1, choline, beta"
                     /codon_start=1
                     /product="choline-phosphate cytidylyltransferase B isoform
                     1"
                     /protein_id="NP_004836.2"
                     /db_xref="CCDS:CCDS14213.1"
                     /db_xref="GeneID:9468"
                     /db_xref="HGNC:HGNC:8755"
                     /db_xref="MIM:300948"
                     /translation="MPVVTTDAESETGIPKSLSNEPPSETMEEIEHTCPQPRLTLTAP
                     APFADETNCQCQAPHEKLTIAQARLGTPADRPVRVYADGIFDLFHSGHARALMQAKTL
                     FPNSYLLVGVCSDDLTHKFKGFTVMNEAERYEALRHCRYVDEVIRDAPWTLTPEFLEK
                     HKIDFVAHDDIPYSSAGSDDVYKHIKEAGMFVPTQRTEGISTSDIITRIVRDYDVYAR
                     RNLQRGYTAKELNVSFINEKRYRFQNQVDKMKEKVKNVEERSKEFVNRVEEKSHDLIQ
                     KWEEKSREFIGNFLELFGPDGAWKQMFQERSSRMLQALSPKQSPVSSPTRSRSPSRSP
                     SPTFSWLPLKTSPPSSPKAASASISSMSEGDEDEK"
     exon            360..459
                     /gene="PCYT1B"
                     /gene_synonym="CCTB; CTB"
                     /inference="alignment:Splign:2.1.0"
     exon            460..576
                     /gene="PCYT1B"
                     /gene_synonym="CCTB; CTB"
                     /inference="alignment:Splign:2.1.0"
     exon            577..728
                     /gene="PCYT1B"
                     /gene_synonym="CCTB; CTB"
                     /inference="alignment:Splign:2.1.0"
     exon            729..807
                     /gene="PCYT1B"
                     /gene_synonym="CCTB; CTB"
                     /inference="alignment:Splign:2.1.0"
     exon            808..950
                     /gene="PCYT1B"
                     /gene_synonym="CCTB; CTB"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1139
                     /gene="PCYT1B"
                     /gene_synonym="CCTB; CTB"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..5558
                     /gene="PCYT1B"
                     /gene_synonym="CCTB; CTB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5537..5542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCYT1B"
                     /gene_synonym="CCTB; CTB"
                     /note="hexamer: AATAAA"
     polyA_site      5558
                     /gene="PCYT1B"
                     /gene_synonym="CCTB; CTB"
                     /note="major polyA site"
ORIGIN      
        1 agtgtcgtct ggttgttata gtgataaact gaggccttgc ctcttggctt ctgggagaga
       61 gagagagaga gaggggcggg gggtaacctc tttacttccc ctagggaaga cagaaagaag
      121 gggagaagaa gcggggggat gggtggaggg tagaggggag aaaaatacgt gacaaagaaa
      181 acattctctg cctgggagga gactctctga gggtgtagag ctagagggag cattcactgg
      241 ccatgccagt agttaccact gatgctgagt cagaaacagg tatcccaaaa tccctttcca
      301 atgagcctcc ctcagaaacc atggaggaaa tagagcacac atgcccacag cctcgactga
      361 ccctgactgc acctgcccca tttgctgatg aaaccaactg ccagtgtcaa gcaccccatg
      421 aaaaactgac cattgctcag gcccgcttag gaacaccagc tgacaggcct gtcagagtat
      481 acgccgatgg aatatttgac ctcttccact caggtcatgc aagagccctt atgcaagcaa
      541 aaacactgtt tcccaacagc tacttgttgg taggagtttg cagtgatgat ctcacccaca
