LOCUS       NM_014982              12865 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens pecanex 1 (PCNX1), transcript variant 1, mRNA.
ACCESSION   NM_014982
VERSION     NM_014982.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12865)
  AUTHORS   Li,J., Tian,H., Pan,J., Jiang,N., Yang,J., Zhou,C., Xu,D., Meng,X.
            and Gong,Z.
  TITLE     Pecanex functions as a competitive endogenous RNA of S-phase kinase
            associated protein 2 in lung cancer
  JOURNAL   Cancer Lett 406, 36-46 (2017)
   PUBMED   28789966
  REMARK    GeneRIF: High PCNX expression is associated with lung cancer.
REFERENCE   2  (bases 1 to 12865)
  AUTHORS   Cai,D.C., Fonteijn,H., Guadalupe,T., Zwiers,M., Wittfeld,K.,
            Teumer,A., Hoogman,M., Arias-Vasquez,A., Yang,Y., Buitelaar,J.,
            Fernandez,G., Brunner,H.G., van Bokhoven,H., Franke,B.,
            Hegenscheid,K., Homuth,G., Fisher,S.E., Grabe,H.J., Francks,C. and
            Hagoort,P.
  TITLE     A genome-wide search for quantitative trait loci affecting the
            cortical surface area and thickness of Heschl's gyrus
  JOURNAL   Genes Brain Behav 13 (7), 675-685 (2014)
   PUBMED   25130324
REFERENCE   3  (bases 1 to 12865)
  AUTHORS   Cummings,A.C., Jiang,L., Velez Edwards,D.R., McCauley,J.L.,
            Laux,R., McFarland,L.L., Fuzzell,D., Knebusch,C., Caywood,L.,
            Reinhart-Mercer,L., Nations,L., Gilbert,J.R., Konidari,I.,
            Tramontana,M., Cuccaro,M.L., Scott,W.K., Pericak-Vance,M.A. and
            Haines,J.L.
  TITLE     Genome-wide association and linkage study in the Amish detects a
            novel candidate late-onset Alzheimer disease gene
  JOURNAL   Ann Hum Genet 76 (5), 342-351 (2012)
   PUBMED   22881374
REFERENCE   4  (bases 1 to 12865)
  AUTHORS   Frank,J., Cichon,S., Treutlein,J., Ridinger,M., Mattheisen,M.,
            Hoffmann,P., Herms,S., Wodarz,N., Soyka,M., Zill,P., Maier,W.,
            Mossner,R., Gaebel,W., Dahmen,N., Scherbaum,N., Schmal,C.,
            Steffens,M., Lucae,S., Ising,M., Muller-Myhsok,B., Nothen,M.M.,
            Mann,K., Kiefer,F. and Rietschel,M.
  TITLE     Genome-wide significant association between alcohol dependence and
            a variant in the ADH gene cluster
  JOURNAL   Addict Biol 17 (1), 171-180 (2012)
   PUBMED   22004471
REFERENCE   5  (bases 1 to 12865)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 12865)
  AUTHORS   Geisinger,A., Alsheimer,M., Baier,A., Benavente,R. and Wettstein,R.
  TITLE     The mammalian gene pecanex 1 is differentially expressed during
            spermatogenesis
  JOURNAL   Biochim Biophys Acta 1728 (1-2), 34-43 (2005)
   PUBMED   15777640
REFERENCE   7  (bases 1 to 12865)
  AUTHORS   Heilig,R., Eckenberg,R., Petit,J.L., Fonknechten,N., Da Silva,C.,
            Cattolico,L., Levy,M., Barbe,V., de Berardinis,V., Ureta-Vidal,A.,
            Pelletier,E., Vico,V., Anthouard,V., Rowen,L., Madan,A., Qin,S.,
            Sun,H., Du,H., Pepin,K., Artiguenave,F., Robert,C., Cruaud,C.,
            Bruls,T., Jaillon,O., Friedlander,L., Samson,G., Brottier,P.,
            Cure,S., Segurens,B., Aniere,F., Samain,S., Crespeau,H., Abbasi,N.,
            Aiach,N., Boscus,D., Dickhoff,R., Dors,M., Dubois,I., Friedman,C.,
            Gouyvenoux,M., James,R., Madan,A., Mairey-Estrada,B., Mangenot,S.,
            Martins,N., Menard,M., Oztas,S., Ratcliffe,A., Shaffer,T.,
            Trask,B., Vacherie,B., Bellemere,C., Belser,C., Besnard-Gonnet,M.,
            Bartol-Mavel,D., Boutard,M., Briez-Silla,S., Combette,S.,
            Dufosse-Laurent,V., Ferron,C., Lechaplais,C., Louesse,C.,
            Muselet,D., Magdelenat,G., Pateau,E., Petit,E.,
            Sirvain-Trukniewicz,P., Trybou,A., Vega-Czarny,N., Bataille,E.,
            Bluet,E., Bordelais,I., Dubois,M., Dumont,C., Guerin,T.,
            Haffray,S., Hammadi,R., Muanga,J., Pellouin,V., Robert,D.,
            Wunderle,E., Gauguet,G., Roy,A., Sainte-Marthe,L., Verdier,J.,
            Verdier-Discala,C., Hillier,L., Fulton,L., McPherson,J.,
            Matsuda,F., Wilson,R., Scarpelli,C., Gyapay,G., Wincker,P.,
            Saurin,W., Quetier,F., Waterston,R., Hood,L. and Weissenbach,J.
