LOCUS       NM_032223               7102 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens pecanex 3 (PCNX3), mRNA.
ACCESSION   NM_032223 XM_374898 XM_934366 XM_941490 XM_945226
VERSION     NM_032223.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7102)
  AUTHORS   Tsunoda,T., Riku,M., Yamada,N., Tsuchiya,H., Tomita,T., Suzuki,M.,
            Kizuki,M., Inoko,A., Ito,H., Murotani,K., Murakami,H., Saeki,Y. and
            Kasai,K.
  TITLE     ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that
            is downregulated in breast cancer
  JOURNAL   EMBO Rep 23 (2), e51182 (2022)
   PUBMED   34927784
REFERENCE   2  (bases 1 to 7102)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 7102)
  AUTHORS   Willer,C.J., Schmidt,E.M., Sengupta,S., Peloso,G.M., Gustafsson,S.,
            Kanoni,S., Ganna,A., Chen,J., Buchkovich,M.L., Mora,S.,
            Beckmann,J.S., Bragg-Gresham,J.L., Chang,H.Y., Demirkan,A., Den
            Hertog,H.M., Do,R., Donnelly,L.A., Ehret,G.B., Esko,T.,
            Feitosa,M.F., Ferreira,T., Fischer,K., Fontanillas,P., Fraser,R.M.,
            Freitag,D.F., Gurdasani,D., Heikkila,K., Hypponen,E., Isaacs,A.,
            Jackson,A.U., Johansson,A., Johnson,T., Kaakinen,M., Kettunen,J.,
            Kleber,M.E., Li,X., Luan,J., Lyytikainen,L.P., Magnusson,P.K.E.,
            Mangino,M., Mihailov,E., Montasser,M.E., Muller-Nurasyid,M.,
            Nolte,I.M., O'Connell,J.R., Palmer,C.D., Perola,M., Petersen,A.K.,
            Sanna,S., Saxena,R., Service,S.K., Shah,S., Shungin,D., Sidore,C.,
            Song,C., Strawbridge,R.J., Surakka,I., Tanaka,T., Teslovich,T.M.,
            Thorleifsson,G., Van den Herik,E.G., Voight,B.F., Volcik,K.A.,
            Waite,L.L., Wong,A., Wu,Y., Zhang,W., Absher,D., Asiki,G.,
            Barroso,I., Been,L.F., Bolton,J.L., Bonnycastle,L.L., Brambilla,P.,
            Burnett,M.S., Cesana,G., Dimitriou,M., Doney,A.S.F., Doring,A.,
            Elliott,P., Epstein,S.E., Ingi Eyjolfsson,G., Gigante,B.,
            Goodarzi,M.O., Grallert,H., Gravito,M.L., Groves,C.J., Hallmans,G.,
            Hartikainen,A.L., Hayward,C., Hernandez,D., Hicks,A.A., Holm,H.,
            Hung,Y.J., Illig,T., Jones,M.R., Kaleebu,P., Kastelein,J.J.P.,
            Khaw,K.T., Kim,E., Klopp,N., Komulainen,P., Kumari,M.,
            Langenberg,C., Lehtimaki,T., Lin,S.Y., Lindstrom,J., Loos,R.J.F.,
            Mach,F., McArdle,W.L., Meisinger,C., Mitchell,B.D., Muller,G.,
            Nagaraja,R., Narisu,N., Nieminen,T.V.M., Nsubuga,R.N., Olafsson,I.,
            Ong,K.K., Palotie,A., Papamarkou,T., Pomilla,C., Pouta,A.,
            Rader,D.J., Reilly,M.P., Ridker,P.M., Rivadeneira,F., Rudan,I.,
            Ruokonen,A., Samani,N., Scharnagl,H., Seeley,J., Silander,K.,
