LOCUS       NM_013363               1896 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens procollagen C-endopeptidase enhancer 2 (PCOLCE2),
            mRNA.
ACCESSION   NM_013363
VERSION     NM_013363.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1896)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1896)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 1896)
  AUTHORS   Sorci-Thomas,M.G., Pollard,R.D. and Thomas,M.J.
  TITLE     What does procollagen C-endopeptidase enhancer protein 2 have to do
            with HDL-cholesteryl ester uptake? Or how I learned to stop
            worrying and love reverse cholesterol transport?
  JOURNAL   Curr Opin Lipidol 26 (5), 420-425 (2015)
   PUBMED   26218419
  REMARK    GeneRIF: Procollagen C-endopeptidase protein 2, atherosclerosis and
            HDL cholesteryl ester catabolism. [Review]
            Review article
REFERENCE   4  (bases 1 to 1896)
  AUTHORS   Zhu,J., Gardner,J., Pullinger,C.R., Kane,J.P., Thompson,J.F. and
            Francone,O.L.
  TITLE     Regulation of apoAI processing by procollagen C-proteinase
            enhancer-2 and bone morphogenetic protein-1
  JOURNAL   J Lipid Res 50 (7), 1330-1339 (2009)
   PUBMED   19237735
  REMARK    GeneRIF: Data indicate that PCPE2 accelerates the proteolytic
            processing of pro-apolipoprotein (apo) AI by enhancing the cleavage
            of the hexapeptide extension present at the N terminus of apoAI.
REFERENCE   5  (bases 1 to 1896)
  AUTHORS   Steiglitz,B.M., Keene,D.R. and Greenspan,D.S.
  TITLE     PCOLCE2 encodes a functional procollagen C-proteinase enhancer
            (PCPE2) that is a collagen-binding protein differing in
            distribution of expression and post-translational modification from
            the previously described PCPE1
  JOURNAL   J Biol Chem 277 (51), 49820-49830 (2002)
   PUBMED   12393877
  REMARK    GeneRIF: PCPE2 is shown to be a glycoprotein that differs markedly
            in the nature of its glycosylation from that of PCPE1
REFERENCE   6  (bases 1 to 1896)
  AUTHORS   Steiglitz,B.M. and Greenspan,D.S.
  TITLE     Assignment of the mouse Pcolce2 gene, which encodes procollagen
            C-proteinase enhancer protein 2, to chromosome 9 and localization
            of PCOLCE2 to human chromosome 3q23
  JOURNAL   Cytogenet Cell Genet 95 (3-4), 244-245 (2001)
   PUBMED   12063410
  REMARK    GeneRIF: Assignment of Pcolce2 gene, which encodes procollagen
            C-proteinase enhancer protein 2, to human chromosome 3q23.
REFERENCE   7  (bases 1 to 1896)
  AUTHORS   Xu,H., Acott,T.S. and Wirtz,M.K.
  TITLE     Identification and expression of a novel type I procollagen
            C-proteinase enhancer protein gene from the glaucoma candidate
            region on 3q21-q24
  JOURNAL   Genomics 66 (3), 264-273 (2000)
   PUBMED   10873381
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY358557.1.
            
            On Nov 22, 2018 this sequence version replaced NM_013363.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358557.1, AY035400.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144, SAMEA2467146
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295992.8/ ENSP00000295992.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1896              AY358557.1         120-2015
FEATURES             Location/Qualifiers
     source          1..1896
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q23"
     gene            1..1896
                     /gene="PCOLCE2"
                     /gene_synonym="PCPE2"
                     /note="procollagen C-endopeptidase enhancer 2"
                     /db_xref="GeneID:26577"
                     /db_xref="HGNC:HGNC:8739"
                     /db_xref="MIM:607064"
     exon            1..270
                     /gene="PCOLCE2"
                     /gene_synonym="PCPE2"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..1435
                     /gene="PCOLCE2"
                     /gene_synonym="PCPE2"
                     /note="procollagen C-proteinase enhancer 2; procollagen
                     COOH-terminal proteinase enhancer 2"
                     /codon_start=1
                     /product="procollagen C-endopeptidase enhancer 2
                     precursor"
                     /protein_id="NP_037495.1"
                     /db_xref="CCDS:CCDS3127.1"
                     /db_xref="GeneID:26577"
                     /db_xref="HGNC:HGNC:8739"
                     /db_xref="MIM:607064"