  TITLE     The DNA sequence and analysis of human chromosome 14
  JOURNAL   Nature 421 (6923), 601-607 (2003)
   PUBMED   12508121
  REMARK    Erratum:[Nature. 2023 Aug;620(7973):E17. doi:
            10.1038/s41586-023-06403-y.. PMID: 37491470]
REFERENCE   8  (bases 1 to 12865)
  AUTHORS   Roux,A.F., Rommens,J.M., Read,L., Duncan,A.M. and Cox,D.W.
  TITLE     Physical and transcription map in the region 14q24.3:
            identification of six novel transcripts
  JOURNAL   Genomics 43 (2), 130-140 (1997)
   PUBMED   9244429
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004825.2, AF233450.1,
            AK027062.1, AC005230.1, AC004817.2 and AW137672.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_014982.2.
            
            Summary: This gene encodes an evolutionarily conserved
            transmembrane protein similar to the pecanex protein in Drosophila.
            The fly protein is a component of the Notch signaling pathway,
            which functions in several developmental processes. [provided by
            RefSeq, Jul 2016].
            
            Transcript Variant: This transcript represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF233450.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304743.7/ ENSP00000304192.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-545               AC004825.2         64816-65360         c
            546-6693            AF233450.1         600-6747
            6694-7136           AK027062.1         1238-1680
            7137-7636           AF233450.1         7191-7690
            7637-7759           AC005230.1         1-123               c
            7760-12449          AC004817.2         123509-128198       c
            12450-12865         AW137672.1         18-433              c
FEATURES             Location/Qualifiers
     source          1..12865
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..12865
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /note="pecanex 1"
                     /db_xref="GeneID:22990"
                     /db_xref="HGNC:HGNC:19740"
                     /db_xref="MIM:617655"
     exon            1..545
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     CDS             393..7418
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pecanex-like protein 1; pecanex homolog 1"
                     /codon_start=1
                     /product="pecanex-like protein 1 isoform 1"
                     /protein_id="NP_055797.2"
                     /db_xref="CCDS:CCDS9806.1"
                     /db_xref="GeneID:22990"
                     /db_xref="HGNC:HGNC:19740"
                     /db_xref="MIM:617655"
                     /translation="MGSQTLQILRQGVWAALSGGWYYDPHQATFVNALHLYLWLFLLG
                     LPFTLYMALPSTMIIVAVYCPVIAAVFIVLKMVNYRLHRALDAGEVVDRTANEFTDQR
                     TKAEQGNCSTRRKDSNGPSDPGGGIEMSEFIREATPPVGCSSRNSYAGLDPSNQIGSG
                     SSRLGTAATIKGDTDTAKTSDDISLSLGQSSSLCKEGSEEQDLAADRKLFRLVSNDSF
                     ISIQPSLSSCGQDLPRDFSDKVNLPSHNHHHHVDQSLSSACDTEVASLVPLHSHSYRK
                     DHRPRGVPRTSSSAVAFPDTSLNDFPLYQQRRGLDPVSELESSKPLSGSKESLVENSG
                     LSGEFQLAGDLKINTSQPPTKSGKSKPLKAEKSMDSLRSLSTRSSGSTESYCSGTDRD
                     TNSTVSSYKSEQTSSTHIESILSEHEESPKAGTKSGRKKECCAGPEEKNSCASDKRTS
                     SEKIAMEASTNSGVHEAKDPTPSDEMHNQRGLSTSASEEANKNPHANEFTSQGDRPPG
                     NTAENKEEKSDKSAVSVDSKVRKDVGGKQKEGDVRPKSSSVIHRTASAHKSGRRRTGK
                     KRASSFDSSRHRDYVCFRGVSGTKPHSAIFCHDEDSSDQSDLSRASSVQSAHQFSSDS
                     SSSTTSHSCQSPEGRYSALKTKHTHKERGTDSEHTHKAHLVPEGTSKKRATRRTSSTN
                     SAKTRARVLSLDSGTVACLNDSNRLMAPESIKPLTTSKSDLEAKEGEVLDELSLLGRA