            Stancakova,A., Stirrups,K., Swift,A.J., Tiret,L.,
            Uitterlinden,A.G., van Pelt,L.J., Vedantam,S., Wainwright,N.,
            Wijmenga,C., Wild,S.H., Willemsen,G., Wilsgaard,T., Wilson,J.F.,
            Young,E.H., Zhao,J.H., Adair,L.S., Arveiler,D., Assimes,T.L.,
            Bandinelli,S., Bennett,F., Bochud,M., Boehm,B.O., Boomsma,D.I.,
            Borecki,I.B., Bornstein,S.R., Bovet,P., Burnier,M., Campbell,H.,
            Chakravarti,A., Chambers,J.C., Chen,Y.I., Collins,F.S.,
            Cooper,R.S., Danesh,J., Dedoussis,G., de Faire,U., Feranil,A.B.,
            Ferrieres,J., Ferrucci,L., Freimer,N.B., Gieger,C., Groop,L.C.,
            Gudnason,V., Gyllensten,U., Hamsten,A., Harris,T.B., Hingorani,A.,
            Hirschhorn,J.N., Hofman,A., Hovingh,G.K., Hsiung,C.A.,
            Humphries,S.E., Hunt,S.C., Hveem,K., Iribarren,C., Jarvelin,M.R.,
            Jula,A., Kahonen,M., Kaprio,J., Kesaniemi,A., Kivimaki,M.,
            Kooner,J.S., Koudstaal,P.J., Krauss,R.M., Kuh,D., Kuusisto,J.,
            Kyvik,K.O., Laakso,M., Lakka,T.A., Lind,L., Lindgren,C.M.,
            Martin,N.G., Marz,W., McCarthy,M.I., McKenzie,C.A., Meneton,P.,
            Metspalu,A., Moilanen,L., Morris,A.D., Munroe,P.B., Njolstad,I.,
            Pedersen,N.L., Power,C., Pramstaller,P.P., Price,J.F., Psaty,B.M.,
            Quertermous,T., Rauramaa,R., Saleheen,D., Salomaa,V.,
            Sanghera,D.K., Saramies,J., Schwarz,P.E.H., Sheu,W.H.,
            Shuldiner,A.R., Siegbahn,A., Spector,T.D., Stefansson,K.,
            Strachan,D.P., Tayo,B.O., Tremoli,E., Tuomilehto,J., Uusitupa,M.,
            van Duijn,C.M., Vollenweider,P., Wallentin,L., Wareham,N.J.,
            Whitfield,J.B., Wolffenbuttel,B.H.R., Ordovas,J.M., Boerwinkle,E.,
            Palmer,C.N.A., Thorsteinsdottir,U., Chasman,D.I., Rotter,J.I.,
            Franks,P.W., Ripatti,S., Cupples,L.A., Sandhu,M.S., Rich,S.S.,
            Boehnke,M., Deloukas,P., Kathiresan,S., Mohlke,K.L., Ingelsson,E.
            and Abecasis,G.R.
  CONSRTM   Global Lipids Genetics Consortium
  TITLE     Discovery and refinement of loci associated with lipid levels
  JOURNAL   Nat Genet 45 (11), 1274-1283 (2013)
   PUBMED   24097068
REFERENCE   4  (bases 1 to 7102)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   5  (bases 1 to 7102)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 7102)
  AUTHORS   Mavaddat,N., Dunning,A.M., Ponder,B.A., Easton,D.F. and
            Pharoah,P.D.
  TITLE     Common genetic variation in candidate genes and susceptibility to
            subtypes of breast cancer
  JOURNAL   Cancer Epidemiol Biomarkers Prev 18 (1), 255-259 (2009)
   PUBMED   19124506
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001362.5 and KF455405.1.
