LOCUS       NM_014801               7530 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens pecanex 2 (PCNX2), transcript variant 1, mRNA.
ACCESSION   NM_014801
VERSION     NM_014801.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7530)
  AUTHORS   Hao,R., Han,P., Zhang,L., Bi,Y., Yan,J., Li,H., Bai,Y., Xu,C.,
            Li,B. and Li,H.
  TITLE     Genetic polymorphisms in the PCNXL2 gene are risk factors for
            thyroid cancer in the Chinese population
  JOURNAL   Future Oncol 17 (34), 4677-4686 (2021)
   PUBMED   34747634
  REMARK    GeneRIF: Genetic polymorphisms in the PCNXL2 gene are risk factors
            for thyroid cancer in the Chinese population.
REFERENCE   2  (bases 1 to 7530)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 7530)
  AUTHORS   Naveed,M., Imran,K., Mushtaq,A., Mumtaz,A.S., Janjua,H.A. and
            Khalid,N.
  TITLE     In silico functional and tumor suppressor role of hypothetical
            protein PCNXL2 with regulation of the Notch signaling pathway
  JOURNAL   RSC Adv 8 (38), 21414-21430 (2018)
   PUBMED   35539910
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7530)
  AUTHORS   Kim,N.G., Rhee,H., Li,L.S., Kim,H., Lee,J.S., Kim,J.H., Kim,N.K.
            and Kim,H.
  TITLE     Identification of MARCKS, FLJ11383 and TAF1B as putative novel
            target genes in colorectal carcinomas with microsatellite
            instability
  JOURNAL   Oncogene 21 (33), 5081-5087 (2002)
   PUBMED   12140758
  REMARK    GeneRIF: Identification of MARCKS, FLJ11383 and TAF1B as putative
            novel target genes in colorectal carcinomas with microsatellite
            instability.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL133380.5, CT004972.1,
            DR731333.1, AL139342.7, AK074078.1, AK021445.1, AK097229.1,
            AK055374.1 and AL122003.17.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014801.3.
            
            Summary: This gene contains coding mononucleotide repeats that are
            associated with tumors of high mcrosatellite instability (MSI-H).
            Defects in this gene are involved in the tumorigenesis of MSI-H
            colorectal carcinomas. [provided by RefSeq, Jun 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This sequence is assembled by in silico methods with
            additional support of similarity to mouse proteins contained in
            NM_175561.3.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000258229.14/ ENSP00000258229.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AL133380.5         8700-8711           c
            13-536              CT004972.1         1-524
            537-596             DR731333.1         184-243
            597-597             AL139342.7         142850-142850       c
            598-1067            DR731333.1         245-714
            1068-1486           AK074078.1         307-725
            1487-1487           AL139342.7         138505-138505       c
            1488-2222           AK074078.1         727-1461
            2223-2223           AL139342.7         132530-132530       c
            2224-2605           AK074078.1         1463-1844
            2606-3110           AK021445.1         570-1074