                     SQLETVTRSRNSLPNQVAFPEGEEQDAVSGAAQASEEAVSFRRERSTFRRQAVRRRHN
                     AGSNPTPPTLLIGSPLSLQDGQQGQQSTAQVKVQSRPPSQAAVLSASASLLVRNGSVH
                     LEASHDNASAVGGSSLHDELGKFSSTLYETGGCDMSLVNFEPAARRASNICDTDSHVS
                     SSTSVRFYPHDVLSLPQIRLNRLLTIDTDLLEQQDIDLSPDLAATYGPTEEAAQKVKH
                     YYRFWILPQLWIGINFDRLTLLALFDRNREILENVLAVILAILVAFLGSILLIQGFFR
                     DIWVFQFCLVIASCQYSLLKSVQPDSSSPRHGHNRIIAYSRPVYFCICCGLIWLLDYG
                     SRNLTATKFKLYGITFTNPLVFISARDLVIVFTLCFPIVFFIGLLPQVNTFVMYLCEQ
                     LDIHIFGGNATTSLLAALYSFICSIVAVALLYGLCYGALKDSWDGQHIPVLFSIFCGL
                     LVAVSYHLSRQSSDPSVLFSLVQSKIFPKTEEKNPEDPLSEVKDPLPEKLRNSVSERL
                     QSDLVVCIVIGVLYFAIHVSTVFTVLQPALKYVLYTLVGFVGFVTHYVLPQVRKQLPW
                     HCFSHPLLKTLEYNQYEVRNAATMMWFEKLHVWLLFVEKNIIYPLIVLNELSSSAETI
                     ASPKKLNTELGALMITVAGLKLLRSSFSSPTYQYVTVIFTVLFFKFDYEAFSETMLLD
                     LFFMSILFNKLWELLYKLQFVYTYIAPWQITWGSAFHAFAQPFAVPHSAMLFIQAAVS
                     AFFSTPLNPFLGSAIFITSYVRPVKFWERDYNTKRVDHSNTRLASQLDRNPGSDDNNL
                     NSIFYEHLTRSLQHSLCGDLLLGRWGNYSTGDCFILASDYLNALVHLIEIGNGLVTFQ
                     LRGLEFRGTYCQQREVEAITEGVEEDEGFCCCEPGHIPHMLSFNAAFSQRWLAWEVIV
                     TKYILEGYSITDNSAASMLQVFDLRKVLTTYYVKGIIYYVTTSSKLEEWLANETMQEG
                     LRLCADRNYVDVDPTFNPNIDEDYDHRLAGISRESFCVIYLNWIEYCSSRRAKPVDVD
                     KDSSLVTLCYGLCVLGRRALGTASHHMSSNLESFLYGLHALFKGDFRISSIRDEWIFA
                     DMELLRKVVVPGIRMSIKLHQDHFTSPDEYDDPTVLYEAIVSHEKNLVIAHEGDPAWR
                     SAVLANSPSLLALRHVMDDGTNEYKIIMLNRRYLSFRVIKVNKECVRGLWAGQQQELV
                     FLRNRNPERGSIQNAKQALRNMINSSCDQPIGYPIFVSPLTTSYSDSHEQLKDILGGP
                     ISLGNIRNFIVSTWHRLRKGCGAGCNSGGNIEDSDTGGGTSCTGNNATTANNPHSNVT
                     QGSIGNPGQGSGTGLHPPVTSYPPTLGTSHSSHSVQSGLVRQSPARASVASQSSYCYS
                     SRHSSLRMSTTGFVPCRRSSTSQISLRNLPSSIQSRLSMVNQMEPSGQSGLACVQHGL
                     PSSSSSSQSIPACKHHTLVGFLATEGGQSSATDAQPGNTLSPANNSHSRKAEVIYRVQ
                     IVDPSQILEGINLSKRKELQWPDEGIRLKAGRNSWKDWSPQEGMEGHVIHRWVPCSRD
                     PGTRSHIDKAVLLVQIDDKYVTVIETGVLELGAEV"
     exon            546..754
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            755..860
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            861..906
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            907..996
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            997..2703
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..2836
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            2837..3021
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            3022..3112
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            3113..3170
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            3171..3388
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            3389..3542
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            3543..3575
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            3576..3747
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            3748..3858
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            3859..3950
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            3951..4060
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            4061..4166
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            4167..4259
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            4260..4410
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            4411..4552