            
            On Oct 11, 2020 this sequence version replaced NM_032223.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.1650330.1,
                                           SRR14038193.2665893.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355703.4/ ENSP00000347931.3
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-485               AP001362.5         96387-96871
            486-689             KF455405.1         139-342             c
            690-877             AP001362.5         97435-97622
            878-977             AP001362.5         97861-97960
            978-1017            AP001362.5         98081-98120
            1018-1113           AP001362.5         98222-98317
            1114-2241           AP001362.5         98551-99678
            2242-2365           AP001362.5         100148-100271
            2366-2544           AP001362.5         100365-100543
            2545-2635           AP001362.5         100950-101040
            2636-2771           AP001362.5         101442-101577
            2772-2893           AP001362.5         102856-102977
            2894-3047           AP001362.5         104102-104255
            3048-3080           AP001362.5         104540-104572
            3081-3252           AP001362.5         104806-104977
            3253-3363           AP001362.5         105082-105192
            3364-3455           AP001362.5         105536-105627
            3456-3565           AP001362.5         105782-105891
            3566-3671           AP001362.5         106016-106121
            3672-3764           AP001362.5         106263-106355
            3765-3915           AP001362.5         106515-106665
            3916-4060           AP001362.5         107515-107659
            4061-4238           AP001362.5         108016-108193
            4239-4347           AP001362.5         109206-109314
            4348-4477           AP001362.5         109430-109559
            4478-4536           AP001362.5         109968-110026
            4537-4752           AP001362.5         110131-110346
            4753-5006           AP001362.5         110962-111215
            5007-5237           AP001362.5         114737-114967
            5238-5341           AP001362.5         115149-115252
            5342-5489           AP001362.5         115584-115731
            5490-5720           AP001362.5         115829-116059
            5721-5995           AP001362.5         116140-116414
            5996-6129           AP001362.5         116785-116918
            6130-6428           AP001362.5         117002-117300
            6429-7102           AP001362.5         117377-118050
FEATURES             Location/Qualifiers
     source          1..7102
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..7102
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /note="pecanex 3"
                     /db_xref="GeneID:399909"
                     /db_xref="HGNC:HGNC:18760"
                     /db_xref="MIM:617657"
     exon            1..689
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             537..6641
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /note="pecanex-like 3; pecanex homolog protein 3; pecanex
                     homolog 3"
                     /codon_start=1
                     /product="pecanex-like protein 3"
                     /protein_id="NP_115599.2"
                     /db_xref="CCDS:CCDS44650.1"
                     /db_xref="GeneID:399909"
                     /db_xref="HGNC:HGNC:18760"
                     /db_xref="MIM:617657"