            3111-3311           AK074078.1         2204-2404
            3312-4297           AK097229.1         129-1114
            4298-6829           AK055374.1         452-2983
            6830-7530           AL122003.17        120277-120977       c
FEATURES             Location/Qualifiers
     source          1..7530
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.2"
     gene            1..7530
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /note="pecanex 2"
                     /db_xref="GeneID:80003"
                     /db_xref="HGNC:HGNC:8736"
                     /db_xref="MIM:617656"
     exon            1..400
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..6661
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pecanex-like protein 2; pecanex homolog 2"
                     /codon_start=1
                     /product="pecanex-like protein 2 isoform 1"
                     /protein_id="NP_055616.3"
                     /db_xref="CCDS:CCDS44335.1"
                     /db_xref="GeneID:80003"
                     /db_xref="HGNC:HGNC:8736"
                     /db_xref="MIM:617656"
                     /translation="MVSQVLQLLRQGVWAALTGGWYHDPEQSKFTNSCHLYLWLFLLL
                     LPLALHLAFPPNAIIVFFYCSAVTIFFTIIKLVSYRLHLMFDKGEVIQQKPSRKEEKP
                     NKDKEAKGEHITNHRNPSNNRQIHNGKKEEASRNLSTPPLRCSSRGQSITSHHSSGPL
                     ELSAQETVEDLKGVILLEDHPIAPVSSTSPGIKVESLPASQAHMLETTTKSVIPVKPV
                     ATETLINGKGKERGGKGQPPLRHRSEGGLVDKGPLKKLPHLSLSQYDLLETDVSFQPW
                     GSENSVLIPEPVSCPRGSIRERVQSKSPQDSLSSSCPQCDTIVAKPVEEPADTSCQVD
                     TSCQGDLPLHQEVDSSDSEVAVTLIDTSQPGDPLSLHEPIKIVITMSSTPNSMTDLES
                     SLHLRVVGTEKTSVKSDAEPTNPGAAGSPNAEQISIPVITLDLPEGGGGGVPCPEGNG
                     SERTPERLKTRVSTNQCSGYGSGEGGNAIKDHSSSSREPWESVSRLTPDTGSESKVGK
                     EGQTNLDPSSCKSSHEKRHARVLSVDSGTDVFLSKSSAEIVNDTEKTMPTSKSDLEAK
                     EGQMPNESNFLEFVSLLESINTSKMTASSQLNGSAEQNEESGLLRDNCSQEKKEEILE
                     NEKPSGHSSKQGKPDLQSQDHTSTGPACTQPAKTTAFFQGNRQRQIIYRVTSQQDSSV
                     LQVISGPETSVQEEISVDAMHVFIDEHGEIRSCYLKSGNQKEGPLQPLPSNNDCLSQA
                     REMQVSSSSTTTSESQDPSSGDPAVSALQQQLLLMVARRTQSETPRHVSQDLEASSCS
                     STQGKFNREQFYKFIIFPGKWIKVWYDRLTLLALLDRTEDIKENVLAILLIVLVSLLG
                     FLTLSQGFCKDMWVLLFCLVMASCQYSLLKSVQPDPASPIHGHNQIITYSRPIYFCVL
                     CGLILLLDTGAKARHPPSYVVYGLKLFSPVFLQSARDYLIVFLYCFPAISLLGLFPQI
                     NTFCTYLLEQIDMLFFGGSAVSGITSAVYSVARSVLAAALLHAVCFSAVKEPWSMQHI
                     PALFSAFCGLLVALSYHLSRQSSDPSVLMSFIQCRLFPKFLHQNLAESAADPLPKKMK
                     DSVTDVLKWDLIVCAVVAVLSFAVSASTVFLSLRPFLSIVLFALAGAVGFVTHYVLPQ
                     LRKHHPWMWISHPILKNKEYHQREVRDVAHLMWFERLYVWLQCFEKYILYPALILNAL
                     TIDAFLISNHRRLGTHWDIFLMIIAGMKLLRTSFCNPVYQFINLSFTVIFFHFDYKDI
                     SESFLLDFFMVSILFSKLGDLLHKLQFVLTYVAPWQMAWGSSFHVFAQLFAIPHSAML
                     FFQTIATSIFSTPLSPFLGSVIFITSYVRPVKFWEKNYNTRRVDNSNTRLAVQIERDP
                     GNDDNNLNSIFYEHLTRTLQESLCGDLVLGRWGNYSSGDCFILASDDLNAFVHLIEIG
                     NGLVTFQLRGLEFRGTYCQQREVEAIMEGDEEDRGCCCCKPGHLPHLLSCNAAFHLRW
                     LTWEITQTQYILEGYSILDNNAATMLQVFDLRRILIRYYIKSIIYYMVTSPKLLSWIK