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            4553..4730
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            4731..4839
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            4840..4969
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            4970..5028
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            5029..5244
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            5245..5498
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            5499..5729
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            5730..5830
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            5831..5981
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            5982..6212
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            6213..6487
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            6488..6693
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            6694..7136
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            7137..7277
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     exon            7278..12865
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8468..8473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /note="hexamer: AGTAAA"
     polyA_site      8491
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /note="major polyA site"
     regulatory      10056..10061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /note="hexamer: AATAAA"
     polyA_site      10080
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /note="major polyA site"
     regulatory      12770..12775
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /note="hexamer: AATAAA"
     polyA_site      12795
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /note="major polyA site"
     regulatory      12844..12849
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /note="hexamer: AATAAA"
     polyA_site      12865
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /note="major polyA site"
ORIGIN      
        1 ctctttctct gcctggccca gggctggcgg ccggcggggg tcgcggcggc ggcagtgggg
       61 gcgctggcgg gccgcgggtg gcgggggccg ggccgcggct ccgggtgtta ggagacaaga
      121 tggcggcggc tctcagaagg ccggtctcct cctctccgcc gtcctccgcc ccgccgctcg
      181 ccgcctcctc ctctcgggtc tcctcctcct cgtttgctgc ctcctcctcc tcctgcagca
      241 gcaccagcga ccgccgaagc gccggctcgc tcacccggag ctccggaggt ggatagacgg
      301 ggcagctgca ggctccggcg accgaggccg agctggggcc ggggcgggga cggcggcggc
      361 ggcggcggcg acggcggcgg cgccgggtgg ggatggggtc gcagacgctg cagatcctcc
      421 gacagggggt gtgggccgcg ctcagcgggg gctggtacta cgacccgcac caggccacct
      481 tcgtgaacgc gctgcacctc tacctgtggc tctttctgct gggcctgccc ttcaccctct
      541 acatggccct tccttctacc atgattatag tagcagttta ttgtcctgtg atagctgctg
      601 ttttcattgt tctgaagatg gtcaactatc gactacacag agcacttgat gctggagaag
      661 ttgtagatag gactgcaaat gagttcacgg atcagcgaac caaagctgaa caaggcaact
      721 gttcaaccag gagaaaagac agcaatggac cgagtgatcc tggtggaggg attgaaatgt
      781 ctgagttcat ccgagaggcc acacccccag ttggttgcag ttccagaaat tcttatgccg
      841 gtctagatcc aagcaaccag attggatctg gttcctcgcg tcttggaaca gcagcaacta
      901 ttaaaggaga tacagacact gctaagactt ctgatgatat cagtttaagt ctgggccaaa
      961 gttctagtct ttgtaaggaa ggaagtgaag aacaagattt ggcagctgat cggaagctct
     1021 ttcgtcttgt ctccaatgac tccttcatct ctattcagcc ttccttatcc tcttgtggac
     1081 aggacttgcc aagggacttc agtgacaaag tgaacctgcc aagtcataac caccaccacc
     1141 atgttgatca gtctctgtcc agcgcctgtg acacagaagt agcttctctt gtacctttac
     1201 actcacactc ttatagaaaa gaccaccggc cgcgaggtgt accacggact tctagctctg