                     /translation="MGSQVLQILRQGVWASLTGGWFFDPHQSTFSNCFHLYVWIFLLI
                     FPFLLYMVLPPSLMVAGVYCLVVAVIFATIKTVNYRLHAMFDQGEIVEKRSSTMGELE
                     EEPAQGDSNPPRDPGVEMTVFRKVSSTPPVRCSSQHSVFGFNQVSELLPRMEDSGPLR
                     DIKELVREQGSNNVIVTSADREMLKLSSQEKLIGDLPQTPPGAVPDPSLASTDSSEPS
                     PLAGDGAPWSGSSMADTPMSPLLKGSLSQELSKSFLTLTQPDRALVRTSSRREQRRGA
                     GGYQPLDRRGSGEPTPQKAGSSDSCFSGTDRETLSSFKSEKTNSTHLDSPPGGPAPEG
                     SDTDPPSEAELPASPDAGVPSDDTLRSFDTVIGAGTPPGLAEPLLVVRPKDLALLRPS
                     KRQPPLRRHSPPGRAPRRPLLEGGGFFEDEDTSEGSELSPASSLRSQRRYSTDSSSST
                     SCYSPESSRGAAGGPRKRRAPHGAEEGTAVPPKRPYGTQRTPSTASAKTHARVLSMDG
                     AGGDVLRPPLAGCKAELEAQVGVEQAASEPVVLPAEARRGPAANQPGWRGELQEEGAV
                     GGAAEETGRRDRSSSVRRTQAIRRRHNAGSNPTPPASVMGSPPSSLQEAQRGRAASHS
                     RALTLPSALHFASSLLLTRAGANVHEACTFDDTSEGAVHYFYDESGVRRSYTFGLAGG
                     GYENPVGQQGEQTANGAWDRHSHSSSFHSADVPEATGGLNLLQPRPVVLQGMQVRRVP
                     LEIPEEQTLMEEAPPRAQHSYKYWLLPGRWTSVRYERLALLALLDRTRGVLENIFGVG
                     LSSLVAFLGYLLLLKGFFTDIWVFQFCLVIASCQYSLLKSVQPDAASPMHGHNWVIAY
                     SRPVYFCICCLLIWLLDALGSAQPFPPVSLYGLTLFSASFFFCARDVATVFTLCFPFV
                     FLLGLLPQVNTCLMYLLEQIDMHGFGGTAATSPLTAVFSLSRSLLAAALLYGFCLGAI
                     KTPWPEQHVPVLFSVFCGLLVALSYHLSRQSSDPTVLWSLIRSKLFPELEERSLETAR
                     AEPPDPLPDKMRQSVREVLHSDLVMCVVIAVLTFAISASTVFIALKSVLGFVLYALAG
                     AVGFFTHYLLPQLRKQLPWFCLSQPVLKPLEYSQYEVRGAAQVMWFEKLYAGLQCVEK
                     YLIYPAVVLNALTVDAHTVVSHPDKYCFYCRALLMTVAGLKLLRSAFCCPPQQYLTLA
                     FTVLLFHFDYPRLSQGFLLDYFLMSLLCSKLWDLLYKLRFVLTYIAPWQITWGSAFHA
                     FAQPFAVPHSAMLFVQALLSGLFSTPLNPLLGSAVFIMSYARPLKFWERDYNTKRVDH
                     SNTRLVTQLDRNPGADDNNLNSIFYEHLTRSLQHTLCGDLVLGRWGNYGPGDCFVLAS
                     DYLNALVHLIEVGNGLVTFQLRGLEFRGTYCQQREVEAITEGVEEDEGCCCCEPGHLP
                     RVLSFNAAFGQRWLAWEVTASKYVLEGYSISDNNAASMLQVFDLRKILITYYVKSIIY
                     YVSRSPKLEVWLSHEGITAALRPVRVPGYADSDPTFSLSVDEDYDLRLSGLSLPSFCA
                     VHLEWIQYCASRRSQPVDQDWNSPLVTLCFGLCVLGRRALGTASHSMSASLEPFLYGL
                     HALFKGDFRITSPRDEWVFADMDLLHRVVAPGVRMALKLHQDHFTSPDEYEEPAALYD
                     AIAANEERLVISHEGDPAWRSAILSNTPSLLALRHVLDDASDEYKIIMLNRRHLSFRV
                     IKVNRECVRGLWAGQQQELVFLRNRNPERGSIQNAKQALRNMINSSCDQPLGYPIYVS
                     PLTTSLAGSHPQLRALWGGPISLGAIAHWLLRTWERLHKGCGAGCNSGGNVDDSDCSG
                     GGGLTSLSNNPPVAHPTPENTAGNGDQPLPPGPGWGPRSSLSGSGDGRPPPLLQWPPP
                     RLPGPPPASPIPTEGPRTSRPPGPGLLSSEGPSGKWSLGGRKGLGGSDGEPASGSPKG
                     GTPKSQAPLDLSLSLSLSLSPDVSTEASPPRASQDIPCLDSSAPESGTPMGALGDWPA
                     PIEERESPAAQPLLEHQY"
     exon            690..877
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            878..977
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1017
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1113
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..2241
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2365
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2544
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..2635
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2771
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            2772..2893
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            2894..3047
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            3048..3080
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            3081..3252
