LOCUS       NM_002570               4272 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens proprotein convertase subtilisin/kexin type 6 (PCSK6),
            transcript variant 1, mRNA.
ACCESSION   NM_002570 XM_001130900
VERSION     NM_002570.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4272)
  AUTHORS   Xu,M., Li,J., Xia,L., Du,Y., Wu,B., Shi,X., Tian,N., Pang,Y.,
            Yi,L., Chen,M., Song,W. and Dong,Z.
  TITLE     PCSK6 exacerbates Alzheimer's disease pathogenesis by promoting
            MT5-MMP maturation
  JOURNAL   Exp Neurol 374, 114688 (2024)
   PUBMED   38216110
  REMARK    GeneRIF: PCSK6 exacerbates Alzheimer's disease pathogenesis by
            promoting MT5-MMP maturation.
REFERENCE   2  (bases 1 to 4272)
  AUTHORS   Oldham,J.M., Allen,R.J., Lorenzo-Salazar,J.M., Molyneaux,P.L.,
            Ma,S.F., Joseph,C., Kim,J.S., Guillen-Guio,B.,
            Hernandez-Beeftink,T., Kropski,J.A., Huang,Y., Lee,C.T.,
            Adegunsoye,A., Pugashetti,J.V., Linderholm,A.L., Vo,V., Strek,M.E.,
            Jou,J., Munoz-Barrera,A., Rubio-Rodriguez,L.A., Hubbard,R.,
            Hirani,N., Whyte,M.K.B., Hart,S., Nicholson,A.G., Lancaster,L.,
            Parfrey,H., Rassl,D., Wallace,W., Valenzi,E., Zhang,Y.,
            Mychaleckyj,J., Stockwell,A., Kaminski,N., Wolters,P.J.,
            Molina-Molina,M., Banovich,N.E., Fahy,W.A., Martinez,F.J.,
            Hall,I.P., Tobin,M.D., Maher,T.M., Blackwell,T.S., Yaspan,B.L.,
            Jenkins,R.G., Flores,C., Wain,L.V. and Noth,I.
  TITLE     PCSK6 and Survival in Idiopathic Pulmonary Fibrosis
  JOURNAL   Am J Respir Crit Care Med 207 (11), 1515-1524 (2023)
   PUBMED   36780644
  REMARK    GeneRIF: PCSK6 and Survival in Idiopathic Pulmonary Fibrosis.
REFERENCE   3  (bases 1 to 4272)
  AUTHORS   Couture,F., Wang,L., Dufour,F., Chabot-Maheux,K., Ekindi Ndongo,N.,
            Sabbagh,R. and Day,R.
  TITLE     PACE4-altCT isoform of proprotein convertase PACE4 as tissue and
            plasmatic biomarker for prostate cancer
  JOURNAL   Sci Rep 12 (1), 6066 (2022)
   PUBMED   35410344
  REMARK    GeneRIF: PACE4-altCT isoform of proprotein convertase PACE4 as
            tissue and plasmatic biomarker for prostate cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4272)
  AUTHORS   Zhao,X., Zhang,X., Wu,Z., Mei,J., Li,L. and Wang,Y.
  TITLE     Up-regulation of microRNA-135 or silencing of PCSK6 attenuates
            inflammatory response in preeclampsia by restricting NLRP3
            inflammasome
  JOURNAL   Mol Med 27 (1), 82 (2021)
   PUBMED   34301174
  REMARK    GeneRIF: Up-regulation of microRNA-135 or silencing of PCSK6
            attenuates inflammatory response in preeclampsia by restricting
            NLRP3 inflammasome.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4272)
  AUTHORS   Tsuji,A., Hine,C., Tamai,Y., Yonemoto,K., Mori,K., Yoshida,S.,
            Bando,M., Sakai,E., Mori,K., Akamatsu,T. and Matsuda,Y.
  TITLE     Genomic organization and alternative splicing of human PACE4
            (SPC4), kexin-like processing endoprotease
  JOURNAL   J Biochem 122 (2), 438-452 (1997)
   PUBMED   9378725
REFERENCE   6  (bases 1 to 4272)
  AUTHORS   Zhong,M., Benjannet,S., Lazure,C., Munzer,S. and Seidah,N.G.