     1261 ctgtggcttt tccagacact tcactgaatg attttcccct ttatcagcaa agacgtggat
     1321 tagatccagt tagtgagtta gaatcttcca agcctctttc tggatccaaa gaatccttgg
     1381 tggaaaattc tggtttatct ggggaatttc agcttgctgg tgacttgaaa atcaatactt
     1441 ctcagccacc cacaaaaagt gggaagagca aacctttgaa agcagagaaa agcatggaca
     1501 gcttgaggag cctgagcaca cggagtagtg ggtcaacaga aagctactgc agtggaacgg
     1561 accgggacac taacagtact gtcagcagct ataaaagtga gcagaccagc tcaactcaca
     1621 tagagagcat cctgtcagag catgaggagt ctcctaaagc aggaacaaaa agtgggagga
     1681 agaaagagtg ctgtgcaggc ccagaggaga agaatagctg tgccagtgac aaaaggacta
     1741 gcagtgaaaa gattgctatg gaagcgagta ccaacagtgg ggttcacgag gccaaggacc
     1801 ccaccccctc tgatgagatg cacaaccaga gaggtctcag cacctctgca tctgaagaag
     1861 ccaataaaaa tccccatgca aatgaattta cttcccaagg ggacagacca cctgggaaca
     1921 ctgcagaaaa caaagaagag aagagtgata agtcagctgt ttctgtggat tccaaagtgc
     1981 gtaaagatgt tggtggaaag caaaaggaag gggatgttcg acctaaatct tctagcgtaa
     2041 tccatcggac agcttctgcc cacaagtcag gcaggagacg cacaggaaaa aaacgggcta
     2101 gcagttttga ttcaagccgg catagggact atgtttgctt tcgaggtgtt tctggtacca
     2161 agccacacag tgctatattt tgtcatgacg aagactctag tgatcagagt gacttgagta
     2221 gagcatcaag tgttcagtct gctcaccagt tcagcagtga tagctcttct agcaccactt
     2281 ctcattcctg tcagtctcct gagggcagat acagtgctct aaagaccaaa cacactcata
     2341 aagaaagggg cacagactct gaacacacac acaaagctca tttggttcct gaaggaacca
     2401 gcaaaaagcg tgcaacacga cggacttcta gcacaaatag tgccaagact cgtgcccgag
     2461 tgttgagcct ggacagtggc acagtagcat gtttgaatga ctcaaacagg ttaatggcac
     2521 ctgaaagtat aaagccctta accacttcaa aatcagatct tgaggccaaa gagggagagg
     2581 tgctagatga gctatcttta ttaggacggg cttcccagtt agagacagtc actcgatcta
     2641 ggaatagctt gccaaaccag gttgcatttc ctgaagggga agagcaagat gcagtcagtg
     2701 gagcagcaca agccagcgag gaggcagtgt catttcgccg tgaacgcagc acatttaggc
     2761 gccaggcagt acggcgccgg cacaatgcag ggagtaaccc tacccctcct acattgctca
     2821 tcggatcacc cctaagcctt caagatggtc agcaaggcca gcagtccaca gcccaggtca
     2881 aagtccagtc ccgcccccct tcccaggctg cagtgctcag tgctagtgcc tccttgctgg
     2941 tgagaaatgg gagtgtccac ttagaagcat cacatgacaa tgcatctgct gtaggcggta
     3001 gcagtttgca cgatgaactt ggtaagttct cttctacgct gtatgagact ggtggctgtg
     3061 atatgtcact tgtgaatttt gaaccagcag caagaagagc atccaatatc tgtgacacag
     3121 attctcatgt atccagttct acctcagttc gattttatcc acatgatgtg ctctctctcc
     3181 cacagattcg attgaataga ctattgacca ttgatacaga tttgttggag caacaggaca
     3241 ttgatctaag ccctgacttg gcagctactt acggcccaac agaagaagct gcccaaaagg
     3301 ttaaacacta ttatcgcttt tggatcctac cccagctgtg gattggcatt aactttgaca
     3361 gactcacact tttggccctg tttgatagaa atcgtgagat cctggaaaat gtgttagctg
     3421 tcatcctggc tattctcgtg gcctttttgg gatctattct tctcatacaa ggattcttca
     3481 gagatatctg ggtcttccag ttctgcctcg tcatagccag ctgtcaatac tcactgctta
     3541 agagtgttca accagattct tcttctccca gacatggtca taatcgtatc attgcctaca
     3601 gtagaccagt ttatttctgc atatgttgcg gtcttatttg gctcttggat tatggtagca
     3661 gaaacctgac tgcaaccaag ttcaaattat atggaataac tttcaccaat ccactggtgt
     3721 ttatatcagc cagggattta gttatagtgt ttacactctg tttcccaata gtgtttttca
     3781 ttggtctcct gcctcaggtg aatacatttg taatgtacct ttgtgaacaa ttggatattc
     3841 atatttttgg tggtaatgcc actacaagcc tgcttgcagc actttacagt tttatctgta
     3901 gcattgttgc agtagcctta ttgtatggat tatgttatgg ggctttaaag gattcttggg
     3961 atggccagca tattccagta cttttctcca ttttttgtgg tttattagtg gcagtgtctt
     4021 accatctcag ccgacaaagc agtgatccat ctgtactttt ctctttagtg caatccaaga
     4081 tttttccaaa aacggaagag aaaaatccag aagaccctct atctgaagta aaagatccac