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            3253..3363
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            3364..3455
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            3456..3565
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            3566..3671
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            3672..3764
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            3765..3915
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            3916..4060
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            4061..4238
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            4239..4347
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            4348..4477
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            4478..4536
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            4537..4752
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            4753..5006
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            5007..5237
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            5238..5341
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            5342..5489
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            5490..5720
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            5721..5995
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            5996..6129
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            6130..6428
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     exon            6429..7102
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      7102
                     /gene="PCNX3"
                     /gene_synonym="PCNXL3"
                     /note="major polyA site"
ORIGIN      
        1 gcatgcgcca ctgcaggctg gcggttcgcg gctccttctt ccggcctcct ccttaggccg
       61 gcaccagcag aagccgggcg agcgcggagc cccaagcaag tgacctgcga ccccgaaagt
      121 ggaccccaga tcctggggtt ctccctggtc cggagactag ggagctgtcg cctgcacccc
      181 gggagcaccc accccacgac cacctctgga tgccgccgac gggtacccgg cccgtgcccc
      241 gcgcctgcct gccggctcgg cccctcggag caattctggg ccaggagtgg ggacccggac
      301 cccgcccctg atgcagcccc acccccgcgt ccgggccttg caccactgac tgtcccggcc
      361 ggccccgccc cctgctcgca ccctcgcgcg gccgagcccc cctcccccgc tgggggaggc
      421 catggcgtga gcgtgaggcc gggccccggg gccctcaggc gccagacggg gcatgggccg
      481 ggggccgccc ccatgagggt cccgggaggg ggggcgcggg cagcagcggc ggggccatgg
      541 ggtcgcaggt gttgcagatc ctgcgccagg gggtgtgggc ctcgctcacc ggcggttggt
      601 tcttcgaccc gcaccagagc accttctcca actgcttcca cctctatgtc tggatcttcc
      661 tgctcatctt tcccttctta ctgtacatgg tcctgcctcc cagcttgatg gtggccggcg
      721 tgtactgcct cgtggtggct gtcatctttg ctactatcaa gactgtcaat tatcggcttc
      781 atgccatgtt tgaccagggc gagatcgtgg agaagcgcag ctctaccatg ggggagctgg
      841 aggaagagcc tgcccagggg gacagcaatc cacccaggga ccccggagtg gagatgacag
      901 tgttccggaa agtcagttcc acacccccgg tgcgctgcag ctcccagcac tctgtgtttg
      961 gcttcaacca ggtctcggag ctgctgcccc gaatggagga ctctgggccc cttagagaca
     1021 tcaaggagct ggtgcgggag cagggcagca acaatgtgat cgtgacttct gccgaccgag
     1081 agatgctgaa gctcagctcg caggagaaac tgattggaga ccttccccag acgcctccag
     1141 gggctgtccc agacccctct cttgccagta cagactcttc agagccttct cccctggctg
     1201 gagatggagc gccctggagt gggagcagca tggctgacac tcccatgagc cccctgctga
     1261 aggggagcct cagccaggag ctgagcaaga gcttcctgac cctgacccag cctgaccggg
     1321 ccctggtgag gaccagcagt cgacgggaac aacgcagggg ggcaggtggc tatcagcccc
     1381 ttgaccggcg gggctcaggg gagcccacgc cccagaaagc cggctcctca gactcctgct