                     /translation="MRGANAWAPLCLLLAAATQLSRQQSPERPVFTCGGILTGESGFI
                     GSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNGHANGQR
                     IGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGDQYCGGLLDR
                     PSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNG
                     GEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYIFRPKKLPTTT
                     EQPVTTTFPVTTGLKPTVALCQQKCRRTGTLEGNYCSSDFVLAGTVITTITRDGSLHA
                     TVSIINIYKEGNLAIQQAGKNMSARLTVVCKQCPLLRRGLNYIIMGQVGEDGRGKIMP
                     NSFIMMFKTKNQKLLDALKNKQC"
     exon            271..379
                     /gene="PCOLCE2"
                     /gene_synonym="PCPE2"
                     /inference="alignment:Splign:2.1.0"
     exon            380..635
                     /gene="PCOLCE2"
                     /gene_synonym="PCPE2"
                     /inference="alignment:Splign:2.1.0"
     exon            636..760
                     /gene="PCOLCE2"
                     /gene_synonym="PCPE2"
                     /inference="alignment:Splign:2.1.0"
     exon            761..897
                     /gene="PCOLCE2"
                     /gene_synonym="PCPE2"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1052
                     /gene="PCOLCE2"
                     /gene_synonym="PCPE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1136
                     /gene="PCOLCE2"
                     /gene_synonym="PCPE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1304
                     /gene="PCOLCE2"
                     /gene_synonym="PCPE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1896
                     /gene="PCOLCE2"
                     /gene_synonym="PCPE2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1877..1882
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCOLCE2"
                     /gene_synonym="PCPE2"
                     /note="hexamer: AATAAA"
     polyA_site      1896
                     /gene="PCOLCE2"
                     /gene_synonym="PCPE2"
                     /note="major polyA site"
ORIGIN      
        1 gtatcccccg gctacctggg ccgccccgcg gcggtgcgcg cgtgagaggg agcgcgcggg
       61 cagccgagcg ccggtgtgag ccagcgctgc tgccagtgtg agcggcggtg tgagcgcggt
      121 gggtgcggag gggcgtgtgt gccggcgcgc gcgccgtggg gtgcaaaccc cgagcgtcta
      181 cgctgccatg aggggcgcga acgcctgggc gccactctgc ctgctgctgg ctgccgccac
      241 ccagctctcg cggcagcagt ccccagagag acctgttttc acatgtggtg gcattcttac
      301 tggagagtct ggatttattg gcagtgaagg ttttcctgga gtgtaccctc caaatagcaa
      361 atgtacttgg aaaatcacag ttcccgaagg aaaagtagtc gttctcaatt tccgattcat
      421 agacctcgag agtgacaacc tgtgccgcta tgactttgtg gatgtgtaca atggccatgc
      481 caatggccag cgcattggcc gcttctgtgg cactttccgg cctggagccc ttgtgtccag
      541 tggcaacaag atgatggtgc agatgatttc tgatgccaac acagctggca atggcttcat
      601 ggccatgttc tccgctgctg aaccaaacga aagaggggat cagtattgtg gaggactcct
      661 tgacagacct tccggctctt ttaaaacccc caactggcca gaccgggatt accctgcagg
      721 agtcacttgt gtgtggcaca ttgtagcccc aaagaatcag cttatagaat taaagtttga
      781 gaagtttgat gtggagcgag ataactactg ccgatatgat tatgtggctg tgtttaatgg
      841 cggggaagtc aacgatgcta gaagaattgg aaagtattgt ggtgatagtc cacctgcgcc
      901 aattgtgtct gagagaaatg aacttcttat tcagttttta tcagacttaa gtttaactgc
      961 agatgggttt attggtcact acatattcag gccaaaaaaa ctgcctacaa ctacagaaca
     1021 gcctgtcacc accacattcc ctgtaaccac gggtttaaaa cccaccgtgg ccttgtgtca
     1081 acaaaagtgt agacggacgg ggactctgga gggcaattat tgttcaagtg actttgtatt
     1141 agccggcact gttatcacaa ccatcactcg cgatgggagt ttgcacgcca cagtctcgat
     1201 catcaacatc tacaaagagg gaaatttggc gattcagcag gcgggcaaga acatgagtgc
     1261 caggctgact gtcgtctgca agcagtgccc tctcctcaga agaggtctaa attacattat
     1321 tatgggccaa gtaggtgaag atgggcgagg caaaatcatg ccaaacagct ttatcatgat
     1381 gttcaagacc aagaatcaga agctcctgga tgccttaaaa aataagcaat gttaacagtg
     1441 aactgtgtcc atttaagctg tattctgcca ttgcctttga aagatctatg ttctctcagt
     1501 agaaaaaaaa atacttataa aattacatat tctgaaagag gattccgaaa gatgggactg
     1561 gttgactctt cacatgatgg aggtatgagg cctccgagat agctgaggga agttctttgc
     1621 ctgctgtcag aggagcagct atctgattgg aaacctgccg acttagtgcg gtgataggaa
     1681 gctaaaagtg tcaagcgttg acagcttgga agcgtttatt tatacatctc tgtaaaagga
     1741 tattttagaa ttgagttgtg tgaagatgtc aaaaaaagat tttagaagtg caatatttat
     1801 agtgttattt gtttcacctt caagcctttg ccctgaggtg ttacaatctt gtcttgcgtt
     1861 ttctaaatca atgcttaata aaatattttt aaagga
//