  TITLE     Functional analysis of human PACE4-A and PACE4-C isoforms:
            identification of a new PACE4-CS isoform
  JOURNAL   FEBS Lett 396 (1), 31-36 (1996)
   PUBMED   8906861
REFERENCE   7  (bases 1 to 4272)
  AUTHORS   Tsuji,A., Higashine,K., Hine,C., Mori,K., Tamai,Y., Nagamune,H. and
            Matsuda,Y.
  TITLE     'Identification of novel cDNAs encoding human kexin-like protease,
            PACE4 isoforms.'
  JOURNAL   Biochem Biophys Res Commun 204 (3), 1381-1382 (1994)
   PUBMED   7980617
  REMARK    Correction to:[Biochem Biophys Res Commun. 1994 Apr
            29;200(2):943-50. doi: 10.1006/bbrc.1994.1541.. PMID: 8179631]
REFERENCE   8  (bases 1 to 4272)
  AUTHORS   Tsuji,A., Higashine,K., Hine,C., Mori,K., Tamai,Y., Nagamune,H. and
            Matsuda,Y.
  TITLE     Identification of novel cDNAs encoding human kexin-like protease,
            PACE4 isoforms
  JOURNAL   Biochem Biophys Res Commun 200 (2), 943-950 (1994)
   PUBMED   8179631
  REMARK    Erratum:[Biochem Biophys Res Commun. 1994 Nov 15;204(3):1381-2.
            doi: 10.1006/bbrc.1994.2616.. PMID: 7980617]
REFERENCE   9  (bases 1 to 4272)
  AUTHORS   Rehemtulla,A., Barr,P.J., Rhodes,C.J. and Kaufman,R.J.
  TITLE     PACE4 is a member of the mammalian propeptidase family that has
            overlapping but not identical substrate specificity to PACE
  JOURNAL   Biochemistry 32 (43), 11586-11590 (1993)
   PUBMED   8218226
REFERENCE   10 (bases 1 to 4272)
  AUTHORS   Kiefer,M.C., Tucker,J.E., Joh,R., Landsberg,K.E., Saltman,D. and
            Barr,P.J.
  TITLE     Identification of a second human subtilisin-like protease gene in
            the fes/fps region of chromosome 15
  JOURNAL   DNA Cell Biol 10 (10), 757-769 (1991)
   PUBMED   1741956
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from M80482.1, AM491522.1,
            AL545278.3, BX428035.2 and BU732171.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002570.4.
            
            Summary: This gene encodes a member of the subtilisin-like
            proprotein convertase family, which includes proteases that process
            protein and peptide precursors trafficking through regulated or
            constitutive branches of the secretory pathway. The encoded protein
            undergoes an initial autocatalytic processing event in the ER to
            generate a heterodimer which exits the ER and sorts to the
            trans-Golgi network where a second autocatalytic event takes place
            and the catalytic activity is acquired. The encoded protease is
            constitutively secreted into the extracellular matrix and expressed
            in many tissues, including neuroendocrine, liver, gut, and brain.