     1441 tcagcggcac tgacagggag acattgagca gcttcaagag tgagaagacc aactccaccc
     1501 atctggacag ccccccaggg gggccagccc ctgagggcag cgacacagac ccaccctctg
     1561 aggctgagct gcctgcctca ccagacgccg gggtcccctc agatgacacg ctgcgttcct
     1621 ttgacacggt cattggagca gggacgccac cgggcctggc tgagccgctc ctggtcgtgc
     1681 ggcccaagga cttggccctg ctacggccta gcaaacggca gccacccctg cgaagacact
     1741 ctccacctgg ccgtgcccct cgacggcccc tgcttgaagg tgggggcttc tttgaggatg
     1801 aagacactag tgagggcagt gaactgagcc cggcctccag tctccgatcg cagcgccgct
     1861 acagtactga cagctcctct tctacttcct gctactcccc tgagagctcc cggggtgcag
     1921 cagggggacc ccggaagcgg agggcccccc atggggctga ggagggaact gctgtgcccc
     1981 ccaagcggcc atatgggacc cagcggacgc ctagtaccgc cagcgctaaa acacatgccc
     2041 gtgtgctgag catggatggg gctgggggtg atgttctgag gcccccactg gctggctgca
     2101 aggcagagct ggaggcccag gttggggtgg agcaggctgc tagtgagcct gttgtgctgc
     2161 ctgctgaggc gcgaagggga cccgctgcca accagcccgg ctggcggggg gagctgcagg
     2221 aggaaggtgc tgtgggggga gcggccgagg agactggcag gcgggaccgc tcaagcagtg
     2281 tgaggcggac ccaggccatt cggagacgcc acaatgcagg cagcaacccc acccctccag
     2341 cctctgtcat gggctcgccg cccagcagcc tgcaggaagc tcagcggggc cgggctgcct
     2401 cccactcccg ggcgctgacg ctgccctctg cgctgcattt cgcctcttca ctgttgctca
     2461 cccgggccgg tgccaatgtg catgaggcct gcacctttga tgacacttct gagggtgctg
     2521 tgcactattt ctacgatgag agcggtgtgc ggcgttccta cacctttggc ctggctggag
     2581 gcggctacga gaaccctgta gggcagcaag gggagcagac agctaatgga gcctgggacc
     2641 gacactcgca ttcctccagc ttccactcgg ctgatgtccc tgaggctaca ggcggcctga
     2701 acctgctgca gccgaggcct gtggttctgc agggcatgca ggtgcgccgg gtgcccctgg
     2761 agatcccgga ggagcagaca ctgatggaag aagcgccacc ccgggcccag catagttaca
     2821 agtactggct tctccctggc cgctggacct ctgtgcgcta tgagcggctt gccctgctgg
     2881 ctctgctgga ccggacgcgg ggagtgctgg agaacatctt cggcgtgggc ctgagcagcc
     2941 ttgtggcctt cctgggctac ctgctgctgc tcaagggctt cttcactgac atctgggtct
     3001 tccagttctg cctggtcatc gcctcctgcc agtactcctt gctgaagagc gtgcagcctg
     3061 atgcggcgtc ccccatgcac ggccacaact gggtgatcgc gtacagccgt cctgtctact
     3121 tctgcatctg ctgtctgctc atctggctgc tggacgccct gggctcagct cagcccttcc
     3181 cacctgtctc cctctacggc ctcacgctct tctctgcctc cttcttcttc tgtgcccgag
     3241 acgtggccac tgtgttcacc ctgtgcttcc ccttcgtctt cctcctgggc ctcctgcccc
     3301 aggtcaacac ctgcctcatg tacctgctgg agcaaataga tatgcacggc ttcgggggca
     3361 cagctgccac cagcccgctc acggcagtct tcagcctctc ccgcagcctg ctggctgctg
     3421 ccctgctcta cggtttctgc cttggggcca tcaagactcc gtggccagag cagcacgtcc
     3481 ctgtcctctt ctcagtcttc tgtggcctcc tggtggcact gtcctaccac ctgagccggc
     3541 agagcagcga ccccaccgtg ctctggtctc tgatccggag caagctgttc cctgagctgg
     3601 aggagcgcag cttggagaca gcccgggccg agcccccgga ccccttgccg gacaagatgc
     3661 gccagtcggt gcgtgaggtc ttgcactccg acctggtgat gtgtgtggtg atcgccgtgc
     3721 tcaccttcgc catcagcgcc agcaccgtct ttattgccct gaagtcggtg ctgggtttcg
     3781 tgttgtacgc actggctggg gccgtgggct tcttcacaca ttacctgctg ccacaactcc
     3841 gcaaacagct gccctggttc tgcctgtcac agcccgtgct gaagccgctg gagtacagcc
     3901 agtatgaagt gcgcggtgcc gcccaggtga tgtggtttga gaagctgtat gctggcctgc
     3961 agtgcgtaga gaagtacctc atctaccccg ccgtggtgct caacgccctc acggtggacg
     4021 cccacacagt cgtcagccac ccggacaagt actgcttcta ctgccgggcg ctgctgatga
     4081 ccgtggctgg gctgaagctg ctgcgctcag ccttctgctg ccccccacag cagtacctga
     4141 cgttggcctt caccgtcctg ctcttccact ttgactaccc gcgcctctcc cagggctttc
     4201 tgcttgacta cttcctcatg tccctgcttt gcagcaagct gtgggacttg ctgtacaagc