     4141 tgcctgaaaa acttagaaat tctgttagtg agcgattaca gtctgacctg gtagtatgca
     4201 ttgtaattgg tgtgctgtat tttgctattc atgtaagcac agtcttcaca gtattgcagc
     4261 ctgccctcaa gtatgtgttg tatacattgg ttggctttgt gggttttgta acccattatg
     4321 tgctgcctca agttagaaaa cagctaccat ggcactgttt ctctcatcct ctgctaaaga
     4381 cactagagta taatcagtat gaagttcgaa atgcagccac tatgatgtgg tttgagaaac
     4441 ttcatgtgtg gcttcttttt gtggagaaga atataatcta tccattgatt gttctcaatg
     4501 aactgagcag cagtgcagag acaattgcta gtccaaagaa actgaataca gaattaggtg
     4561 ctttaatgat cactgttgct ggtttgaagt tgctacgatc ctcttttagc agccctacat
     4621 atcagtatgt tacagtcatc tttactgtgc tgtttttcaa atttgactat gaagcttttt
     4681 cagagaccat gctgttggat ctcttcttta tgtccatact cttcaacaag ctttgggaac
     4741 tactttataa attgcagttt gtgtatacct atattgcccc atggcagatc acatggggtt
     4801 ctgctttcca tgcttttgct cagccttttg cagtgcctca ttcagccatg ctgtttattc
     4861 aggctgctgt ctcggccttc ttctctactc cactgaaccc ctttctggga agtgcaatat
     4921 tcatcacttc atatgtccga cctgtgaaat tctgggagag agactataac acaaaacgag
     4981 tggatcattc aaataccaga ttggcttccc agcttgatag aaatccagga tcagatgaca
     5041 acaatctgaa ttccatcttt tatgagcatt taactagatc cctacagcac agcctctgtg
     5101 gtgatttgct actaggacgg tggggaaact acagtacagg ggactgtttc atccttgcct
     5161 ctgactatct caatgcatta gtacacctta tagagatagg caatggtctg gtcacttttc
     5221 agctgcgggg acttgaattc agaggtacct actgtcaaca acgggaagtg gaggccatta
     5281 ctgaaggtgt agaggaagat gaaggatttt gctgttgtga acctggccat attcctcaca
     5341 tgctttcatt taatgctgca tttagccagc gatggctagc ttgggaagtg atagtcacaa
     5401 agtacattct ggagggttat agcatcactg ataacagtgc tgcttctatg cttcaagtct
     5461 ttgatcttcg gaaagtactc accacttact atgtcaaggg tatcatttat tatgttacga
     5521 cctcgtctaa gctagaggag tggctagcta atgagacaat gcaggaagga cttcgtctgt
     5581 gtgctgatcg caattatgtc gatgtggacc cgacctttaa tccaaacatt gatgaagact
     5641 atgaccaccg actggcaggc atatctaggg agagtttctg tgtgatttac ctcaactgga
     5701 tagagtactg ctcttcccga agagcaaagc ctgtggatgt ggacaaagat tcatccctag
     5761 tgactctctg ttatggactc tgtgttctgg gacggagagc tttggggact gcatcccatc
     5821 atatgtccag taatttagag tcattcctct atggattgca tgccctattt aaaggagatt
     5881 tccgtatttc ttcaattcga gatgaatgga tctttgctga catggaattg ctaagaaaag
     5941 tagtagtccc tgggatccgt atgtccatta aacttcatca ggatcatttt acttctccag
     6001 atgaatatga tgaccctact gtgctctatg aagccatagt atctcatgag aagaacctcg
     6061 taatagccca tgaaggggac cctgcatggc ggagtgcagt acttgccaac tctccctcct
     6121 tgcttgctct gcggcatgtc atggatgatg gcaccaatga atataaaatc atcatgctca
     6181 acagacgcta cctgagcttc agggtcatta aagtgaataa ggaatgtgtc cgaggtcttt
     6241 gggcagggca acagcaggag cttgtttttc tacgtaaccg taacccagag agaggtagca
     6301 tccaaaatgc aaagcaagcc ctgagaaaca tgataaactc atcttgtgat caacctattg
     6361 gctacccaat ctttgtctca cccctgacaa cttcttactc tgacagccac gaacagctta
     6421 aagacattct tgggggtcct atcagcttgg gaaatatcag gaacttcata gtgtcaacct
     6481 ggcacaggct taggaaaggt tgcggagctg gatgtaacag tggtggcaat attgaagatt
     6541 ctgatactgg aggtgggact tcctgcactg gtaacaatgc aacaactgcc aacaatcccc
     6601 acagcaacgt gacccaggga agcattggaa atcctgggca gggatcagga actggactcc
     6661 acccacctgt cacatcttat cctccaacac taggcactag ccacagctct cactctgtgc
     6721 agtcgggcct ggtcagacag tctcctgccc gggcctcagt agccagccag tcttcctact
     6781 gctatagcag ccggcattca tccctccgga tgtccaccac tgggtttgtg ccttgtcggc
     6841 gctcttctac tagtcagata tcgcttcgaa acttgccatc atccatccaa tcccgactgt
     6901 cgatggtgaa ccaaatggaa ccctcaggtc agagcggcct ggcctgtgtg cagcacggcc
     6961 tgccttcctc cagcagctcc agccaaagca tcccagcctg caaacatcac actctcgtgg
     7021 gctttcttgc gacagaggga ggtcagagca gtgccactga tgcacagcca ggcaacacct