                     NESLLKSLQPFAKWHYIERDLAMFNINIDDDYVPCLQGITRASFCNVYLEWIQHCARK
                     RQEPSTTLDSDEDSPLVTLSFALCTLGRRALGTAAHNMAISLDSFLYGLHVLFKGDFR
                     ITARDEWVFADMDLLHKVVAPAIRMSLKLHQDQFTCPDEYEDPAVLYEAIQSFEKKVV
                     ICHEGDPAWRGAVLSNKEELLTLRHVVDEGADEYKVIMLHRSFLSFKVIKVNKECVRG
                     LWAGQQQELIFLRNRNPERGSIQNNKQVLRNLINSSCDQPLGYPMYVSPLTTSYLGTH
                     RQLKNIWGGPITLDRIRTWFWTKWVRMRKDCNARQHSGGNIEDVDGGGAPTTGGNNAP
                     SGGSQESSAEQPRKGGAQHGVSSCEGTQRTGRRKGRSQSVQAHSALSQRPPMLSSSGP
                     ILESRQTFLQTSTSVHELAQRLSGSRLSLHASATSLHSQPPPVTTTGHLSVRERAEAL
                     IRSSLGSSTSSTLSFLFGKRSFSSALVISGLSAAEGGNTSDTQSSSSVNIVMGPSARA
                     ASQATRHLSEPCEPPDATEQGQLHDRCLAEAVADTLGVVCRRASQEDMGLDDTASQQS
                     VSDEQ"
     exon            401..606
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     exon            607..727
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     exon            728..764
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     exon            765..2081
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2229
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2375
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2469
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2605
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2606..2751
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2752..2905
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2906..2938
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2939..3110
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3111..3221
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3222..3313
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3314..3423
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3424..3520
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3521..3613
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3614..3764
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3765..3906
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3907..4084
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     exon            4085..4193
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     exon            4194..4323
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     exon            4324..4382
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     exon            4383..4598
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     exon            4599..4852
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     exon            4853..5086
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     exon            5087..5199
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     exon            5200..5344
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     exon            5345..5575
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     exon            5576..5850
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     exon            5851..6038
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     exon            6039..6487
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     exon            6488..7530
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7512..7517