            This gene encodes one of the seven basic amino acid-specific
            members which cleave their substrates at single or paired basic
            residues. Some of its substrates include transforming growth factor
            beta related proteins, proalbumin, and von Willebrand factor. This
            gene is thought to play a role in tumor progression and left-right
            patterning. Alternatively spliced transcript variants encoding
            different isoforms have been identified. [provided by RefSeq, Feb
            2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the predominant isoform (PACE4-AI, also
            known as PACE4 and PACE4-A).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M80482.1, SRR1803617.132000.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000611716.5/ ENSP00000482760.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-315               M80482.1           133-447
            316-316             AM491522.1         44-44
            317-1431            M80482.1           449-1563
            1432-1432           AL545278.3         275-275
            1433-1747           M80482.1           1565-1879
            1748-1748           BX428035.2         343-343
            1749-4271           M80482.1           1881-4403
            4272-4272           BU732171.1         23-23               c
FEATURES             Location/Qualifiers
     source          1..4272
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.3"
     gene            1..4272
                     /gene="PCSK6"
                     /gene_synonym="PACE4; SPC4"
                     /note="proprotein convertase subtilisin/kexin type 6"
                     /db_xref="GeneID:5046"
                     /db_xref="HGNC:HGNC:8569"
                     /db_xref="MIM:167405"
     exon            1..334
                     /gene="PCSK6"
                     /gene_synonym="PACE4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..2947
                     /gene="PCSK6"
                     /gene_synonym="PACE4; SPC4"
                     /EC_number="3.4.21.-"
                     /note="isoform PACE4-AI preproprotein is encoded by
                     transcript variant 1; paired basic amino acid cleaving
                     system 4; subtilisin-like proprotein convertase 4;
                     subtilisin/kexin-like protease PACE4; paired basic amino
                     acid cleaving enzyme 4"
                     /codon_start=1
                     /product="proprotein convertase subtilisin/kexin type 6
                     isoform PACE4-AI preproprotein"
                     /protein_id="NP_002561.1"
                     /db_xref="CCDS:CCDS73790.1"
                     /db_xref="GeneID:5046"
                     /db_xref="HGNC:HGNC:8569"
                     /db_xref="MIM:167405"
                     /translation="MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPL
                     APRPWRWLLLLALPAACSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGN
                     LEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYF
                     NDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPN
                     YDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGI
                     RMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGR
                     QGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATT
                     YSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLV
                     KTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDK
                     RPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGT
                     KSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKE
                     WSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPPKAALSPSQVEVPEDEEDYTAQS
                     TPGSANILQTSVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGD
                     TAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCL
                     KCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCV
                     GPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSSRN
                     CSRCKTGFTQLGTSCITNHTCSNADETFCEMVKSNRLCERKLFIQFCCRTCLLAG"
     exon            335..439
                     /gene="PCSK6"
