LOCUS       NM_174895                747 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens Purkinje cell protein 2 (PCP2), transcript variant 1,
            mRNA.
ACCESSION   NM_174895 XM_058956
VERSION     NM_174895.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 747)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 747)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 747)
  AUTHORS   Xu,Y., Sulaiman,P., Feddersen,R.M., Liu,J., Smith,R.G. and Vardi,N.
  TITLE     Retinal ON bipolar cells express a new PCP2 splice variant that
            accelerates the light response
  JOURNAL   J Neurosci 28 (36), 8873-8884 (2008)
   PUBMED   18768681
  REMARK    GeneRIF: characterization of the mouse 136 aa conserved isoform,
            Ret-PCP2
REFERENCE   4  (bases 1 to 747)
  AUTHORS   Serinagaoglu,Y., Zhang,R., Zhang,Y., Zhang,L., Hartt,G., Young,A.P.
            and Oberdick,J.
  TITLE     A promoter element with enhancer properties, and the orphan nuclear
            receptor RORalpha, are required for Purkinje cell-specific
            expression of a Gi/o modulator
  JOURNAL   Mol Cell Neurosci 34 (3), 324-342 (2007)
   PUBMED   17215137
REFERENCE   5  (bases 1 to 747)
  AUTHORS   Willard,F.S., McCudden,C.R. and Siderovski,D.P.
  TITLE     G-protein alpha subunit interaction and guanine nucleotide
            dissociation inhibitor activity of the dual GoLoco motif protein
            PCP-2 (Purkinje cell protein-2)
  JOURNAL   Cell Signal 18 (8), 1226-1234 (2006)
   PUBMED   16298104
  REMARK    GeneRIF: The data demonstrate that PCP-2 is a comparatively weak
            GoLoco motif protein that exhibits highest affinity interactions
            and GDI activity toward Galphai1, Galphai2, and Galphai3 subunits.
REFERENCE   6  (bases 1 to 747)
  AUTHORS   Zhang,X., Zhang,H. and Oberdick,J.
  TITLE     Conservation of the developmentally regulated dendritic
            localization of a Purkinje cell-specific mRNA that encodes a
            G-protein modulator: comparison of rodent and human Pcp2(L7) gene
            structure and expression
  JOURNAL   Brain Res Mol Brain Res 105 (1-2), 1-10 (2002)
   PUBMED   12399102
REFERENCE   7  (bases 1 to 747)
  AUTHORS   Luo,Y. and Denker,B.M.
  TITLE     Interaction of heterotrimeric G protein Galphao with Purkinje cell
            protein-2. Evidence for a novel nucleotide exchange factor
  JOURNAL   J Biol Chem 274 (16), 10685-10688 (1999)
   PUBMED   10196137
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC025387.1 and BC038715.1.
            
            On Nov 22, 2018 this sequence version replaced NM_174895.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025387.1, AK130855.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311069.6/ ENSP00000310585.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                BC025387.1         35-69
            36-741              BC038715.1         1-706
            742-747             BC025387.1         776-781
FEATURES             Location/Qualifiers
     source          1..747
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..747
                     /gene="PCP2"
                     /gene_synonym="GPSM4; PCD5"
                     /note="Purkinje cell protein 2"
                     /db_xref="GeneID:126006"
                     /db_xref="HGNC:HGNC:30209"
                     /db_xref="MIM:619344"
     exon            1..313
                     /gene="PCP2"
                     /gene_synonym="GPSM4; PCD5"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..673
                     /gene="PCP2"
                     /gene_synonym="GPSM4; PCD5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Purkinje cell-specific protein L7; Purkinje cell protein 2
                     homolog; CTD-3214H19.6; Purkinje cell-specific protein 2"
                     /codon_start=1
                     /product="Purkinje cell protein 2 homolog isoform 1"
                     /protein_id="NP_777555.1"
                     /db_xref="CCDS:CCDS32893.1"
                     /db_xref="GeneID:126006"
                     /db_xref="HGNC:HGNC:30209"
                     /db_xref="MIM:619344"
                     /translation="MMDQEEKTEEGSGPCAEAGSPDQEGFFNLLSHVQGDRMEGQRCS
                     LQAGPGQTTKSQSDPTPEMDSLMDMLASTQGRRMDDQRVTVSSLPGFQPVGSKDGAQK
                     RAGTLSPQPLLTPQDPTALGFRRNSSPQPPTQAP"
     exon            314..428
                     /gene="PCP2"
                     /gene_synonym="GPSM4; PCD5"
                     /inference="alignment:Splign:2.1.0"
     exon            429..553
                     /gene="PCP2"
                     /gene_synonym="GPSM4; PCD5"
                     /inference="alignment:Splign:2.1.0"
     exon            554..747
                     /gene="PCP2"
                     /gene_synonym="GPSM4; PCD5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      723..728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCP2"
                     /gene_synonym="GPSM4; PCD5"
                     /note="hexamer: AATAAA"
     polyA_site      747
                     /gene="PCP2"
                     /gene_synonym="GPSM4; PCD5"
                     /note="major polyA site"
ORIGIN      
        1 agtcattgct gctgggcaca gcgaggtcca agctcaggtc gccctgcccc ctacccacca
       61 tgccagatcc agcatcgttg tgggcaaaca attatctgga tgatctttat ggggcttaag
      121 cttgggtggg agcagatggg gcatgagctg gggatttggg gatgggggga atccacaccc
      181 ccacgtcctg gacgtttaaa aggccctctc tggcactggg ccggggcaga ggccagcaga
      241 aaagtgactg gagtccaggg acatgatgga tcaggaggag aagacggagg aaggctcagg
      301 cccctgtgcc gaggcgggct ccccagacca ggagggcttc ttcaatctgc tgagccacgt
      361 gcagggcgac cggatggagg gacagcgctg ttcactgcaa gccgggccgg gccagaccac
      421 caagagccag agcgacccca cccccgagat ggacagcctc atggacatgc tggccagtac
      481 ccagggccgc cgcatggatg accaacgtgt gacagtcagc agcctgcccg gcttccagcc
      541 cgtggggtcc aaggacggag cacagaaacg agctgggacc ctcagtcccc aacccctgct
      601 cacccctcag gacccgaccg ctctcggctt ccgtcggaac agcagccccc agcccccgac
      661 acaagccccc tgagggcctg aggcatcctg ggtctcactc ggcccccaaa aactgataaa
      721 agaataaaac acttaaatga ataacaa
//
