LOCUS       NM_024028               2507 bp    mRNA    linear   PRI 16-FEB-2025
DEFINITION  Homo sapiens prenylcysteine oxidase 1 like (PCYOX1L), transcript
            variant 1, mRNA.
ACCESSION   NM_024028
VERSION     NM_024028.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2507)
  AUTHORS   Petenkova,A., Auger,S.A., Lamb,J., Quellier,D., Carter,C., To,O.T.,
            Milosevic,J., Barghout,R., Kugadas,A., Lu,X., Geddes-McAlister,J.,
            Fichorova,R., Sykes,D.B., Distefano,M.D. and Gadjeva,M.
  TITLE     Prenylcysteine oxidase 1 like protein is required for neutrophil
            bactericidal activities
  JOURNAL   Nat Commun 14 (1), 2761 (2023)
   PUBMED   37179332
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2507)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 2507)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA368718.1, AK075414.1 and BP397957.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024028.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075414.1, SRR1803614.48167.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274569.9/ ENSP00000274569.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               DA368718.1         40-209
            171-2018            AK075414.1         171-2018
            2019-2507           BP397957.1         12-500
FEATURES             Location/Qualifiers
     source          1..2507
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q32"
     gene            1..2507
                     /gene="PCYOX1L"
                     /note="prenylcysteine oxidase 1 like"
                     /db_xref="GeneID:78991"
                     /db_xref="HGNC:HGNC:28477"
     exon            1..111
                     /gene="PCYOX1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1508
                     /gene="PCYOX1L"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; prenylcysteine oxidase-like"
                     /codon_start=1
                     /product="prenylcysteine oxidase 1-like isoform 1
                     precursor"
                     /protein_id="NP_076933.3"
                     /db_xref="CCDS:CCDS4296.1"
                     /db_xref="GeneID:78991"
                     /db_xref="HGNC:HGNC:28477"
                     /translation="MARAAPLLAALTALLAAAAAGGDAPPGKIAVVGAGIGGSAVAHF
                     LQQHFGPRVQIDVYEKGTVGGRLATISVNKQHYESGAASFHSLSLHMQDFVKLLGLRH
                     RREVVGRSAIFGGEHFMLEETDWYLLNLFRLWWHYGISFLRLQMWVEEVMEKFMRIYK
                     YQAHGYAFSGVEELLYSLGESTFVNMTQHSVAESLLQVGVTQRFIDDVVSAVLRASYG
                     QSAAMPAFAGAMSLAGAQGSLWSVEGGNKLVCSGLLKLTKANVIHATVTSVTLHSTEG
                     KALYQVAYENEVGNSSDFYDIVVIATPLHLDNSSSNLTFAGFHPPIDDVQGSFQPTVV
                     SLVHGYLNSSYFGFPDPKLFPFANILTTDFPSFFCTLDNICPVNISASFRRKQPQEAA
                     VWRVQSPKPLFRTQLKTLFRSYYSVQTAEWQAHPLYGSRPTLPRFALHDQLFYLNALE
                     WAASSVEVMAVAAKNVALLAYNRWYQDLDKIDQKDLMHKVKTEL"
     exon            112..318
                     /gene="PCYOX1L"
                     /inference="alignment:Splign:2.1.0"
     exon            319..493
                     /gene="PCYOX1L"
                     /inference="alignment:Splign:2.1.0"
     exon            494..705
                     /gene="PCYOX1L"
                     /inference="alignment:Splign:2.1.0"
     exon            706..846
                     /gene="PCYOX1L"
                     /inference="alignment:Splign:2.1.0"
     exon            847..2507