     4261 tgcgtttcgt gctgacctac atcgcgccct ggcagatcac ctggggctcg gctttccacg
     4321 cttttgccca gccgtttgcc gtgccacact cggccatgct gttcgtccag gccctgctct
     4381 cggggctctt ctccacgcct ctcaacccac tgctaggcag tgccgtcttc atcatgtcct
     4441 acgctcggcc cctcaagttc tgggagcgcg actacaacac taaacgtgtg gatcattcca
     4501 acacccgcct ggtcacacag ctggacagga accctggcgc tgatgacaac aacctcaact
     4561 ccatcttcta tgagcacttg acacgttcgc tgcagcacac actgtgtggg gacctggtgc
     4621 tgggccgctg gggcaactat ggccctggtg actgcttcgt cctggcctct gactacctca
     4681 acgccctggt gcacctcatc gaggttggca atggcctcgt caccttccag ctgcgtggcc
     4741 ttgagttccg gggcacttac tgccagcagc gcgaggtgga ggctatcacc gagggtgtgg
     4801 aggaggacga gggctgttgc tgctgtgaac ctggccacct gccacgggtc ctgtccttca
     4861 atgctgcctt tgggcagcgc tggctggctt gggaggtaac agccagcaag tacgtgctgg
     4921 agggctatag cattagtgac aataatgctg cctccatgct gcaggttttc gacctccgca
     4981 agatcctcat cacctactat gtcaagagca tcatctacta cgtgagccgc tcaccaaagc
     5041 tggaggtgtg gctcagccat gagggcatca cggcagccct gaggcctgtg cgggtgcccg
     5101 gctatgccga ctcggatccc accttctcgc tgagtgtgga tgaggactat gacctccgcc
     5161 tgtctggcct ctcgctgccc tccttttgtg ctgtgcacct cgagtggatc cagtactgcg
     5221 cctcccggcg cagccagccc gtggaccagg attggaactc cccgctggtc acgctgtgtt
     5281 ttggcctgtg tgtgctgggc cgccgggccc tggggacagc ctctcacagc atgtctgcaa
     5341 gcctggagcc cttcctctac ggcctgcacg ccctgttcaa gggggatttt cgcatcacct
     5401 ccccacgtga cgagtgggtc tttgccgaca tggacctgct tcaccgcgtt gtggcgcctg
     5461 gggttcgcat ggccctcaag cttcaccagg accacttcac gtccccagat gaatatgagg
     5521 agccagcagc cctatacgat gccattgcgg ccaacgagga gcggctggtc atctcacatg
     5581 agggtgaccc agcatggcgc agcgccatcc tcagcaacac gccctccctg ctggcgctgc
     5641 gccatgtcct ggatgatgcc tccgacgagt acaagatcat catgctcaac cggcgccacc
     5701 tcagcttccg agtcatcaag gtgaaccggg agtgcgtgcg cggcctgtgg gccgggcagc
     5761 agcaggagct ggtgttcctg cgcaaccgca accccgagcg tggcagcatc cagaacgcca
     5821 agcaggcgct tcgcaacatg atcaactcct cctgtgacca gccgctgggc taccccatct
     5881 acgtgtcgcc tctcaccacc tcgctggctg gcagccaccc ccagctacgg gcactgtggg
     5941 gtggccccat cagcctgggt gccattgccc actggctcct gcgcacctgg gagaggcttc
     6001 acaagggctg tggcgccggc tgcaatagtg gcgggaacgt ggatgattca gactgtagtg
     6061 ggggcggtgg cctgacctcc ctcagcaata acccccccgt ggcacacccc acacctgaga
     6121 acacggcagg caatggtgac caacccctcc caccaggccc tggctggggg ccgcggtcct
     6181 ccctgagtgg ctctggtgat gggcggcccc cacctctgct gcagtggcct ccccctcggc
     6241 tccctggacc accccctgca tcgcctatcc ccacagaggg tccccggacc tcacggcccc
     6301 ctggcccggg tctcctcagt tctgagggcc ccagtggaaa gtggagcctg gggggccgga
     6361 aggggctggg aggatctgac ggggagccag cctcagggag ccccaaagga ggtaccccca
     6421 aatctcaggc gcctctagac ctcagcctca gcctcagcct cagcctcagc cccgatgtca
     6481 gcactgaggc ctcacccccc agagcttccc aggacattcc ttgcttggac agcagtgccc
     6541 ctgagagtgg cacacctatg ggtgccctgg gcgactggcc tgcccctatt gaggagcgtg
     6601 agagcccggc agcccagccc ctgctggaac accagtactg agctacctgg cgcccactgg
     6661 accacctcct aggattcagt aacggacctg ctctgctgcc tctctgctgg accacagaac
     6721 tgagtggctt tggcctacat gtctgaaccc tgacctttgg ctgccttggc cagagtacca
     6781 aaactgagtg acccagacct ctgaccttga cccctgatct ctctcatccc cagtccaggg
     6841 cctgggctcc ccagatggag gcagtcagcc tcccagccag gccctaagag ccaaaccatg
     6901 ggctggtccc acttggagcc tgtggccagg accacctcag cccctgggcc tgcactgcct
     6961 gcaggtgtgg cccccttggc ctggacctgg ggcctgaatt gtgggaaggg tggtttcttt
     7021 ctttcctttt ttttcttttc tttttttttt ttttttttgt gcttcggaga catcagaatt
     7081 aataacacta tttttgattt tg
//