     7081 taagtcctgc caacaattca cactccagaa aggcagaagt gatttacaga gtccaaattg
     7141 tggatcccag tcaaattctg gaagggatca acctgtctaa aaggaaagag ctacagtggc
     7201 ctgatgaagg aatccggtta aaagctggga gaaatagctg gaaagactgg agtccgcagg
     7261 agggcatgga aggccatgtg attcaccgat gggtgccttg cagcagagat ccaggtacca
     7321 gatcccacat cgacaaggca gtgcttctgg tccagattga tgataaatat gtgactgtaa
     7381 ttgaaactgg ggtactagaa cttggggctg aagtgtgagc cagtgtttat tataaagaca
     7441 tttctttttc cctctcaatt ccaaggcatt ggaaaaagag aggaacaagc agaagatgcc
     7501 tgcaggtatc actttgatcc tatgtgggag cgactgaaaa tagaatgagc ttggttaagc
     7561 acctctcctt tgcccttcac cctgactcct gtcactgtct ccatccccaa ataaagctga
     7621 aatatttttt taagttagct gccgagaaaa cattttgcat gaaggataaa gttctgttaa
     7681 aatacatcct taaaaaaagt ttttcctatg cattgcctat gctttaaatc aacaaactct
     7741 tcatttctaa actatgatct catatttttc taatttcttt gccaaaaata attgccatgt
     7801 tttgtcatag aacatgaaat tcatttacct tgatttttaa gaacagacca gtgtagaaat
     7861 gttccttttg acttatagca gtataaaagt ttaatgtaca gtgaaagaga ctatgaacag
     7921 acatagattt atcttattcc ttgagcgcta aaaactttaa taaaaaaaac tgcactaatt
     7981 ttttacagca atgcactaaa gtctgagatt tctcagaaca tttatttata tataaaaata
     8041 aaataccatt atttaaattg cctttgggat tagccccttc cctttcctta taaacacagg
     8101 tagcaggaac tgtgctgctc atttttctgt tagtagtgtg tacttcatgc caggacattg
     8161 ggtattttct ttaaagtgaa tatagaatct caagatatac gtagcttcat cattgacatt
     8221 tcccagagcc aatagtcagc ggatcggtct tgtgaacacc actgccagct cctgtgtcta
     8281 catctcagag gagcccatgt gctctgcttc tctccaccag agcaagctct gctgggcgtg
     8341 cttctgggaa gaaaacaatt ttctttaaga agaagatgaa tgtccaggaa tttaaagaaa
     8401 ggatcgattg ccttttattt atgagtttct agctcttgaa gttattcaca tgcagttcag
     8461 ttagtcaagt aaaatttttt ttcaaataaa agtatccaag tggtgcagtt attattatat
     8521 ccctctttaa taattttgct ttttattttt cccctcttct ttttctgtta cttgaatttt
     8581 atttcctgta atttatagtg tgtagctgta aattgaaata tttataactg tgaaattgac
     8641 ttaattcata tgttgtctca taactttatt ttttttaaat gcatattcag ggaaatatat
     8701 tactcatatt tacaattggg cgatatagga acttcaattt agatttaatt tgcaactctt
     8761 agcatttttt aaatccttga taaaattttc ccttttggtg tgaaactcca aagaaaattg
     8821 tacatctcct ctgagcattt aggagcagcc atctttctac cccttgtgaa taaatcattg
     8881 aaagaaacag gtaaaattaa ttttaatgat acattttgtt tcacccagta tagtcaaagt
     8941 attactattt catcatatgt cactagccat atttcaagta ctcaatagct acatgtacct
     9001 agtggctact gtattagaca gtacagattt aaagtatctt ttgttgaggt gacagaagag
     9061 agaagctgtt tttcctacca attctgatgt agatctcaca ttatagcata acattacagt
     9121 agaaggaatg aaaactaaga aagtaaatag tgaacataca gaacttactg catttccact
     9181 ttaaaaccta tttattttcc ctttttctaa ttttaaactt ttgtggtcat tcagaaccta
     9241 atgtgccttg tgttgacatt tccatagact tcacacttta caaaatttac tgtttaaaaa
     9301 tacttgtcaa atgatttact gaacctttat acaaaagtac cctttctaaa ttgaccattt
     9361 aaaaatgtat ttttgtgata ccgtcattat gttctgcatt tgcctcattt tggcagatct
     9421 acagtatgcc attaaagttt agtgttgttt ttggttttgg agggtttttt tctgaaactg
     9481 aatttataat ctatttctct gtatacgtat atttttaaaa tcttctgaaa ggaactatgt
     9541 tccctgctgc ttcttccctt tctgaagtga atatgatctt ttcatggtca ttgcctagat
     9601 aaaagtagag ccttttcaat cttagatgga agataattca ttttcccaca cagaaaaaaa
     9661 atctgacctt tacatgattt aatctgaagg gctagaattt tttaatttct agcccctcct
     9721 ccaaaaaaat tttaaacaca tcacatactc tgaaaagtca gatttcaaat gcaagactag
     9781 actttatatg gaacatatat gttgggtttt gattttgggt agcaattgac atatattttt
     9841 ctcaaaacaa gttgaatttt gttaacatat ataattcttt agtgaattta taaattagga
     9901 accctgagaa gaagccctgt tgtttttctt aagagtctaa aactgacaat cttttaaaaa