      601 aattcaaagg tttcaccgtg atgaatgaag ccgagagata cgaagctctc agacactgtc
      661 gctacgtaga cgaagttatc agagatgctc cctggacact cacgccagag tttctggaaa
      721 aacacaagat tgactttgtg gctcatgatg acattccgta ttcctctgct ggctctgatg
      781 atgtttacaa gcacataaag gaagcaggga tgttcgttcc aacgcagaga acagaaggca
      841 tctcaacatc ggacatcatt accagaattg ttcgtgacta tgatgtttat gcccgacgta
      901 acctccagag agggtataca gccaaggaac tgaatgtcag ctttataaat gagaagaggt
      961 accgtttcca gaaccaagtg gacaaaatga aggaaaaagt caagaatgtg gaggaaagat
     1021 caaaggaatt tgtgaacaga gtggaagaaa agagccatga tctaattcaa aagtgggaag
     1081 agaagtcaag ggaattcatt ggcaacttcc tagaactgtt tggacctgat ggagcatgga
     1141 agcagatgtt ccaggagagg agcagccgga tgctgcaggc cttatccccg aagcagagcc
     1201 ctgtgagcag cccaacccgg agccggtccc cttcccgctc cccatcgccc accttctcat
     1261 ggcttccact caaaacctca cccccttcct cacccaaagc agcctcagcc tctatcagca
     1321 gcatgagcga gggggatgag gatgaaaagt agaggctgct gggaggcaag agccgcacca
     1381 tgcaggatgg ggaggagggc gagagtcaca gggttgcctg ggtggtgttt gaagggtaat
     1441 agtcacagga gctgcagctc agcagagaga ccctgaactc tgctaaggga aggtcttggg
     1501 accagttctc tctcactctc cgtacagctg aagagttggg cgaggtgcag agacttctag
     1561 ctggacaacc tacacaaacc ttagcgtcta gagtcactct aaccttgcta aggaaggatg
     1621 cagagttccc tagagagact tgcactgatg gggtgacttc tgctttggtc cttccaccac
     1681 ccccaccaag taaaccacct gtggcagcgg ctgttccctc aacctgctac ttctgcgtcc
     1741 ataagggtcc tgcacgttgc ctcccaccac cccagctctg ccagaataaa attgtttcca
     1801 atagaggtgg caaagtgctt ctgaaatagt cgagaaaaag acagattcca acctcctcag
     1861 tccagccact gagacctgat gttggaacgc atcagctcct tccagttcca tgaatgtggc
     1921 tcatagacaa agccttgctt taggctggtt ataaaaggtc atctagtgtg aaccttaact
     1981 ttttattcaa aggacagttt tgtcaagaac tccacgtaag gcctgatgtg ctcctggttg
     2041 tactttctca tcactggttt gacttcattg ttttgcagaa attaccttaa tccgtgggaa
     2101 ctgcaacaaa gaaaaacttc ctaatatata aaaaagagga gctgctttgc tttgcctcca
     2161 ggtttagcgg acaagaaatg tctcctgaag cttctcctta aaggatgcta ttatggaatg
     2221 gcttttccca tttctgacca gttaacagtt tcatagacct caagtaacag tttgaggtat
     2281 caaacatagt ataccaatag ggggtgctac ctgcacgtat ctgttctata tatgctccaa
     2341 tatgtcatcc ccgggtgtat cccatgtgca atatgagtat atagtggtgg cattttataa
     2401 tagaccccac tcctgcgctc caccataata ctcctctgaa atccttggtc tcaagaaaca
     2461 tctgttctct tgtgacttgg gcactttgtc aagcttattc cagattcctg tggaaacgtt
     2521 ttatcccaac caggaaatta gtattttgtt ctcgtggcct cctataacat ttttgggtga
     2581 aggagaactc aagacttttt acagagaact gtgggctcag ttatgatctc agcatctgaa
     2641 tggtctaggt agtatcacca ttatctctgg ccctaggttt gccaagtagg atgaagactc
     2701 taagtgttcc tgctgagttg tccaaaggtc ctgctcctta gtcacctgtg cgaaatgagc
     2761 agggagagtt aaggcataga accaaactct ttgggttatt gtatgggtat gccagtaaat
     2821 tcagacacag agctggggtc tgactgaata gaggcccaaa ccagcaactt gtaggcagag
     2881 cccagaatct cttgtgatag aaatacccct tttcagaggc cttgggaacc agccttctag
     2941 gtgacaaggg gacaaccagt gaaggaaggc ggcatgtctt tccccttctt gttggggttg
     3001 aactacctcc ctatccactt ggagatgagt gctgtctgct gtgaagcaaa actatgaggc