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /note="hexamer: ATTAAA"
     polyA_site      7530
                     /gene="PCNX2"
                     /gene_synonym="PCNXL2"
                     /note="major polyA site"
ORIGIN      
        1 ctccctcgga catggcgctc acctgcccgg ccgcagcagc cggctccggc gccgcggttc
       61 gcgggtccgg gcggaagagc agctccagct tcaaacgtgg ggtggaagga ggcggcgggg
      121 gcgacggcgg cggcgacggc gggggcgcgg cccgcgggcc cgggtgttag acctgaggga
      181 gcctggagat ccggccgggg cgcgcagggt gcagcggggc gctcaccagc cccggggcgc
      241 agccggcatg gtgtcccagg tgctgcagct gctccggcag ggcgtgtggg ccgcgctcac
      301 cgggggctgg taccacgacc cggagcagag caagttcacc aacagctgcc acctctacct
      361 gtggctgttc ctcctgctgc tgcccctggc cctgcacctg gcttttcctc caaatgcgat
      421 cattgtattt ttctactgca gtgcagtgac tatattcttc acaataatca aactggtcag
      481 ttatcgccta cacctcatgt ttgacaaagg agaagtaatt cagcaaaagc cctccagaaa
      541 ggaagaaaag ccaaataaag acaaggaggc caaaggtgaa cacataacta atcacagaaa
      601 tccaagcaat aataggcaga ttcacaatgg caaaaaggaa gaggccagtc gaaacctctc
      661 cacgcctccc ctccgctgca gctccagagg gcaaagcata acctctcatc actcttctgg
      721 gccattggag ttgtcagcac aggaaactgt agaagatctc aaaggtgtca ttctattaga
      781 agaccatccc atagcaccag tgtcatctac ctcacctggt atcaaagtgg aaagcttacc
      841 tgcgtctcaa gcacacatgc tggaaaccac gaccaagtca gtaatacctg taaaaccagt
      901 tgccacagaa actctcatca atggtaaagg aaaggaaaga ggaggcaagg ggcagcctcc
      961 tttgcgccac agatccgagg gtggcttagt ggataaggga cccttgaaga agttgcccca
     1021 cctgtctttg tctcagtatg acttactaga aacagacgtt tctttccagc cgtgggggag
     1081 tgagaattca gtcctgattc cagaacctgt cagttgtccc cggggctcca taagggaacg
     1141 ggtacaaagc aagtcacctc aggacagcct gagcagcagc tgccctcaat gtgacaccat
     1201 cgtggccaag cctgtggagg agccagcaga cacatcctgt caggtagata cctcctgcca
     1261 gggggacctg cccttgcacc aggaagtgga ctcctcagat agtgaggtag ctgttactct
     1321 catcgatact tctcaacccg gagacccact gagtctacat gagcccataa aaattgttat
     1381 cacgatgagc agtaccccaa actccatgac agatttggaa agctccctcc acctgagggt
     1441 ggttggcaca gagaagacca gtgtaaagtc tgacgctgag cccactaacc caggggcggc
     1501 cggttctcca aatgccgagc agatctcaat tcctgtaatc accctggacc tgcctgaggg
     1561 tgggggagga ggtgttccct gtcccgaagg caatggaagt gaaaggactc cagagagact
     1621 gaagacgagg gtatccacca atcagtgttc tggctacgga tctggggagg ggggaaatgc
     1681 catcaaggat cacagttctt catcacggga accctgggaa tcggtgtccc ggcttacacc
     1741 tgatacaggc tccgagtcta aggtggggaa ggaaggccag actaaccttg acccatcgtc
     1801 ttgtaagtcc agccatgaaa agaggcatgc ccgggtgctc agtgtggaca gtgggacaga
     1861 tgtcttcttg agtaaaagtt ctgcagaaat tgttaacgat acagagaaaa caatgccaac
     1921 ttccaaatct gacctagagg ctaaggaagg acaaatgcca aatgagtcca acttcctgga
     1981 atttgtctcc ctgttagaat ccattaatac ttccaagatg acggcatcca gtcaactgaa
     2041 tggctcagct gagcagaatg aagaaagtgg gcttctccga gataactgtt cccaggaaaa
     2101 aaaggaggaa atcctggaaa atgaaaagcc cagtggacac agttctaagc aaggaaaacc
     2161 agatttgcaa agtcaagacc atactagcac cggccccgca tgcactcagc ctgccaagac
     2221 cacagccttt tttcagggca atagacaaag acagataatc tacagggtaa cttcccaaca
     2281 agatagttct gtcttgcaag tcatcagtgg gcctgaaaca tctgtacaag aagagatatc
     2341 tgtggatgct atgcatgtct tcattgatga acatggggaa attagatcct gttatttaaa