                     /gene_synonym="PACE4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            440..550
                     /gene="PCSK6"
                     /gene_synonym="PACE4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            551..694
                     /gene="PCSK6"
                     /gene_synonym="PACE4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            695..771
                     /gene="PCSK6"
                     /gene_synonym="PACE4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            772..860
                     /gene="PCSK6"
                     /gene_synonym="PACE4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1033
                     /gene="PCSK6"
                     /gene_synonym="PACE4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1246
                     /gene="PCSK6"
                     /gene_synonym="PACE4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1347
                     /gene="PCSK6"
                     /gene_synonym="PACE4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1451
                     /gene="PCSK6"
                     /gene_synonym="PACE4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1569
                     /gene="PCSK6"
                     /gene_synonym="PACE4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1758
                     /gene="PCSK6"
                     /gene_synonym="PACE4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1895
                     /gene="PCSK6"
                     /gene_synonym="PACE4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2075
                     /gene="PCSK6"
                     /gene_synonym="PACE4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2114
                     /gene="PCSK6"
                     /gene_synonym="PACE4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2217
                     /gene="PCSK6"
                     /gene_synonym="PACE4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2414
                     /gene="PCSK6"
                     /gene_synonym="PACE4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2502
                     /gene="PCSK6"
                     /gene_synonym="PACE4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..2606
                     /gene="PCSK6"
                     /gene_synonym="PACE4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..2736
                     /gene="PCSK6"
                     /gene_synonym="PACE4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2737..2849
                     /gene="PCSK6"
                     /gene_synonym="PACE4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2850..4272
                     /gene="PCSK6"
                     /gene_synonym="PACE4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4252..4257
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCSK6"
                     /gene_synonym="PACE4; SPC4"
                     /note="hexamer: AATAAA"
     polyA_site      4272
                     /gene="PCSK6"
                     /gene_synonym="PACE4; SPC4"
                     /note="major polyA site"
ORIGIN      
        1 actcgcagct cgggcgccgc gcgagcctgt cgccgctatg cctccgcgcg cgccgcctgc
       61 gcccgggccc cggccgccgc cccgggccgc cgccgccacc gacaccgccg cgggcgcggg
      121 gggcgcgggg ggcgcggggg gcgccggcgg gcccgggttc cggccgctcg cgccgcgtcc
      181 ctggcgctgg ctgctgctgc tggcgctgcc tgccgcctgc tccgcgcccc cgccgcgccc
      241 cgtctacacc aaccactggg cggtgcaagt gctgggcggc ccggccgagg cggaccgcgt
      301 ggcggcggcg cacgggtacc tcaacttggg ccagattgga aacctggaag attactacca
      361 tttttatcac agcaaaacct ttaaaagatc aaccttgagt agcagaggcc ctcacacctt
      421 cctcagaatg gacccccagg tgaaatggct ccagcaacag gaagtgaaac gaagggtgaa
      481 gagacaggtg cgaagtgacc cgcaggccct ttacttcaac gaccccattt ggtccaacat
      541 gtggtacctg cattgtggcg acaagaacag tcgctgccgg tcggaaatga atgtccaggc
      601 agcgtggaag aggggctaca caggaaaaaa cgtggtggtc accatccttg atgatggcat
      661 agagagaaat caccctgacc tggccccaaa ttatgattcc tacgccagct acgacgtgaa
      721 cggcaatgat tatgacccat ctccacgata tgatgccagc aatgaaaata aacacggcac
      781 tcgttgtgcg ggagaagttg ctgcttcagc aaacaattcc tactgcatcg tgggcatagc
      841 gtacaatgcc aaaataggag gcatccgcat gctggacggc gatgtcacag atgtggtcga