     9961 tcataatact tttctagtaa ttgcatcagg gaattggtga taattgaaga aagatccatt
    10021 tcttaagaat aatttgatct aaattattat atggaaataa acatacttgt gttaactaaa
    10081 ttgatcataa attcttgttc ctgcctcacc cctcaccccc cagagaatag tgagtgactc
    10141 gtttagattc tctgcttttt ttcagttatg tacaagactt cagcatacat taatgtcttt
    10201 agtttataaa tttgccaatg ctttaatttc cataatttga aagttaaaag atgtaactaa
    10261 aatactagct tttttattca tttccttttg gtggagttgt atgattgaaa actttgcttt
    10321 ttcttgttta attcttccgc caccccctct tttgagagaa aggtaatcgt ggaatgagtt
    10381 ataaattatt gccttttttt cctttatttc tttcattcag tggcaaaaaa cattttataa
    10441 ctcctaagtt tttggttaat cttccaactt ataccttggt gtgaactctc tttttacacc
    10501 attttcaaca ctggataaaa ctttaatgtt gactttttgc taaagaactt taatttttcc
    10561 aagaatctag attaacataa gatgttgata tttaaggaac ttggaagagt aagtggtgag
    10621 gctgtatgta tattttttaa gagattacct tttaggaaat tagtgaacaa acttaaccag
    10681 tgttctgcct tctttgactt tgttactgga ggatgataat ctatttctat tagattcgaa
    10741 gtattttgga aaatatttca agtatatctg aactacttat aattcttaaa acagaagtag
    10801 tcagacaata tttgtatcct aagtgagata tggaaaatta ctctgtatac taaatgtcag
    10861 gcaatgaaaa tgtaagtttt tgtgtagaaa acccattaag aagatgtgtt tttctttctg
    10921 aattagttta tttttccatc acataccaaa atataaaaat cagcctcaca tttttcagca
    10981 agtttagctt atagccttga taaattcctc tgtgcttctg agcagcatcc ttctgcctct
    11041 gcttagcagc tctgcatttg gtggattgct gttgtgagtc attcatccag cactgggcct
    11101 tttaagctga agattcaccc agtgtctaaa gttgtccttt tcttatagct agctttcaag
    11161 catctttcct cctaaataaa tatgtgactt gagaaaaagg taataatgat tttgtcagaa
    11221 ttctttgaat ttatatttac tagctactta accataaact gctgtccaga ttgttaattt
    11281 catttatatt tattttaatt aatttgtcat gaatatggac aaagcctttt ctggggtgtg
    11341 tgtgtgtgtg tatgtttgtt ttttaagtcg tcattattca ttcgtattct ttttctgtgt
    11401 aatgtaatca tataaagtta ctttggacag agacccagtt aattttctct tttgatagga
    11461 tacatggttt agataaggta taaagtgtcc ctttttattc tagaggcttt tcctttaatt
    11521 cagagattag tggagataat aacgtcagtc aaggctaatg tggtacatgg aacttgctaa
    11581 tggaggttgg acattctgtt tcagtcttac atggatattg tttcattggt gttgaggaag
    11641 aaaaaaatta gatactacca tgcattggga cagcataatt ctaatattac attgaatatg
    11701 gctttttaaa aataagtatt aaaaagccaa tcgttttctc catttatcta tcttttttgt
    11761 ttgtttttaa tttggttgat tgatatgcac ccaggccgtc ttatttttac ttgttaaatg
    11821 tctgtctagg aagaactgtg attggaaagg aattaattat tatacaaata aatctggtag
    11881 gatatgagtg gagtaagttt gcttgaaaca gaagtatatt ttctactttg aatcacctca
    11941 ccagagtcat ctgtcaagaa ttatgtataa caatttatct ttattgccta catacaacat
    12001 actttttctg aattaagata acttctattt gtgagttgaa cttcattatc tgccattttg
    12061 tggaatcaac cttacattct ttggtggaac tagagctgat tgtcaccaca aggttatatg
    12121 acaactctgt tctaagactt atacctatta tatagggtta tacctttttt cttatgcctc
    12181 agctctgtac ctgacaattt atgattcagt ggagccaagc tagaaggaac aaaggtcatc
    12241 taacactgtg atggggatga attcctgagt tttacctgca caatgaggtg gtgccccgga
    12301 attcacaaca gagtagtgat agagcataag atggctgctc cagatgactc ttgggtttag
    12361 tgtacttgtg attgaacaag attttttatc tatgaagctt gattctacaa ccaaaataat
    12421 agaaatgggg gggggggggg gaatcatgtc tgcttatgct ttttaaaagc ttatagttta
    12481 agtaaaagta aaatgtaaaa actgattaaa cctatacaag tctggcaatg agctctgcat
    12541 gaggaaatgg aaggaggaat attgaaaatg attctaggaa agtgaacgta agaaaggaaa
    12601 atgggttttc cttttctgat catgggctct ggaaagtatt catggccttt accagcattc
    12661 agtataaacc agagataagg acatatgtac ttacgtgtgt ctgtgagtgt gtgtgtgtct
    12721 gagtgttatt ctgaacagct tgtaaatatt gtagttgttt aaaatggaaa ataaaagctg
    12781 agttcttttg gcaaatatat tgcatcaaaa atacagtatt gacagtggat aaaacactga
    12841 ggaaataaat tttttttcat tttgc
//