     2401 atctggaaat cagaaagaag gccctttaca gcctctacca tcaaataatg actgtctctc
     2461 tcaggctcga gagatgcagg tcagctcctc cagtaccaca acttctgaga gtcaagatcc
     2521 gtcttctggg gaccctgccg tcagtgccct tcagcaacag ctgttactga tggtggctcg
     2581 caggacccag tcggaaaccc cacggcatgt gagtcaggat ctggaagcct cgtcatgttc
     2641 ttcaacacaa ggaaaattta accgagagca gttttacaaa tttatcattt tccctggcaa
     2701 gtggattaaa gtctggtatg atcgactgac cttgctggca ttacttgatc gaactgaaga
     2761 catcaaggag aatgtactgg cgattttact cattgtcctg gtttccctcc ttggatttct
     2821 gaccttgagc caaggctttt gcaaagatat gtgggtgctc ctcttctgcc tcgtcatggc
     2881 cagctgccag tactccctgc taaagagtgt tcagcctgac cccgcctcac caatacacgg
     2941 acacaaccaa atcataacat atagcagacc aatctatttt tgtgtgctgt gtggccttat
     3001 tttgcttctt gatacagggg ccaaagccag gcaccctccc agttacgttg tgtatggcct
     3061 gaagctcttc tctccagtgt ttctacaatc agctagggac tacttaatag tatttttata
     3121 ttgcttccct gctatttccc tccttgggct cttcccgcaa atcaacactt tctgcactta
     3181 tcttttggag caaattgaca tgctgttttt tggtggttct gctgtgtctg ggataacctc
     3241 ggctgtttac agtgtggccc ggagcgtctt ggctgccgcc ctgctccacg cagtctgctt
     3301 cagtgcagtg aaggaaccgt ggagcatgca acacatcccg gcactgtttt cggccttctg
     3361 tggcctcttg gtcgcccttt cttaccatct gagccgtcag agcagtgacc catctgtact
     3421 catgtccttc atccaatgca ggctgtttcc taaattttta catcaaaatc tggcagagtc
     3481 agctgctgac cctctcccca agaagatgaa agattcagtg acggatgtct taaaatggga
     3541 tctcatcgtc tgcgcagtgg ttgctgtcct ctcatttgca gtcagcgcca gcactgtatt
     3601 cctgtcattg cgaccatttc tcagcatcgt gctgtttgcc ttggctggag ccgtggggtt
     3661 tgtaacacat tacgtgctcc ctcagctccg caagcatcat ccctggatgt ggatttcaca
     3721 ccccattctc aaaaacaaag agtatcatca acgggaagtg agagatgttg cccatttaat
     3781 gtggttcgaa agactctatg tttggcttca gtgttttgaa aaatacatct tgtacccagc
     3841 gctaattttg aatgccctca ctattgatgc atttttaata agcaatcacc ggagacttgg
     3901 tacccactgg gacatttttc tgatgatcat tgctggcatg aagctgttgc ggacatcatt
     3961 ctgcaacccg gtttaccagt ttattaactt gagcttcact gtcatctttt tccactttga
     4021 ctacaaagat atttcagaga gcttcttact ggatttcttc atggtgtcca ttttatttag
     4081 caagctcggg gacctgcttc acaagttaca gttcgtcctg acatatgtgg ctccttggca
     4141 gatggcttgg ggttcttcgt ttcacgtgtt tgctcagctc tttgccattc ctcattctgc
     4201 catgcttttc tttcagacga ttgccacatc aatcttttct accccattga gcccatttct
     4261 tgggagtgtc attttcatca catcatatgt caggccagtg aaattctggg agaaaaacta
     4321 caatacaagg cgagtggata attccaacac aagactggca gtccaaattg aaagagatcc
     4381 agggaatgat gacaacaatc tcaattccat tttttatgaa cacttgacaa ggaccctcca
     4441 ggagtccctc tgtggagact tagttcttgg acgttggggc aactacagct ctggcgattg
     4501 ctttattttg gcttcagatg acctcaatgc ctttgttcac ctgattgaaa ttggaaatgg
     4561 tcttgtcacc tttcaacttc gaggactgga attccgagga acctactgcc agcagaggga
     4621 ggtagaagcc atcatggagg gcgacgagga ggacagaggc tgctgctgct gcaaaccagg
     4681 ccacttgcct cacctgctgt cctgcaacgc tgcctttcac ctccgctggc tcacctggga
     4741 aatcacgcag acccagtaca tcctggaggg ctacagcatc ctggacaaca acgcggccac
     4801 catgctgcag gtgtttgacc tccgaaggat cctcatccgc tactacatca agagtataat
     4861 atactatatg gtaacgtctc ccaaactcct ctcctggatc aaaaatgaat cacttctgaa
     4921 gtccctgcag ccctttgcca agtggcatta cattgagcgt gaccttgcaa tgttcaacat