                     /gene="PCYOX1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2487..2492
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCYOX1L"
                     /note="hexamer: AGTAAA"
     polyA_site      2507
                     /gene="PCYOX1L"
                     /note="major polyA site"
ORIGIN      
        1 gtgctgcccg ctcgccgccc gccatggccc gcgcagcccc gctgctcgcc gcgttgaccg
       61 cgctcctcgc cgccgccgct gctggcggag atgccccgcc gggcaaaatc gcggtggttg
      121 gggctgggat tgggggctct gctgtggccc attttctcca gcagcacttt ggacctcggg
      181 tgcagatcga cgtgtacgag aagggaaccg tgggtggccg cttggccacc atctcagtca
      241 acaagcagca ctatgagagc ggggctgcct ccttccactc cctgagcctg cacatgcagg
      301 acttcgtcaa gctgctgggg ctgaggcacc ggcgcgaggt ggtgggcagg agcgccatct
      361 tcggcgggga gcacttcatg ctggaggaga ctgactggta cctgctgaac ctcttccgcc
      421 tctggtggca ctatggcatc agcttcctga ggctgcagat gtgggtggag gaggtcatgg
      481 agaagttcat gaggatctat aagtaccagg cccacggcta tgccttctcg ggtgtggagg
      541 agctgctcta ctcactgggg gagtccacct ttgttaacat gacccagcac tctgtggctg
      601 agtccctgct gcaggtgggc gtcacgcagc gctttattga tgatgtcgtt tctgctgtcc
      661 tgcgggccag ctatggccag tcagcagcga tgcccgcctt tgcaggagcc atgtcactag
      721 ccggggccca aggcagcctg tggtctgtgg aaggaggcaa taagctggtt tgttccggtt
      781 tgctgaagct caccaaggcc aatgtgatcc atgccacagt gacctctgtg accctgcaca
      841 gcacagaggg gaaagccctg taccaggtgg cgtatgagaa tgaggtaggc aacagctctg
      901 acttctatga catcgtggtc atcgccaccc ccctgcacct ggacaacagc agcagcaact
      961 taacctttgc aggcttccac ccgcccattg atgacgtgca gggctctttc cagcccaccg
     1021 tcgtctcctt ggtccacggc tacctcaact cgtcctactt cggtttccca gaccctaagc
     1081 ttttcccctt tgccaacatc cttaccacag atttccccag cttcttctgc actctggaca
     1141 acatctgccc tgtcaacatc tctgccagct tccggcgaaa gcagccccag gaggcagctg
     1201 tttggcgagt ccagtccccc aagcccctct ttcggaccca gctaaagacc ctgttccgtt
     1261 cctattactc agtgcagaca gctgagtggc aggcccatcc cctctatggc tcccgcccca
     1321 cgctcccgag gtttgcactc catgaccagc tcttctacct caatgccctg gagtgggcgg
     1381 ccagctccgt ggaggtgatg gccgtggctg ccaagaatgt ggccttgctg gcttacaacc
     1441 gctggtacca ggacctagac aagattgatc aaaaagattt gatgcacaag gtcaagactg
     1501 aactgtgagg gctctaggga gagcctggga actttcatcc cccactgaag atggatcatc
     1561 ccacagcagc ccaggactga ataagccatg ctcgcccacc aggcttcttt ctgacccctc
     1621 atgtatcaag catctccagg tgacctactg tctgcctata ttaagggtcc acacggcggc
     1681 tgctgctttt ttttaagggg gaaagtaaga aaagagaagg aaatccaagc cagtatattt
     1741 gttttattta ttttttttaa gaagaaaaaa gttcatcttc acaaggtgct tcagacttgg
     1801 tttcttagct agaaaccaga agactacggg agggaatata aggcagagaa ctatgagtct
     1861 tattttatta ctgtttttca ctacctactc ccacaatgga caatcaattg aggcaaccta
     1921 caagaaaaca tttacaacca gatggttaca aataaagtag aagggaagat cagaaaacct
     1981 aagaaatgat catagctcct ggttactgtg gacttgatgg atttgaagta cctagttcag
     2041 aactccctag tcaccatctc caagcctgtc aacatcactg catattggag gagatgactg
     2101 tggtaggacc caaggaagag atgtgtgcct gaatagtcgt caccatatct ccaagcttcc
     2161 tggcaaccag tgggaaaaga aacatgcgag gctgtaggaa gagggaagct cttccttggc
     2221 acctagagga attagccatt ctcttcctta tgcaaagatt gaggaatgca acaatataaa
     2281 gaagagaagt ccccagatgg tagagagcag tcatatctta cccctagatg ttcatcccag
     2341 cagaagaaag aagaaggtgt tggggtagga ttcttcagag gttagcctgg tactttctca
     2401 tcagacacta gcttgaagta agaggagaat tatgcttttc tttgcttttt ctacaaaccc
     2461 ttaaaaatca cttgttttaa aaagaaagta aaagcccttt tcattcc
//