     3061 tgagctggct tggaacctct ttgttcttgg cactttcctt ctccaggact ctgggaagca
     3121 ctcatatggg acagagggct ggcaggaaca tggcatgtga agaagaaaac ttctttttgc
     3181 agtcaagggc cacccagaat attgctcttc agagagggac aagggcctca ttcttccatt
     3241 tggtctctgt cttccatcat gcactcaggt caagccatgc aagtctgcct accatttgag
     3301 ttagttggca cttgtagcag tgaaggatga ggccagccag gcaagggaag gtggcgggaa
     3361 caagggaaga gaaaaggagg aaagaagttc ctggagggag gaaaggagga taaagaaaat
     3421 ctgctctcat aaaaccattt caggacctca ctttacaggt gagactctct tgggaaggcc
     3481 tttgtgcccc tgctccatgg cccagggcag atagattcac ttttacctga atcttatact
     3541 ctggagcaaa tagtgtatca ggctgactat acatttgcag gccttacacg ccatactgac
     3601 aggtgccact tacgtgactc atcagataat gtcaccattg ctgccaatta tgggaaataa
     3661 ctaatgccta ttccagggat gagcccaaac cacacataaa tgggttctaa atctcaccct
     3721 cctaacctgc agtgagtccc cccgttccac cctcttgagg ctgcaaatct actgagaagg
     3781 aatgggaagg attctacaac ccaacttttg atactttttg gccatctctc agtctctccc
     3841 agcccctacc cccacaccac ctccctgctc ccaggcagag accgggttgc actttgttag
     3901 ggccagcagg tcaactgtaa tggccaagag tgagttaagg ctggaatgag aaatatgccc
     3961 caagcttgga ggggtaagca ggaataacac aaagcaagga aagagattct ttttgcccta
     4021 gtgaggaaag gaagcttcag aatgagggct ggaggatagc aacttaggac tgcagaaggg
     4081 ggcagcttat gaagatggga gaaagtggga ctgaagttgt aggggagcag gagggtagtg
     4141 attttccgct tttctttctt tctttctttt actttctttc tctttctttc tctctctctc
     4201 tctttctttt tctttcttct ttctcttttt ctttcctctt tttctttctt tctttttctt
     4261 tctctttctt ccttctttct ttcattcttc tttgttcttt cttctttctt tctttttttt
     4321 tttttttgag atggagtttt gctcttgttg ctcaggctgg agtgcaatgg cacaatctcg
     4381 gctcactgca gcctccacct cccaggttca aggggttctt ctgcctcagc ctcccaagta
     4441 gctgggatta caggtgcctg ccacgacacc cagctaattt ttgtatgttt agtagagacg
     4501 gggtttcacc atgttggcca ggctggtctc aaattcctga cctcaggtga ttctcccgcc
     4561 tcggcctccc aaagtgctgg gattatgagc acgagccacg gcgtccagcc gattttccgc
     4621 tccctttcaa gtgttaactc accccctgac aggtgaagag ggaagggttc cttttacgca
     4681 caaccaaggt tagcaaatgc ccatgcagga tatggggtcc ctgcctctct ggttgcttca
     4741 tttcagcact tctatattag ctgcttatgg ggaccctaaa atgaactggt cacccctcca
     4801 ccagctaaga aacaagggtg ggattgctgt gccataagtc acactgaacg acttgcttct
     4861 ggcaagcatg ctcctgtgtg tcaggacctt accaaggcaa agaaatgcca ggctcaagag
     4921 gagcaggacg tgagacattg gcctggcttc taacctggtc tgagtggaag agacacagct
     4981 tagggatttc agttttgctc ttaggctact agatactgtt atttcacccc ctgagggagg
     5041 gacaggaaga gcacggattt attttctctc cgtcttcagt acttatttta gcatctagtc
     5101 ataccccagg gagagatgcg agacggtgtc actggctcag ctgaagcaga tgagcccgtc
     5161 tctagcagag atgtgcctgt ttcttaggca tccgttcagc actagtcttg gccatcagat
     5221 ttttaaaaaa gaaatagctc atgaggcatt tgcaacttct cctctctaga cttctttcta
     5281 gttttcctct gttgtgtcac tgcgatgtgt ccagggacaa agccataagt agagcataca
     5341 tacttaagac tatgctgtac atataagaca agacctgtct gggttaaagc acgaccttat
     5401 gcccaagcat ttactctggt gctgaataac gcgaactact ggaatcagcc tcccccaact
     5461 ctgcgcgccc cctgcccccc tgctcctatc ccattcttgc tctcaaatgg accacaccat
     5521 tctcaactcg tttataaata aagggatgca gaattgca
//