     4981 taacattgat gatgactacg tcccgtgtct ccaggggatc acacgagcta gcttctgcaa
     5041 tgtttatcta gaatggattc aacactgtgc acggaaaaga caagagcctt caacgaccct
     5101 ggacagtgac gaggactctc ccttggtgac tctgtccttc gccctgtgca ccctggggag
     5161 gagagctctg ggaacagccg ctcacaatat ggccatcagc ctggattctt tcctgtatgg
     5221 cctccatgtc ctcttcaaag gtgacttcag aataacagca cgtgacgagt gggtatttgc
     5281 tgacatggac ctactgcata aagttgtagc tccagctatc aggatgtccc tgaaacttca
     5341 ccaggaccag ttcacttgcc ctgacgagta tgaagaccca gcagtcctct acgaggccat
     5401 ccagtccttc gagaagaagg tggtcatctg ccacgagggc gacccggcct ggcggggcgc
     5461 agtgctgtcc aacaaggaag agctgctcac cctgcggcac gtggtggacg agggtgccga
     5521 cgagtacaag gtcatcatgc tccacagaag cttcctgagc ttcaaggtga tcaaggttaa
     5581 caaagaatgc gtccgaggac tttgggccgg gcagcagcag gagcttatat ttcttcgcaa
     5641 ccgcaatccg gagcgcggca gtatccagaa caataagcag gtcctgcgga acttgattaa
     5701 ctcctcctgc gatcagcccc tggggtaccc catgtatgtc tccccactaa ccacatccta
     5761 cctagggaca cacaggcagc tgaagaacat ctggggtgga cccatcactt tggacagaat
     5821 taggacctgg ttctggacca agtgggtaag gatgcggaag gattgcaatg cccgccagca
     5881 cagtggcggc aacattgaag acgtggacgg aggaggggcc ccgacgacag gtggcaacaa
     5941 tgccccgagt ggtggcagcc aggagagcag cgcagaacag cccagaaaag gcggtgctca
     6001 gcacggggtg tcatcctgtg aagggacaca gagaacaggc aggaggaaag gcaggagcca
     6061 gtccgtgcag gcacactcag cgctaagcca aaggccgccc atgctgagct catctggccc
     6121 catcttagag agccgccaaa cattcctcca gacgtccacc tcagtgcacg agctggccca
     6181 gaggctctcg ggcagccggc tctccttgca cgcctcggcc acgtccctgc actctcagcc
     6241 cccgcccgtc accaccaccg gccacctgag tgtccgtgag cgggccgagg cgctcatcag
     6301 gtccagcctg ggctcctcca ccagctccac cctgagcttc ctcttcggca agaggagctt
     6361 ttccagcgcg ctcgtcattt ccggactctc tgctgcggag gggggcaata ccagtgacac
     6421 ccagtcatcc agcagcgtca acatcgtgat gggcccctca gccagggctg ccagccaggc
     6481 cactcggcac ctctccgagc catgtgagcc ccctgatgcc accgagcagg ggcagcttca
     6541 tgaccgatgt ctggctgagg ctgtggcgga cactctcggg gttgtctgca ggagagcaag
     6601 ccaggaggac atgggcctgg acgacacggc ctcgcagcaa agtgtgtcag acgagcagtg
     6661 acgggcgtgc ggccgggcgg ggaggctggc tcccccacac ctcccacctg cattgctctc
     6721 cctcgtgctc cccaaatcac cacaaccaac caataccgcg atccatgagg gactcctcct
     6781 gtggaaaagg agagctgttc cagaacacag aactgatctc aggtttttga aaaaaaaaaa
     6841 aaaaaaaaaa aaaaaatcaa acaacaacaa caaaaaaacc tcacatgatg gggaaacaaa
     6901 aaaaagcaac aaagaagcca caccacacct ccctggccag gcacagcgct gcccagagcg
     6961 gcacaccgcg gacagcacca cacatgttcc agaatctgaa atctcaaaag ccattcacta
     7021 acttaaaaca actcaacaga gccatgaaac aaatgccctg atgaaaataa gacaactgca
     7081 tgttacatca tcggcacttt atacattact gttaccatga aaaagaaatg aacagcagca
     7141 cgtctgatac catcagctgg gcagatgcat taaggttaaa tctaagtgtc aagaaaaccc
     7201 tatttcttta taatatttat gcagctgtta agcgtaacat ggtggcagct tcacaacaag
     7261 aaccgtgatc atgcatgcag tcatgtctcc agtattctgt gaaaagccag gatacgttag
     7321 gatgtgagtt tagaaactga gtccattcgg tgcatggaaa tccaccgcgg agtcacacaa
     7381 tgctcctcac tgtagtccag gcgattggtg ggccgccagc accctgcggg cttcacaggg
     7441 acgcgtgctt gttctccaag ccccgcaacc cttactgtgc acacaacatc gcacacacct
     7501 ttgtttttga aattaaaatg tttatagtta
//