      901 ggcaaagtcg ctgggcatca gacccaacta catcgacatt tacagtgcca gctgggggcc
      961 ggacgacgac ggcaagacgg tggacgggcc cggccgactg gctaagcagg ctttcgagta
     1021 tggcattaaa aagggccggc agggcctggg ctccattttc gtctgggcat ctgggaatgg
     1081 cgggagagag ggggactact gctcgtgcga tggctacacc aacagcatct acaccatctc
     1141 cgtcagcagc gccaccgaga atggctacaa gccctggtac ctggaagagt gtgcctccac
     1201 cctggccacc acctacagca gtggggcctt ttatgagcga aaaatcgtca ccacggatct
     1261 gcgtcagcgc tgtaccgatg gccacactgg gacctcagtc tctgccccca tggtggcggg
     1321 catcatcgcc ttggctctag aagcaaacag ccagttaacc tggagggacg tccagcacct
     1381 gctagtgaag acatcccggc cggcccacct gaaagcgagc gactggaaag tgaacggcgc
     1441 gggtcataaa gttagccatt tctatggatt tggtttggtg gacgcagaag ctctcgttgt
     1501 ggaggcaaag aagtggacag cagtgccatc gcagcacatg tgtgtggccg cctcggacaa
     1561 gagacccagg agcatcccct tagtgcaggt gctgcggact acggccctga ccagcgcctg
     1621 cgcggagcac tcggaccagc gggtggtcta cttggagcac gtggtggttc gcacctccat
     1681 ctcacaccca cgccgaggag acctccagat ctacctggtt tctccctcgg gaaccaagtc
     1741 tcaacttctg gcaaagaggt tgctggatct ttccaatgaa gggtttacaa actgggaatt
     1801 catgactgtc cactgctggg gagaaaaggc tgaagggcag tggaccttgg aaatccaaga
     1861 tctgccatcc caggtccgca acccggagaa gcaagggaag ttgaaagaat ggagcctcat
     1921 actgtatggc acagcagagc acccgtacca caccttcagt gcccatcagt cccgctcgcg
     1981 gatgctggag ctctcagccc cagagctgga gccacccaag gctgccctgt caccctccca
     2041 ggtggaagtt cctgaagatg aggaagatta cacagctcaa tccaccccag gctctgctaa
     2101 tattttacag accagtgtgt gccatccgga gtgtggtgac aaaggctgtg atggccccaa
     2161 tgcagaccag tgcttgaact gcgtccactt cagcctgggg agtgtcaaga ccagcaggaa
     2221 gtgcgtgagt gtgtgcccct tgggctactt tggggacaca gcagcaagac gctgtcgccg
     2281 gtgccacaag gggtgtgaga cctgctccag cagagctgcg acgcagtgcc tgtcttgccg
     2341 ccgcgggttc tatcaccacc aggagatgaa cacctgtgtg accctctgtc ctgcaggatt
     2401 ttatgctgat gaaagtcaga aaaattgcct taaatgccac ccaagctgta aaaagtgcgt
     2461 ggatgaacct gagaaatgta ctgtctgtaa agaaggattc agccttgcac ggggcagctg
     2521 cattcctgac tgtgagccag gcacctactt tgactcagag ctgatcagat gtggggaatg
     2581 ccatcacacc tgcggaacct gcgtggggcc aggcagagaa gagtgcattc actgtgcgaa
     2641 aaacttccac ttccacgact ggaagtgtgt gccagcctgt ggtgagggct tctacccaga
     2701 agagatgccg ggcttgcccc acaaagtgtg tcgaaggtgt gacgagaact gcttgagctg
     2761 tgcaggctcc agcaggaact gtagcaggtg taagacgggc ttcacacagc tggggacctc
     2821 ctgcatcacc aaccacacgt gcagcaacgc tgacgagaca ttctgcgaga tggtgaagtc
     2881 caaccggctg tgcgaacgga agctcttcat tcagttctgc tgccgcacgt gcctcctggc
     2941 cgggtaaggg tgcctagctg cccacagagg gcaggcactc ccatccatcc atccgtccac
     3001 cttcctccag actgtcggcc agagtctgtt tcaggagcgg cgccctgcac ctgacagctt
     3061 tatctcccca ggagcagcat ctctgagcac ccaagccagg tgggtggtgg ctcttaagga
     3121 ggtgttccta aaatggtgat atcctctcaa atgctgcttg ttggctccag tcttccgaca
     3181 aactaacagg aacaaaatga attctgggaa tccacagctc tggctttgga gcagcttctg
     3241 ggaccataag tttactgaat cttcaagacc aaagcagaaa agaaaggcgc ttggcatcac
     3301 acatcactct tctccccgtg cttttctgcg gctgtgtagt aaatctcccc ggcccagctg
     3361 gcgaaccctg ggccatcctc acatgtgaca aagggccagc agtctacctg ctcgttgcct
     3421 gccactgagc agtctgggga cggtttggtc agactataaa taagataggt ttgagggcat
     3481 aaaatgtatg accactgggg ccggagtatc tatttctaca tagtcagcta cttctgaaac
     3541 tgcagcagtg gcttagaaag tccaattcca aagccagacc agaagattct atcccccgca
     3601 gcgctctcct ttgagcaagc cgagctctcc ttgttaccgt gttctgtctg tgtcttcagg
     3661 agtctcatgg cctgaacgac cacctcgacc tgatgcagag ccttctgagg agaggcaaca
     3721 ggaggcattc tgtggccagc caaaaggtac cccgatggcc aagcaattcc tctgaacaaa
     3781 atgtaaagcc agccatgcat tgttaatcat ccatcacttc ccattttatg gaattgcttt
     3841 taaaatacat ttggcctctg cccttcagaa gactcgtttt taaggtggaa actcctgtgt
     3901 ctgtgtatat tacaagccta catgacacag ttggatttat tctgccaaac ctgtgtaggc
     3961 attttataag ctacatgttc taatttttac cgatgttaat tattttgaca aatatttcat
     4021 atattttcat tgaaatgcac agatctgctt gatcaattcc cttgaatagg gaagtaacat
     4081 ttgccttaaa ttttttcgac ctcgtctttc tccatattgt cctgctcccc tgtttgacga
     4141 cagtgcattt gccttgtcac ctgtgagctg gagagaaccc agatgttgtt tattgaatct
     4201 acaactctga aagagaaatc aatgaagcaa gtacaatgtt aaccctaaat taataaaaga
     4261 gttaacatcc ca
//
